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Phosphatized rare star-like mouth disc of Punctatus and its functional morphology from the earliest Cambrian of the South Shaanxi China

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Frontiers in Biology 2008年第1期3卷 106-112页

作者： Yunhuan LIU Yong LI Tiequan SHAO Zhixin ZHU Wanqian ZHANG Zhuo WANG weixian yang Rongxi LI Earth Science Faculty Chang’an UniversityXi’an 710054China Chinese Academy of Geological Sciences Beijing100037China

The Meishucun stage is the prelude in decipher-ing the Cambrian *** this prominent stage,rapid radioactive evolution and body-plan innovation have taken place and different associations of organism have been *** this paper we report several 3D-preserved rare star-like fossils with finely preserved soft tissues which were recovered from the Kuanchuanpu Member of the Dengying Formation in South Shaanxi,China in *** studying on functional morphology and analogy with mouthpart of Punctatus,there are evidences that this star-like organism approaches the coelenterates in systematic classification and the centre of star-like organism is its *** appearance of coelenterates marks the real beginning of metazoan ***,it has the prominent position in the origin and evolutionary history of *** the star-like organism represents the early types of coelenterate with original *** new materials provide new evidence for the origin,evolution and the functional evolution of the metazoan during the early stage of the Cambrian Explosion.

关键词： rare star-like mouth disc Punctatus coelenterat functional morphology Kuanchuanpu Member of the Dengying Formation Ningqiang Shaanxi

Factors associated with dysglycemia and its post-surgical resolution in patients with pheochromocytomas

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Science China(Life Sciences) 2023年第2期66卷 411-414页

作者： Lin Zhao Xu Meng Qiongyu Zhang Yi Zhou Ting Zhang Tao Tian Hua Fan Huadong Zhu Yecheng Liu Fang Luo Linping Wang weixian yang Xianliang Zhou Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100037China Emergency Department State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Family Medicine&Division of General Internal Medicine Department of MedicineState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Urology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Dear Editor,Pheochromocytomas are rare neuroendocrine tumors originating from chromaffin cells in the adrenal medulla(Neumann et al., 2019). A number of case reports and small cohorts have reported the association between dysglycemia and pheochromocytomas(Elenkova et al., 2020;Khatiwada et al., 2020;Krumeich et al., 2021). However, there are few large sample studies reporting the outcomes of dysglycemia in patients with pheochromocytomas after resection.

关键词： patients cytoma

Study on the Action Mechanism of Euphorbia peplus in the Treatment of Alzheimer s Disease Based on UPLC-Q-TOF-MS/MS Combined with Network Pharmacology and Molecular Docking

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Agricultural Biotechnology 2023年第4期12卷 122-131页

作者： Liping ZHANG Weiqing ZHANG weixian yang Meihui DUAN Meiqi WEI People’s Hospital of Anshun City Guizhou Province Anshun 561000China

[Objectives]Based on UPLC-Q-TOF-MS/MS,network pharmacology and molecular docking techniques,the mechanism of Euphorbia peplus in the treatment of Alzheimer s disease(AD)was studied.[Methods]The UPLC-Q-TOF-MS/MS technique was used to rapidly analyze the chemical components of *** components and potential targets of *** were retrieved from TCMSP and Swiss Target Prediction database,and AD targets were screened using GeneCards *** targets of *** in the treatment of AD were *** PPI network was constructed using String platform,and the network topology of Cytoscape software was used to compute and screen key targets,and the GO and KEGG pathway enrichment analysis was carried out in Metascape database to construct the"component-target-pathway-disease"*** docking was used to predict the binding properties of active ingredients and targets.[Results]The results of UPLC-Q-TOF-MS/MS showed that 83 compounds were identified from ***,including 19 terpenoids,10 phenolic acids and phenols,16 flavonoids,2 phenylpropanoids,4 coumarins,1 alkaloid,1 anthraquinone and 30 other *** results of network pharmacological analysis showed that 82 active ingredients were screened,and 279 common targets were identified for the treatment of AD,among which the key targets were ALB(albumin),GAPDH(glyceraldehyde triphosphate dehydrogenase),TNF(tumor necrosis factor),AKT1(serine/threonine protein kinase 1),and IL6(interleukin-6).KEGG enrichment analysis showed that key signaling pathways include cancer pathways,lipid and atherosclerosis,Alzheimer s disease,insulin resistance,serotonergic synapses,calcium signaling pathway,cAMP signaling pathway and other signaling *** docking results showed that 14-deoxyandrographolide,dehydroandrographolide,licochalcone B,apigenin and naringenin may be the key components of *** in the treatment of AD.[Conclusions]The results suggest that *** can be used to treat Alzheimer s

关键词： Euphorbia peplus Alzheimer s disease Network pharmacology Molecular docking

Study on the Action Mechanism of Isodon suzhouensis Stems in the Treatment of Prostate Cancer Based on UPLC-Q-TOF-MS/MS Combined with Network Pharmacology and Molecular Docking

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Agricultural Biotechnology 2023年第5期12卷 91-97页

作者： Peigui LIU Weiqing ZHANG Xianji LIU Meihui DUAN weixian yang Meiqi WEI People's Hospital of Anshun City Anshun 561000China

[Objectives]This study was conducted to explore the action mechanism of chemical components from stems of Isodon suzhouensis on prostate cancer based on UPLC-Q-TOF-MS/MS technique,network pharmacology,and molecular docking validation.[Methods]UPLC-Q-TOF-MS/MS was applied to search active components in stems of ***,and SwissTargetPrediction and PharmaMapper databases were used to predict their potential *** GeneCards database was adopted to screen the targets of prostate cancer,and the targets of the active components and the targets of prostate cancer were intersected to obtain common targets.A protein-protein interaction network was constructed,and also,an"active component-target-disease-pathway"network was constructed using Metascape for gene ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment ***,AutoDock was adopted to perform molecular docking verification on key active components and core targets.[Results]Sixty three active components were screened from stems of ***,and they had 233 common targets with prostate cancer,mainly involving biological processes such as protein phosphorylation,response to hormones,active regulation of cell movement,cell response to lipids,and response to oxidative stress,as well as pathways in cancer,prostate cancer,micro ribonucleic acids in cancer,p53 signaling pathway,NF-κB signaling pathway and other signaling pathways,exerting anti-tumor *** docking showed that the top 5 key active components had good binding ability with the top 5 core targets.[Conclusions]Active components from stems of *** can exert therapeutic effects on prostate cancer through multiple targets and pathways.

关键词： Stem of Isodon suzhouensis UPLC-Q-TOF-MS/MS Network pharmacology Molecular docking Prostatic cancer

围绝经期女性代谢异常与心血管疾病风险的研究进展

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中国循环杂志 2023年第7期38卷 771-775页

作者：孟旭杨伟宪中国医学科学院、北京协和医学院国家心血管病中心、阜外医院心内科北京100037

围绝经期指从出现绝经趋势的迹象开始,持续到末次月经后1年。除激素水平改变外,围绝经期可伴随多种代谢异常,主要表现为代谢综合征患病率升高、脂质代谢紊乱、体重和体脂增加、血压水平升高、胰岛素抵抗与2型糖尿病风险升高。其中脂质... 详细信息

围绝经期指从出现绝经趋势的迹象开始,持续到末次月经后1年。除激素水平改变外,围绝经期可伴随多种代谢异常,主要表现为代谢综合征患病率升高、脂质代谢紊乱、体重和体脂增加、血压水平升高、胰岛素抵抗与2型糖尿病风险升高。其中脂质代谢紊乱主要包括总胆固醇(TC)、低密度脂蛋白胆固醇、甘油三酯水平升高,TC与高密度脂蛋白胆固醇(HDL-C)的比值升高,其中TC/HDL-C比值具有良好的心血管疾病风险预测价值。围绝经期代谢紊乱的发生与性激素水平的改变及其继发的一系列病理生理改变相关,可带来更高的心血管疾病风险。相关机制的探讨有助于为临床提供潜在的干预靶点。

关键词：女性围绝经期代谢异常心血管疾病

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梨树氮肥总量控制试验效果分析

农业技术与装备 2016年第7期 10-11,14页

作者：杨卫仙山西省吕梁市交城县农业委员会山西交城030500

通过田间试验,研究了氮肥总量控制对梨树产量和效益的影响。结果表明,梨树氮肥不同施用量能明显改善植株的产量性状,提高梨树的产量和效益,增产幅度为4.32%~11.24%,增加纯收入136.4~355.3元/0.067 hm^2;氮肥不同用量产量达极显著水平;... 详细信息

通过田间试验,研究了氮肥总量控制对梨树产量和效益的影响。结果表明,梨树氮肥不同施用量能明显改善植株的产量性状,提高梨树的产量和效益,增产幅度为4.32%~11.24%,增加纯收入136.4~355.3元/0.067 hm^2;氮肥不同用量产量达极显著水平;氮肥总量控制,以每0.067 hm^2施39-6-12增产效果最佳。

关键词：梨树氮肥总量控制产量效益

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交城县东坡底乡中低产田改造效果分析

农业技术与装备 2019年第4期 44-45页

作者：杨卫仙交城县农业委员会山西交城030500

基本农田建设是土地整治规划的重要组成部分,在国家高度重视基本农田建设的大背景下,文章对交城县东坡底乡燕家庄等村基本农田土地整治项目实施情况进行了总结。文章就该项目实施后产生的经济、社会及生态效益进行了分析。

关键词：基本农田建设中低产田改造措施效益

醒脑开郁针结合耳穴压豆治疗中风后抑郁24例

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光明中医 2018年第10期33卷 1448-1449页

作者：杨伟先偃师市中医院康复科河南偃师471900

目的探究醒脑开郁针结合耳穴压豆对中风后抑郁患者抑郁(HAMD)评分及生活质量的影响。方法选取2015年3月—2017年2月我院48例中风后抑郁患者,随机数字表法分为2组,各24例。对照组予以氟哌噻吨美利曲辛片,实验组予以醒脑开郁针+耳穴压豆,... 详细信息

目的探究醒脑开郁针结合耳穴压豆对中风后抑郁患者抑郁(HAMD)评分及生活质量的影响。方法选取2015年3月—2017年2月我院48例中风后抑郁患者,随机数字表法分为2组,各24例。对照组予以氟哌噻吨美利曲辛片,实验组予以醒脑开郁针+耳穴压豆,均治疗1个疗程。对比2组HAMD评分、生活质量(GQOL-74)。结果治疗后实验组GQOL-74评分高于对照组,HAMD评分低于对照组,差异有统计学意义(P<0.05)。结论醒脑开郁针结合耳穴压豆可降低中风后抑郁患者HAMD评分,提高生活质量。

关键词：郁证醒脑开郁针耳穴压豆中风后抑郁

流行性出血热胸部X线表现(附131例分析)

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实用放射学杂志 1992年第10期8卷 603-606页

作者：吴渭贤杨正汉浙江省衢州市人民医院放射科

本文报道EHF131例、其中胸部有异常X线改变67例、就其常见胸部X线改变和临床病理的关系及转归等进行探讨。最常见的X线改变为肺充血、间质性肺水肿、少量胸腔积液、其次为肺泡性肺水肿和心脏增大。

关键词：流行性出血热 X线诊断病理