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Chinese Chemical Letters 2024年第7期35卷 367-371页

作者： Luyu Zhang Zirong Dong Shuai Yu Guangyue Li weiwen kong Wenjuan Liu Haisheng He Yi Lu Wei Wu Jianping Qi Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China School of Pharmacy Shandong Academy of SciencesQilu University of TechnologyJi'nan 250353China College of Chemical Engineering North China University of Science and TechnologyTangshan 063210China

This research aims to develop a non-invasive strategy for small interfering RNA(siRNA)nasal delivery based on ionic liquids(ILs)and cationic lipid(2,3-dioleoyloxy-propyl)-trimethylammonium-chloride(DOTAP).Other than the classical role of penetration enhancer,ILs also acted as superior solvents to simultaneously load siRNA and DOTAP,forming siRNA-DOTAP-ILs(siRNA-DILs)*** nasal mucosa penetration,DOTAP and ILs components self-assembled into cationic lipid nanocomplexes to load siRNA for enhanced in situ *** siRNA-DILs demonstrated resistance against RNase,significant mucosa penetration,prolonged nasal retention,and satisfying gene-silencing efficacy at lower ***,DILs were also able to deliver KCa3.1-targeted siRNA effectively for the treatment of allergic rhinitis in rat model by nasal ***,DILs have great potentials to deliver biological macromolecules across nasal mucosa by in situ dynamic self-assembly.

关键词： Ionic liquids Cationic lipids Lipid nanoparticles siRNA Allergic rhinitis

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基于特征选择和流形学习的人脸年龄预测研究

数字通信世界 2024年第6期 64-65,68页

作者：孔维纹无锡旅游商贸高等职业技术学校江苏无锡214000

近年来,人类外观年龄估计在个人安全和执法等方面的广泛应用,已成为一个热门的研究课题,并引起了学术界和市场的广泛关注。为了实现年龄估计的目标,大量学者提出了相关方法,其中,借助累积属性编码导出的模型通过保留年龄的邻近相似性来... 详细信息

近年来,人类外观年龄估计在个人安全和执法等方面的广泛应用,已成为一个热门的研究课题,并引起了学术界和市场的广泛关注。为了实现年龄估计的目标,大量学者提出了相关方法,其中,借助累积属性编码导出的模型通过保留年龄的邻近相似性来达到良好的性能。然而,上述方法忽略了提取的面部特征的几何结构。事实上,数据的几何结构会极大地影响预测的准确性。为此,该文提出一种通过联合特征选择和流形学习范式的年龄估计算法,称为特征选择和保持几何的最小二乘回归。与其他方法相比,该方法不仅保留了面部表征中的几何结构,还选择了有区别性的特征。最后,在Morph2数据集上进行了相关实验,结果证明该方法达到了最佳性能。

关键词：人脸年龄预测累积属性编码特征选择流形学习

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Combining Trend-Based Loss with Neural Network for Air Quality Forecasting in Internet of Things

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Computer Modeling in Engineering & Sciences 2020年第11期125卷 849-863页

作者： weiwen kong BaoweiWang School of Computer and Software Nanjing University of Information Science and TechnologyNanjing210044China Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science and TechnologyNanjing210044China Engineering Research Center of Digital Forensics Ministry of EducationNanjing210044China

Internet of Things(IoT)is a network that connects things in a special *** embeds a physical entity through an intelligent perception system to obtain information about the component at any *** connects various *** has the ability of information transmission,information perception,and information *** air quality forecasting has always been an urgent problem,which affects people’s quality of life *** far,many air quality prediction algorithms have been proposed,which can be mainly classified into two *** is regression-based prediction,the other is deep learning-based ***-based prediction is aimed to make use of the classical regression algorithm and the various supervised meteorological characteristics to regress themeteorological *** learning methods usually use convolutional neural networks(CNN)or recurrent neural networks(RNN)to predict the meteorological *** an excellent feature extractor,CNN has achieved good performance in many *** the same way,as an efficient network for orderly data processing,RNN has also achieved good ***,few or none of the above methods can meet the current accuracy requirements on ***,there is no way to pay attention to the trend monitoring of air quality *** the sake of accurate results,this paper proposes a novel predicted-trend-based loss function(PTB),which is used to replace the loss function in *** the same time,the trend of change and the predicted value are constrained to obtain more accurate prediction results of PM_(2.5).In addition,this paper extends the model scenario to the prediction of the whole existing training data *** the data on the next day of the model is mixed labels,which effectively realizes the prediction of all *** experiments show that the loss function proposed in this paper is effective.

关键词： Air quality forecasting Internet of Things recurrent neural network predicted trend loss function

爆炸冲击波和爆生气体的动态作用演化机制的实验与数值分析

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煤炭学报 2024年第S1期49卷 248-260页

作者：王雁冰孔维文左进京李林青吴宝杨陶志刚国家能源集团煤炭开采水资源保护与利用国家重点实验室中国矿业大学(北京)力学与土木工程学院北京科技大学土木与资源工程学院

在岩石爆破过程中，爆炸冲击波和爆生气体的波动机理尚不清楚。通过高速纹影系统和超压测试系统并结合AUTODYN数值模拟分析，对爆炸冲击波和爆生气体的波动机理开展研究。设计了不同炸药类型和装药结构下的5种药包，通过纹影照片直观地... 详细信息

在岩石爆破过程中，爆炸冲击波和爆生气体的波动机理尚不清楚。通过高速纹影系统和超压测试系统并结合AUTODYN数值模拟分析，对爆炸冲击波和爆生气体的波动机理开展研究。设计了不同炸药类型和装药结构下的5种药包，通过纹影照片直观地显示爆生产物的动态作用演化过程。对比分析5种情况下爆炸冲击波和爆生气体在流场中的波动变化，将数值模拟结果与纹影实验结果进行对比并反演了炸药内部爆轰波动过程。结果表明：爆炸冲击波与爆生气体一开始伴随扩展，并以起爆点为中心向外以球形传播。在传播过程中，爆炸冲击波与爆生气体逐渐分离，爆炸冲击波传播速度大于爆生气体的传播速度。在不同的装药结构情况下，爆炸冲击波和爆生气体的分离特征不同，分离的时间随药包外壳约束作用的增强而缩短。在不同的炸药类型情况下，爆炸冲击波和爆生气体的波动形态基本相同，但因炸药材料本身物理力学参数不同，所以爆炸冲击波和爆生气体传播过程中的速度和压力变化会有差异。当存在切口时，爆炸冲击波和爆生气体会优先从切口处向外传播，然后向其他方向进行绕流，切口方向的压力和速度都会变大，切口方向能量集中且管壁优先破坏，达到定向破坏的效果。数值模拟中爆炸冲击波和爆生气体的波动变化形态与纹影实验结果在形态上较为吻合。

关键词：爆炸冲击波爆生气体高速纹影动态演化 AUTODYN

A Dual-Chaining Watermark Scheme for Data Integrity Protection in Internet of Things

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Computers, Materials & Continua 2019年第3期58卷 679-695页

作者： Baowei Wang weiwen kong Wei Li Neal NXiong Jiangsu Engineering Centre of Network Monitoring Jiangsu Collaborative Innovation Center on Atmospheric Environment and Equipment TechnologySchool of Computer and SoftwareNanjing University of Information Science&TechnologyNanjing210044China Engineering Research Center of Electronic Information and Control from Fujian Provincial Education Department Fuzhou350108China Department of Mathematics and Computer Science Northeastern State UniversityOklahomaUSA.

Chaining watermark is an effective way to verify the integrity of streaming data in wireless network environment,especially in resource-constrained sensor networks,such as the perception layer of Internet of Things ***,in all existing single chaining watermark schemes,how to ensure the synchronization between the data sender and the receiver is still an unsolved *** the synchronization points are attacked by the adversary,existing data integrity authentication schemes are difficult to work properly,and the false negative rate might be up to 50 *** the additional fixed group delimiters not only increase the data size,but are also easily detected by *** this paper,we propose an effective dual-chaining watermark scheme,called DCW,for data integrity protection in smart campus IoT *** proposed DCW scheme has the following three characteristics:(1)In order to authenticate the integrity of the data,fragile watermarks are generated and embedded into the data in a chaining way using dynamic grouping;(2)Instead of additional fixed group delimiters,chained watermark delimiters are proposed to synchronize the both transmission sides in case of the synchronization points are tampered;(3)To achieve lossless integrity authentication,a reversible watermarking technique is *** experimental results and security analysis can prove that the proposed DCW scheme is able to effectively authenticate the integrity of the data with free distortion at low cost in our smart meteorological Internet of Things system.

关键词： Dual-chaining reversible watermark integrity authentication Internet of things.

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植物Metacaspase研究进展

植物学报 2012年第5期47卷 543-549页

作者：马聪孔维文扬州大学园艺与植物保护学院植物病理实验室扬州225009

过敏性坏死反应是植物的一种重要的抗病机制,类似于动物细胞凋亡,它是一种程序性细胞死亡(programmed cell death,PCD)过程。目前,已经确定半胱天冬蛋白酶(caspase)在动物PCD过程中起核心作用。在植物中,尚未发现其直系同源蛋白,但是有... 详细信息

过敏性坏死反应是植物的一种重要的抗病机制,类似于动物细胞凋亡,它是一种程序性细胞死亡(programmed cell death,PCD)过程。目前,已经确定半胱天冬蛋白酶(caspase)在动物PCD过程中起核心作用。在植物中,尚未发现其直系同源蛋白,但是有一类与其结构相似的蛋白酶,称为metacaspase。在植物不同的PCD过程中,有的依赖于metacaspase,而有的则不依赖于该类蛋白酶。目前对metacaspase的结构和功能已有了初步的研究,对其深入的研究则进展缓慢,其具体的生物学功能和在PCD信号路径中的定位有待进一步探索。

关键词：半胱天冬蛋白酶 metacaspase 程序性细胞死亡

Conformation and Counterion Distribution of Polyelectrolyte in Solution as Viewed from Dielectric Approach

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Chinese Journal of Polymer Science 2024年第9期42卷 1278-1301,I0005页

作者： kong-Shuang Zhao College of Chemistry Beijing Normal UniversityBeijing 100875China

Polyelectrolyte solutions are more variable than uncharged macromolecule due to electrical interaction between charged molecules and surrounding ***,the subject of polyelectrolyte solutions has attracted a wide range of interests in both basic and applied research,and has also been extensively ***,the understanding of the molecular dynamics and conformation of polyelectrolytes in solution remains to be deepened,and universal consensus on some key issues have not been *** methods have contributed to solving the above problems in different ways,including dielectric relaxation spectroscopy(DRS).In this perspective,we briefly reviewed the history of dielectric spectroscopic research on polyelectrolyte solution,with emphasis on summarizing our *** particular,we expound the characteristics of DRS and its ability to obtain the internal information of the system of ***,we evaluate the advantages and limitations of the dielectric method and discussed future prospects of this field.

关键词： Polyelectrolyte Dielectric relaxation spectroscopy Chain conformation Thermosensitive microgel PNIPAM microgel Spherical polyelectrolyte brushes

Flat jet electrochemical milling of TC4 alloy with tailoring backward parallel flow

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Chinese Journal of Aeronautics 2024年第4期37卷 574-592页

作者： Huanghai kong Ningsong QU College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In flat jet electrochemical milling, the electrolyte forms a backward parallel flow after impacting the workpiece, resulting in a weak current density distribution on the workpiece. Poor surface quality usually occurs on the machined titanium alloy surface because it inevitably suffers from the weak current density. In this study, a method of flat jet electrochemical milling with tailoring the backward parallel flow was proposed to eliminate the negative effects caused by the weak current density. Multiphysics simulations are carried out to comprehend the mechanism of flat jetEC milling with tailoring backward parallel flow and better construct the novel tool *** on flat jet electrochemical milling of TC4 alloy with and without tailoring backward parallel flow are conducted. The results reveal that, compared with flat jet electrochemical milling without tailoring backward parallel flow, the recommended tool reduces the surface roughness by86% to 93%, and improves the material removal rate by 93% to 163% with different feed ***, the recommended tool is more conducive to maintaining the inherent hardness of the material. Finally, a surface with low Sa of 0.37 μm is obtained.

关键词： Flat jet electrochemical milling TC4 alloy Surface roughness Micro-hardness Material removal rate

Soil inorganic amendments produce safe rice by reducing the transfer of Cd and increasing key amino acids in brown rice

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Journal of Environmental Sciences 2024年第2期136卷 121-132页

作者： Fanyi kong Shenggao Lu Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment Key Laboratory of Environmental Remediation and Ecosystem HealthMinistry of EducationCollege of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China

The digestibility of cadmium(Cd)in brown rice is directly related to amino acid metabolism in rice and human *** our field study,three kinds of alkaline calcium-rich soil inorganic amendments(SIAs)at three dosages were applied to produce safe rice and improve the quality of rice in Cd-contaminated *** the increased application of SIA,Cd content in iron plaque on rice root significantly increased,the transfer of Cd from rice root to grain significantly decreased,and then Cd content in brown rice decreased *** vitro digestibility of Cd in brown rice was estimated by a physiologically based extraction *** showed that more than 70%of Cd in brown rice could be digested by simulated gastrointestinal *** on the total and digestible Cd contents in brown rice to evaluate the health risk,the application of 2.25 ton SIA/ha could produce safe rice in acidic slightly Cd-contaminated paddy *** amino acids(AAs)in brown rice were determined by high-performance liquid *** contents of 5 key AAs(KAAs)that actively respond to environmental changes increased significantly with the increased application of *** structural equation model indicated that KAAs could be affected by the Cd translocation capacity from rice root to grain,and consequently altered the ratio of indigestible Cd in brown *** formation of indigestible KAAs-Cd complexes by combining KAAs(phenylalanine,leucine,histidine,glutamine,and asparagine)with Cd in brown rice could be considered a potential mechanism for reducing the digestibility of Cd.

关键词： Cadmium digestibility Soil inorganic amendments Safe rice Amino acid Priming effect Health risk

A New Species of the Genus Boulenophrys(Anura,Megophryidae)from Eastern Guangdong,China

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Asian Herpetological Research 2024年第1期15卷 12-21页

作者： Zhaochi ZENG Jian WANG Honghui CHEN weiwen XIAO Binbin ZHAN Yuanhang LI Shishi LIN Guangdong Polytechnic of Environmental Protection Engineering Foshan 528216GuangdongChina

A new horned toad species,Boulenophrys elongata ***.,is described from ***,Huidong County,eastern Guangdong,*** new species is phylogenetically closest to ***,which is restricted to the east of the Pearl River Estuary(i.e.,Shenzhen City and Hong kong SAR).The new species can be distinguished from all recognized congeners by a combination of morphological characters and genetic divergences in the combined mitochondrial 16S,12S and CO1 *** recommend the new species be listed as Data Deficient(DD)in the IUCN categorization,pending further investigation.

关键词： Boulenophrys elongata sp.nov. Lianhua Mountains molecular phylogeny morphology taxonomy