检索结果-南通市图书馆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

煤矿通风安全预警系统研究

能源与节能 2024年第3期 136-138页

作者：茹维维山西兰花集团东峰煤矿有限公司山西晋城048000

井下通风系统在整个煤矿通风系统中起着至关重要的作用。通风系统的应用可以保障井下空气流通,提供适合的温度、湿度等,从而为矿井工人提供一个良好的工作环境;通风系统还可以有效排出井下的有害气体及粉尘,从而避免安全事故的发生。良... 详细信息

井下通风系统在整个煤矿通风系统中起着至关重要的作用。通风系统的应用可以保障井下空气流通,提供适合的温度、湿度等,从而为矿井工人提供一个良好的工作环境;通风系统还可以有效排出井下的有害气体及粉尘,从而避免安全事故的发生。良好的煤矿通风安全预警系统可以对井下的实际情况进行监测,并做出相应的预警和发出警报。对煤矿通风安全预警系统所存在的问题及系统设计等做出了相应的分析与研究。

关键词：安全煤矿通风预警系统

在线全文

学校读者我要写书评

暂无评论

汉中市生态旅游气候资源特征分析

绿色科技 2024年第2期26卷 15-19页

作者：郑薇薇孟茹黄泽群汉中市气象局陕西汉中723000

气候资源合理开发利用是生态文明建设的重要组成部分。通过分析汉中市2015-2022年SO_(2)、NO_(2)、PM_(10)、PM_(2.5)质量浓度,空气质量指数(AQI),环境空气质量优良天数,大气空气质量综合指数以及市域内11个国家气象站气温、降水量、降... 详细信息

气候资源合理开发利用是生态文明建设的重要组成部分。通过分析汉中市2015-2022年SO_(2)、NO_(2)、PM_(10)、PM_(2.5)质量浓度,空气质量指数(AQI),环境空气质量优良天数,大气空气质量综合指数以及市域内11个国家气象站气温、降水量、降水日数、日照等气象观测资料,评估汉中市生态旅游气候资源特征,以期为合理规划和深度挖掘汉中市生态旅游气候资源提供科学依据。结果表明:2015-2022年汉中市主要大气污染物质量浓度整体呈逐年下降趋势;大气空气质量综合指数呈逐年下降趋势,2022年达到最低;2015-2022年环境空气质量优良天数均达到280 d以上,呈逐年明显增加趋势;大气空气质量指数月分布呈先减后增的变化趋势,1月份最高,达到中度污染级别,10月份最小,达优秀级别。2015-2022年汉中市年平均气温为14.5℃,极端最高气温为42.0℃,出现在8月份,极端最低气温为-15.6℃,出现在1月份;年均降水量为980.1 mm,降水主要集中在每年的6-10月份,年降水日数集中在每年的4-10月份,年均日照时数为1525.9 h,每年的2-8月份日照时数较多,均在100 h以上,峰值出现在7月份。

关键词：生态旅游空气质量气候汉中市

猪源E.coli HPI通过NLRP3/ASC/Caspase-1诱导巨噬细胞焦亡的机制

在线全文

学校读者我要写书评

暂无评论

中国兽医学报 2024年第3期44卷 450-457页

作者：沈珏邓静王浩肖金龙万全张博赵维薇赵汝肖鹏高洪云南农业大学动物医学学院云南昆明650201 云南农业大学食品科学技术学院云南昆明650201 云南农业大学动物科学技术学院云南昆明650201

为探讨猪源E.coli高致病性毒力岛(high pathogenicity island,HPI)对巨噬细胞焦亡的影响,以内毒素(LPS)联合三磷酸腺苷(ATP)建立焦亡阳性对照,使用E.coli WT株(E.coli HPI^(+))和前期构建的E.coli HPI敲除株(E.coliΔHPI)感染巨噬细胞,在感染后不同时间点收集细胞,运用PI染色观察细胞膜损伤情况;RT-qPCR测定NLRP3/ASC/Caspase-1焦亡通路中关键因子的mRNA水平;共聚焦观察NLRP3和Caspase-1的炎性复合体的组装;Western blot技术测定GSDMD和cleaved-GSDMD的表达。结果显示,与E.coliΔHPI组相比,E.coli HPI^(+)焦亡通路关键因子NLRP3、ASC、Caspase-1、GSDMD及炎症因子IL-18、IL-1β的mRNA水平均升高;NLRP3和Caspase-1蛋白的表达量升高,共聚焦观察到共定位;E.coli HPI^(+)组的GSDMD及其活性形式cleaved-GSDMD的表达水平高于E.coliΔHPI组。E.coli HPI感染巨噬细胞后,通过上调NLRP3/ASC/Caspase-1通路中关键因子mRNA的水平,诱导NLRP3和Caspase-1炎性复合体的组装,促进cleaved-GSDMD的表达,从而加剧细胞膜损伤,最终诱导巨噬细胞发生焦亡。

关键词：大肠杆菌高致病性毒力岛巨噬细胞细胞焦亡 NLRP3/ASC/Caspase-1通路

CeO_(2-x) modified ru/γ-Al_(2)O_(3) catalysts for ammonia decomposition reaction

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2023年第6期41卷 801-809,I0001页

作者： Qinglu Meng Haoxin Liu Kai Xu weiwei Wang Chunjiang Jia Key Laboratory for Colloid and Interface Chemistry Key Laboratory of Special Aggregated MaterialsSchool of Chemistry and Chemical EngineeringShandong UniversityJinan 250100China

Developing high-performance ammonia decomposition catalysts for preparing COx-free hydrogen shows great practical significance.Herein,CeO_(2) is used as a promoter to modulate the metal-support interaction to enhance the catalytic performance of ru/Al_(2)O_(3) catalysts.A series of 1ru/xCe-10AI(x=0.5,1,or 3)catalysts was prepared by a facile colloidal deposition method.We find that the optimized 1 ru/1Ce-10Al catalyst exhibits excellent activity for the decomposition of ammonia with a very high hydrogen yield of7097 mmolH2/(gru·min)at 450℃.It is confirmed that ru species are highly dispersed on the support surface as stable small clusters(~1.3 nm).More importantly,due to the interaction between ru species and partially reduced CeO_(2-x),the electron density of ru species is increased,which is beneficial to the high activity of the 1 ru/xCe-10Al catalysts.This work paves a way to construct high-efficiency ammonia decomposition catalysts modified by CeO_(2).

关键词： Ammonia decomposition ru clusters CeO_(2-x)promoter Metal-support interaction Rare earths

Benefit of rituximab maintenance is associated with Follicular Lymphoma International Prognostic Index in patients with follicular lymphoma

在线全文

学校读者我要写书评

暂无评论

Blood Science 2023年第2期5卷 118-124页

作者： ru Li Tingyu Wang rui Lyv Yi Wang Ying Yu Yuting Yan Qi Sun Wenjie Xiong Wei Liu weiwei Sui Wenyang Huang Huijun Wang Chengwen Li Jun Wang Dehui Zou Gang An Jianxiang Wang Lugui Qiu Shuhua Yi State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Tianjin Institutes of Health Science Tianjin 301600China.

Rituximab maintenance(RM)prolongs the progression-free survival(PFS)of responding patients with follicular lymphoma(FL),but the maintenance efficacy in different Follicular Lymphoma International Prognostic Index(FLIPI)risk group is still confusing.We performed a retrospective analysis of the effect of RM treatments in patients with FL responding to induction therapy based on their FLIPI risk assessment carried out prior to treatment.We identified 93 patients between 2013 and 2019 who received RM every 3 months for≥4 doses(RM group),and 60 patients who did not accept RM or received rituximab less than 4 doses(control group).After a median follow-up of 39 months,neither median overall survival(OS)nor PFS was reached for the entire population.The PFS was significantly prolonged in the RM group compared to the control group(median PFS NA vs 83.1 months,P=.00027).When the population was divided into the 3 FLIPI risk groups,the PFS differed significantly(4-year PFS rates,97.5%vs 88.8%vs 72.3%,P=.01)according to group.There was no significant difference in PFS for FLIPI low-risk patients with RM compared to the control group(4-year PFS rates,100%vs 93.8%,P=.23).However,the PFS of the RM group was significantly prolonged for FLIPI intermediate-risk(4-year PFS rates,100%vs 70.3%,P=.00077)and high-risk patients(4-year PFS rates,86.7%vs 57.1%,P=.023).These data suggest that standard RM significantly prolongs the PFS of patients assigned to intermediate-and high-risk FLIPI groups but not to low-risk FLIPI group,and pending larger-scale studies to validate.

关键词： Follicular lymphoma Follicular lymphoma international prognostic index Induction therapy Maintenance Progressionfree survival Rituximab

Activating interfacial S sites of MoS_(2) boosts hydrogen evolution electrocatalysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2022年第3期15卷 1809-1816页

作者： Shuo Geng Fenyang Tian Menggang Li Yequn Liu Jie Sheng weiwei Yang Yongsheng Yu Yanglong Hou Laboratory for Space Environment and Physical Science Research Center of Basic Space ScienceHarbin Institute of TechnologyHarbin 150001China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China Analytical Instrumentation Center State Key Laboratory of Coal ConversionInstitute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China Beijing Key Laboratory for Magnetoelectric Materials and Devices(BKL-MMD) Beijing Innovation Center for Engineering Science and Advanced Technology(BIC-ESAT)School of Materials Science and EngineeringPeking UniversityBeijing 100871China

The hydrogen evolution reaction(HER)of molybdenum disulfide(MoS_(2))is limited in alkaline and acid solution because the active sites are on the finite edge with extended basal plane remaining inert.Herein,we activated the interfacial S sites by coupling with ru nanoparticles on the inert basal plane of MoS_(2)nanosheets.The density functional theory(DFT)calculation and experimental results show that the interfacial S electronic structure was modulated.And the results of∆G H*demonstrate that the adsorption of H on the MoS_(2)was also optimized.With the advantage of interfacial S sites activation,the ru-MoS_(2)needs only overpotential of 110 and 98 mV to achieve 10 mA·cm^(–2)in both 0.5 M H_(2)SO_(4)and ^(1) M KOH solution,respectively.This strategy paves a new way for activating the basal plane of other transition metal sulfide electrocatalysts for improving the HER performance.

关键词： electronic structure interfacial S sites d-band center hydrogen evolution reaction

Mesoporous silica stabilized MOF nanoreactor for highly selective semi-hydrogenation of phenylacetylene via synergistic effect of Pd and ru single site

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2022年第3期15卷 1983-1992页

作者： Zhenxing Li Mingliang Hu Jiahao Liu weiwei Wang Yanjie Li Wenbin Fan Yixuan Gong Jiasai Yao Ping Wang Miao He Yongle Li State Key Laboratory of Heavy Oil Processing College of New Energy and MaterialsBeijing Key Laboratory of Biogas Upgrading UtilizationChina University of Petroleum(Beijing)Beijing 102249China Department of Physics International Center of Quantum and Molecular Structuresand Shanghai Key Laboratory of High Temperature SuperconductorsShanghai UniversityShanghai 200444China Division of Chemistry and Chemical Engineering California Institute of Technology1200 California Blvd.PasadenaCalifornia 91125USA

Selective semi-hydrogenation of phenylacetylene to styrene is a crucial step in the polystyrene industry.Although Pd-based catalysts are widely used in this reaction due to their excellent hydrogenation activity,the selectivity for styrene remains a great challenge.Herein,we designed a mesoporous silica stabilized Pd-ru@ZIF-8(MS Pd-ru@ZIF-8)nanoreactor with novel Pd and ru single site synergistic catalytical system for semi-hydrogenation of phenylacetylene.The nanoreactor exhibited a superior performance,achieving 98%conversion of phenylacetylene and 96%selectivity to styrene.Turnover frequency(TOF)of nanoreactor was up to as high as 2,188 h^(−1),which was 25 times and 5 times more than the single metal species catalysts,mesoporous silica stabilized Pd@ZIF-8 nanoreactor(MS Pd@ZIF-8),and mesoporous silica stabilized ru@ZIF-8 nanoreactor(MS ru@ZIF-8).This catalytic activity was attributed to the synergistic effect of Pd and ru single site anchored strongly into the framework of ZIF-8,which reduced the desorption energy of styrene and increased the hydrogenation energy barrier of styrene.Importantly,since the ordered mesoporous silica was introduced into the nanoreactor shell to stabilize ZIF-8,MS Pd-ru@ZIF-8 showed excellent reusability and stability.After the five cycles,the catalytical activity and selectivity still remained.This work provides insights for a synergistic catalytic system based on single-site active sites for selective hydrogenation reactions.

关键词： mesoporous silica metal–organic frameworks(MOF) semi-hydrogenation of phenylacetylene synergistic effect single site

Mannotriose regulates learning and memory signal transduction in the hippocampus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2013年第32期8卷 3020-3026页

作者： Lina Zhang weiwei Dai Xueli Zhang Zhangbin Gong Guoqin Jin Department of Biochemistry Institute of Basic MedicineShanghai University of Traditional Chinese Medicine

Rehmannia is a commonly used Chinese herb, which improves ieaming and memory. However, the crucial components of the signal transduction pathway associated with this effect remain elusive. Pri- mary hippocampal neurons were cultured in vitro, insulted with high-concentration （1 × 10-4 mol/L） cor- ticosterone, and treated with 1 × 104 mol/L mannotriose. Thiazolyl blue tetrazolium bromide assay and western blot analysis showed that hippocampal neuron survival rates and protein levels of glucocorti- cold receptor, serum and glucocorticoid-regulated protein kinase, and brain-derived neurotrophic factor were all dramatically decreased after high-concentration corticosterone-induced injury. This effect was reversed by mannotriose, to a similar level as ru38486 and donepezil. Our findings indicate that mannotriose could protect hippocampal neurons from high-concentration corticosterone-induced injury. The mechanism by which this occurred was associated with levels of glucocorticoid receptor protein, serum and glucocorticoid-regulated protein kinase, and brain-derived neurotrophic factor.

关键词： neural regeneration traditional Chinese medicine Rehmannia mannotriose corticosterone hippocampus neurons learning and memory grants-supported paper neuroregeneration

一例MAP2K1基因新发变异所致的心-面-皮肤综合征患儿的临床分析

在线全文

学校读者我要写书评

暂无评论

中华医学遗传学杂志 2022年第10期39卷 1129-1134页

作者：曹鸿垚童光磊黄茹周陶成张苇苇安徽省儿童医院合肥230000 欧蒙未一医学检验实验室杭州310013

目的探讨一例由MAP2K1基因变异引起的心-面-皮肤综合征(cardio-facio-cutaneous syndrome,CFCS)患儿基因型与表型的对应关系。方法收集疑似CFCS患儿及其父母的外周血样,提取基因组DNA,对患儿及父母采用全外显子组测序,最后用Sanger测序... 详细信息

目的探讨一例由MAP2K1基因变异引起的心-面-皮肤综合征(cardio-facio-cutaneous syndrome,CFCS)患儿基因型与表型的对应关系。方法收集疑似CFCS患儿及其父母的外周血样,提取基因组DNA,对患儿及父母采用全外显子组测序,最后用Sanger测序对可疑变异位点进行验证。结果患儿为男性,具有典型的CFCS面容以及发育迟滞。经全外显子组检测分析发现患儿的MAP2K1基因第3外显子上存在1个新发的杂合错义变异c.389A>G(p.Tyr130Cys),Sanger测序验证了该结果,根据最新美国医学遗传学与基因组学学会评级指南判定为疑似致病性变异。结论患儿临床未发现心脏结构、功能的异常以及癫痫发作,但具有典型面容及皮肤异常,伴有生长发育迟缓、智能障碍、泌尿系统结构异常。该病例丰富了MAP2K1基因变异导致的CFCS表型谱。

关键词：心-面-皮肤综合征全外显子组测序 MAP2K1基因新发变异