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地震作用下非等宽平台路堑边坡的动力响应研究

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自然灾害学报 2024年第2期33卷 122-131页

作者：王哲王陈宾柏威伟廖军吴福宝唐刚中铁第四勘察设计院集团有限公司湖北武汉430063 成都理工大学环境与土木工程学院四川成都610059

非等宽平台设计是提高碎裂岩体路堑高边坡动力稳定性的有效方法之一,在规范平台宽度不小于2 m背景下,研究该类型边坡的动力响应特征具有重要工程应用价值。通过FLAC3D有限元软件计算三级台阶式边坡平台位置的PGA放大系数、塑性变形区和... 详细信息

非等宽平台设计是提高碎裂岩体路堑高边坡动力稳定性的有效方法之一,在规范平台宽度不小于2 m背景下,研究该类型边坡的动力响应特征具有重要工程应用价值。通过FLAC3D有限元软件计算三级台阶式边坡平台位置的PGA放大系数、塑性变形区和最大剪应变,然后基于数值模拟结果设计大型振动台物理模拟试验开展非等宽台阶式边坡变形失稳特征和PGA放大系数变化研究,对二级平台宽度引起的边坡破坏程度进行分析,提出路堑边坡工程设计建议。数值模拟表明,随着中间平台宽度增加PGA放大系数先减后增,考虑平台的分割效应下建议该工程二级平台宽度为4 m;物理试验表明,边坡易在平台处产生应力集中,平台分割效应使边坡逐渐分解为局部破坏,地震作用下发生累进变形破坏,分为缓慢变形、加速变形和失稳破坏阶段。研究成果为该类型路堑边坡平台的设计提供了依据。

关键词：路堑边坡数值模拟振动台试验动力响应平台宽度地震

3种寄主挥发物中引起旋幽夜蛾嗅觉反应的活性组分分析

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植物保护 2024年第3期50卷 188-194,218页

作者：杨安沛张航白微微丁瑞丰李广阔新疆农业科学院植物保护研究所农业农村部西北荒漠绿洲作物有害生物综合治理重点实验室乌鲁木齐830091

为探究植物挥发物中引起旋幽夜蛾嗅觉电生理反应的活性组分,本研究采用动态顶空吸附法收集藜、甜菜和棉花植株的挥发物,利用气相色谱触角电位联用仪(GC-EAD)和气相色谱质谱联用仪(GC-MS)定性鉴定寄主挥发物中引起旋幽夜蛾嗅觉反应的活... 详细信息

为探究植物挥发物中引起旋幽夜蛾嗅觉电生理反应的活性组分,本研究采用动态顶空吸附法收集藜、甜菜和棉花植株的挥发物,利用气相色谱触角电位联用仪(GC-EAD)和气相色谱质谱联用仪(GC-MS)定性鉴定寄主挥发物中引起旋幽夜蛾嗅觉反应的活性组分。结果表明,藜挥发物中有6种活性组分,甜菜和棉花挥发物中各有5种,其中乙酸叶醇酯、1,2-二乙苯、对二乙苯、壬醛、二乙二醇丁醚为3种植物共有的挥发物组分,异佛尔酮仅在藜挥发物中发现。触角电位(EAG)测定结果显示,以上6种组分都能引起旋幽夜蛾雌雄成虫的EAG反应,且随浓度增加EAG相对反应值增大。雌雄成虫对壬醛和异佛尔酮的EAG反应最强烈,其次是乙酸叶醇酯和1,2-二乙苯。在相同浓度条件下,雌雄成虫对同种化合物的EAG反应无性别特异性。本研究为探明旋幽夜蛾定位寄主机制及开发行为调控产品提供基础。

关键词：旋幽夜蛾植物挥发物触角电位 GC-EAD

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基于FT模式的应用型本科院校思政课程创新研究——以“汽车服务企业管理”为例

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时代汽车 2024年第13期 52-54页

作者：曹克晶柏薇薇张慧星齐齐哈尔工程学院黑龙江齐齐哈尔161005

本文以“FT”应用型课程建设模式为基础,融入立德树人思想和“学生中心、产出导向、持续改进”的教育教学理念,针对应用型本科院校校企合作企业的岗位工作特点和环境,设计“汽车服务企业管理”的项目,并围绕家国情怀、爱岗敬业、诚实守... 详细信息

本文以“FT”应用型课程建设模式为基础,融入立德树人思想和“学生中心、产出导向、持续改进”的教育教学理念,针对应用型本科院校校企合作企业的岗位工作特点和环境,设计“汽车服务企业管理”的项目,并围绕家国情怀、爱岗敬业、诚实守信、创新意识等内容,融入基于岗位职业道德的“三五”能力,从课程思政的定位、设计、实施与评价“四要素”入手,构建课程思政的三级矩阵模型和考核评价标准,实现“自上而下”的分解课程思政目标,自下而上地达成课程思政目标。从课前、课中、课后“三阶段”实施课程思政,实现全方位全过程的思政育人。

关键词： FT 课程思政 “四三”模式创新

Energy-absorbing porous materials:Bioinspired architecture and fabrication

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Nano Research 2024年第2期17卷 679-690页

作者： Junheng Zhao Meng Li Jiewei Chen weiwei Gao Hao bai State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310058China

Energy-absorbing materials are widely used in transportations,sports,and the military ***,porous materials,including natural and artificial materials,have attracted tremendous attentions due to their light weight and excellent energy absorption *** review summarizes the recent progresses in the natural and artificial energy-absorbing porous ***,we review the typical natural porous materials including cuttlebone,bighorn sheep horn,pomelo peel,and sunflower stem *** architectures,energy absorption abilities,and mechanisms of these typical natural materials and their bioinspired materials are ***,we provide a review on the fabrication methods of artificial energy-absorbing porous materials,such as conventional foaming and three-dimensional(3D)***,we address the challenges and prospects for the future development of energy-absorbing porous *** importantly,our review provides a direct guidance for the design and fabrication of energy-absorbing porous materials required for various engineering applications.

关键词： energy-absorbing porous materials natural materials natural structures bioinspired materials

血镁在慢性肾脏病及其矿物质与骨异常中作用的研究进展

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中国血液净化 2024年第8期23卷 605-608页

作者：白伟伟杜书同马伟华王雅静王娜河北省沧州市人民医院肾内科沧州061000

慢性肾脏病矿物质和骨异常(chronic kidney disease-mineral and bone disorder,CKD-MBD)是慢性肾脏病(chronic kidney disease,CKD)患者的常见并发症,是一种涉及不同矿物质和骨代谢异常的全身性疾病,也包括血管钙化的发生,对患者的生... 详细信息

慢性肾脏病矿物质和骨异常(chronic kidney disease-mineral and bone disorder,CKD-MBD)是慢性肾脏病(chronic kidney disease,CKD)患者的常见并发症,是一种涉及不同矿物质和骨代谢异常的全身性疾病,也包括血管钙化的发生,对患者的生存质量和长期预后产生重要影响。尽管多年来对CKD-MBD发病机制的认识已不断完善,但血镁水平对其演变的影响和重要性直到近年才得到重视。本文综述了血镁的生理功能、血镁与CKD及CKD-MBD的关系及相互作用机制,调控血镁水平有可能成为治疗CKD-MBD的新靶点。

关键词：镁慢性肾脏病矿物质与骨异常

Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma

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Cancer Biology & Medicine 2023年第3期20卷 196-217页

作者： Tianxing Zhou Quan Man Xueyang Li Yongjie Xie Xupeng Hou Hailong Wang Jingrui Yan Xueqing Wei weiwei bai Ziyun Liu Jing Liu Jihui Hao Department of Pancreatic Cancer Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Hepatopancreatobiliary Surgery Tongliao City HospitalTongliao 028000China Department of Breast Oncoplastic Surgery Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerKey Laboratory of Breast Cancer Prevention and TherapyTianjin Medical UniversityMinistry of EducationTianjin 300060China Department of Cancer Cell Biology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerKey Laboratory of Breast Cancer Prevention and TherapyTianjin Medical UniversityMinistry of EducationTianjin 300060China Department of Diagnostic and Therapeutic Ultrasonography Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerKey Laboratory of Breast Cancer Prevention and TherapyTianjin Medical UniversityMinistry of EducationTianjin 300060China

Objective:Pancreatic ductal adenocarcinoma(PDAC)is an aggressive ***8^(+)T cells,cancer stem cells(CSCs),and tumor budding(TB)have been significantly correlated with the outcome of patients with PDAC,but the correlations have been independently *** addition,no integrated immune-CSC-TB profile for predicting survival in patients with PDAC has been ***:Multiplexed immunofluorescence and artificial intelligence(AI)-based comprehensive analyses were used for quantification and spatial distribution analysis of CD8^(+)T cells,CD133^(+)CSCs,and *** vivo humanized patient-derived xenograft(PDX)models were *** analysis,calibration curve,time-dependent receiver operating characteristic curve,and decision curve analyses were performed using R ***:The established‘anti-/pro-tumor’models showed that the CD8^(+)T cell/TB,CD8^(+)T cell/CD133^(+)CSC,TB-adjacent CD8^(+)T cell,and CD133^(+)CSC-adjacent CD8^(+)T cell indices were positively associated with survival of patients with *** findings were validated using PDX-transplanted humanized mouse *** integrated nomogram-based immune-CSC-TB profile that included the CD8^(+)T cell/TB and CD8^(+)T cell/CD133^(+)CSC indices was established and shown to be superior to the tumor-nodemetastasis stage model in predicting survival of patients with ***:‘Anti-/pro-tumor’models and the spatial relationship among CD8^(+)T cells,CSCs,and TB within the tumor microenvironment were *** strategies to predict the prognosis of patients with PDAC were established using AI-based comprehensive analysis and machine learning *** nomogram-based immune-CSC-TB profile can provide accurate prognosis prediction for patients with PDAC.

关键词： Artificial intelligence CD8 CSCs tumor budding PDAC nomogram

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

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Frontiers of Medicine 2024年第1期18卷 147-168页

作者： weiwei Xian Mohammad Asad Shuai Wu Zhixin bai Fengjiao Li Junfeng Lu Gaoyu Zu Erin Brintnell Hong Chen Ying Mao Guomin Zhou Bo Liao Jinsong Wu Edwin Wang Linya You Department of Human Anatomy&Histoembryology School of Basic Medical SciencesFudan UniversityShanghai200032China Cumming School of Medicine University of CalgaryCalgaryAlbertaT2N 4N1Canada Glioma Surgery Division Department of NeurosurgeryHuashan HospitalFudan UniversityShanghai200040China Department of Pathology Huashan HospitalFudan UniversityShanghai200040China Department of Neurosurgery Huashan HospitalFudan UniversityShanghai200040China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Fudan UniversityShanghai200040China School of Mathematics and Statistics Hainan Normal UniversityHaikou570100China

The association of neurogenesis and gliogenesis with glioma remains *** conducting single-cell RNA-seq analyses on 26 gliomas,we reported their classification into primitive oligodendrocyte precursor cell(pri-OPC)-like and radial glia(RG)-like tumors and validated it in a public cohort and TCGA *** RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR mutations,and the pri-OPC-like ones were prone to carrying TP53 *** subclones only in pri-OPC-like tumors showed substantially down-regulated MHC-I genes,suggesting their distinct immune evasion ***,the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinct *** specific genes not expressed in normal immune cells were found in glioma-infiltrating *** example,glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptors IGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes,*** expression was positively correlated with those of immune checkpoint genes(e.g.,LGALS33)and poor survivals as validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat *** finding indicated a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune evasion.

关键词： single-cell RNA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape

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彝族《指路经》崇生生命观的意义指向

楚雄师范学院学报 2023年第5期38卷 86-93页

作者：白伟伟贵州工程应用技术学院艺术学院贵州毕节551700

彝族《指路经》使用频率高、影响大,其内蕴一种崇生的生命观。其崇生生命观包括四个意义指向:一是肯定“本源”生命——元生命的至美;二是肯定生命的“绽出”过程——日常生活;三是对生命之力即生命力的高扬——“尚力”;四是崇生的终... 详细信息

彝族《指路经》使用频率高、影响大,其内蕴一种崇生的生命观。其崇生生命观包括四个意义指向:一是肯定“本源”生命——元生命的至美;二是肯定生命的“绽出”过程——日常生活;三是对生命之力即生命力的高扬——“尚力”;四是崇生的终极目标在于实现“永生”。对《指路经》崇生生命观的研究既可为丰富中华民族的美学精神提供美学资源,亦可为解决现代人的生存困境提供某种启示。

关键词：彝族《指路经》崇生生命观

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双柳煤矿工作面供电系统的设计

煤炭与化工 2022年第9期45卷 58-60,64页

作者：白伟伟山西汾西矿业(集团)有限责任公司双柳煤矿山西柳林033300

在对双柳煤矿33 (4) 20工作面及顺槽主要设备采煤机、刮板输送机、转载机、破碎机等的功率和电压分析的基础上,确定了移动变电站的数量为4个,对应的变压器视在功率分别为4000、4000、2000、315 kVA。对工作面供电系统进行了设计,根据实... 详细信息

在对双柳煤矿33 (4) 20工作面及顺槽主要设备采煤机、刮板输送机、转载机、破碎机等的功率和电压分析的基础上,确定了移动变电站的数量为4个,对应的变压器视在功率分别为4000、4000、2000、315 kVA。对工作面供电系统进行了设计,根据实际情况,对高压侧电缆和低压侧电缆进行了设计计算,确定型号。将设计的供电系统应用到煤矿工程实践中,目前运行时间超过1 a,经现场人员反馈,供电系统整体运行稳定,为安全高效开采奠定了良好的基础。

关键词：供电系统移动变电站设计应用