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Broadband NIR-emitting Te cluster-doped glass for smart light source towards night-vision and NIR spectroscopy applications

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Photonics Research 2022年第5期10卷 1187-1193页

作者： LINLING TAN YANQING FU SHILIANG KANG lothar WONDRACZEK CHANGGUI LIN YUANZHENG YUE Laboratory of IR Materials and Devices Research Institute of Advanced TechnologiesKey Laboratory of Photoelectric Detection Materials and Devices of Zhejiang ProvinceNingbo UniversityNingbo 315211China Otto Schott Institute of Materials Research University of Jena07743 JenaGermany Department of Chemistry and Bioscience Aalborg University9220 AalborgDenmark

Broadband near-infrared(NIR)-emitting materials are crucial components of the next generation of smart NIR light sources based on blue light-emitting diodes(LEDs). Here, we report a Te cluster-doped borate glass, which exhibits ultra-broadband emission around 980 nm with a full-width at half-maximum(FWHM) of 306 nm under blue light excitation. We propose adjustments of glass chemistry and processing condition as a means for topochemical tailoring of the NIR photoemission characteristics in such materials. Through implementing strongly reducing conditions during glass melting, Te clusters with broad NIR photoluminescence can be generated and stabilized once the melt is vitrified to the glassy state. Tunability of the NIR emission peak over the wavelength range of 904 to 1026 nm is possible in this way, allowing for fine adjustments of spectral properties relative to the stretching vibrations of common chemical bonds, for example, in water, proteins, and fats. This potentially enables high sensitivity in NIR spectroscopy. We further demonstrate potential application of glass-converted LEDs in night vision.

关键词： Broadband glass smart

Travel time and alternative configurations analysis for automated storage/retrieval systems based on geometrical method

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Journal of Southeast University(English Edition) 2007年第S1期23卷 161-167页

作者：马新露赵林度 lothar Schulze 东南大学经济管理学院南京210096 汉诺威大学物流规划与控制系德国汉诺威30167

In order to evaluate the efficiency of the automated storage/retrieval system(AS/RS)accurately,and compare different layouts of the AS/RS using mean travel time,under randomized storage conditions,an exact,geometry-based analytical model is *** model can be used to compute the expected single-command and dual-command travel time for a storage/retrieval(S/R)machine which can travel simultaneously horizontally and vertically as it moves along a storage *** rack may be either square in time or non square in ***,the alternative layouts of the AS/RS and travel-time models are *** with setting the I/O point at the left-lower corner of the rack,setting the I/O point at any point at the vertical edge can help enhance the efficiency of the AS/RS.

关键词： travel time model automated storage/retrieval system geometry method Tchebychev approximation

Emerging consensus on the mechanism of polyspecific substrate recognition by the multidrug transporter P-glycoprotein

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Cancer Drug Resistance 2019年第3期2卷 471-489页

作者： Di Xia Fei Zhou lothar Esser Laboratory of Cell Biology National Cancer InstituteCenter for Cancer ResearchNational Institutes of HealthBethesdaMD 20892USA

P-glycoprotein(P-gp or ABCB1)is a member of the broad family of ABC transporters.P-gp participates in the establishment of physiological barriers limiting cellular access of a large number of toxic *** thus plays important roles in the pharmacokinetics of these *** cells and cells infected by viruses exploit the presence of P-gp to fend off drug treatment,rendering them *** multidrug resistance caused by expression of ABC transporters has gained increasing attention in the field of drug ***,studies of P-gp,especially from structural investigations by both cryo-electron microscopy and X-ray crystallography,have provided high-resolution mechanistic details for the function of this *** with increasing resolution and accuracy in various substrate-and inhibitor-bound forms are available for analysis and a consensus on the mechanism of substrate polyspecificity is *** use of new structural information may aid development of P-gp inhibitors as well as compounds that may bypass P-gp action.

关键词： P-glycoprotein multidrug resistance substrate polyspecificity structure ABC transporter

Biomechanische Untersuchungsergebnisse ber die verbesserte Verankerung von Pedikelschraubenmit resorbierbarem Zement in menschenlichen Wirbelk rpern

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2001年第1期21卷 48-51页

作者：邵景范罗永湘 Luo Yongxiang Lutz Claes lothar Kinzl Abteilung für Chirurgie Tongji KlinikTongji medizinisches institutHuazhong Universitat für Wissenschaft und Technik Abteilung für Unfallchirurgie Hand-und Wiederherstellungschirurgie der Universitat UlmDeutschland Abteilung für Unfallchirurgische Forschung und Biomechanik der Universitat Ulm Deutschland

Die Prim rstabilit t von Pedikelschrauben im Knochen h ngt in hohem Masse von der Knochendichte ab. Die Augmentation mit Zement ist ein klinisch einsetzbares Verfahren, um die Schrauben Verankerung im osteoporotischen Knochen zu *** dieser Studie wurde eine neuartiges resorbierbares Knochenersatzmaterial (α BSM TM ) für diese Augmentation benutzt. Biomechanische Testungen wurden in vitro bei 16 Lendwirbelk rpern (L3-L5) aus 6 Individuen(75,2±13,7 Jahre) durchgeführt. Vor der biomechanischen Testung wurde bei allen Pr paraten die trabekul re Knochendichte mittels pQCT gemessen und beide Pedikel mit USS Pedikelschrauben (5,0 mm × 45 mm) besetzt, von welchen eine mit α BSM TM augmentiert war. Beim axialen Auszugstest wurden die maximale axiale Auszugskraft (F max) sowie die Energieaufnahme bestimmt. Der Medianwert der F max stieg beim Auszugstest durch die Zementierung mit α BSM TM um 80 % von 370 N (ohne Zement) auf 665 N (mit Zement). Die Energieaufnahme bis zum Erreichen der F max (E F max) und bei Dislokation bis 2,0 mm (E 2 mm) steigerte sich ebenfalls um 83 % und 68 %. Die Unterschiede waren signifikant. (Wilcoxon′s Test, P <0,01) Die Ausreisskrafte F max (ohne oder mit Zement) korrelierten eng mit der Knochendichte ( r =0,9056 und r =0,9585). Unsere Resultate zeigen, da eine Augmentation mit dem α BSM TM die primare Stabilitat von Pedikelschrauben verbessern kann. Der Effekt scheint auf einer Optimierung der Kontaktfl che und einer Aussteifung der schraubennahen Spongiosa zu beruhen. Das Material k nnte geeignet sein, die Verankerung von Pedikelschrauben bei osteoporotischen Patieten zu verbessern.

关键词： Biomechanik Zement Pedikelschraube Stabilit t Wirbelk rper

Biophotonic sensors with integrated Si_(3)N_(4)-organic hybrid (SiNOH) lasers for point-of-care diagnostics

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Light(Science & Applications) 2021年第4期10卷 648-659页

作者： Daria Kohler Gregor Schindler lothar Hahn Johannes Milvich Andreas Hofmann Kerstin Lange Wolfgang Freude Christian Koos Institute of Photonics and Quantum Elearo nics(IPQ) Karlsruhe Institute of Technology(KIT)Engesserstrasse 576131 KarlsruheGermany lnstitute of Microstructure Technology(IMT) Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Robert Bosch GmbH Robert-Bosch-Campus 171272 RenningenGermany lnstitute for Autom ation and Applied Informatics(IAI) Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Early and efficient disease diagnosis with low-cost point-of-care devices is gaining importance for personalized medicine and public health *** this context,waveguide-(WG)-based optical biosensors on the siliconnitride(Si_(3)N_(4))platform represent a particularly promising option,offering highly sensitive detection of indicative biomarkers in multiplexed sensor arrays operated by light in the visible-wavelength ***,while passive Si_(3)N_(4)-based photonic circuits lend themselves to highly scalable mass production,the integration of low-cost light sources remains a *** this paper,we demonstrate optical biosensors that combine Si_(3)N_(4)sensor circuits with hybrid on-chip organic *** Si_(3)N_(4)-organic hybrid(SiNOH)lasers rely on a dye-doped cladding material that are deposited on top of a passive WG and that are optically pumped by an external light *** of the devices is simple:The underlying Si_(3)N_(4)WGs are structured in a single lithography step,and the organic gain medium is subsequently applied by dispensing,spin-coating,or ink-jet printing processes.A highly parallel read-out of the optical sensor signals is accomplished with a simple *** our proof-of-concept experiment,we demonstrate the viability of the approach by detecting different concentrations of fibrinogen in phosphate-buffered saline solutions with a sensor-length(L-)-related sensitivity of S/L=0.16 rad nM^(-1)mm^(-1).To our knowledge,this is the first demonstration of an integrated optical circuit driven by a co-integrated low-cost organic light *** expect that the versatility of the device concept,the simple operation principle,and the compatibility with cost-efficient mass production will make the concept a highly attractive option for applications in biophotonics and point-of-care diagnostics.

关键词： passive waveguide pumped

Lateral dipole moments induced by all-cis-pentafluorocyclohexyl groups cause unanticipated effects in self-assembled monolayers

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Nano Research 2023年第8期16卷 11030-11041页

作者： Christian Fischer Saunak Das Qingzhi Zhang Yangbiao Liu lothar Weinhardt David O’Hagan Michael Zharnikov Andreas Terfort Institute of Inorganic and Analytical Chemistry Goethe University FrankfurtMax-von-Laue-Straße 760438 Frankfurt am MainGermany Applied Physical Chemistry Heidelberg UniversityIm Neuenheimer Feld 25369120 HeidelbergGermany School of Chemistry University of St AndrewsNorth HaughSt AndrewsFifeKY169STUK Institute for Photon Science and Synchrotron Radiation Karlsruhe Institute of Technology(KIT)Hermann-v.-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Institute for Chemical Technology and Polymer Chemistry(ITCP) Karlsruhe Institute of Technology(KIT)Engesserstr.18/2076128 KarlsruheGermany Department of Chemistry and Biochemistry University of NevadaLas Vegas(UNLV)4505 Maryland ParkwayLas VegasNV 89154-4003USA

All-cis-hexafluoro-and all-cis-pentafluoro-cyclohexane(PFCH)derivatives are new kinds of materials,the structures and properties of which are dominated by the highly dipolar Janus-face ***,we report on the effects of integrating the PFCH groups into self-assembled monolayers(SAMs)of alkanethiolates on Au(111).Monolayers with an odd(eleven)and even(twelve)number of methylene groups were characterized in detail by several complementary experimental tools,supported by theoretical ***,all the data show a high similarity of both kinds of monolayers,nearly lacking the typically observed odd-even *** new monolayers have a packing density about 1/3 lower than that of non-substituted alkanethiolate monolayers,caused by the bulkiness of the PFCH *** orientations of the PFCH groups and the alkyl chains could be determined independently,suggesting a conformation similar to the one found in the solid state structure of an analogous *** in the SAMs the PFCH groups are slightly tilted away from the surface normal with the axial fluorine atoms pointing downwards,most of the dipole moments of the group remain oriented parallel to the surface,which is a unique feature for a SAM *** consequences are much lower water contact angles compared to other partly fluorinated SAMs as well as rather moderate work function *** interaction between the terminal PFCH moieties results in an enhanced stability of the PFCH-decorated SAMs toward exchange reaction with potential molecular substituents in spite of the lower packing density of these films.

关键词： odd-even-effects work function self-assembled monolayer(SAM) kinetic stability infrared-reflection absorption spectroscopy X-ray photoelectron spectroscopy

High-aspect 3D two-photon polymerization structuring with widened objective working range (WOW-2PP)

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Light(Science & Applications) 2013年第1期2卷 9-12页

作者： Kotaro Obata Ayman El-Tamer lothar Koch Ulf Hinze Boris N Chichkov Laser Zentrum Hannover e.V. 30419 HannoverGermany

We developed a novel two-photon polymerization(2PP)configuration for fabrication of high-aspect three-dimensional(3D)structures,with an overall height larger than working distance of the microscope objective used for laser beam focusing into a photosensitive *** method is based on a modified optical 2PP setup,where a microscope objective(1003 high N.A.),immersion oil and cover glass can be moved together into the photosensitive material,resulting in an effective higher and wider objective working range(WOW-2PP).The proposed technique enables the fabrication of high-aspect structures with sub-micrometer process resolution.3D structures with a height of 7 mm are demonstrated,which could hardly be built with the conventional 2PP set-up due to refractive index mismatch and laser beam disturbances.

关键词： femtosecond laser large-scale structuring laser material processing photochemistry two-photon polymerization

CuZr-based bulk metallic glass and glass matrix composites fabricated by selective laser melting

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Journal of Materials Science & Technology 2021年第22期81卷 139-150页

作者： Liang Deng Long Zhang Konrad Kosiba RenéLimbach lothar Wondraczek Gang Wang Dongdong Gu Uta Kühn Simon Pauly Leibniz IFW Dresden Institute for Complex MaterialsHelmholtzstraße 20D-01069DresdenGermany Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Otto Schott Institute of Materials Research University of JenaFraunhoferstraße 6D-07743 JenaGermany Laboratory for Microstructure Institute of MaterialsShanghai UniversityShanghai200444China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing210016China University of Applied Sciences Aschaffenburg Würzburger Straße 45D-63743AschaffenburgGermany

Monolithic bulk metallic glass and glass matrix composites with a relative density above 98%were produced by processing Cu_(46)Zr_(46)Al_(8)(at.%)via selective laser melting(SLM).Their microstructures and mechanical properties were systematically examined.B2 CuZr nanocrystals(30-100 nm in diameter)are uniformly dispersed in the glassy matrix when SLM is conducted at an intermediate energy *** B2 CuZr nanocrystals nucleate the oxygen-stabilized big cube phase during a remelting *** presence of these nanocrystals increases the structural heterogeneity as indirectly revealed by mircrohardness and nanoindentation *** corresponding maps in combination with calorimetric data indicate that the glassy phase is altered by the processing *** the formation of crystals and a high overall free volume content,all additively manufactured samples fail at lower stress than the as-cast glass and without any plastic *** inherent brittleness is attributed to the presence of relatively large pores and the increased oxygen content after selective laser melting.

关键词： Selective laser melting CuZr-based glass Bulk metallic glass matrix composites Phase formation Mechanical properties

Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells

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Journal of Molecular Cell Biology 2021年第6期13卷 433-444页

作者： Lei Duan Sarah Calhoun Daeun Shim Ricardo E.Perez lothar A.Blatter Carl G.Maki Department of Cell and Molecular Medicine Rush University Medical CenterChicagoIL 60612USA Department of Molecular Biophysics and Physiology Rush University Medical CenterChicagoIL 60612USA

Tamoxifen(TAM)is the first-line endocrine therapy for estrogen receptor-positive(ER+)breast cancer(BC).However,acquired resistance occurs in∼50%***,although the PI3K/AKT/mTOR pathway is a viable target for treatment of endocrine therapy-refractory patients,complex signaling feedback loops exist,which can counter the effectiveness of inhibitors of this ***,we analyzed signaling pathways and metabolism in ER+MCF7 BC cell line and their TAM-resistant derivatives that are co-resistant to endoxifen using immunoblotting,quantitative polymerase chain reaction,and the Agilent Seahorse XF *** found that activation of AKT and the energy-sensing kinase AMPK was increased in TAM and endoxifen-resistant ***,ERRα/PGC-1βand their target genes MCAD and CPT-1 were increased and regulated by AMPK,which coincided with increased fatty acid oxidation(FAO)and autophagy in TAM-resistant *** of AKT feedback-activates AMPK and ERRα/PGC-1β-MCAD/CPT-1 with a consequent increase in FAO and autophagy that counters the therapeutic effect of endoxifen and AKT ***,our results indicate increased activation of AKT and AMPK with metabolic reprogramming and increased autophagy in TAM-resistant *** inhibition of AKT and FAO/autophagy is necessary to fully sensitize resistant cells to endoxifen.

关键词： endoxifen fatty acid oxidation autophagy AMPK AKT