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Bioprinted constructs that simulate nerve-bone crosstalk to improve microenvironment for bone repair

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Bioactive Materials 2023年第9期27卷 377-393页

作者： Tianchang Wang Wentao Li Yuxin Zhang Xiang Xu Lei Qiang weiqiang miao Xiaokun Yue Xin Jiao Xianhao Zhou Zhenjiang Ma Shuai Li Muliang Ding Junfeng Zhu Chi Yang Hui Wang Tao Li Xin Sun Jinwu Wang Shanghai Key Laboratory of Orthopedic Implant Department of Orthopedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineNo.639 Zhizaoju RoadShanghai200011China Sports Medicine Department Beijing Key Laboratory of Sports InjuriesPeking University Third HospitalNo.49North Garden RoadHaidian DistrictBeijing100191China Peking University Institute of Sports Medicine No.49North Garden RoadHaidian DistrictBeijing100191China Department of Oral Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai200011China School of Materials Science and Engineering Southwest Jiaotong UniversityChengdu610031China Department of Orthopedics The First Affiliated HospitalZhejiang University School of Medicine79 Qingchun RdHangzhou310003China Department of Orthopaedics The Second Xiangya HospitalCentral South UniversityChangsha410001HunanChina Institute of Rehabilitation Medicine School of Rehabilitation ScienceShanghai University of Traditional Chinese MedicineEngineering Research Center of Traditional Chinese Medicine Intelligent RehabilitationMinistry of EducationShanghai201210China Department of Orthopedic Surgery Xin Hua Hospital Affiliated with Shanghai Jiao Tong University School of MedicineNo.1665Kongjiang RoadShanghai200092China

Crosstalk between nerves and bone is essential for bone repair,for which Schwann cells(SCs)are crucial in the regulation of the *** that exosomes are critical paracrine mediators for intercellular communication that exert important effects in tissue repair,the aim of this study is to confirm the function and molecular mechanisms of Schwann cell-derived exosomes(SC-exos)on bone regeneration and to propose engineered constructs that simulate SC-mediated nerve-bone *** promoted the proliferation and differentiation of bone marrow mesenchymal stem cells(BMSCs)through *** molecular mechanism studies demonstrated that SC-exos promoted BMSC osteogenesis by regulating the TGF-βsignaling pathway via ***,SC-exos promoted the migration and tube formation performance of endothelial progenitor ***,the SC-exos@G/S constructs were developed by bioprinting technology that simulated SC-mediated nerve-bone crosstalk and improved the bone regeneration microenvironment by releasing SC-exos,exerting the regulatory effect of SCs in the microenvironment to promote innervation,vascularization,and osteogenesis and thus effectively improving bone repair in a cranial defect *** study demonstrates the important role and underlying mechanism of SCs in regulating bone regeneration through SC-exos and provides a new engineered strategy for bone repair.

关键词： Schwann cells Microenvironment Nerve-bone crosstalk Exosomes Bioprinting

Solvent effects on Diels-Alder reaction in ionic liquids:A reaction density functional study

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Chinese Journal of Chemical Engineering 2024年第2期66卷 180-188页

作者： Zijiang Dou weiqiang Tang Peng Xie Shuangliang Zhao Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology and School of Chemistry and Chemical Engineering Guangxi UniversityNanning 530004China State Key Laboratory of Chemical Engineering and School of Chemical Engineering East China University of Science and TechnologyShanghai 200237China

Extensive experimental studies have been performed on the Diels-Alder(DA)reactions in ionic liquids(ILs),which demonstrate that the IL environment can significantly influence the reaction rates and ***,the underlying microscopic mechanism remains *** this work,the multiscale reaction density functional theory is applied to explore the effect of 1-butyl-3-methylimidazolium hexafluorophosphate([BMIM][PF_(6)])solvent on the reaction of cyclopentadiene(CP)with acrolein,methyl acrylate,or *** analyzing the free energy landscape during the reaction,it is found that the polarization effect has a relatively small influence,while the solvation effect makes both the activation free energy and reaction free energy *** addition,the rearrangement of local solvent structure shows that the cation spatial distribution responds more evidently to the reaction than the anion,and this indicates that the cation plays a dominant role in the solvation effect and so as to affect the reaction rates and selectivity of the DA reactions.

关键词： Solvent effect Ionic liquids Diels-Alder reaction Reaction density functional theory

Fe-Zn alloy, a new biodegradable material capable of reducing RoS and inhibiting oxidative stress

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Regenerative Biomaterials 2024年第2期3卷 114-122页

作者： Shuaikang Yang weiqiang Wang Yanan Xu Yonghui Yuan Shengzhi Hao School of Materials Science and Engineering Dalian University of TechnologyDalian 116024PR China Clinical Research Center for Malignant Tumor of Liaoning Province Cancer Hospital of Dalian University of TechnologyShenyang 110042PR China

Fe-based biodegradable materials have attracted significant attention due to their exceptional mechanical properties and favorable ***,research on Fe-based materials mainly focuses on regulating the degradation ***,excessive release of Fe ions during material degrada-tion will induce the generation of reactive oxygen species(ROS),leading to oxidative stress and ***,the con-trol of RoS release and the improvement of biocompatibility for Fe-based materials are very *** this study,new Fe-Zn alloys were prepared by electrodeposition with the intention of using Zn as an antioxidant to reduce oxidative damage during alloy ***,the impact of three potential degra-dation ions(Fe^(2+),Fe^(3+),Zn^(2+))from the Fe-Zn alloy on human endothelial cell(EC)activity and migration ability was ***,cell adhesion,cell activity,ROs production and DNA damage were assessed at various locations surrounding the ***,the influence of different concentrations of Zn^(2+) in the medium on cell viability and ROS production was *** levels of ROS exhibited evident toxic effects on ECs and promoted DNA *** an antioxidant,Zn?+effectively reduced ROS production around Fe and improved the cell viability on its surface at a concentration of 0.04 mmol/*** findings demonstrate that Fe-Zn alloy can attenuate the ROS generated from Fe degradation therebyenhancingcytocompatibility.

关键词： biodegradable iron Fe-Zn alloys reactive oxygen species oxidative stress cytocompatibility

A review of rock macro-indentation:Theories,experiments,simulations,and applications

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2351-2374页

作者： weiqiang Xie Xiaoli Liu Xiaoping Zhang Xinmei Yang Xiaoxiong Zhou State Key Laboratory of Hydroscience and Engineering Tsinghua UniversityBeijing100084China Yunlong Lake Laboratory of Deep Underground Science and Engineering Xuzhou221116China State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan430072China

Rock macro-indentation plays a fundamental role in mechanical rock breaking for various rock engineering application,such as drilling,tunneling,cutting,and *** the past decades,extensive research has been conducted to understand the indentation mechanisms and responses through various *** review aims to provide an overview of the current status and recent advancements in theories,experiments,numerical simulations,and applications of macro-indentation in rock *** starts with elaborating on the mechanisms of macro-indentation,followed by a discussion of the merits and limitations of commonly used *** factors and their effects on indentation test results are then *** numerical simulation methods for rock macro-indentation are highlighted,along with their advantages and ***,the applications of indentation tests and indentation indices in characterizing rock properties are *** reveals that compression-tension,compression-shear,and composite models are widely employed in rock *** the compression-tension model is straightforward to use,it may overlook the anisotropic properties of *** the other hand,the composite model provides a more comprehensive description of rock indentation but requires complex ***,factors,such as indentation rate,indenter geometry,rock type,specimen size,and confining pressure,can significantly influence the indentation *** methods for macro-indentation encompass continuous medium,discontinuous medium,and continuous-discontinuous medium methods,with selection based on their differences in ***,rock macro-indentation can be practically applied to mining engineering,tunneling engineering,and petroleum drilling *** indices serve as valuable tools for characterizing rock strength,brittleness,and *** review sheds light on the development of rock macro-inde

关键词： Rock macro-indentation Indentation test Indentation indices Mechanism Rock breaking

Time-lagged Effects of the Spring Atmospheric Heat Source over the Tibetan Plateau on Summer Precipitation in Northeast China during 1961–2020:Role of Soil Moisture

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Advances in Atmospheric Sciences 2024年第8期41卷 1527-1538页

作者： Yizhe HAN Dabang JIANG Dong SI Yaoming MA weiqiang MA Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China National Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Dingri 858200China Kathmandu Center of Research and Education Chinese Academy of SciencesBeijing 100101China China-Pakistan Joint Research Center on Earth Sciences Chinese Academy of SciencesIslamabad 45320Pakistan

The spring atmospheric heat source(AHS)over the Tibetan Plateau(TP)has been suggested to affect the Asian summer monsoon and summer precipitation over South ***,its influence on the summer precipitation in Northeast China(NEC)remains *** connection between spring TP AHS and subsequent summer precipitation over NEC from 1961 to 2020 is analyzed in this *** illustrate that stronger spring TP AHS can enhance subsequent summer NEC precipitation,and higher soil moisture in the Yellow River Valley-North China region(YRVNC)acts as a *** spring,the strong TP AHS could strengthen the transportation of water vapor to East China and lead to excessive rainfall in the ***,soil moisture increases,which regulates local thermal conditions by decreasing local surface skin temperature and sensible *** to the memory of soil moisture,the lower spring sensible heat over the YRVNC can last until mid-summer,decrease the land–sea thermal contrast,and weaken the southerly winds over the East Asia–western Pacific region and convective activities over the South China Sea and tropical western *** modulates the East Asia–Pacific teleconnection pattern,which leads to a cyclonic anomaly and excessive summer precipitation over NEC.

关键词： Tibetan Plateau atmospheric heat source Northeast China summer precipitation soil moisture

Potassium isotopic signatures of modern offshore detrital sediments from different climatic regimes and the implications

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Science China Earth Sciences 2024年第2期67卷 405-419页

作者： Jun MU Tianyu CHEN Qian YU Shichao AN Jianfang CHEN Xuefa SHI weiqiang LI State Key Laboratory for Mineral Deposits Research School of Earth Sciences and EngineeringNanjing UniversityNanjing210023China Ministry of Education Key Laboratory for Coast and Island Development School of Geography and Ocean ScienceNanjing UniversityNanjing210023China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou310012China Key Laboratory of Marine Geology and Metallogeny First Institute of OceanographyMinistry of Natural ResourcesQingdao266061China

Potassium isotopes are a novel tracer for continental *** K isotope studies on chemical weathering generally targeted weathering profiles under a particular climate region,yet the effects of chemical weathering on K isotopes under different climatic backgrounds remain ***,little is known about the K isotope signatures of modern unconsolidated detrital ***,we report K isotopic data of surficial seafloor sediments from continental shelves along the east coast of China(ECC),as well as those around the tropical Hainan island in the northern South China *** ECC sediments have a relatively narrow distribution ofδ^(41)K(with reference to NIST3141a)values,which range from(-0.40±0.01)‰to(-0.57±0.04)‰,with an average of(-0.51±0.09)‰.By contrast,δ^(41)K values of Hainan offshore sediments display a larger variation,ranging from(-0.28±0.07)‰to(-0.67±0.02)‰.Theδ^(41)K values of Hainan offshore sediments exhibit negative correlations with the chemical index of alteration(CIA),Al/K,Ti/K,and total iron(FeT),which underlines the control of chemical weathering on K isotopic signatures of detritus inputs into *** also measured Mg isotope compositions for the same samples;interestingly,the variability inδ^(26)Mg of the samples is small(~0.24‰)for all ECC and Hainan offshore sediments,andδ^(26)Mg values do not show clear correlations with indexes of chemical *** study demonstrates the link between K isotopic variability of detrital sediments and climatic conditions including rainfall intensity,which indicates that K isotopes of the detrital component of marine sediments could be applied to study Earth’s climate in deep ***δ^(41)K values of the offshore detrital sediments are significantly less variable than those of pelagic marine sediments,highlighting the importance of distinguishing the effects of diagenesis and neoformation of clay minerals from continental weathering in attempts to study deep-time climate-weathering

关键词： Potassium isotopes Magnesium isotopes Chemical weathering Detrital sediments Climatic regimes Mean annual precipitation

LncRNA HOTTIP facilitated tumor growth via stimulating the hnRNPA2B1/DKK1/Wnt/β-catenin regulatory axis in hepatocellular carcinoma

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Genes & Diseases 2024年第4期11卷 53-56页

作者： weiqiang Zeng Chuanjian Shi Liqiang Deng Weiming Fu Jinfang Zhang Cancer Center Shenzhen Hospital(Futian)of Guangzhou University of Chinese MedicineShenzhenGuangdong 518000China Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China

Hepatocellular carcinoma(HcC)has become the fifth leading cause of cancer mortality worldwide in the past decade.1 Dysregulated long noncoding RNAs(lncRNAs)are closely associated with its occurrence and *** identified IncRNA named"HOXA transcript at the distal tip"(HOTTIP)has been considered as an oncogene in multiple ***,the mechanism underlying HOTTiP-mediated hepatocarcinogenesis remains mostly unknown.

关键词： DKK1 mortality stimulating

Catalytic Effect of Transition Metal Complexes of Triaminoguanidine on the Thermolysis of Energetic NC/DEGDN Composite

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火炸药学报 2024年第3期47卷 209-219,I0003页

作者： Mohammed Dourari Ahmed Fouzi Tarchoun Djalal Trache Amir Abdelaziz Roufaida Tiliouine Tessnim Barkat weiqiang Pang Energetic Materials Laboratory(EMLab) Teaching and Research Unit of Energetic ProcessesEcole Militaire PolytechniqueBP 17Bordj El-Bahri16046AlgiersAlgeria Xi′an Modern Chemistry Research Institute Xi′an 710065China

The transition metal complexes of triaminoguanidine(TAG-M,where M=Cobalt(Co)or Iron(Fe))have been *** catalytic effect of these complexes on the thermolysis of energetic composite based on nitrocellulose and diethylene glycol dinitrate,has been *** characterization of the resulting energetic composites was carried out using scanning electron microscopy(SEM),X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),and differential scanning calorimetry(DSC).Isoconversional kinetic analysis was performed to determine the Arrhenius parameters associated with the thermolysis of the elaborated energetic *** is found that TAG-M complexes have strong catalytic effect on the thermo-kinetic decomposition of NC/DEGDN by decreasing the apparent activation energy and significantly increased the total heat *** models that govern the decomposition processes are also studied,and it is revealed that different reaction processes are accomplished by introduction metal complexes of ***,this study serves as a valuable reference for future research focused on the investigation of catalytic combustion features of solid propellants.

关键词： triaminoguanidine transition metal complexes nitrocellulose diethylene glycol dinitrate catalytic effect

Potentially Suitable Area and Change Trends of Tulipa iliensis under Climate Change

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Phyton-International Journal of Experimental Botany 2024年第5期93卷 981-1005页

作者： Douwen Qin weiqiang Liu Jiting Tian Xiuting Ju College of Agriculture and Animal Husbandry Qinghai UniversityXining810016China Key Laboratory of Qinghai Province for Landscape Plants Research Plateau Flower Research CentreQinghai UniversityXining810016China

Tulipa iliensis,as a wild plant resource,possesses high ornamental value and can provide abundant parental materials for tulip *** objective of this research was to forecast the worldwide geographical spread of Tulipa iliensis by considering bioclimatic,soil,and topographic variables,the findings of this research can act as a benchmark for the conservation,management,and utilization of Tulipa iliensis as a wild plant *** results indicate that all 12 models have an area under curve(AUC)of the receiver operating characteristic curve(ROC)values greater than 0.968 for the paleoclimatic,current,and future climate scenarios,this suggests an exceptionally high level of predictive accuracy for the *** distribution of Tulipa iliensis is influenced by several key *** factors include the mean temperature of the driest quarter(Bio9),calcium carbonate content(T_CACO3),slope,precipitation of the driest month(Bio14),Basic saturation(T_BS),and precipitation of the coldest quarter(Bio19).During the three paleoclimate climate scenarios,the appropriate habitats for Tulipa iliensis showed a pattern of expansion-contraction ***,the total suitable area accounted for 13.38%,12.28%,and 13.28%of the mainland area,*** to the current climate scenario,the High-suitability area covers 61.78472×10^(4)km^(2),which accounts for 6.57%of the total suitable area,The Midsuitability area covers 190.0938×10^(4)km^(2),accounting for 20.2%of the total suitable area,this represents a decrease of 63.53%~67.13%compared to the suitable area of Tulipa iliensis under the paleoclimate *** the Shared Socioeconomic Pathways(SSP)scenarios,in 2050 and 2090,Tulipa iliensis is projected to experience a decrease in the High,Mid,and Low-suitability areas under the SSP126 climate scenario by 7.10%~12.96%,2.96%~4.27%and 4.80%~7.96%,*** to the SSP245 scenario,the high suitability area experienced a slight expansion of

关键词： Tulipa iliensis MaxEnt model climate change distribution of suitable habitats