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Clean Energy 2022年第3期6卷 528-533页

作者： Lei Guo Aihua Xing weiping zhu Fei Li Zhihui Guo National Institute of Clean and Low Carbon Energy Beijing 102211China

As the core technology of methanol-to-olefins(MTO),the development of a high-efficiency and low-cost molecular sieve catalyst has always been the most important ***,SAPO-34 molecular sieves were synthesized by using three different compositions of amorphous aluminium silicate as both Si and Al source under the same *** structure and composition of synthesized SAPO-34s were investigated using X-ray diffraction and X-ray fluorescence,while the morphology and physical properties were characterized using scanning electron microscopy,N2 adsorption-desorption and ammonia temperature-programmed desorption *** to the silica sol as the Si source,the SAPO-34s prepared with amorphous aluminium silicate show the higher solid yields and crystallinity,larger surface area and lower numbers of acid *** the effect of Si,the effect of the Al source on the textural structure and catalytic performance of SAPO-34s in MTO reactions was investigated in *** results confirmed that the SAPO-34s prepared using amorphous aluminium silicate have low Si content and hierarchical structure,which results in a longer catalytic lifetime and higher selectivity for light *** sample S2 exhibited the longest lifetime of 214 min and the highest selectivity for light olefins of 85.37%.This also provides a potential for the approach to obtain a high-efficiency catalyst with enhanced catalytic performance and low cost.

关键词： methanol-to-olefins SAPO-34 amorphous aluminium silicate catalytic performance

NCL-based mitochondrial-targeting fluorescent probe for the detection of Glutathione in living cells

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Chinese Chemical Letters 2021年第12期32卷 3899-3902页

作者： Tongxia Jin Mengyu Cui Dan Wu weiping zhu Yufang Xu Xuhong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

Glutathione(GSH) plays a critical role in maintaining cellular redox homeostasis in biological *** is a pivotal organelle for cellular aerobic respiration and its disorder is associated with impaired redox balance, leading to cell death. In this work, we designed and synthesized a non-invasive“off-on” mitochondrial-targeting fluorescent probe QZ for the detection of GSH in living cells. Based on the mechanism of native chemical ligation(NCL) and fluorescence resonance energy transfer(FRET), a rhodamine B derivative, QZ was prepared, by choosing aromatic thioester bond as the selective reaction site. QZ exhibited excellent detection capability for GSH over Cys and Hcy. Upon addition of GSH to QZ solution, a remarkably enhanced fluorescence was observed with a limit of detection of 2.98 μmol/***, QZ was found to possess the specific mitochondrial localization ability in cell imaging experiments. Moreover, with exogenous and endogenous stimulations, QZ could image GSH in living cells.

关键词： Fluorescent probe Glutathione NCL In vivo imaging

Novel seven-membered ring-fused naphthalimide derivatives with potentials for cancer theranostics

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Chinese Chemical Letters 2023年第4期34卷 236-239页

作者： Yonghui Yang Xiayu Shi zhuo Chen Yufang Xu Xuhong Qian weiping zhu State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologyShanghai key Laboratory of New Drug DesignSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

Naphthalimide derivatives have good planarity and large conjugated structure and therefore possess photophysical properties and biological activities. Previously, our group discovered seven-membered heterocyclic derivatives via modifying 4-and 5-positions of naphthalimide skeleton and found the derivatives had good water solubility and showed large stokes shift and strong fluorescence in water. In this article, we designed and synthesized more seven-membered ring-fused naphthalimide derivatives(Y1-Y16)by introducing different substitutions on the imide group. Among them, Y1, Y5, Y9 were found to show similar cytotoxic activities with Amonafide against A549 and HL60 cells, with IC50values at 10^(-6)mol/*** is more, the asymmetry derivatives(Y1 and Y5) showed high fluorescent quantum yields in the aqueous phase(Ф = 0.47). Considering the great fluorescence quantum yields in water and the potent anti-tumor activities of the representative seven-membered ring-fused naphthalimides, they have potentials to be used as agents for cancer theranostics.

关键词： Seven-membered ring Antitumor activity High fluorescent quantum yield Theranostics

Application of Geophysical and Remote Sensing Methods to Predict for Potash Resource

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Acta Geologica Sinica(English Edition) 2014年第S1期88卷 289-290页

作者： zhu weiping ZHANG Yongmei China Aero Geophysical Survey & Remote Sensing Center for Land and Resources School of Earth Sciences and Resource China University of Geosciences

1 Introduction Potassium is listed as one of the shortage of mineral resources in *** and remote sensing technology plays an important role in prospecting for potash ressources.

关键词： Application of Geophysical and Remote Sensing Methods to Predict for Potash Resource

A lysosomal targeting fluorescent probe and its zinc imaging in SH-SY5Y human neuroblastoma cells

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Chinese Chemical Letters 2019年第1期30卷 55-57页

作者： Houna Duan Yu Ding Chusen Huang weiping zhu Rui Wang Yufang Xu State Key Laboratory of Bioreactor Engineerring Shanghai Key Laboratory of Chemical Biology School of Pharmacy East China University of Science and Technology The Education Ministry Key Laboratory of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials Department of ChemistryCollege of Life and Environmental Sciences Shanghai Normal University Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology

Zinc plays a significant role in oxidative balance and central nervous systems. Herein, we reported a highly sensitive fluorescent probe DR, bearing a morpholine group and a BPEN ligand in the naphthalimide fluorophore. Upon Zn2+binding, DR exhibited remarkable fluorescence enhancement, and showed high sensitivity to Zn2+with the association constant of 4.9 ? 108 L/mol, and the detection limit of15 nmol/L. Confocal imaging experiments indicated that DR was able to localize to lysosomes in MCF-7 cells. Moreover, upon H2 O2 stimulation in SH-SY5 Y cells, endogenous release of Zn2+was observed.

关键词： Naphthalimide Zinc ions Cellular imaging Lysosome Fluorescent probe

A highly sensitive fluorescent probe for tracking intracellular zinc ions and direct imaging of prostatic tissue in mice

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Chinese Chemical Letters 2020年第11期31卷 2933-2936页

作者： Yuyu Wang Houna Duan Hongyuan Shi Shiwei Zhang Yufang Xu weiping zhu Xuhong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China Department of Radiology Jiangsu Province HospitalFirst Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

A highly sensitive fluorescent sensor ZnDN was designed,synthesized and used for tracking intracellular zinc ions in various living cells and direct imaging of prostatic tissue in *** was prepared from the heterocyclic-fused naphthalimide fluorophore,and the zinc receptor,N,N-bis(2-pyridylmethyl)ethylenediamine(BPEN).Upon addition of Zn2+to the solutions of ZnDN,a remarkable fluorescence enhancement was observed,which could be attributed to the photo-induced electron transfer(PET)*** ZnDN exhibited high sensitivity toward Zn2+in phosphate buffer solution,with a limit of detection of 4.0 x 10-9 mol/L,it was further applied for the imaging of exogenous and endogenous Zn21 in different living *** cells imaging experiments suggested that ZnDN could image the changes of intracellular free zinc ions,and could be used for two-photon ***,flow cytometry suggested that ZnDN could distinguish cancerous prostate cells from normal *** experiments indicated that ZnDN had the potential in imaging prostate tissue in vivo.

关键词： Fluorescent probe Zinc ion Prostate cells Naphthalimide In vivo imaging

Programmed co-assembly of DNA-peptide hybrid microdroplets by phase separation

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Chinese Chemical Letters 2022年第3期33卷 1545-1549页

作者： Shengtao Yao Yue Liao Rizhao Pan weiping zhu Yufang Xu Yangyang Yang Xuhong Qian School of Pharmacy Shanghai Key Laboratory of Chemical BiologyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering East China University of Science and Technology Shanghai 200237China

Biopolymers, including DNA and peptides have been used as excellent self-assembling building blocks for programmable single-component or hybrid materials, due to their controlled molecular ***, combining two assembling principles of DNA-based programmability and peptide-based specific molecular interactions for hybrid structures to microscale has not yet been achieved. In this study,we describe a hybrid microsystem that emerges from the co-assembly of DNA origami structure and short elastin-like polypeptide conjugated oligonucleotides, and initiates liquid-liquid phase separation to generate microdroplets upon heating above the transition temperature. Moreover, the hybrid microdroplets are capable for guest molecule trapping and perform bi-/tri-enzymatic cascades with rate enhancements as open “microreactors”. Our programmed assembled DNA-peptide microsystem represents a new combination of DNA nanotechnology and peptide science and opens potential application routes toward lifeinspired biomaterials.

关键词： Self-assembly Microdroplet DNA origami Phase separation Elastin-like polypeptides

A ratiometric fluorescent probe for alkaline phosphatase with high sensitivity

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Chinese Chemical Letters 2020年第1期31卷 125-128页

作者： Yangyang Yang Chen Zhang Rizhao Pan Shiwei Zhang Shengtao Yao Yao Tang Weilong zhu Liyue Wang weiping zhu Yufang Xu Xuhong Qian Shanghai Key Laboratory of Chemical Biology School of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China

Alkaline phosphatase(ALP)is one of essential biomarkers in mammalian *** we report a ratiometric probe for ALP,which is rationally designed and synthesized by employing ESIPT fluorophore N-(3-(benzo[d]thiazol-2-yl)-4-hydroxyphenyl)benzamide(BTHPB).The enzymatic dephosphorylation converts the probe to BTHPB,which exhibits a large spectral red-shift(120 nm),allowing extremely high sensitivity of ALP sensing at 0.004 mU/*** probe also shows excellent biocompatibility and has been applied for monitoring the endogenic ALP in living cells.

关键词： Fluorescent probe Alkaline phosphatase Ratiometric ESIPT Biomarker

大宁–吉县区块深部煤层气多轮次转向压裂技术及应用

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煤田地质与勘探 2024年第2期52卷 147-160页

作者：熊先钺甄怀宾李曙光王红娜张雷宋伟林海徐凤银李忠百朱卫平王成旺陈高杰中联煤层气国家工程研究中心有限责任公司北京100095 中石油煤层气有限责任公司北京100028 中油油气勘探软件国家工程研究中心有限公司北京100080 中国石油天然气股份有限公司青海油田分公司甘肃敦煌736202 中国石油学会北京100724

鄂尔多斯盆地东缘大宁-吉县区块深部煤层气资源丰度高,煤储层天然裂缝与煤自身割理裂隙发育、煤体结构好、机械强度高、顶底板封盖能力强,为大规模体积压裂缝网的形成提供了有利条件。超大规模压裂改造工艺使深部煤层气单井产量获得重... 详细信息

鄂尔多斯盆地东缘大宁-吉县区块深部煤层气资源丰度高,煤储层天然裂缝与煤自身割理裂隙发育、煤体结构好、机械强度高、顶底板封盖能力强,为大规模体积压裂缝网的形成提供了有利条件。超大规模压裂改造工艺使深部煤层气单井产量获得重大突破,但示踪剂监测结果显示,水平井各压裂段产气效果贡献不均一、资源动用存在盲区、综合效益未达预期。指出深部煤储层形成超大规模有效缝网面临两类主要挑战:(1)深部煤层裂缝扩展规律认识不清;(2)现有压裂技术存在过度改造及改造不充分区域。基于此问题,提出适合深部煤储层改造的多轮次转向缝网弥合压裂技术。首先,分析深部煤层超大规模缝网形成的可行性;其次结合现场压裂数据与微地震监测结果,分析地层曲率、倾角等对压裂裂缝扩展的影响;最后建立应力场计算方法,以此为依据,进行多轮次转向工艺优化及现场试验。在大宁-吉县区块现场进行试验验证,井周微应力场非均匀区域水力裂缝实现了较为均匀的扩展,增大了裂缝整体改造体积,单井产气效果较周边井有明显提升,其中DJ55井5轮次压裂,储层改造体积达到243.6×10^(4)m^(3),生产340 d累产气量970.5×10^(4)m^(3),平均日产气量2.85×10^(4)m^(3),日产量和压力均保持稳定,改造效果较好,预计采收储量(EUR)大于3000×10^(4)m^(3),产气潜力较大;JS8-6P05井第1-7段采用2~3轮次压裂,压后日产气量8.59×10^(4)m^(3),相比各段均采用单轮次压裂的JS8-6P04井加砂规模降低41.9%、压裂费用降低21%,但2口井水平段千米日产气量相当。试验效果表明,多轮次压裂工艺在一定程度上解决了水平井两侧应力差异而导致的裂缝单侧扩展问题,促进井筒两侧压裂裂缝趋于均匀扩展,极大程度上保障了深部煤储层资源动用程度和压后产量,是深部煤层气压裂工艺降本增效的主要技术途径。

关键词：鄂尔多斯盆地东缘深部煤层气超大规模压裂微应力场多轮次

A review of ^(17)O isotopic labeling techniques for solid-state NMR structural studies of metal oxides in lithium-ion batteries

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Magnetic Resonance Letters 2024年第2期4卷 46-53页

作者： Xiaoli Xia Lei zhu weiping Tang Luming Peng Junchao Chen School of Chemistry and Chemical Engineering Shanghai Jiao Tong University800 Dongchuan RoadShanghai200240China Key Laboratory of Mesoscopic Chemistry of Ministry of Education and Collaborative Innovation Center of Chemistry for Life Sciences School of Chemistry and Chemical EngineeringNanjing University163 Xianlin RoadNanjing210023China State Key Laboratory of Space Power-Sources Technology Shanghai Institute of Space Power-SourcesShanghai200245China

Recent advances in utilizing ^(17)O isotopic labeling methods for solid-state nuclear magnetic resonance(NMR)investigations of metal oxides for lithium-ion batteries have yielded extensive insights into their structural and dynamic ***,we commence with a brief introduction to recent research on lithium-ion battery oxide materials studied using ^(17)O solid-state NMR *** we delve into a review of ^(17)O isotopic labeling methods for tagging oxygen sites in both the bulk and surfaces of metal *** last,the unresolved problems and the future research directions for advancing the ^(17)O labeling technique are discussed.

关键词： ^(17)O solid-state NMR ^(17)O isotopic labeling methods Bulk and surfaces of metal oxides DFT calculation