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BioTreasury:a community-based repository enabling indexing and rating of bioinformatics tools

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Science China(Life Sciences) 2024年第2期67卷 221-229页

作者： Qi Zhao Xin Zhou Jingxing Wu Jieyi Cai Xiaoqiong Bao Lin Tang Chaoye Wang Chunlei Liu Yukai Wang Yuyan Teng Mohan Zheng weiping mu Zhixiang Zuo Yubin Xie Xiaotong Luo Jian Ren School of Life Sciences State Key Laboratory of Oncology in South ChinaCancer CenterGuangdong Provincial Clinical Research Center for CancerSun Yat-sen UniversityGuangzhou 510060China Institute of Precision Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Institute of Gastroenterology Department of General SurgeryGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510275China

The exponential growth of bioinformatics tools in recent years has posed challenges for scientists in selecting the most suitable one for their data analysis ***,to aid scientists in making informed choices,a community-based platform that indexes and rates bioinformatics tools is urgently *** this study,we introduce Bio Treasury(http://***),an integrated communitybased repository that provides an interactive platform for users and developers to share their experiences in various bioinformatics *** Treasury offers a comprehensive collection of well-indexed bioinformatics software,tools,and databases,totaling over 10,000 *** the past two years,we have continuously improved and maintained Bio Treasury,adding several exciting features,including creating structured homepages for every tool and user,a hierarchical category of bioinformatics tools and classifying tools using large language model(LLM).Bio Treasury streamlines the tool submission process with intelligent ***,Bio Treasury provides a wide range of social features,for example,enabling users to participate in interactive discussions,rate tools,build and share tool collections for the *** believe Bio Treasury can be a valuable resource and knowledge-sharing platform for the biomedical *** empowers researchers to effectively discover and evaluate bioinformatics tools,fostering collaboration and advancing bioinformatics research.

关键词： bioinformatics tools index tool database rating system large language model tool collections shari

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科研论文题目英译浅谈

中国科技翻译 2005年第2期18卷 17-19页

作者：沐卫萍扬州职业大学外语系扬州市225009

科研论文题目是文章内容的高度概括,它对读者具有影响力,可使读者首先明确论文研究的主题。本文结合笔者的工作经验,着眼于英文题目的特点,详细阐述论文题目英译时应注意的几个问题,并介绍汉语常见论文题目的英译方法。

关键词：论文题目科研文章内容论文研究工作经验英文题目英译方法影响力读者汉语

高职院校学生英语写作中的常见问题分析及其对策探究

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广西大学梧州分校学报 2005年第4期15卷 87-90页

作者：沐卫萍扬州职业大学外语系江苏扬州250001

英语写作能有效地促进英语知识的内化,有助于学习者检验英语的句法结构和词语的使用,从而有效地促进二语习得。高职院校学生的英语写作一直是英语教学中最薄弱的环节。本文首先分析了高职院校学生英语写作中的常见问题,并针对这些问... 详细信息

英语写作能有效地促进英语知识的内化,有助于学习者检验英语的句法结构和词语的使用,从而有效地促进二语习得。高职院校学生的英语写作一直是英语教学中最薄弱的环节。本文首先分析了高职院校学生英语写作中的常见问题,并针对这些问题提出了改进英语写作教学、提高学生英语写作能力的几点策略。

关键词：高职院校写作常见问题对策

A Study on Comprehensive Evaluation Model of Product Producing Process Capability

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A Study on Comprehensive Evaluation Model of Product Produci...

喷射超高韧性水泥基复合材料加固带裂缝素混凝土梁的力学性能试验研究

The 8th International Conference on Reliability,Maintainability and Safety(ICRMS 2009)

作者： weiping mu Yihai He Wenbing Chang Zhao Ma Department of System Engineering of Engineering Technology Beijing University of Aeronautics and Astronautics Beijing China

＜正＞Process Capability Index is a widely used tool for quality *** methods of Process Capability evaluation are limited to machining *** are no suitable methods for comprehensive evaluation of total producing process *** this paper,a comprehensive evaluation model of product producing process capability is proposed,so that data of all stages can be fully *** for machining capability evaluation are extended to purchasing,assembling and delivery inspection and an index system of producing process capability evaluation is *** addition,analytic hierarchy process is used to determine the weight of each stage and then producing process capability index is achieved by summing. Finally,an application example is analyzed to show that the entire producing capability can be evaluated *** should play an important part in monitoring and improving producing process capability.

关键词： Producing Process Quality Evaluation Process Capability Index Comprehensive Evaluation Model

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世界地震工程 2018年第1期34卷 166-172页

作者：李伟平穆富江王激扬丁海洋徐世烺浙江省交通规划设计研究院浙江杭州310006 浙江大学浙江杭州310058

对既有受损混凝土结构的加固维修是地震灾后重建的重点之一。应用喷射超高韧性水泥基复合材料(UHTCC)的拉伸应变硬化特性,研究了带裂缝混凝土梁底部喷射20mm薄层UHTCC的加固作用。结果表明:薄层喷射UHTCC对混凝土梁的弯曲强度和弯曲刚... 详细信息

对既有受损混凝土结构的加固维修是地震灾后重建的重点之一。应用喷射超高韧性水泥基复合材料(UHTCC)的拉伸应变硬化特性,研究了带裂缝混凝土梁底部喷射20mm薄层UHTCC的加固作用。结果表明:薄层喷射UHTCC对混凝土梁的弯曲强度和弯曲刚度有明显的加固作用,可将带预制裂缝的混凝土梁极限承载力提高117.5%,使受损混凝土梁的承载能力恢复到相同尺寸无损混凝土梁承载能力相当的水平;此外混凝土梁底部薄层喷射UHTCC能将裂缝宽度控制在0.1mm以下的微裂缝,有利于提高混凝土梁的耐久性。

关键词：喷射UHTCC 修复加固裂缝控制力学性能

COX-2、MMP-9在胃癌中的表达及意义

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滨州医学院学报 2014年第1期37卷 1-4,8页

作者：牟卫平刘晶刘荣耀周帅黄飞滨州医学院附属医院消化内科滨州256603 滨州医学院附属医院内镜中心滨州医学院人体解剖与组织胚胎学研究所

目的研究胃癌组织中COX-2、MMP-9的表达的临床意义以及二者的相互关系。方法应用免疫组织化学方法检测收集的52例胃癌标本中COX-2、MMP-9蛋白的表达,并将检测结果进行分析。结果 52例胃癌组织中COX-2、MMP-9蛋白的阳性表达率分别为78%和... 详细信息

目的研究胃癌组织中COX-2、MMP-9的表达的临床意义以及二者的相互关系。方法应用免疫组织化学方法检测收集的52例胃癌标本中COX-2、MMP-9蛋白的表达,并将检测结果进行分析。结果 52例胃癌组织中COX-2、MMP-9蛋白的阳性表达率分别为78%和70%,而在胃正常组织中均呈低表达或不表达,两者有显著性差异(P0.05);COX-2的表达与MMP-9的表达显著相关(P<0.05,r=0.3587)。结论 COX-2可诱导MMP-9的表达,并在促进胃癌的侵袭转移中发挥重要作用。

关键词：胃癌环氧化酶-2 基质金属蛋白酶-9 Cyclooxygenase-2 Matrix metalloproteinase-9

Development of Land Surface Model BCC＿AVIM2.0 and Its Preliminary Performance in LS3MIP/CMIP6

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Journal of Meteorological Research 2019年第5期33卷 851-869页

作者： weiping LI Yanwu ZHANG Xueli SHI Wenyan ZHOU Anning HUANG Mingquan mu Bo QIU Jinjun JI Laboratory for Climate Studies National Climate CenterChina Meteorological Administration(CMA)Beijing 100081China CMA–NJU Joint Laboratory for Climate Prediction Studies Nanjing University(NJU)Nanjing 210023China Department of Atmospheric Sciences Nanjing UniversityNanjing 210023China Department of Earth System Science University of CaliforniaIrvineIrvineCA 92697-3100USA Jiangsu Provincial Key Laboratory of Geographic Information Science and Technology International Institute for Earth System ScienceNanjing UniversityNanjing 210023China Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China

The improvements and validation of several parameterization schemes in the second version of the Beijing Climate Center Atmosphere–Vegetation Interaction Model(BCC_AVIM2.0) are introduced in this study. The main updates include a replacement of the water-only lake module by the common land model lake module(Co LM-lake) with a more realistic snow–ice–water–soil framework, a parameterization scheme for rice paddies added in the vegetation module, renewed parameterizations of snow cover fraction and snow surface albedo to accommodate the varied snow aging effect during different stages of a snow season, a revised parameterization to calculate the threshold temperature to initiate freeze(thaw) of soil water(ice) rather than being fixed at 0°C in BCC_AVIM1.0, a prognostic phenology scheme for vegetation growth instead of empirically prescribed dates for leaf onset/fall, and a renewed scheme to depict solar radiation transfer through the vegetation canopy. The above updates have been implemented in BCC_AVIM2.0 to serve as the land component of the BCC Climate System Model(BCC_CSM). Preliminary results of BCC_AVIM in the ongoing Land Surface, Snow, and Soil Moisture Model Intercomparison Project(LS3 MIP) of the Coupled Model Intercomparison Project Phase 6(CMIP6) show that the overall performance of BCC_AVIM2.0 is better than that of BCC_AVIM1.0 in the simulation of surface energy budgets at the seasonal timescale. Comparing the simulations of annual global land average before and after the updates in BCC_AVIM2.0 reveals that the bias of net surface radiation is reduced from-12.0 to-11.7 W m-2 and the root mean square error(RMSE) is reduced from 20.6 to 19.0 W m-2;the bias and RMSE of latent heat flux are reduced from 2.3 to-0.1 W m-2 and from 15.4 to14.3 W m-2, respectively;the bias of sensible heat flux is increased from 2.5 to 5.1 W m-2 but the RMSE is reduced from 18.4 to 17.0 W m-2.

关键词： BCC_AVIM2.0 LS3MIP CMIP6 surface radiation sensible heat flux latent heat flux

Exposure of benzo[a]pyrene induces HCC exosome-circular RNA to activate lung fibroblasts and trigger organotropic metastasis

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Cancer Communications 2024年第7期44卷 718-738页

作者： Wei mu Pengfei Gu Huating Li Jinjin Zhou Yulun Jian weiping Jia Yang Ge School of Public Health Center for Single-cell OmicsShanghai Jiao Tong University School of MedicineShanghaiP.R.China Shanghai Key Laboratory of Diabetes Mellitus Department of Endocrinology and MetabolismShanghai Diabetes InstituteShanghai Clinical Center for DiabetesShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiP.R.China

Background:Benzo[a]pyrene(B[a]P),a carcinogen pollutant produced by combustion processes,is present in the western diet with grilled *** exposure of B[a]P in hepatocellular carcinoma(HCC)cells promotes metastasis rather than primary proliferation,implying an unknown mechanism of B[a]P-induced *** that exosomes carry bioactive molecules to distant sites,we investigated whether and how exosomes mediate cancer-stroma communications for a toxicologically associated ***:Exosomes were isolated from B[a]P stimulated BEL7404 HCC cells(7404-100Bap Exo)at an environmental relevant dose(100 nmol/L).Lung preeducation animal model was prepared via injection of exosomes and *** inflammatory genes of educated lungs were evaluated using quantitative reverse transcription PCR *** LM3 cells transfected with firefly luciferase were next injected to monitor tumor burdens and organotropic *** of B[a]P-exposed exosomes were determined by ceRNA *** between circular RNA(circRNA)and microRNAs(miRNAs)were detected using RNA pull-down in target lung *** in situ hybridization and RNA immunoprecipitation assay was used to evaluate the“on-off”interaction of circRNA-miRNA *** further developed an adenoassociated virus inhalation model to examine mRNA expression specific in lung,thereby exploring the mRNA targets of B[a]P induced circRNA-miRNA ***:Lung fibroblasts exert activation phenotypes,including focal adhesion and motility were altered by 7404-100Bap *** the exosome-educated in vivo model,fibrosis factors and pro-inflammatory molecules of are up-regulated when injected with *** to non-exposed 7404 cells,circ_0011496 was up-regulated following B[a]P treatment and wasmainly packaged into 7404-100Bap *** circ_0011496 were delivered and competitively bound to miR-486-5p in recipient *** down-regulation of miR-486-5p converted fi

关键词： benzo(a)pyrene cancer associate fibroblast circular RNA exosome organotropic metastasis

Investigation of Brucellosis Caused by Raw Goat Milk—Fujian Province,China,April–June,2019

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China CDC weekly 2021年第20期3卷 430-433页

作者： mu Di Zhongfa Tao weiping Hua Jiandong Chen Jingming Cao Yanqin Deng Huihui Liu Lijie Zhang Yishan Chen Qiulan Chen Wenwu Yin Chinese Center for Disease Control and Prevention Infectious Diseases Management OfficeBeijingChina China Chinese Field Epidemiology Training Project BeijingChina Guizhou Provincial Center for Disease Control and Prevention GuiyangGuizhouChina Zhangping County Center for Disease Control ZhangpingFujianChina Fujian Provincial Center for Disease Control and Prevention FuzhouFujianChina Emory University AtlantaUSA.

Summary What is already known about this topic?Brucellosis is one of the most important zoonotic diseases in *** milk and dairy products are essential pathways for foodborne transmission of *** can completely kill Brucella *** milk,and milk-borne transmission is mainly related to unhealthy dietary hygiene habits and insufficient epidemic control among animals.

关键词： China. Fujian Pasteur