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稳定同位素标记-高效液相色谱-串联质谱法测定动物源性食品中12种利尿剂

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化学研究与应用 2024年第8期36卷 1941-1949页

作者：吴恋戴琴姚静唐柏杨廖梅杨小琪石培育陈世奇宋娟成都市食品检验研究院四川成都611130 国家市场监管重点实验室(营养与健康化学计量及应用) 北京100029 国家市场监管重点实验室(调味品监管技术) 重庆401102

本研究建立了稳定同位素标记-高效液相色谱串联质谱法测定动物源性食品中12种利尿剂的方法。试样经5%甲酸乙腈提取,通过式固相萃取柱净化,采用液相色谱-质谱/质谱仪测定,同位素内标法定量。12种利尿剂在各自浓度范围内线性关系良好,平... 详细信息

本研究建立了稳定同位素标记-高效液相色谱串联质谱法测定动物源性食品中12种利尿剂的方法。试样经5%甲酸乙腈提取,通过式固相萃取柱净化,采用液相色谱-质谱/质谱仪测定,同位素内标法定量。12种利尿剂在各自浓度范围内线性关系良好,平均回收率介于71.3%~104.7%,相对标准偏差介于1.2%~11.1%(n=6)。该方法具有灵敏度高、准确性好、操作简单、检测效率高等特点,能够满足多种动物源性食品中12种利尿剂的检测需求。

关键词：高效液相色谱-串联质谱动物源性食品利尿剂稳定同位素标记

Authentic compound-free strategy for simultaneous determination of primary coumarins in Peucedani Radix using offline high performance liquid chromatography–nuclear magnetic resonance spectroscopy–tandem mass spectrometry

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Acta Pharmaceutica Sinica B 2018年第4期8卷 645-654页

作者： yao Liu Qingqing song Wenjing Liu Peng Li Jun Li Yunfang Zhao Liang Zhang Pengfei Tu Yitao Wang Yuelin song Modern research Center for Traditional Chinese Medicine School of Chinese Materia MedicaBeijing University of Chinese Medicine State Key Laboratory of Quality research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of Macao State Key Laboratory of Tea Plant Biology and Utilization Anhui Agricultural University

Herein, a strategy is proposed for the simultaneous determination of primary coumarins in Peucedani Radix(Chinese name: Qianhu). The methodology consists of three consecutive steps: 1) Semi-preparative LC in combination with a home-made automated fraction collection module to fragment the universal metabolome standard into ten fractions(Frs. I–X); 2) LC–accurate MS/MS and quantitative1 H NMR spectroscopy conducted in parallel to acquire the qualitative and quantitative data of each fraction; 3) Robust identification and quantification of components by use of LC coupled to multiple reaction monitoring. In this final step, the most significant fractions(Frs. III–X) were pooled to serve as the pseudo-mixed standard solution. Meticulous online parameter optimization was performed to obtain the optimal parameters, including ion transitions and collision energies. Concerns were particularly paid onto pursuing the parameters being capable of monitoring regiospecific isomers, notably praeruptorin E vs. 3′-isovaleryl-4′-angeloylkhellactone. The quantitative performance of the method was validated according to diverse assays. Eleven primary coumarins(1–11) were unambiguously identified and absolutely quantified, even though no external reference compound was used. Above all, the integrated strategy not only provides a feasible pipeline for the quality assessment of Peucedani Radix, but more importantly, shows the potential for authentic compound-free quantitative evaluation of traditional Chinese medicines.

关键词： Authentic compoundindependent quantitation Offline LC–NMR–MS/MS Automated fraction collection module Quantitative1H NMR Peucedani Radix Regio-specific monitoring

Fluorescent Silicon Nanorods-Based Nanotheranostic Agents for Multimodal Imaging-Guided Photothermal Therapy

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Nano-Micro Letters 2019年第4期11卷 293-307页

作者： Mingyue Cui Sangmo Liu Bin song Daoxia Guo Jinhua Wang Guyue Hu Yuanyuan Su yao He Laboratory of Nanoscale Biochemical Analysis institute of Functional Nano&Soft Materials(FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow University199 Ren’ai RoadSuzhou 215123JiangsuPeople’s Republic of China

The utilization of diagnosis to guide/aid therapy procedures has shown great prospects in the era of personalized medicine along with the recognition of tumor heterogeneity and ***,a kind of multifunctional silicon-based nanostructure,i.e.,gold nanoparticles-decorated fluorescent silicon nanorods(Au@SiNRs),is fabricated and exploited for tumor-targeted multimodal imaging-guided photothermal *** particular,the prepared Au@SiNRs feature high photothermal conversion efficiency(~43.9%)and strong photothermal stability(photothermal performance stays constant after five-cycle NIR laser irradiation),making them high-performance agents for simultaneously photoacoustic and infrared thermal *** Au@SiNRs are readily modified with targeting peptide ligands,enabling an enhanced tumor accumulation with a high value of^8.74%ID g?*** advantages of these unique merits,the Au@SiNRs are superbly suitable for specifically ablating tumors in vivo without appreciable toxicity under the guidance of multimodal ***,all the mice treated with the Au@SiNRs remain alive,and no distinct tumor recurrence is observed during 60-day investigation.

关键词： Gold nanoparticle Fluorescent silicon nanorods Nanotheranostic Multimodal imaging Photothermal therapy Tumor target

Solid ion transition route to 3D S-N-codoped hollow carbon nanosphere/graphene aerogel as a metal-free handheld nanocatalyst for organic reactions

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Nano research 2017年第10期10卷 3486-3495页

作者： Jing Pan Shuyan song Junqi Li Fan Wang xin Ge Shuang yao xiao Wang Hongjie Zhang College of Chemistry Jilin University Changchun 130012 China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

A novel metal-free bulk nanocatalyst, S--N-codoped hollow carbon nanosphere/ graphene aerogel （SNC-GA-1000）, has been successfully fabricated using a facile and clean solid ion transition route. In this method, ZnS is used as the hard template and S source, while polydopamine acts as a reducing agent and carbon source. At a high annealing temperature, Zn metal is reduced and evaporates, leaving only free S vapor to diffuse into the carbon layer. Interestingly, the as-obtained SNC-GA-1000 exhibits much higher catalytic activity in an organic reduction reaction than unloaded bare S--N-codoped carbon nanospheres. Hydrothermal reduction of the graphene oxide sheets loaded with ZnSC@olydopamine core-shell nanospheres （ZnS@PDA） affords a three-dimensional bulk graphene aerogel. Although nanosized catalysts exhibit high catalytic activities, their subsequent separation is not always satisfactory, making post-treatment difficult. This approach achieves a trade-off between activity and separability. More importantly, due to the 3D structural nature, such bulk and handheld nanocatalysts can be easily separated and recycled.

关键词： bulk nanocatalyst solid ion transition graphene aerogel S-N-codoped metal-free

基于聚乙烯亚胺修饰磁性纳米粒的分散固相萃取/高效液相色谱法测定水中非甾体抗炎药

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中国药科大学学报 2024年第4期55卷 485-492页

作者：汤晓航宋会林姚丽莹秦国文王星晨柳文媛纪顺利东台市人民医院药学科东台224200 中国药科大学药学院南京210009 芜湖职业技术学院芜湖生命健康研究中心芜湖241000

环境水样中非甾体抗炎药(NSAIDs)的长期存在不仅会影响水生生物的生命安全,扰乱生态系统环境,而且会对人类健康构成严重威胁。采用溶剂热法首先制备了氨基功能化Fe_(3)O_(4)纳米粒子(Fe_(3)O_(4)-NH_(2))。随后,通过室温下水溶液中的席... 详细信息

环境水样中非甾体抗炎药(NSAIDs)的长期存在不仅会影响水生生物的生命安全,扰乱生态系统环境,而且会对人类健康构成严重威胁。采用溶剂热法首先制备了氨基功能化Fe_(3)O_(4)纳米粒子(Fe_(3)O_(4)-NH_(2))。随后,通过室温下水溶液中的席夫碱反应,以戊二醛为交联剂,将具有支链结构的聚乙烯亚胺(PEI)成功地接枝到Fe_(3)O_(4)纳米粒子上,合成了一种可回收的PEI接枝磁性纳米吸附剂(Fe_(3)O_(4)@PEI)并将其应用于环境水中NSAIDs的检测。通过各种表征手段研究了Fe_(3)O_(4)@PEI的组成特性,并对影响NSAIDs萃取效果的参数进行了优化。Fe_(3)O_(4)@PEI对4种NSAIDs具有高吸附性,与高效液相色谱联用可对环境水样中的酮洛芬、萘普生、双氯芬酸和托芬那酸4种NSAIDs进行定量分析,在1~500μg/mL范围内,色谱峰面积与质量浓度呈良好的线性关系,样品在3种不同添加水平下的加标回收率在85.6%~107.8%,日内精密度均小于7.8%(n=6),日间精密度均小于9.5%(n=3)。该方法操作简单、准确高效,可用于环境水样中非甾体抗炎药的测定。

关键词：非甾体抗炎药聚乙烯亚胺磁性固相萃取纳米粒高效液相色谱法

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Climate change and Chinese farmers: Perceptions and determinants of adaptive strategies

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Journal of Integrative Agriculture 2018年第4期17卷 949-963页

作者： ZHAI Shi-yan song Gen-xin QIN yao-chen YE xin-yue Mark Leipnik College of Environment and Planning/Laboratory of Geospatial technology for the Middle and Lower Yellow River Regions/Key research institute of Yellow River Civilization and Sustainable Development & Collaborative Innovation Center on Yellow River Civilization of Henan Province Henan University Key Laboratory of Geographic Information Science Ministry of Education East China Normal University Department of Geography Kent State University Department of Geography & Geology Sam Houston State University

Farmers’ perceptions, beliefs, adaptive strategies, and barriers regarding climate change are critical to promoting sustainable ecosystems and societal stability. This paper is based on an extensive survey of 1 500 farmers and their households in Henan Province in China during 2013–2014. Henan is the largest agricultural province in China with over 51 million farmers. The survey results showed that approximately 57% of the respondents perceived the direct impact of climate change during the past 10 years, with 70.3% believing that climate change posed a risk to their livelihood. Not surprisingly, most farmers reported that they have adopted new measures to mitigate the negative impacts of climate change. The main barriers hindering farmers’ adopting adaptation measures were lack of funds and timely information. A multinomial logit model revealed that land ownership, knowledge of crop variety and the causes of climate change, as well as the belief of climate change, were all positively related to the likelihood of employing adaptive strategies. Moreover, the percentage of households engaging in agriculture activity, and years of engaging in farming were both negatively correlated with famer’s likelihood of adopting adaptation strategies. More importantly, farmers with high incomes were less likely to adopt adaptive strategies and more willing to engage in other business activities. In conclusion, it is important to communicate climate change related information and government policies in rural areas, promote farmer associations and other educational outreach efforts to assist Chinese farmers to deal with climate change.

关键词： climate change Chinese farmers adaptive strategies Henan Province

Recent progress in theoretical and computational investigations of structural stability and activity of single-atom electrocatalysts

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Progress in Natural Science:Materials International 2019年第3期29卷 256-264页

作者： Youwei Wang Erhong song Wujie Qiu xiaolin Zhao yao Zhou Jianjun Liu Wenqing Zhang State Key Laboratory of high Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of Sciences Department of Physics and Shenzhen institute for Quantum Science & technology Southern University of Science and Technology

This review has been made an attempt to seek some observed descriptors to comprehensively optimize structural stability and catalytic activity of single-atom catalysts. Electronic structure analysis can reveal the underlying mechanisms of atomic phy-chemical properties and local coordination structures on binding strength. The free electrons around Fermi level play an important role to determine the binding strength, which can be further influenced by electronegativity difference between single atom and nearby support atoms. This investigation can contribute to understanding the underlying mechanisms for the design of stable and active catalysts, and further provide a deep insight to the potential pathways in the research field of single-atom catalysts.

关键词： SAC Recent progress in theoretical and computational investigations of structural stability and activity of single-atom electrocatalysts

research on the dynamic response of connecting rod bearing bush wear of reciprocating machine under variable working conditions

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high technology Letters 2023年第2期29卷 148-158页

作者：张进杰 song Chunyu LEI Fuchang WANG yao ZHI Haifeng LIU Fengchun Beijing Key Laboratory of Health Monitoring and Self-Healing of high-end Mechanical Equipment Beijing University of Chemical TechnologyBeijing 100029P.R.China China North Engine research institute(Tianjin) Tianjin 300400P.R.China

As a type of reciprocating machine, the reciprocating compressor has a compact structure and many excitation *** the small end bearing of the connecting rod is worn, it is easy to cause the sintering of the bearing and the abnormal vibration of the *** on the characteristics of poor lubrication state and complex force of connecting rod small head bearing, a mixed lubrication model considering oil groove feed was established, and the dynamic simulation of the reciprocating compressor model with lubricated bearings was carried out;considering different speeds and gas load conditions, the law of the impact of the eigenvalues changing with working conditions was *** fault simulation experiment was carried out by selecting representative working conditions, which verified the correctness of the simulation *** study found that two contact collisions between the pin and the bearing bush occurred in one cycle, the collision impact was more severe under the wear fault, and the existence of the gap made the dynamic response more sensitive to the change of working *** research provides ideas for the location and feature extraction of fault symptom signal angular segments in the process of complex measured signal processing.

关键词： small head tile wear lubrication variable working condition impact

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen Jing-Yu Tang Rui-Rui Fan Qiang Li Gong Li Dong Liu Zheng-yao Jin xing-Zhu Cui Tian-xiang Chen Yi-Wei Yang Rong Liu Han Yi Yang Li Zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao Ping Cao Qi-Ping Chen Zhen Chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-xiong Huang Wei-Hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang Ling Kang Bo Li Chao Li Jia-Wen Li xiao Li Jie Liu Shu-Bin Liu Guang-Yuan Luan Chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren xi-Chao Ruan Zhao-Hui song Kang Sun Zhi-xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen xiao-Guang Wu Xuan Wu Li-Kun xie Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Mo-Han Zhang Qi-Wei Zhang xian-Peng Zhang Yu-Liang Zhang Yue Zhang Zhi-Yong Zhang Mao-Yuan Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French institute of Nuclear Engineering and technology Sun Yat-sen UniversityZhuhai 519082China institute of high-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest institute of Nuclear technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method