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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy.and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy.and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Fabrication of quaternary Mg-Zn-y-Ce quasi-crystal alloys and their strengthening effects on AZ91 magnesium alloys

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China Foundry 2010年第4期7卷 342-348页

作者： Wang Zhifeng Zhao weimin Li Haipeng Liang Chunyong School of Materials Science and Engineering Hebei University of Technology Tianjin 300130 China

Quaternary Mg-Zn-y-Ce quasi-crystal-containing alloys were fabricated using a metal mold casting route. The microstructures of Mg-Zn-y-Ce alloys and the distribution of the major elements were analyzed. The differences in morphology.and micro-hardness between quaternary Mg-Zn-y-Ce quasi-crystals and ternary Mg- Zn-y quasi-crystals were discussed. The result showed that the micro-hardness of Mg-Zn-y-Ce quasi-crystals reached peak value when the content of Ce was 0.8at.%. Subsequently, various contents of Mg-Zn-y-0.8Ce alloys were used to strengthen AZ91 magnesium alloys. The microstructural modification and mechanical properties of reinforced AZ91 alloys with and without solution, as well as their aging treatments, were also studied. Further research showed that aging-treated AZ91-10wt.%(Mg-Zn-y-0.8at.%Ce) alloys exhibited excellent mechanical properties: their Brinell hardness, tensile strength, and elongation were HV91, 252 MPa, and 4.1%, respectively. Through this study, the range of application of AZ91 alloys can further be extended.

关键词： quasi-crystals magnesium alloys AZ91 strengthening effects Mg-Zn-y-Ce

Fabrication of Mg-Zn-y-based quasi-crystal by pouring melt into different cooling media

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China Foundry 2012年第3期9卷 207-214页

作者： Wang Zhifeng Zhao weimin Qin Chunling Hur Bo-young School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China Light Metals Group Korea Institute of Materials ScienceChangwon 642-831Republic of Korea School of Nano and Advanced Materials Engineering Gyeongsang National UniversityJinju 660-701Republic of Korea

Mg-Zn-y-based quasi-crystal （QC） alloys were fabricated by pouring melts into different cooling media. The effects of different cooling rates on the QC morphology, size, volume fraction and micro-hardness were studied. Multi-component Mg-Zn-y-based QC alloys were synthesized based on amorphous design principle. QC morphology transformation and its influencing factors were analyzed. Micro/nano spherical quasi-crystals （QCs） were fabricated through a wedge-shaped copper mould and their forming mechanism were discussed by atoms cluster theory, optimum cooling rate theory.and the known crucial criteria. The results of research show that with the cooling rate reduced, the solidified morphology of QC phase changes from near-spherical, micro petals （1 to 2 um） to big petals （20 um） and finally grows up to bulk pentagon or hexagon （200 to 400 um）. Multi-component micro-spherical QCs possess higher value of micro-hardness than petal-like QCs with the same components, and also higher than ternary micro-Mg-Zn-y QCs. The fine master alloys containing micro-QCs （0.4 um） and nano-QCs （about 300 nm and 40 nm） have been fabricated correspondingly on the middle and the tip of wedge-shaped castings. A morphology evolution schematic diagram of Mg-Zn-y-based QCs is included in this paper.

关键词： quasi-crystals cooling media magnesium alloy Mg-Zn-y-based alloys

Input-Output Production Structure and Non-Linear Production Possibility Frontier

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Journal of Systems Science & Complexity 2021年第2期34卷 706-723页

作者： JIANG weimin FAN Jin TIAN Kailan College of Economics and Management Nanjing Forestry UniversityNanjing 210037China

Input-output(Leontief)production function is widely used in economic *** diminishing marginal rate of return is a very well accepted economic *** production function normally results in a linear production possibility frontier(PPF)due to its linear feature,whereas diminishing marginal rate of return implies a non-linear *** this paper,the authors aim to fix this problem by considering multiple primary inputs in a simplified two-sector *** authors find that it is possible to curve a non-linear PPF by using Leontief production function when the authors add heterogeneous primary *** authors also discuss the PPF using non-linear production ***,the authors propose that three commonly used economic presumptions cannot hold in the same *** presumptions are"single primary input","fixed-proportion inputs"and"law of diminishing marginal returns".

关键词： Input output analysis marginal rate of transformation non-substitution theorem production possibility frontier

Effects of the fourth component and undercooling on morphology of primary Mg-Zn-y icosahedral quasicrystal phase under normal casting conditions

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China Foundry 2009年第4期6卷 293-299页

作者： Wang Zhifeng Zhao weimin Bo-young Hur Huang Chunying yu Chengquan School of Materials Science and Engineering Hebei University of Technology Tianjin 300130 China School of Nano and Advanced Materials Engineering Gyeongsang National University Jinju 660-701 Korea

The paper presents some results of the investigation on effects of the fourth component(Ti,C,Sb or Cu)and undercooling on the morphology,size and forming process of primary Mg-Zn-y icosahedral quasicrystal phase(I-phase)under normal casting *** result shows that the addition of certain amount of fourth component can transform I-phase morphology from petal-like to ***,I-phase will grow up to petal-like if superfluous addition of the fourth component *** is also found that the solidified morphology of I-phase depends on the stability of spherical I-phase during the subsequent growth,and critical radius of maintaining the spherical I-phase interface relatively ***,mini-sized spherical I-phase can be produced with high content of the fourth component by *** findings are beneficial for industrializing Mgbased quasicrystals.

关键词： magnesium alloy quasicrystal fourth component morphology degree of undercooling

AN APPROACH TO CONSTRUCT AN END-REGULAR GRAPH

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Applied Mathematics(A Journal of Chinese Universities) 1998年第2期13卷 171-178页

作者： LI weimin Department of Mathematics Shanghai Jiaotong University Shanghai

Abstract In this paper,an approach to construct a nontrivial end regular graph of any order under some conditions are given.

关键词： Endomorphism regularity monoid graph

Preparation and Mechanical Properties of Zirconia Ceramics Doped with Different y_(2)O_(3)Contents

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Journal of Wuhan University of Technology(Materials Science) 2023年第6期38卷 1287-1292页

作者： SONG yanwei ZHAO Xiaoqing WANG Aiyang XIONG yan DONG yanling WANG weimin State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China School of Materials and Chemical Engineering Hubei University of TechnologyWuhan 430068China

The sintering behavior and mechanical properties of zirconia doped with 2.0mol%-3.0mol%y_(2)O_(3)were studied by pressure-less *** experimental results show that the densification temperature of zirconia ceramics increases gradually with the decrease of y_(2)O_(3)doping content by which decreases the sintering driving force due to the lower oxygen vacancy concentration of the ***,the bending strength and fracture toughness of the prepared zirconia ceramics increase with the decrease of y_(2)O_(3)doping *** can be attributed to the fact that the phase stability of tetragonal zirconia decreases with the decrease of y_(2)O_(3)doping content,which is easier to induce"phase transformation toughening"and dissipate impact *** relative density,bending strength and fracture toughness of 2.0 mol%y_(2)O_(3)doped zirconia ceramics(2.0y-ZrO_(2))sintered at 1525℃are 99.00%,1256.65±20.82 MPa and 9.85±0.13 MPa·m^(1/2),respectively.

关键词： yttria-stabilized tetragonal zirconia polycrystal(y-TZP)ceramics sintering behaviors mechanical properties

Effect of dosage of expandable graphite,dimethyl methylphosphonate,triethanolamine,and isocyanate on fluidity,mechanical,and flame retardant properties of polyurethane materials in coal reinforcement

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International Journal of Mining Science and Technology 2016年第2期26卷 345-352页

作者： Hu Xiangming Wang Deming Cheng weimin Key Laboratory of Gas and Fire Control for Coal Mines of Ministry of Education Faculty of Safety EngineeringChina University of Mining and Technology Key Laboratory of Mine Disaster Prevention and Control College of Resource and Environmental EngineeringShandong University of Science and Technology Department of Resources and Environment Binzhou University

In this study,orthogonal experiments were conducted to investigate the influence of expandable graphite(EG),dimethyl methylphosphonate(DMMP),triethanolamine(TEA),and isocyanate content on the compressive and bonding strengths,oxygen index,and fluidity of rigid polyurethane foam(RPUF).The results revealed that EG significantly increased the oxygen index of RPUF,enlarged the diameter of foam cells,and decreased the cell-closed content in foam;thus,leading to a pressure drop in ***,excessive EG was capable of reducing the fluidity of polyurethane *** exhibited significant influence on the compressive strength of RPUF,which dropped initially.and then *** had a remarkable effect on the flame retardant property.and compressive strength of *** strength of RPUF initially displayed an increase followed by a decrease with increasing dosage of DMMP,and achieved the maximum value at DMMP dosage of 4%.DMMP could effectively reduce the diameter of RPUF cells leading to an increase in the percentage of close area in *** displayed the flame-retardation effects mainly in the gas phase leading to a significant enhancement in the oxygen index of ***,the compressive strength and bonding strength of RPUF decrease significantly with the increase of isocyanate content due to the increased blowing efficiency by the CO_*** oxygen index and flowing length of foam increased with the increase in isocyanate dosage.

关键词： Rigid polyurethane foam Expandable graphite Compressive strength Flame retardant Scanning electron microscopy(SEM) Microstructure