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Magnesium promotes vascularization and osseointegration in diabetic states

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International Journal of Oral Science 2024年第1期16卷 122-133页

作者： linfeng Liu Feiyu Wang Wei Song Danting Zhang weimin lin Qi Yin Qian Wang Hanwen Li Quan Yuan Shiwen Zhang State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Oral Implantology West China Hospital of StomatologySichuan UniversityChengduChina

Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral *** has been proved to promote bone healing under normal ***,we elucidate the mechanism by which Mg^(2+)promotes angiogenesis and osseointegration in diabetic *** generated a diabetic mice model and demonstrated thealveolar bone healing was compromised,with significantly decreased *** then developed Mg-coating implants with hydrothermal *** implants successfully improved the vascularization and osseointegration in diabetic ***,Mg^(2+)promoted the degradation of Kelch-like ECH-associated protein 1 (Keap1) and the nucleation of nuclear factor erythroid 2-related factor 2 (Nrf2) by up-regulating the expression of sestrin 2 (SESN2) in endothelial cells,thus reducing theelevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under ***,our data suggested that Mg^(2+)promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondria metabolism.

关键词： healing diabetic impaired

Dynamic mechanical loading facilitated chondrogenic differentiation of rabbit BMSCs in collagen scaffolds

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Regenerative Biomaterials 2019年第2期6卷 99-106页

作者： Wanxu Cao weimin lin Hanxu Cai Yafang Chen Yi Man Jie Liang Qiguang Wang Yong Sun Yujiang Fan Xingdong Zhang National Engineering Research Center for Biomaterials Sichuan University29 Wangjiang RoadChengdu 610064China State Key Laboratory of Oral Diseases Department of Oral ImplantologyWest China Hospital of StomatologySichuan UniversityChengdu 610041China Sichuan Testing Center for Biomaterials and Medical Devices Sichuan University29 Wangjiang RoadChengdu 610064China

Mechanical signals have been played close attention to regulate chondrogenic differentiation of bone marrow mesenchymal stem cells(BMSCs).In this study,dynamic mechanical loading simulation with natural frequencies and intensities were applied to the 3D cultured BMSCs–collagen scaffold *** investigated the effects of dynamic mechanical loading on cell adhesion,uniform distribution,proliferation,secretion of extracellular matrix(ECM)and chondrogenic differentiation of BMSCs–collagen scaffold *** results indicated that dynamic mechanical loading facilitated the BMSCs adhesion,uniform distribution,proliferation and secretion of ECM with a slight contraction,which significantly improved the mechanical strength of the BMSCs–collagen scaffold constructs for better mimicking the structure and function of a native *** expression results indicated that dynamic mechanical loading contributed to the chondrogenic differentiation of BMSCs with higher levels of AGG,COL2A1 and SOX9 genes,and prevented of hypertrophic process with lower levels of COL10A1,and reduced the possibility of fibrocartilage formation due to down-regulated *** conclusion,this study emphasized the important role of dynamic mechanical loading on promoting BMSCs chondrogenic differentiation and maintaining the cartilage phenotype for in vitro reconstruction of tissue-engineered cartilage,which provided an attractive prospect and a feasibility strategy for cartilage repair.

关键词： bone marrow mesenchymal stem cells collagen I dynamic mechanical loading cartilage tissue engineering

METTL3-mediated m^(6)A RNA methylation regulates dorsal lingual epithelium homeostasis

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International Journal of Oral Science 2022年第3期14卷 287-296页

作者： Qiuchan Xiong Caojie Liu Xin Zheng Xinyi Zhou Kexin Lei Xiaohan Zhang Qian Wang weimin lin Ruizhan Tong Ruoshi Xu Quan Yuan State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Thoracic Oncology Cancer Centerand Laboratory of Clinical Cell TherapyWest China HospitalSichuan UniversityChengduChina

The dorsal lingual epithelium,which is composed of taste buds and keratinocytes differentiated from K14^(+)basal cells,discriminates taste compounds and maintains the epithelial barrier.N6-methyladenosine(m^(6)A)is the most abundant mRNA modification in eukaryotic *** METTL3-mediated m^(6)A modification regulates K14^(+)basal cell fate during dorsal lingual epithelium formation and regeneration remains *** we show knockout of Mettl3 in K14^(+)cells reduced the taste buds and enhanced *** of Mettl3 led to increased basal cell proliferation and decreased cell division in taste *** Mettl3 knock-in mice showed little impact on taste buds or keratinization,but displayed increased proliferation of cells around taste buds in a protective manner during post-irradiation ***,we revealed that the most frequent m^(6)A modifications were enriched in Hippo and Wnt signaling,and specific peaks were observed near the stop codons of Lats1 and *** study elucidates that METTL3 is essential for taste bud formation and could promote the quantity recovery of taste bud after radiation.

关键词： METTL3-mediated m^(6)A RNA methylation regulates dorsal lingual epithelium homeostasis RNA

Genomic alterations in oral multiple primary cancers

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International Journal of Oral Science 2024年第1期16卷 145-153页

作者： Wen Wang Qian Wang Shiying Sun Pengfei Zhang Yuyu Li weimin lin Qiwen Li Xiao Zhang Zhe Ma Haiyan Lu Hebei Key Laboratory of Stomatology Hebei Clinical Research Center for Oral DiseasesHebei Medical UniversityShijiazhuangChina Department of Orthodontics School and Hospital of StomatologyHebei Medical UniversityShijiazhuangChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Preventive Dentistry School and Hospital of StomatologyHebei Medical UniversityShijiazhuangHebeiChina

Oral squamous cell carcinoma (OSCC) is the predominant type of oral cancer, while some patients may develop oral multiple primary cancers (MPCs) with unclear etiology. This study aimed to investigate the clinicopathological characteristics and genomic alterations of oral MPCs. Clinicopathological data from patients with oral single primary carcinoma (SPC, n=202) and oral MPCs (n=34) were collected and compared. Copy number alteration (CNA) analysis was conducted to identify chromosomal-instability differences among oral MPCs, recurrent OSCC cases, and OSCC patients with lymph node metastasis. Whole-exome sequencing was employed to identify potential unique gene mutations in oral MPCs patients. Additionally, CNA and phylogenetic tree analyses were used to gain preliminary insights into the molecular characteristics of different primary tumors within individual patients. Our findings revealed that, in contrast to oral SPC, females predominated the oral MPCs (70.59%), while smoking and alcohol use were not frequent in ***, long-term survival outcomes were poorer in oral MPCs. From a CNA perspective, no significant differences were observed between oral MPCs patients and those with recurrence and lymph node metastasis. In addition to commonly mutated genes such as CASP8, TP53 and MUC16, in oral MPCs we also detected relatively rare mutations, such as HS3ST6 and RFPL4A. Furthermore, this study also demonstrated that most MPCs patients exhibited similarities in certain genomic regions within individuals, and distinct differences of the similarity degree were observed between synchronous and metachronous oral MPCs.

关键词： alterations metastasis oral

Solar Thermal Application for the Dairy Industry in Taiwan

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Journal of Power and Energy Engineering 2017年第12期5卷 10-15页

作者： Keh-Chin Chang weimin lin Kung-Ming Chung Energy Research Center National Cheng Kung University Taiwan Department of Accounting Information Tainan University of Technology Taiwan

Taiwan has been developing clean energy and solar heating for hot water production is a mature technology. The subsidy program (2000-2016) for solar water heaters means that the cumulative area of solar collectors installed was approximately 2.52 million square meters at the end of 2016, in which more than 93% have been installed in the domestic sector. Industrial heat processes represent an area for solar thermal application. This study presents field measurements for solar water heaters installed for sterilization in dairy industry. Global solar radiation can be correlated with the system’s thermal efficiency reasonably well. As a pre-heating system, financial viability is validated.

关键词： Solar Thermal Solar Water Heater Dairy Industry Thermal Efficiency

Mapping the immune microenvironment for mandibular alveolar bone homeostasis at single-cell resolution

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Bone Research 2021年第1期9卷 97-108页

作者： weimin lin Qiwen Li Danting Zhang Xiaohan Zhang Xingying Qi Qian Wang Yaqian Chen Caojie Liu Hanwen Li Shiwen Zhang Yuan Wang Bin Shao Li Zhang Quan Yuan State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengduChina Department of Oral Implantology West China Hospital of StomatologySichuan UniversityChengduChina Department of Respiratory and Critical Care Medicine Frontiers Science Center for Disease-related Molecular NetworkCenter of Precision MedicinePrecision Medicine Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduChina

Alveolar bone is the thickened ridge of jaw bone that supports *** is subject to constant occlusal force and pathogens invasion,and is therefore under active bone remodeling and *** bone holds a distinct niche from long bone considering their different developmental origin and postnatal remodeling ***,a systematic explanation of alveolar bone at single-cell level is still ***,we construct a single-cell atlas of mouse mandibular alveolar bone through single-cell RNA sequencing(scRNA-seq).A more active immune microenvironment is identified in alveolar bone,with a higher proportion of mature immune cells than in long *** all immune cell populations,the monocyte/macrophage subpopulation most actively interacts with mesenchymal stem cells(MSCs)*** bone monocytes/macrophages express a higher level of Oncostatin M(Osm)compared to long bone,which promotes osteogenic differentiation and inhibits adipogenic differentiation of *** summary,our study reveals a unique immune microenvironment of alveolar bone,which may provide a more precise immune-modulatory target for therapeutic treatment of oral diseases.

关键词： alveolar mandibular homeostasis

The Intranet of NARI and Its Application Development

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Electricity 1999年第2期 27-29页

作者： Yu Cang lin Feng lin weimin Shen Jialin(Nanjing Automation Research Institute)

Nanjing Automation Research Institute (NARI) is a specialized institute that engages in the researches of automation of electric mper system and its application. The paper introduces the architecture of NARI Intranet as well as the techniques and application development on the Intranet. The first stage network of NARI and the building and the second stage network are both introduced. We lay emphasis on the system softWare used in NAm intranet, network management software developed by ourselves according to the characteristic of NARI network users, technique characteristics of application system on this platform and its running status. The paper also discusses the further development of NARI network application.

关键词： Intranet The Intranet of NARI and Its Application Development

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基于数字证书认证的电力安全拨号认证系统

电力系统自动化 2009年第19期33卷 52-55,100页

作者：秦超张涛林为民国网电力科学研究院/南京南瑞集团公司江苏省南京市210003

针对电力远程拨号系统的安全防护需求,对其相关安全隐患进行了分析,并设计和实现了基于数字证书认证的电力安全拨号认证系统,分析了其技术特点。该系统可对拨号客户端和拨号网关进行数字证书互验及客户端可信接入,对传输数据进行加密、... 详细信息

针对电力远程拨号系统的安全防护需求,对其相关安全隐患进行了分析,并设计和实现了基于数字证书认证的电力安全拨号认证系统,分析了其技术特点。该系统可对拨号客户端和拨号网关进行数字证书互验及客户端可信接入,对传输数据进行加密、签名,避免敏感信息泄漏及篡改,并可进行细粒度访问控制和用户行为审计,有效地解决了电力远程拨号系统相关安全隐患,对电力二次系统安全防护具有重要意义。

关键词：挑战握手验证协议公钥基础设施证书权威认证机构加密隧道智能卡双因素认证

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左翼电影的现代性审美特征

当代电影 2006年第5期 145-147页

作者：林伟民华东师范大学传播学院副教授200062

左翼电影是一股红色艺术思潮,却引领上海大都市文化新时尚,其原因在于社会物质生活条件、都市时代氛围的客观因素和左翼电影激进而带有现代性意味的美学风格的主观因素这两个方面。本文探讨左翼电影生存和发展的必然性,以及其现代性审... 详细信息

左翼电影是一股红色艺术思潮,却引领上海大都市文化新时尚,其原因在于社会物质生活条件、都市时代氛围的客观因素和左翼电影激进而带有现代性意味的美学风格的主观因素这两个方面。本文探讨左翼电影生存和发展的必然性,以及其现代性审美主要特征:先锋性、鼓动性、真实性、时代精神和视觉形象性。

关键词：左翼电影文化新时尚现代性审美特征