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Hyperpolarization-activated cyclic nucleotide-gated 2 contributes to electroacupuncture analgesia on lumbar disc herniation-induced radicular pain through activation of microglia in spinal dorsal horn

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Journal of Traditional Chinese Medicine 2022年第3期42卷 372-378页

作者： QIN Qingguang CHEN Zujiang fan weimin LI Junhua LIAO Liqing LI Yikai School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China

OBJECTIVE:To explore the mechanisms of dorsal root ganglia and spinal microglia cascade cross in electroacupuncture(EA)analgesia in the treatment of lumbar disc ***:A rat model of lumbar disc herniation(LDH)was established,EA was administered at Huantiao(GB30)acupoint 30 min once a day,for 3 *** and after modeling,and after EA,mechanical allodynia thresholds were ***-activated cyclic nucleotide-gated 2(HCN2)in dorsal root ganglia was detected by quantitative polymerase chain reaction(qPCR)and Western blot.C-X3-C motif chemokine ligand 1(CX3CL1)and activity of microglia in spinal cord was observed separately via qPCR and immunofluorescence ***:The mechanical allodynia threshold of the right planta of model rats was significantly reduced(P<0.01),EA increased the mechanical pain threshold of rats(P<0.01),and decreased HCN2 mRNA,and protein expression,reduced the expression of CX3CL1 and the activation of ***7288(a blocker of HCN channel)reduced the analgesic effect of EA from 1.83±0.84 to 0.74±0.20(P<0.05),and the expression of CX3CL1 in the spinal cord decreased from 0.52±0.11 to 0.15±0.05(P<0.01).CONCLUSION:EA analgesia on the radicular pain of LDH is *** reduced the expression of HCN2 channel in the dorsal root ganglion,thereby decreasing the noxious stimulation entered to microglia in spinal dorsal *** work supports EA is an effective treatment for radicular pain of LDH.

关键词： intervertebral disc displacement radicular pain electroacupuncture ganglia,spinal hyperpolarization-activated cyclic nucleotide-gated channels microglia

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Preparation and self-assembly of amphiphilic polymer with aggregation-induced emission characteristics

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Science China Chemistry 2012年第5期55卷 772-778页

作者： QIN AnJun ZHANG Ya HAN Ning MEI Ju SUN JingZhi fan weimin TANG Ben Zhong MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Department of Chemistry Zhejiang UniversityHangzhou 310027China College of Medicine Zhejiang UniversityHangzhou 310027China Department of Chemistry Institute of Molecular Functional MaterialsState Key Laboratory of Molecular NeuroscienceThe Hong Kong University of Science&TechnologyClear Water BayKowloonHong KongChina

An amphiphilic polymer bearing tetraphenylethene (TPE) moiety was synthesized by convenient reactions. The polymer exhibits unique aggregation-induced emission (AIE) characteristics and can self-assemble to size-tunable particles in DMF/water mixtures. The polymer nanoparticles can be used for cell imaging, which provides a potential stable fluorescent tool to monitor the distribution of drugs and bioconjugates in living cells.

关键词： amphiphilic polymer aggregation-induced emission tetraphenylethene self-assembly cell imaging

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Summary of 2000 Fujian Hui'an China Sculpture Art Festival

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China & The World Cultural Exchange 2000年第6期66卷 36-39页

作者： fan weimin

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Ferromagnetism in sp^(2) carbon

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Nano Research 2023年第12期16卷 12883-12900页

作者： Wenxiang Wang Julienne Impundu Jiyou Jin Zhisheng Peng Hui Liu Zheng Wei Yushi Xu Yu Wang Jiawang You weimin fan Yong Jun Li Lianfeng Sun CAS Key Laboratory of Nanosystem and Hierarchical Fabrication Nanofabrication laboratoryCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China The GBA National Institute for Nanotechnology Innovation Guangzhou 510700China

The bulk,pristine sp^(2) carbons,such as graphite,carbon nanotubes,and graphene,are usually assumed to be typical diamagnetic ***,over the past two decades,there have been many reports about the ferromagnetism in these sp^(2) carbon materials,which have attracted intense interest for basic research and potential *** this review,we focus on the evidence and developments of the emergent ferromagnetism in sp^(2) carbon revealed by nine kinds of experimental methods:magnetic force microscopy(MFM),magnetization measurements with physical property measurement system(PPMS),X-ray magnetic circular dichroism(XMCD),scanning tunneling microscopy(STM),miniaturized magnetic particle inspection(MPI),anomalous Hall effect(AHE),mechanical deflection of carbon nanotube cantilevers,magnetoresistance,and spin-related devices(spin field effect transistor and spin memory).The advantages,conclusions,challenges,and future of these methods are *** ferromagnetism in sp^(2) carbon will open a door to explore exotic physical phenomena and lay the basis for the development of integrated circuit of spintronics,which is fundamentally different from charge-based conventional electronics.

关键词： ferromagnetism sp^(2)carbon anomalous Hall effect spin devices magnetoresistance

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Risk and Intellectual Property in Technical Standard Competition： A Game Theory Perspective

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China Communications 2014年第5期11卷 136-143页

作者： XU Chaofeng fan weimin WANG Changfeng XIN Zhanhong School of Economics and Management Beijing University of Posts and Telecommunications Beijing 100876 China

Technical standard is typically characterized by network *** key point for a technical standard is the consumers' choice,which is based on consumers' maximum *** a technical standard becomes a national standard,its interests have been integrated into the national *** interests are divided into economic profits and security *** the perspective of consumers' choice,this paper deals with the main factors which affect the result of technical standard competition- the risk and profits of intellectual property based on the assumption of bounded rationality and dynamic game theory.

关键词： standard competition risk intellectual property game theory

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雕塑新时代,铸就最强音——改革开放40年“贡献人物奖”获得者范伟民访谈”

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雕塑 2019年第1期 14-17页

作者：安然范伟民国家发改委中国经济导报 <雕塑>杂志社

1978年改革开放至今,走过了40年历程。40年来,无数人以敢闯敢干的勇气和自我革新的担当,在所处的各个行业领域里,顽强拼搏,奋力进取,闯出了一条创新发展之路,实现了从"赶上时代"到"引领时代"的伟大跨越。其中,著名雕塑家、陶瓷陶艺家、... 详细信息

1978年改革开放至今,走过了40年历程。40年来,无数人以敢闯敢干的勇气和自我革新的担当,在所处的各个行业领域里,顽强拼搏,奋力进取,闯出了一条创新发展之路,实现了从"赶上时代"到"引领时代"的伟大跨越。其中,著名雕塑家、陶瓷陶艺家、《雕塑》杂志社社长范伟民,在改革开放之年考入中央工艺美术学院,献身于雕塑艺术事业的研究与传播。至今在改革开放大潮中创新发展,开拓进取,40年如一日,书写了在雕塑艺术事业中的多个传奇——披荆斩棘创建《雕塑》杂志,呕心沥血成立雕塑社团,不遗余力发展工艺美术,举办各类全国艺术大展,组织高端中外艺术交流,倡导订立雕塑行业行规,推动艺术业界健康发展,开展雕塑艺术培训教育,挖掘扶持艺术新人……不仅带领他的团队为我国雕塑事业的发展做出了极大努力,也在个人艺术创作方面取得了多项突破,既有雕塑、陶瓷、景泰蓝、琉璃方面取得的创作成果,也有艺术概念、理论研究、行业规范方面的个人观点。40年来,他以他的人格魅力与业务能力、行业贡献受到了业界的重视与推崇!国家发改委中国经济导报记者安然对《雕塑》杂志社社长范伟民予以专访并形成文字,本刊摘选刊登如下:

关键词：改革开放雕塑家范伟中央工艺美术学院艺术事业行业规范人物强音

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通痹七物方对痛风性关节炎NLRP3炎症小体、线粒体自噬蛋白的影响

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中药新药与临床药理 2020年第7期31卷 769-774页

作者：范为民皖南医学院弋矶山医院中医科安徽芜湖241001 南方医科大学中医药学院广东广州510515

目的探讨通痹七物方对痛风性关节炎(Gouty Arthritis,GA)大鼠的防治作用及对NOD样受体蛋白3(NOD-like receptor protein 3,NLRP3)炎症小体、线粒体自噬蛋白的影响。方法将36只大鼠随机分为空白对照组,模型组,秋水仙碱组,通痹七物方低、... 详细信息

目的探讨通痹七物方对痛风性关节炎(Gouty Arthritis,GA)大鼠的防治作用及对NOD样受体蛋白3(NOD-like receptor protein 3,NLRP3)炎症小体、线粒体自噬蛋白的影响。方法将36只大鼠随机分为空白对照组,模型组,秋水仙碱组,通痹七物方低、中、高剂量组,每组6只。空白对照组、模型组给予同体积生理盐水,秋水仙碱组给予秋水仙碱0.3 mg·kg^-1水溶液,通痹七物方低、中、高剂量组分别给予通痹七物方浓缩配方颗粒800、1600、3200 mg·kg^-1水溶液。上述各组连续灌胃给药7 d。第5天给药后,除空白对照组外,其余各组大鼠右膝关节腔注射0.1 mL单钠尿酸盐(Monosodium urate,MSU)结晶溶液,进行模型制备。以上各组在模型制备24 h、48 h后进行步态评分,实验结束观察病理组织形态,检测血清肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)的含量,检测NLRP3、半胱氨酸蛋白酶1(Caspase-1)、白细胞介素1β(IL^-1β)、自噬微管相关蛋白轻链3B(Autophagy microtubule associated protein light chain 3B,LC3B)、P62、抗增殖蛋白2(PHB2)蛋白的表达。结果与空白对照组比,模型组的步态评分明显上升,滑膜病理提示细胞增生、间质高度水肿伴大量中性粒细胞浸润,血清TNF-α、IL-6水平升高。滑膜NLRP3、Caspase-1、IL^-1β、LC3B、P62、PHB2蛋白表达量不同程度增加,差异有统计学意义(P<0.01,P<0.05)。与模型组相比,秋水仙碱组,通痹七物方低、中、高剂量组上述指标均有不同程度的改善,差异有统计学意义(P<0.01,P<0.05)。结论通痹七物方能够防治痛风性关节炎,其作用机制可能与调控线粒体自噬,抑制NLRP3炎症小体激活有关。

关键词：通痹七物方痛风性关节炎 NLRP3 炎症小体线粒体自噬大鼠

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Dietary Cadmium Intake and Risks of Adverse Pregnancy Outcomes in Rural Women of Jiangxi Province

Dietary Cadmium Intake and Risks of Adverse Pregnancy Outcom...

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第十七届中国科协年会——分12　新时代下大营养观专题论坛

作者： WANG Yanyan FU Junjie HE Jiafen fan weimin YANG Yan Department of Nutrition School of Public Health Sun Yat-sen University (Northern Campus) Jiangxi Province Center for Disease Control and Prevention

Cadmium(Cd) is a ubiquitous toxic metal that has been shown to be teratogenic and embryotoxic after long-term exposure. The diet is the main source of Cd exposure in non-smokers. However, the relationships between dietary Cd intake and adverse pregnancy outcomes haven’t been studied before. Therefore, we evaluated the association of dietary Cd intake and adverse pregnancy outcome, spontaneous abortion, stillbirth and birth defects by the cross-sectional study in Jiangxi province, China. Sociodemographic information, pregnancy experience and dietary habit information were collected from 1346 fertile women, who were 25-54 years old. Local food samples were directly collected from local farmland, and Cd concentrations were determined by flame atomic absorption spectrophotometry. Non-conditional binary logistic regression models were used to model the associations between dietary Cd intake and adverse pregnancy outcomes. The results showed that the median(quartile range) Cd intake was 24.766(13.228-56.819) μg/d. Based on the full adjusted models, the ORs(95% CIs) for adverse pregnancy outcome and spontaneous abortion, comparing the highest quartile versus the lowest quartile of dietary Cd intake, were 1.700(95%CI: 1.056, 2.735) and 2.173(95%CI: 1.239, 3.813), while the ORs(95% CIs) for stillbirth and birth defects were 1.472(95%CI: 0.551, 3.932) and 0.565(95%CI: 0.164, 1.953), respectively. Dietary Cd intake was significantly positively associated with adverse pregnancy outcome and spontaneous abortion(P=0.008, 0.010, respectively), nevertheless, the linear trends didn’t observed in fully adjusted models using stillbirth and birth defects as the dependent *** conclusion, dietary Cd intake is positively associated with adverse pregnancy outcome and spontaneous abortion, however, no significant associations are observed with stillbirth and birth defects. Additional work should to be done to explore the causal relationship between dietary Cd intake and adverse pre

关键词： dietary Cd exposure adverse pregnancy outcome spontaneous abortion stillbirth birth defects

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FLOOD SIMULATION IN DONGTING LAKE DRAINAGE AREA AND ITS FLOOD CONTROL

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Geotectonica et Metallogenia 1998年第Z1期22卷 90-96页

作者： Huang Huaiyong Du Guoquan fan weimin and Chen Guanghao(Changsha Institute of Geotectonics, Academia Sinica, Changsha 410013)

On the basis of water-balance equation in Dongting Lake and Xiang Zi Yuan-Li River drainage areas, a possib1e flood height relating to the rainfall precipitation in these areas has been inferred. According to the flood simulation, some synthetic maintenance strategies to prevent future catastrophic f1oods in Dongting Lake drainage area have been also presented.

关键词： Dongting Lake drainage area flood simulation synthetic maintenance

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有关闭原则的两部件串联可修系统的可靠性分析

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上海交通大学学报 1989年第2期23卷 9-15页

作者：许承明范伟民南京粮食经济学院上海交通大学应用数学系

本文提出了广义关闭原则,包括单向和双向关闭原则.在这一原则下,讨论了两部件串联可修系统.其中假定部件1的寿命服从Erlang 分布,其余为一般分布,利用补充变量的方法,我们得到系统的瞬态可用度和失效频度的Laplace 变换,以及稳态可用度... 详细信息

本文提出了广义关闭原则,包括单向和双向关闭原则.在这一原则下,讨论了两部件串联可修系统.其中假定部件1的寿命服从Erlang 分布,其余为一般分布,利用补充变量的方法,我们得到系统的瞬态可用度和失效频度的Laplace 变换,以及稳态可用度和失效频度的表示,其结果不仅推广了文献[1]的工作,并从中得到文献[2]的全部结论.

关键词：系统可靠性关闭原则可修系统

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