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中药菩人丹对单纯型糖尿病视网膜病变患者视野及电生理的影响

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疑难病杂志 2019年第10期18卷 1035-1038页

作者：王海彬张垒董志军石晶王英爽付笑笑张铁民董微莉承德医学院附属医院眼科

目的观察中药菩人丹对单纯性糖尿病视网膜病变(SDR)患者眼底照相、眼底荧光血管造影(FFA)、视野、视觉电生理的影响。方法 2016年1-12月承德医学院附属医院眼科收治SDR患者48例(96眼)。随机数字表法分成2组,观察组24例(48眼),给予中药... 详细信息

目的观察中药菩人丹对单纯性糖尿病视网膜病变(SDR)患者眼底照相、眼底荧光血管造影(FFA)、视野、视觉电生理的影响。方法 2016年1-12月承德医学院附属医院眼科收治SDR患者48例(96眼)。随机数字表法分成2组,观察组24例(48眼),给予中药菩人丹粉剂口服,每次9 g,2次/d;对照组24例(48眼),给予羟苯磺酸钙分散片口服,每次500 mg,3次/d。2组均治疗3个月,观察患者治疗前后眼底照相、FFA、视野平均敏感度(MS)、视网膜电图震荡电位(ERG-QPs)的变化。结果治疗3个月后观察组总有效率高于对照组,但差异无统计学意义(P>0.05)。与治疗前比较,治疗3个月后2组患者眼底照相及FFA的改变情况(出血、渗出、微血管瘤、视网膜循环时间)差异亦无统计学意义(P>0.05)。视野平均敏感度均显著提高(P0.05),观察组ERG-OPsO1、O2潜伏期缩短,振幅增加,差异有统计学意义(P<0.05),且均优于对照组(P<0.05)。结论中药菩人丹可明显改善SDR患者的眼底出血、渗出、微血管瘤,提高视野MS值,缩短ERG-OPsO1、O2潜伏期,增加振幅,有效治疗SDR。

关键词：糖尿病视网膜病变菩人丹眼底荧光血管造影视野视网膜电图

Facile preparation of pristine graphene using urea/glycerol as efficient stripping agents

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Nano Research 2018年第2期11卷 820-830页

作者： Jianping Chen weili Shi Zhaodongfang Gao Tao Wang Shan Wang Lijie dong Quanling Yang Chuanxi Xiong State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and School of Materials Science and Engineering Wuhan University of Technology Wuhan China National & Local Joint Engineering Research Center for Applied Technology of Hybrid Nanomaterials Henan University Kaifeng China

Large-scale exfoliation of defect-free and few-layer graphene by an inexpensive and environmentally-friendly route has been a significant challenge for a long time. Here we show that high-quality, few-layer graphene with high stability and low defect content can be obtained from natural graphite via a simple stirring process in urea/glycerol, with yields of up to 12 wt.%. We also demonstrate that this facile method can be applied to the exfoliation of other two-dimensional materials, such as molybdenum disulfide and boron nitride. The as-prepared graphene was further composited with polyvinylidene fluoride （PVDF） and the composite exhibited a low percolation threshold of 0.05 vol.%. The incorporation of low （4.5 vol.%） graphene amounts led to a significant increase in the thermal conductivity of the graphene-PVDF composites.

关键词： urea/glyceroLpristine graphene thermal conductivity graphene-basedcomposite

Development of environment-insensitive and highly emissive BODIPYs via installation of N,N'-dialkylsubstituted amide at meso position

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Chinese Chemical Letters 2022年第9期33卷 4175-4178页

作者： Junping Bai Junliang Zhou Xin Ji Nannan Wang Xiaochun dong Wei Wu weili Zhao School of Pharmacy Institutes of Integrative MedicineFudan UniversityShanghai 201203China Key Laboratory for Special Functional Materials of Ministry of Education School of Materials Science and EngineeringHenan UniversityKaifeng 475004China

Fluorescent dyes play a crucial role in fluorescence imaging and sensing ***,there is a dilemma that they are usually intrinsically hydrophobic which lacks of emission in water and modification with ionic groups to access water solubility may result in poor membrane *** dyes with strong fluorescence emission in both nonpolar and polar solvents are highly *** this manuscript,we reported a strategy to develop fluorescent BODIPY dyes via installation of amide moiety at meso position of 1,3,5,7-tetramethyl-BODIPY and discovered that N,N'-dialkylsubstituted BODIPY amides possessed highly fluorescent emission with favorable environment-insensitive properties.

关键词： Fluorescent dyes BODIPY Environment-insensitive Bioimaging

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浅谈白酒鸡尾酒对传统白酒行业发展的影响

酿酒 2021年第3期48卷 14-16页

作者：董伟丽秦明星刘露露郭雪园肖莉王晓斌安徽古井贡酒股份有限公司安徽亳州236922

中国白酒有广泛的消费群体,但一直没能真正打开以女性和年轻人为首的国内消费市场以及大多数国外消费市场。如何针对这类消费者开发一类新的饮用方法对中国白酒的未来发展显得尤为重要。鸡尾酒一般以烈酒为基酒,且已进入中国市场并逐渐... 详细信息

中国白酒有广泛的消费群体,但一直没能真正打开以女性和年轻人为首的国内消费市场以及大多数国外消费市场。如何针对这类消费者开发一类新的饮用方法对中国白酒的未来发展显得尤为重要。鸡尾酒一般以烈酒为基酒,且已进入中国市场并逐渐被此类消费者接受。若以鸡尾酒的表现形式将中国白酒这类厚重的酒类轻盈地展现出来,从而使更多消费者接触中国白酒,对中国酒企的利益不可估量。

关键词：中国白酒鸡尾酒基酒

Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy

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Nano Research 2017年第3期10卷 794-801页

作者： Yu Cai weili Si Qianyun Tang Pingping Liang Chengwu Zhang Peng Chen QiZhang Wei Huang Xiaochen dong ing 211816 China School of Chemical and Biomedical Engineering Nanyang Technological University 70 Nanyang Drive N 1.3-B3-08 Singapore ingTech) 30 South Puzhu Road Naniing 211816 China

Therapeutic nanoparticles （NPs） based on the donor-acceptor-donor structured small organic molecule diketopyrrolopyrrole （SDPP） were prepared using a simple reprecipitation approach. These near-infrared radiation-absorbing NPs have high photothermal conversion efficiency and are able to selectively target cancer tissues through the enhanced permeability and retention effect. Benefiting from these advantages, SDPP NPs can serve as an excellent therapeutic agent for highly efficient and noninvasive photoacoustic imaging-guided photothermal therapy. Experiments using mouse tumor models showed that the SDPP NPs exhibited exceptional tumor ablation ability under laser irradiation （660 nm, 1.0 *** 2）, even at a low dose （0.16 ***^-1）.

关键词： photothermal therapy photoacoustic imaging diketopyrrolopyrrole donor-acceptor-donor

Biomineralized CO gas-releasing nanoprodrug for endoplasmic reticulum stress mediated cancer therapy

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Nano Research 2023年第5期16卷 7373-7382页

作者： Rui Gu Wanlan Yang Lifei Han Chao Liu Yatao Xu Yunlong Liu weili Si Wenjun Wang Xiaochen dong Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211816China School of Physical Science and Information Technology Liaocheng UniversityLiaocheng 252059China Breast Disease Center.Zhongda Hospital School of MedicineSoutheast UniversityNanjing 210009China School of Chemistry&Materials Science Jiangsu Normal UniversityXuzhou 221116China

The anti-tumor effect of therapeutic carbon monoxide(CO)has been considered concerning the electron transport chain on the inner mitochondrial ***,a tumor microenvironment and photo-responsive CO nanoplatform Ca-Flav nanoparticles(NPs)were constructed through biomineralizing acryloyl-modified flavonol,which could release CO both in normoxia and hypoxia conditions upon irradiation at tumor *** in vitro experiments demonstrated that the endoplasmic reticulum stress-related signal pathways could be activated through oxidative stress caused by CO mediated mitochondrial biogenesis and calcium ion turbulence induced by Ca_(3)(PO_(4))_(2)acidolysis,resulting in mitochondrial dysfunction and cell *** addition,the Ca-Flav NPs exhibited excellent biocompatibility and tumor inhibition effect in *** work provides new insight into the potential characteristics of CO,paving a new way to engineer more efficient treatment based on CO.

关键词： carbon monoxide gas therapy mitochondrial endoplasmic reticulum

Diketopyrrolopyrrole-Au(I) as singlet oxygen generator for enhanced tumor photodynamic and photothermal therapy

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Science China Chemistry 2020年第1期63卷 55-64页

作者： Xiaoyu Huang Rui Gu Jiewei Li Nan Yang Zijin Chen weili Si Peng Chen Wei Huang Xiaochen dong Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211800China School of Chemical and Biomedical Engineering Nanyang Technological UniversityNanyang 637459Singapore School of Chemistry and Materials Science Nanjing University of Information Science&TechnologyNanjing 210044China Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University(NPU)Xi'an 710072China

Diketopyrrolopyrrole(DPP)derivatived photosensitizers(PSs)with near infrared(NIR)absorption and good photophysical properties have drawn tremendous attention in cancer ***,current DPP derivatives present unsatisfactory quantum yield of singlet oxygen(1O2)due to the large energy gap between the excited singlet and triplet *** tackle this challenge,herein the DPP core is functionalized with triphenylphosphine-Au(I)group(Th DPP-Au),leading to a high1O2 quantum yield of *** calculation attributes the enhancement to spin-orbit coupling and population of the triplet excition upon *** hydrophilic Th DPP-Au nanoparticals(NPs)are prepared via nano-reprecipitation,which displays homogeneous size and excellent light absorption ability(ε=4.382×104 M-1cm-1).And the Th DPP-Au NPs exhibit low dark toxicity and high phototoxicity,which can effectively kill tumor cells via 1O2 induced mitochondrial apoptotic pathway upon ***,in vivo experiments demonstrate that Th DPP-Au NPs can selective accumulation in tumor and present excellent synergistic photodynamic/photothermal therapy guided by fluorescence and photothermal dual imaging.

关键词： diketopyrrolopyrrole-Au(I) singlet oxygen photodynamic therapy photothermal therapy

Gastrointestinal lipolysis and trans-epithelial transport of SMEDDS via oral route

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Acta Pharmaceutica Sinica B 2021年第4期11卷 1010-1020页

作者： Fei Xia Zhongjian Chen Quangang Zhu Jianping Qi Xiaochun dong weili Zhao Wei Wu Yi Lu Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Self-microemulsifying drug delivery systems(SMEDDSs)have recently returned to the limelight of academia and industry due to their enormous potential in oral delivery of ***,information on gastrointestinal lipolysis and trans-epithelial transport of SMEDDS is ***-caused quenching(ACQ)fuorescent probes are utilized to visualize the in vivo behaviors of SMEDDSs,because the released probes during lipolysis are quenched upon contacting *** SMEDDSs composed of medium chain triglyceride and different ratios of Tween-80 and PEG-400 are set as models,meanwhile Neoral?was used as a *** SMEDDS droplets reside in the digestive tract for as long as 24 h and obey frst order kinetic law of *** increased chain length of the triglyceride decreases the lipolysis of the *** vivo imaging of main tissues and histological examination confrm the trans-epithelial transportation of the SMEDDS *** 2%-4%of the given SMEDDSs are transported via the lymph route following epithelial uptake,while liver is the main ***-2 cell lines confrm the cellular uptake and trans-epithelial *** conclusion,a fraction of SMEDDSs can survive the lipolysis in the gastrointestinal tract,permeate across the epithelia,translocate via the lymph,and accumulate mainly in the liver.

关键词： SMEDDS In vivo fate Lipolysis Trans-epithelial transport Lymph Aggregation-caused quenching Caco-2 Absorption

Graphene and cobalt phosphide nanowire composite as an anode material for high performance lithium-ion batteries

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Nano Research 2016年第3期9卷 612-621页

作者： Jun Yang Yu Zhang Chencheng Sun Hongzheng Liu Laiquan Li weili Si Wei Huang Qingyu Yan Xiaochen dong Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University (NanjingTech) Nanjing 211816 China School of Materials Science and Engineering Nanyang Technological University Singapore 639798 Singapore

The synthesis of a composite of cobalt phosphide nanowires and reduced graphene oxide （denoted CoP/RGO） via a facile hydrothermal method combined with a subsequent annealing step is reported. The resulting composite presents large specific surface area and enhanced conductivity, which can effectively facilitate charge transport and accommodates variations in volume during the lithiation/de-lithiation processes. As a result, the CoP/RGO nanocomposite manifests a high reversible specific capacity of 960 mA·h-g-1 over 200 cycles at a current density of 0.2 A·g-1 （297 mA·h·g-1 over 10,000 cycles at a current density of 20 A.g-1） and excellent rate capability （424 mA·h·g-1 at a current density of 10 A·g-1）.

关键词： cobalt phosphide nanowires anodes lithium-ion battery