Diketopyrrolopyrrole-Au(I) as singlet oxygen generator for enhanced tumor photodynamic and photothermal therapy

作     者：Xiaoyu Huang Rui Gu Jiewei Li Nan Yang Zijin Chen Weili Si Peng Chen Wei Huang Xiaochen Dong Xiaoyu Huang;Rui Gu;Jiewei Li;Nan Yang;Zijin Cheng;Weili Si;Peng Chen;Wei Huang;Xiaocnen Dong

作者机构：Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM)Nanjing Tech University(NanjingTech)Nanjing 211800China School of Chemical and Biomedical EngineeringNanyang Technological UniversityNanyang 637459Singapore School of Chemistry and Materials ScienceNanjing University of Information Science&TechnologyNanjing 210044China Shaanxi Institute of Flexible Electronics(SIFE)Northwestern Polytechnical University(NPU)Xi'an 710072China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2020年第63卷第1期

页      面：55-64页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science of Foundation of China(61525402,61775095,21704043) Jiangsu Provincial Key Research and Development Plan(BE2017741) the Natural Science Foundation of Jiangsu Province(BK20170990,17KJB150020) the Six talent peak innovation team in Jiangsu Province(TD-SWYY-009) 

主　　题：diketopyrrolopyrrole-Au(I) singlet oxygen photodynamic therapy photothermal therapy 

摘      要：Diketopyrrolopyrrole(DPP)derivatived photosensitizers(PSs)with near infrared(NIR)absorption and good photophysical properties have drawn tremendous attention in cancer ***,current DPP derivatives present unsatisfactory quantum yield of singlet oxygen(1O2)due to the large energy gap between the excited singlet and triplet *** tackle this challenge,herein the DPP core is functionalized with triphenylphosphine-Au(I)group(Th DPP-Au),leading to a high1O2 quantum yield of *** calculation attributes the enhancement to spin-orbit coupling and population of the triplet excition upon *** hydrophilic Th DPP-Au nanoparticals(NPs)are prepared via nano-reprecipitation,which displays homogeneous size and excellent light absorption ability(ε=4.382×104 M-1cm-1).And the Th DPP-Au NPs exhibit low dark toxicity and high phototoxicity,which can effectively kill tumor cells via 1O2 induced mitochondrial apoptotic pathway upon ***,in vivo experiments demonstrate that Th DPP-Au NPs can selective accumulation in tumor and present excellent synergistic photodynamic/photothermal therapy guided by fluorescence and photothermal dual imaging.