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Synthetic damage effect assessment through evidential reasoning approach and neural fuzzy inference:Application in ship target

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Chinese Journal of Aeronautics 2022年第8期35卷 143-157页

作者： Tianle YAO Run MIAO weili WANG Zhirong LI Jun dong Yajuan GU Xuefei YAN Ordnance Engineering College Naval University of EngineeringWuhan 430000China Xi’an Modern Chemistry Research Institute Xi'an 710065China Department of Equipment Command and Management Army Engineering UniversityShijiazhuang 050003China Institute of Systems Engineering Academy of Military ScienceBeijing 100082China

The damage effect assessment of anti-ship missiles combines system science and weapon science,which can provide reference for the assessment of battlefield damage *** order to solve the difficulty of heterogeneous data aggregation and the difficulty in constructing the mapping between factors and damage effect,this paper analyzes the specific damage process of the anti-ship missile to the ship,and proposes a synthetic Evidential Reasoning(ER)–Adaptive Neural Fuzzy Inference System(ANFIS)to assess the damage *** solve the problem of fuzziness and uncertainty of criteria in the assessment process,the belief structure model is used to transform qualitative and quantitative information into a unified mathematical structure,and ER algorithm is used to fuse the information of lower-level *** order to solve the problem of fuzziness and uncertainty of the information contained in the first-level variables,and the strong non-linear characteristics of the mapping between first-level variables and damage effect,the ANFIS with selfadaptation and self-learning is *** map between the three first-level variables and damage effect is established,and the interaction process of the various factors in the damage effect assessment are *** analysis shows that assessment model has good *** result analysis and comparative analysis show that the process proposed in this paper can effectively assess the damage effect of anti-ship missiles,and all criteria data are objective and comparable.

关键词： ANFIS Belief structure model Damage effect assessment ER approach Ship target

Biomimetic thiamine- and niacin-decorated liposomes for enhanced oral delivery of insulin

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Acta Pharmaceutica Sinica B 2018年第1期8卷 97-105页

作者： Haisheng He Yi Lu Jianping Qi weili Zhao Xiaochun dong Wei Wu Key Laboratory of Smart Drug Delivery of MOE and PLA School of Pharmacy Fudan University

Biomimetic nanocarriers are emerging as efficient vehicles to facilitate dietary absorption of biomacromolecules. In this study, two vitamins, thiamine and niacin, are employed to decorate liposomes loaded with insulin, thus facilitating oral absorption via vitamin ligand–receptor interactions. Both vitamins are conjugated with stearamine, which works to anchor the ligands to the surface of *** prepared under optimum conditions have a mean particle size of 125–150 nm and an insulin entrapment efficiency of approximately 30%–36%. Encapsulation into liposomes helps to stabilize insulin due to improved resistance against enzymatic disruption, with 60% and 80% of the insulin left after 4 h when incubated in simulated gastric and intestinal fluids, respectively, whereas non-encapsulated insulin is broken down completely at 0.5 h. Preservation of insulin bioactivity against preparative stresses is validated by intra-peritoneal injection of insulin after release from various liposomes using the surfactant Triton X-100. In a diabetic rat model chemically induced by streptozotocin, both thiamine-and niacindecorated liposomes showed a comparable and sustained mild hypoglycemic effect. The superiority of decorated liposomes over conventional liposomes highlights the contribution of vitamin ligands. It is concluded that decoration of liposomes with thiamine or niacin facilitates interactions with gastrointestinal vitamin receptors and thereby facilitates oral absorption of insulin-loaded liposomes.

关键词： Liposomes Vitamin Thiamine Niacin Insulin Biomimetic Oral Drug delivery

Sulfur-based autotrophic denitrification from the micro-polluted water

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Journal of Environmental Sciences 2016年第6期28卷 180-188页

作者： weili Zhou Xu Liu Xiaojing dong Zheng Wang Ying Yuan Hui Wang Shengbing He School of Environmental Science and Engineering Shanghai Jiaotong University

Eutrophication caused by high concentrations of nutrients is a huge problem for many natural lakes and reservoirs. Removing the nitrogen contamination from the low C/N water body has become an urgent need. Autotrophic denitrification with the sulfur compound as electron donor was investigated in the biofilter reactors. Through the lab-scale experiment,it was found that different sulfur compounds and different carriers caused very different treatment performances. Thiosulfate was selected to be the best electron donor and ceramsite was chosen as the suitable carrier due to the good denitrification efficiency, low cost and the good resistibility against the high hydraulic loads. Later the optimum running parameters of the process were determined. Then the pilot-scale experiment was carried out with the real micro-polluted water from the West Lake, China. The results indicated that the autotrophic denitrification with thiosulfate as electron donor was feasible and applicable for the micro-polluted lake water.

关键词： Autotrophic denitrification Micro-polluted water Thiosulfate HRT Hydraulic loading rate

Late Glacial glacier-climate modeling in two valleys on the eastern slope of Samdainkangsang Peak, Nyaiqentanggulha Mountains

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Science China Earth Sciences 2017年第1期60卷 135-142页

作者： XU XiangKe dong GuoCheng PAN BaoLin HU Gang BI weili LIU JinHua YI ChaoLu Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau Research Chinese Academy of Sciences Beijing 100101 China state Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Xi 'an 710061 China College of Resources Environment and Tourism Capital Normal University Beijing 100048 China

Well-preserved Late Glacial moraines in the Barenduo and Yuqiongqu valleys on the eastern slope of the Samdainkangsang Peak present an opportunity to reconstruct glacier extents and examine the character of the climate during the Late Glacial stage in the Nyaiqentanggulha Mountains. This study employs a coupled mass-balance and ice-flow model to reconstruct the glacier extents in the two valleys and assess the magnitudes of temperature and precipitation change during the Late Glacial period. Model results indicate that during the Late Glacial, the Barenduo valley contained an ice volume of 1.67x 108 m3, with the equilibrium-line altitude （ELA） being -5500 m asl; and the Yuqiongqu valley had an ice volume of 5.56x 108 m3, with the ELA being -5470 m asl. A climate scenario, temperature depression of 2.6-2.8°C and 60-70%, percent of modern （1981-2010） precipitation, can sustain both of the Late Glacial glacier extents in the two valleys. A 50% increase or decrease from modern precipitation would have been coupled with the respective Late Glacial temperature depressions of 1.6 and 3.0°C in the Barenduo valley, and 2.1 and 2.8°C in the Yuqiongqu valley.

关键词： Glacier-climate modeling Late Glacial Glacier extent Paleoclimate Samdainkangsang Peak

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浅谈酿酒原料的质量控制和保障对策

酿酒 2024年第6期51卷 128-130页

作者：董伟丽刘露露秦明星刘国英张新高安徽古井贡酒股份有限公司安徽亳州236800

酿酒原料的质量对酿酒行业至关重要,直接影响到酿酒品质和效率。然而,当前酿酒原料的质量控制存在诸多问题,亟待解决。本文从酿酒原料的质量控制问题现状、原因分析、控制和保障对策等方面进行了深入探讨,旨在为酿酒行业的质量控制提供... 详细信息

酿酒原料的质量对酿酒行业至关重要,直接影响到酿酒品质和效率。然而,当前酿酒原料的质量控制存在诸多问题,亟待解决。本文从酿酒原料的质量控制问题现状、原因分析、控制和保障对策等方面进行了深入探讨,旨在为酿酒行业的质量控制提供理论和实践指导,促进酿酒产业的可持续发展。

关键词：酿酒原料质量控制不合格品处理质量追溯

A Turn-On Fluorescent Probe for Highly Selective and Sensitive Detection of Palladium

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Chinese Journal of Chemistry 2016年第7期34卷 715-719页

作者： Junliang Zhou Jian Zhang Hang Ren Xiaochun dong Xing Zheng weili Zhao Institute of Pharmacy and Pharmacology University of South China Hengyang Hunan 421001 China School of Pharmacy Fudan University Shanghai 201203 China Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study Hengyang Hunan 421001 China

A novel turn-on fluorescent probe for the detection of palladium has been designed. The probe can selectively and sensitively detect palladium in solution, and the limit of detection was calculated to be 11.4 nmol·L-... 详细信息

关键词： fluorescent probe palladium living cell

Near-infrared Aza-BODIPY Dyes Through Molecular Surgery for Enhanced Photothermal and Photodynamic Antibacterial Therapy

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Chemical Research in Chinese Universities 2021年第4期37卷 951-959页

作者： YU Qing HUANG Xuan ZHANG Tian WANG weili YANG dongliang SHAO Jinjun dong Xiaochen Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing210009P.R.China

The widespread use of high-dose antibiotics will not only lead to the rapid acquisition of antibiotic resistance and increased incidence of drug-resistant bacterial infections, but also produce toxic side effects on normal tissues. Herein, two near-infrared dyes BDP-4PTZ and BDP-4DPA were synthesized, and the electron donors of diphenylamine and phenothiazine with the only difference of sulphur(S)-lock between the two phenyl rings were introduced onto the electron acceptor aza-dipyrromethene boron difluoride(aza-BODIPY) through molecular surgery. Through co-precipitation into nanoparticles(NPs), BDP-4PTZ NPs and BDP-4DPA NPs were fabricated with good biocompatibility. Upon 660 nm photoirradiation, BDP-4PTZ NPs and BDP-4DPA NPs showed excellent photothermal conversion efficiency(43% and 50%, respectively) and reactive oxygen species(ROS) production performance(ca. 3.6 and 6 times higher than that of indocyanine green, respectively). In vitro antibacterial experiments indicated that both NPs could effectively destroy the bacteria’s membrane to eradicate drug-resistant bacteria. Furthermore, the bacterial abscess was effectively eliminated after treatment with BDP-4DPA NPs under 660 nm photoirradiation without adverse effects. Thus, through molecular surgery, BDP-4DPA without the S-lock demonstrates synergistic photothermal and photodynamic antimicrobial activities, which is promising for further molecular design towards effective neo-antimicrobial phototherapy.

关键词： Aza-dipyrromethene boron difluoride(aza-BODIPY) Photothermal therapy Photodynamic therapy Photosensitizer Antibacterial therapy

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TGG晶体缺陷的研究

长春理工大学学报（自然科学版） 2015年第3期38卷 81-85页

作者：徐嘉林董玮利彭海益刘旺金维召林海李春长春理工大学材料科学与工程学院长春130022

TGG晶体是一种具有高菲尔德常数、低吸收系数、高热导率和高激光损伤阈值的磁光晶体。利用固相法和液相法合成多晶原料,采用中频感应加热提拉法,提拉生长TGG磁光晶体。通过对熔体组分、拉速、转速、热效应分析,得出了生长无缺陷晶体的... 详细信息

TGG晶体是一种具有高菲尔德常数、低吸收系数、高热导率和高激光损伤阈值的磁光晶体。利用固相法和液相法合成多晶原料,采用中频感应加热提拉法,提拉生长TGG磁光晶体。通过对熔体组分、拉速、转速、热效应分析,得出了生长无缺陷晶体的最佳工艺参数。以液相法合成多晶原料,温度梯度为0.02~0.04℃/mm,拉速为1.0~1.2mm/h,转速为10~15r/min生长出无杂质、无开裂的优质TGG磁光晶体。

关键词：组分挥发拉速转速热效应缺陷

结直肠癌患者血清CEA、CA_(19-9)的检测价值

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胃肠病学和肝病学杂志 2000年第2期9卷 122-123页

作者：闫卫利陈玉民董晖刘凤兰王莹天津市第三医院检验科天津300250

目的　探讨癌胚抗原 (CEA)、糖链抗原 (CA19 9)在结直肠癌的诊断、观察预后、监测复发转移中的应用价值。方法　CEA采用ELISA法、CA19 9采用放免法 ,对 19例结肠癌、2 6例直肠癌、30例正常人进行了分析 ,并在术后定期检查。结果　结直... 详细信息

目的　探讨癌胚抗原 (CEA)、糖链抗原 (CA19 9)在结直肠癌的诊断、观察预后、监测复发转移中的应用价值。方法　CEA采用ELISA法、CA19 9采用放免法 ,对 19例结肠癌、2 6例直肠癌、30例正常人进行了分析 ,并在术后定期检查。结果　结直肠癌患者血清CEA、CA19 9水平升高 ,与对照组相比有显著性差异 (P <0 0 0 1) ;手术彻底、预后良好的病人CEA、CA19 9水平下降 ,可恢复至正常 ;术后复发者CEA、CA19 9重又异常升高 ,伴广泛转移者升高更加显著 ,并且CEA、CA19 9的升高出现在临床症状和X线异常改变之前。结论　CEA、CA19 9对结直肠癌的诊断有一定的价值 ,对于判断手术预后。

关键词：结肠肿瘤直肠肿瘤 CEA CA19-9抗原检测