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Endothelial dysfunction in COVID-19 calls for immediate attention:the emerging roles of the endothelium in inflammation caused by SARS-CoV-2

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Frontiers of Medicine 2021年第4期15卷 638-643页

作者： weijian hang Chen Chen Xin AZhang Dao Wen Wang Division of Cardiology Department of Internal Medicineand Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological DisordersTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Physiology University of Oklahoma Health Sciences CenterOklahoma CityOK 73104

The COVID-19 pandemic has caused numerous deaths around the world.A growing body of evidence points to the important role of overwhelming inflammatory responses in the pathogenesis of COVID-19 and the effectiveness of anti-inflammation therapy against COVID-19 is *** addition to affecting the lungs,COVID-19 can be a severe systemic inflammatory disease that is related to endothelial *** are calling for closer attention to endothelial dysfunction in COVID-19 not only for fully revealing the pathogenic mechanism of COVID-19 but also for properly adjusting the strategy of clinical intervention.

关键词： COVID-19 endothelial dysfunction inflammation reaction cytokine storm

Gut microbiota-dependent phenylacetylglutamine in cardiovascular disease:current knowledge and new insights

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Frontiers of Medicine 2024年第1期18卷 31-45页

作者： Yaonan Song Haoran Wei Zhitong Zhou Huiqing Wang weijian hang Junfang Wu Dao Wen Wang Division of Cardiology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan430030China

Phenylacetylglutamine(PAGln)is an amino acid derivate that comes from the amino acid *** are increasing studies showing that the level of PAGln is associated with the risk of different cardiovascular *** this review,we discussed the metabolic pathway of PAGln production and the quantitative measurement methods of *** summarized the epidemiological evidence to show the role of PAGln in diagnostic and prognostic value in several cardiovascular diseases,such as heart failure,coronary heart disease/atherosclerosis,and cardiac *** underlying mechanism of PAGln is now considered to be related to the thrombotic potential of platelets via adrenergic ***,other possible mechanisms such as inflammatory response and oxidative stress could also be induced by ***,since PAGln is produced across different organs including the intestine,liver,and kidney,the cross-talk among multiple organs focused on the function of this uremic toxic ***,the prognostic value of PAGln compared to the classical biomarker was discussed and we also highlighted important gaps in knowledge and areas requiring future investigation of PAGln in cardiovascular diseases.

关键词： PAGln cardiovascular disease gut microbiota uremic metabolite biomarker

China's treatment regimen for fulminant myocarditis is bringing wonderful achievement to the world

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Science China(Life Sciences) 2019年第2期62卷 282-284页

作者： Jing Zhang weijian hang Rutai Hui Qiong Zhao Shashank S.Desai Cardiovascalar Intensive Care Unit Fuwai Huazhong Cardiovascular Hospital Division of Cardiology Department of Internal Medicine Tongji Hospital Tongji Medical College Huazhong University of Science & Technology Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Advanced Heart Failure/Transplant Program Inova Heart and Vascular Institute Inova Fairfax Hospital

Fulminant myocarditis is characterized by acute and severe inflammation with injury of myocardium globally. It has a fulminant course and high in-hospital mortality rate of up to50%-70%. It onsets rapidly after viral ... 详细信息

关键词： China’s treatment regimen for fulminant myocarditis is bringing wonderful achievement to the world

SAC-1 ensures epithelial endocytic recycling by restricting ARF-6 activity

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SAC-1 ensures epithelial endocytic recycling by restricting ...

Militarine对离体大鼠胸主动脉环的舒张作用及机制研究

第五届中国秀丽线虫大会

作者： Dan Chen Chao Yang Sha Liu weijian hang Xianghong Wang Juan Chen Anbing Shi Department of Biochemistry and Molecular Biology School of Basic Medicine and the Collaborative Innovation Center for Brain ScienceTongji Medical CollegeHuazhong University of Science and Technology Institute for Brain Research Huazhong University of Science and Technology Key Laboratory of Neurological Disease of National Education Ministry Tongji Medical CollegeHuazhong University of Science and Technology

Arf6/ARF-6 is a crucial regulator of the endosomal PI(4,5)P2 pool in endocytic *** further characterize ARF-6 regulation,we performed an ARF-6 interactor screen in *** and identified SAC-1,the homolog of the phosphoin...

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中华中医药学刊 2015年第3期33卷 617-620页

作者：徐晓雪徐广涛李小鹏钟旭韩伟健许枬辽宁中医药大学药学院辽宁大连116600

目的:研究从手掌参中分离的Militarine对离体大鼠胸主动脉环的舒张作用并探讨其可能的机制。方法:记录去甲肾上腺素(NE)和KCl预收缩的离体大鼠主动脉环张力变化,观察Militarine的舒血管作用及不同工具药对其作用的影响。结果:Militarin... 详细信息

目的:研究从手掌参中分离的Militarine对离体大鼠胸主动脉环的舒张作用并探讨其可能的机制。方法:记录去甲肾上腺素(NE)和KCl预收缩的离体大鼠主动脉环张力变化,观察Militarine的舒血管作用及不同工具药对其作用的影响。结果:Militarine可以抑制去甲肾上腺素(NE,1×10-4mol·L-1)和KCl(1.8 mol·L-1)引起去内皮和内皮完整的离体大鼠胸主动脉环的收缩作用,但二者有明显差别;L-硝基精氨酸甲酯(LNAME,1×10-4mol·L-1)、亚甲蓝(MB,1×10-5mol·L-1)、吲哚美辛(INDO,1×10-5mol·L-1)均能一定程度抑制Militarine对胸主动脉环的舒张作用;钾离子通道阻断剂四乙基胺(TEA,1×10-3mol·L-1)、格列苯脲(glibenclamide,1×10-5mol·L-1)、Ba Cl2(1×10-4mol·L-1)可明显减弱Militarine对血管环的舒张作用;在无钙环境下,预孵育Militarine对去甲肾上腺素引起的血管环收缩有明显抑制作用。结论:Militarine有内皮依赖性和非内皮依赖性的血管舒张作用,其作用机制可能涉及激活内皮细胞中NO/c GMP通路,开放钾离子通道和抑制钙离子内流。

关键词： Militarine 手掌参胸主动脉环血管舒张钾通道阻滞剂钙通道

吡非尼酮改善自发性高血压大鼠心肌及主动脉纤维化

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中国心血管杂志 2023年第5期28卷 446-453页

作者：李娜杭伟健舒鸿洋章子璇程佳陈娟周宁华中科技大学同济医学院附属同济医院心内科武汉430030 华中科技大学同济医学院生物化学与分子生物学系武汉430030

目的探讨吡非尼酮能否改善高血压导致的心脏及主动脉纤维化。方法Wistar-Kyoto大鼠(WKY)10只,自发性高血压大鼠(SHR)12只。适应性喂养后利用简单随机方法分为4组:WKY+溶剂组(n=5),WKY+吡非尼酮组(n=5),SHR+溶剂组(n=6),SHR+吡非尼酮组(n... 详细信息

目的探讨吡非尼酮能否改善高血压导致的心脏及主动脉纤维化。方法Wistar-Kyoto大鼠(WKY)10只,自发性高血压大鼠(SHR)12只。适应性喂养后利用简单随机方法分为4组:WKY+溶剂组(n=5),WKY+吡非尼酮组(n=5),SHR+溶剂组(n=6),SHR+吡非尼酮组(n=6)。分别予以生理盐水或吡非尼酮(200 mg·kg^(-1)·d^(-1))灌胃,持续8周。连续监测大鼠尾动脉血压。8周后,心脏超声测定大鼠心脏结构和功能变化,病理实验检测大鼠心脏及主动脉形态变化,分子生物实验测定纤维蛋白原和波形蛋白等纤维化标志物水平。结果SHR尾动脉压明显高于WKY(均为P<0.01),吡非尼酮干预与生理盐水干预相比,大鼠血压无统计学差异。与WKY+溶剂组相比,SHR+溶剂组心肌血管周围和间质胶原含量分别增加了131.3%和126.9%,纤维蛋白原和波形蛋白表达含量分别增加了112.0%和241.0%(均为P<0.01)。与SHR+溶剂组相比,SHR+吡非尼酮组心肌血管周围和间质胶原含量分别下降了41.1%和44.9%,纤维蛋白原和波形蛋白表达含量分别下降了43.3%和42.2%(均为P<0.01)。胸主动脉染色显示,与SHR+溶剂组相比,SHR+吡非尼酮组胶原含量减少了29.3%,SHR+吡非尼酮组纤维蛋白原含量下降了26.5%(均为P<0.01)。弹力纤维染色显示,SHR+溶剂组较WKY+溶剂组弹力纤维含量减少了37.9%,SHR+吡非尼酮组较SHR+溶剂组弹力纤维含量增加了61.0%(P<0.01)。结论吡非尼酮不影响大鼠血压,但可缓解SHR心肌和主动脉纤维化,减轻心肌和主动脉重构,改善主动脉弹性。

关键词：吡非尼酮自发性高血压心肌纤维化主动脉纤维化

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Effects of Annual Straw Returning with Different Tillage Patterns on Greenhouse Gas Emissions in Double-rice System

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Effects of Annual Straw Returning with Different Tillage Pat...

2016年全国青年作物栽培与生理学术研讨会

作者： Jun Zhang Samoura Mohamed Lamine Xiaoning hang Afreh Daniel Haoyu Qian Aixing Deng weijian Zhang Institute of Crop Sciences Chinese Academy of Agricultural Sciences/Key Laboratory of Crop Physiology and EcologyMinistry of Agriculture Chongqing Academy of Agricultural Sciences

【BACKGROUND】Rice straw impacts rice productivity and ***,large amount of researches focused on the effects of tillage managements and straw incorporation on soil fertility and grain ***,the interaction of annual straw returned to the field and tillage patterns received less attention.【MATERIALS AND METHODS】 In this study,field experiments about annual straw returning(total straw returning,as "-S";and no straw returning as control) and tillage managements(annual rotary tillage,as "RT" and annual plowing tillage,as "PT") were carried out(located Jiangxi province Yujiang city since 2008) on the double cropping rice region in south of *** productivity,greenhouse gas emissions(CH,NO),soil carbon sequestration and net greenhouse potential were measured.【RESULTS】The results showed that straw returningincreased the early rice yield by 12.1%,while there was no significant effect on the annual yield,in addition,straw returning made up for the grain yield decline caused by fully long-term plowing *** the rotary tillage,straw returning significantly increased the late rice season methane(CH) emission and global warming potential(GWP) by 33.2%and30.6%,respectively,while showedless affect at the early rice *** the other hand,there was no significant effectof straw returning on CH and GWP in the two rice seasons under plowing ***-tillageaveragely reduced GWP and GHGI value entiretwo yearsdouble ricecroppingby 45.1%and 31.8%significantly when compared with plowing *** terms of medium and long effects,the annual carbon sequestration rate of 0-20 cm soil layer under rotary tillage with straw returning could reach up to 635.2 kg CO-eq haa,and was significantly83.3%higher,alsothe net greenhouse gaspotential was significantly 58%greater than that in PT.【CONCLUSION】The present study suggested that,under the fully annual straw returning,reasonable tillage patterns(such as plowing) could be effective to mitigate g

关键词： Rice Annual straw returning Greenhouse gas emissions C sequestration Net global warming potential

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基于3D点云边界点特征的航空叶片位姿识别

计算机集成制造系统 2024年第12期30卷 4233-4245页

作者：韩奉林李炜健苏斌彭沆李其鑫中南大学机电工程学院湖南长沙410012 中南大学极端服役性能精准制造全国重点实验室湖南长沙410012

针对航空叶片在加工过程中定位成本高、效率低且精度难以保证的问题,提出一种基于3D点云边界点特征配准算法的航空叶片位姿识别方法,通过一次扫描即可快速、精确定位航空叶片在空间中的具体位置。首先,通过结构光相机获取工件的点云数... 详细信息

针对航空叶片在加工过程中定位成本高、效率低且精度难以保证的问题,提出一种基于3D点云边界点特征配准算法的航空叶片位姿识别方法,通过一次扫描即可快速、精确定位航空叶片在空间中的具体位置。首先,通过结构光相机获取工件的点云数据并对其进行预处理;随后,根据邻域点在切平面的投影向量夹角提取点云边界点作为配准的关键点;计算关键点的快速点特征直方图(FPFH)描述子,采用采样一致性初始配准(SAC-IA)算法求解粗配准矩阵;然后使用点到面的最近点迭代(ICP)算法进行精配准。最后,进行机器人视觉定位实验验证,结果表明针对航空叶片,所提算法显著提高了配准精度,均方误差为0.654 0 mm^(2);对于航空叶片在空间中位置的识别误差在1 mm以内,能够满足定位需求。

关键词：航空叶片加工定位点云配准边界特征

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冷冻消融治疗肺癌的免疫反应及其增强机制的研究探析

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甘肃科技 2023年第4期39卷 72-75,101页

作者：吴航杨维建甘肃中医药大学中西医结合学院甘肃兰州730000 甘肃省中医院外五科(肿瘤外科) 甘肃兰州730050

肺癌是全世界范围内发病率最高的恶性肿瘤疾病,死亡率也位居各类恶性肿瘤前列。给人们身心带来巨大痛苦,因此寻找更高效的方式治疗肺癌迫在眉睫,在外科治疗微创化,甚至超微创化的大背景下,冷冻消融技术应运而生,而且得到了蓬勃的发展。... 详细信息

肺癌是全世界范围内发病率最高的恶性肿瘤疾病,死亡率也位居各类恶性肿瘤前列。给人们身心带来巨大痛苦,因此寻找更高效的方式治疗肺癌迫在眉睫,在外科治疗微创化,甚至超微创化的大背景下,冷冻消融技术应运而生,而且得到了蓬勃的发展。因其是纯物理能量转换、消融能力大、消融部位精确、疗效确切、无明显痛苦、不良反应少及组织修复治疗效果较好而被公认为是恶性肿瘤治疗的“绿色疗法”。经皮冷冻消融术是目前唯一可用于周围肺肿瘤冷冻免疫治疗的技术。除了上述优点外,有研究表明冷冻消融治疗过程中能够产生疫苗样作用,激活机体免疫,诱发“远位效应”,对肺癌的局部和全身起到双重治疗作用。还有研究显示冷冻消融与粒细胞-巨噬细胞集落刺激因子、Toll样受体激动剂、细胞过继疗法、免疫检查点抑制剂等结合能够增强治疗肺癌的效果。然而,如何利用、加强冷冻消融的远位效应仍然是治疗肺癌,尤其是晚期肺癌的关键。

关键词：冷冻消融免疫反应肺癌免疫增强机制综述

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