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Adenosine triphosphate mediates the pain tolerance effect of manual acupuncture at Zusanli(ST36) in mice

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Journal of Traditional Chinese Medicine 2024年第4期44卷 660-669页

作者： LI Zhongzheng ZHAO Yadan ma weigang Zhang Yonglong XU Zhifang XI Qiang LI Yanqi QIN Siru ZHANG Zichen WANG Songtao ZHAO Xue LIU Yangyang GUO Yi GUO Yongming Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin 301617China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 301617China Department of Acupuncture and Moxibustion Qingdao Hiser Hospital Affiliated of Qingdao University(Qingdao Traditional Chinese Medicine Hospital)Qingdao 266033China School of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China School of Acupuncture and Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin 301617China

OBJECTIVE:To investigate the mechanisms behind the effects of acupuncture in Traditional Chinese Medicine,we delved into the adenosine triphosphate/peripheral purinergic P2X receptor 3(ATP/P2X3)receptor signaling system as an indicator of the body's energy state,commonly referred to as"Qi".METHODS:The tail-flick test was utilized to explore the impact of acupuncture on pain tolerance threshold(PTT)in mice,while also assessing adenosine(ADO)levels and adenylate energy charge(EC)at Zusanli(ST36).The study further investigated the dose-dependent effects of acupuncture on PTT and ADO levels at Zusanli(ST36).To shed light on the underlying mechanisms of acupuncture's effects,the study examined the impact of ATP,a P2X3 receptor antagonist,and adenosine disodium on PTT following acupuncture ***:Acupuncture at Zusanli(ST36)led to significant improvements in PTT in mice,with the most effective interventions being twirling for 2 min and needle retention for 28 *** interventions also resulted in significant increases in ATP *** effects of acupuncture were further augmented by administration of different doses of ATP at Zusanli(ST36),and pretreatment with a P2X3 receptor antagonist decreased *** EC peaked at 30 min after intraperitoneal injection of ATP,and pretreatment with various doses of *** 30 min prior to acupuncture increased PTT in a dose-dependent ***,pretreatment with an *** intramuscular injection of adenosine disodium enhanced the effects of ***:This research provides compelling evidence that ATP is involved in the regulation of PTT through acupuncture,revealing new avenues for achieving enhanced clinical outcomes.

关键词： acupuncture point ST36(Zusanli) adenosine triphosphate receptors,purinergic P2X3 energy state

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缺陷对石墨烯热传导性质影响的模拟研究

工程热物理学报 2024年第6期45卷 1767-1772页

作者：陈斌马维刚清华大学工程力学系热科学与动力工程教育部重点实验室北京100084

石墨烯作为新型高导热材料,在微器件散热领域具有极大的应用潜力。本文通过第一性原理计算分别研究了N、O修饰及N掺杂等三种类型缺陷对石墨烯热传导性质的影响。结果表明,添加缺陷后石墨烯热导率降低程度为N修饰>O修饰>N掺杂,三种缺陷... 详细信息

石墨烯作为新型高导热材料,在微器件散热领域具有极大的应用潜力。本文通过第一性原理计算分别研究了N、O修饰及N掺杂等三种类型缺陷对石墨烯热传导性质的影响。结果表明,添加缺陷后石墨烯热导率降低程度为N修饰>O修饰>N掺杂,三种缺陷下室温热导率分别为60.7 W/(m·K)、81.2 W/(m·K)和2180 W/(m·K)。添加缺陷后低频声子弛豫时间显著降低,石墨烯晶体的严格周期性排列被破坏而造成的声子散射率增加是热导率大幅下降的主要原因。

关键词：石墨烯热导率声子缺陷第一性原理

Tunable Anisotropic Lattice Thermal Conductivity in One-Dimensional Superlattices from Molecular Dynamics Simulations

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Journal of Thermal Science 2022年第4期31卷 1068-1075页

作者： WANG Xiuqi AN Meng ma weigang ZHANG Xing Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering MechanicsTsinghua UniversityBeijing 100084China College of Mechanical and Electrical Engineering Shaanxi University of Science and TechnologyXi'an 710021China

Engineering nanostructured superlattices provides an effective solution toward the realization of high-performance thermoelectric device and thermal management materials,where the anisotropic thermal conductivity is critical for designing orientation-dependent thermal ***,the lattice thermal conductivity anisotropy of Al/Ag superlattices as one typical example of superlattice materials is investigated utilizing non-equilibrium molecular dynamics *** cross-plane and in-plane lattice thermal conductivities of one-dimensional superlattices are in the ranges of 0.5–3.2 W/(m·K)and 1.8–5.1 W/(m·K)at different period lengths,respectively,both of which are smaller than those of bulk *** specifically,the cross-plane lattice thermal conductivity of superlattices increases with the period length,while the in-plane phonon thermal conductivity first increases and then trends to convergence,resulting in the non-monotonic thermal anisotropy *** further reveal the microscopic phonon transport mechanism,the interfacial phonon thermal resistance,density of states and spectral phonon transmission coefficient including anharmonic phonon properties under different period lengths are *** results can be helpful for understanding phonon transport in low-dimensional materials and provide guidance for optimizing the thermal conductivity anisotropy of superlattice materials in the application ranging from thermoelectric devices to thermal management in micro/nano systems.

关键词： anisotropic thermal conductivity superlattices phonon transport molecular dynamical simulations

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数字金融对城市碳排放的非线性影响研究

国土资源科技管理 2024年第1期41卷 115-128页

作者：马卫刚王兴启石河子大学经济与管理学院新疆石河子832000

数字金融在经济社会全面绿色转型中发挥政策集成和导向作用,是降碳减排的重要工具。本文基于金融领域的数字化变革现实,以2011—2021年中国284个地级市面板数据为基础,运用固定效应模型、中介效应模型和调节效应模型探究数字金融对碳排... 详细信息

数字金融在经济社会全面绿色转型中发挥政策集成和导向作用,是降碳减排的重要工具。本文基于金融领域的数字化变革现实,以2011—2021年中国284个地级市面板数据为基础,运用固定效应模型、中介效应模型和调节效应模型探究数字金融对碳排放的非线性影响及潜在机制。研究发现:数字金融对碳排放存在先增后减的倒“U”型影响,这一趋势通过一系列稳健性检验得以证实。异质性分析表明,这种倒“U”型影响主要发生在外围城市和资源型城市,在非资源型城市表现为负向线性关系。中介效应分析凸显了技术创新和创业活动作为数字金融影响碳排放的关键途径。调节效应分析强调了地方政府经济增长目标将削弱数字金融对碳排放的倒“U”型影响,环境治理目标则强化两者的倒“U”型关系。地方政府应从数字金融的发展方向、作用方向和配置方向着手,释放碳减排红利。

关键词：数字金融碳排放倒“U”型创新创业政府双重目标

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Dual-wavelength flash Raman mapping method for measuring thermal diffusivity of the suspended nanowire

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Science China(Technological Sciences) 2020年第5期63卷 748-754页

作者： HU YuDong FAN AoRan WANG HaiDong ma weigang ZHANG Xing Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering MechanicsTsinghua UniversityBeijing 100084China

In this paper,we present a dual-wavelength flash Raman(DFR)mapping method for measuring the thermal diffusivity of a suspended nanowire.A heating pulse is used to heat the nanowire sample,and a probing pulse of different wavelength is used to measure the increase in *** laser absorption coefficient can be eliminated by normalization,and the thermal diffusivity of the sample can be extracted from the normalized temperature *** infinite heat conduction model is used in this method to avoid the influence of boundary thermal *** changing the position of the probing laser center,the measurement sensitivity of thermal diffusivity can be further *** position of maximum sensitivity is influenced by the thermal diffusivity of the nanowire,width of the heating pulse,radius of the heating laser spot,and characteristic length of the *** comprehensively analyze the influences of the various parameters,obtain the best measurement conditions,and attain maximum sensitivity,we propose a dimensionless physical model to analyze the heat conduction of the suspended *** on the analysis of the best dimensionless parameters,the corresponding appropriate measurement conditions can be *** analysis shows that when the radius of the heating laser spot is 1%of the length of the nanowire,the sensitivity of the DFR mapping method can be more than four times that of the concentric DFR method for measuring the thermal diffusivity of the nanowire.

关键词： DFR mapping method thermal diffusivity nanowire dimensionless analysis

Dual-Wavelength Laser Flash Raman Spectroscopy Method for In-Situ Measurements of the Thermal Diffusivity: Principle and Experimental Verification

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Journal of Thermal Science 2019年第2期28卷 159-168页

作者： FAN Aoran HU Yudong ma weigang WANG Haidong ZHANG Xing Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering Mechanics Tsinghua University

This paper presents an in-situ, non-contact, non-destructive "dual-wavelength laser flash Raman spectroscopy method" for measuring the thermal diffusivity. In this method, a heating pulse is used to heat the sample and another pulsed laser with a different wavelength and negligible heating effect is used as a probe to measure the sample temperature changes during the heating and cooling periods from the Raman peak shifts. The sample temperature rise and fall curves are measured by changing the delay between the heating pulse and the probing pulse with the thermal diffusivity then characterized by fitting the temperature curves. The time delay between the heating and probing pulses can be precisely controlled with a minimum step of 100 ps. Hence, the temperature variation can be scanned with an ultra-high temporal resolution of up to 100 ps, which significantly improves the measurement accuracy of transient thermal parameters. The measurement accuracy of this method has been verified using a bulk material model and experiments. The measured thermal diffusivity of a silicon sample has been obtained to be 8.8×10^(-5 )m^2/s with a 3% difference between the measured value and the average result for bulk silicon in the literature which verifies the reliability and accuracy of this method.

关键词： dual-wavelength laser flash Raman spectroscopy method thermal diffusivity Raman spectroscopy nanomaterials bulk materials

Thermoelectric Properties of an Individual Suspended Single-Crystalline Sb_(2)Se_(3)Nanowire

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Journal of Thermal Science 2022年第4期31卷 1106-1114页

作者： DU Yanzheng SHI Shaoyi MIAO Tingting ma weigang maI Liqiang ZHANG Xing Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering Mechanics Tsinghua UniversityBeijing 100084China Beijing Key Laboratory of Process Fluid Filtration and Separation College of Mechanical and Transportation EngineeringChina University of PetroleumBeijing 102249China State Key Laboratory of Advanced Technology for materials Synthesis and Processing Wuhan University of TechnologyWuhan430070China

Nanowires exhibit excellent thermoelectric performance,due to the stronger quantum confinement and phonon scattering effect compared to bulk ***,it is a challenge to accurately evaluate the thermoelectric performance of *** this paper,the thermoelectric properties of an individual suspended Sb_(2)Se_(3) nanowire have been characterized by comprehensive T-type method,including thermal conductivity,electrical conductivity,Seebeck coefficient and figure of *** thermal conductivity increases from 0.57 W/(m·K)to 3.69 W/(m·K)with temperature increasing from 80 K to 320 *** lattice vibration dominates the heat conduction process,and due to its flawless crystal structure,the thermal conductivity is not lower than the reported values of bulk Sb_(2)Se_(3).The electrical conductivity increases from 7.83 S/m to 688 S/m in the temperature range of 50 K–320 K,which is a great improvement compared with the corresponding bulk *** 294 K,the Seebeck coefficient of the Sb_(2)Se_(3) nanowire is–1120μV/K and the corresponding figure of merit is 0.064.

关键词： Sb_(2)Se_(3)nanowire thermoelectric properties thermal conductivity Seebeck coefficient electrical conductivity

Motion trajectory prediction based on a CNN-LSTM sequential model

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Science China(Information Sciences) 2020年第11期63卷 248-268页

作者： Guo XIE Anqi SHANGGUAN Rong FEI Wenjiang JI weigang ma Xinhong HEI School of Automation and Information Engineering School of Computer Science and EngineeringXi'an University of Technology

Accurate monitoring the surrounding environment is an important research direction in the field of unmanned systems such as bio-robotics, and has attracted much research attention in recent years. The trajectories of surrounding vehicles should be predicted accurately in space and time to realize active defense and running safety of an unmanned system. However, there is uncertainty and uncontrollability in the process of trajectory prediction of surrounding obstacles. In this study, we propose a trajectory prediction method based on a sequential model, that fuses two neural networks of a convolutional neural network(CNN) and a long short-term memory network(LSTM). First, a box plot is used to detect and eliminate abnormal values of vehicle trajectories, and valid trajectory data are obtained. Second, the trajectories of surrounding vehicles are predicted by merging the characteristics of CNN space expansion and LSTM time expansion;the hyper-parameters of the model are optimized according to a grid search algorithm, which satisfies the double-precision prediction requirement in space and time. Finally, data from next generation simulation(NGSIM) and Creteil roundabout in France are taken as test cases; the correctness and rationality of the method are verified by prediction error indicators. Experimental results demonstrate that the proposed CNNLSTM method is more accurate and features a shorter time cost, which meets the prediction requirements and provides an effective method for the safe operation of unmanned systems.

关键词： bio-robots unmanned system outlier detection hyper-parameters trajectory prediction

Reduction in thermal conductivity of monolayer WS_(2) caused by substrate effect

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Nano Research 2022年第10期15卷 9578-9587页

作者： Yufeng Zhang Qian Lv Aoran Fan Lingxiao Yu Haidong Wang weigang ma Ruitao Lv Xing Zhang Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering MechanicsTsinghua UniversityBeijing 100084China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Key Laboratory of Advanced materials(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Understanding the substrate and temperature effect on thermal transport properties of transition metal dichalcogenides(TMDs)monolayers are crucial for their future ***,a dual-wavelength flash Raman(DF-Raman)method is used to measure the thermal conductivity of monolayer WS_(2) at a temperature range of 200–400 *** measurement accuracy can be guaranteed in this method since the influence of both the laser absorption coefficient and temperature-Raman coefficient can be eliminated through *** room-temperature thermal conductivity of suspended and supported WS_(2) are 28.5±2.1(30.3±2.0)and 15.4±1.9(16.9±2.1)W/(m·K),respectively,with a~50%reduction due to substrate *** dynamics(MD)simulations reveal that the suppression of acoustic phonons is mainly responsible for the striking *** behaviors of optical phonons are also unambiguously investigated using Raman spectroscopy,and the in-plane optical mode,E(Γ),is surprisingly found to be slightly enhanced while out-of-plane mode,A1g(Γ),is suppressed due to substrate interaction,mutually verified with MD *** study provides a solid understanding of the phonon transport behavior of WS_(2) with substrate interaction,which provides guidance for TMDs-based nanodevices.

关键词： monolayer WS_(2),thermal conductivity,substrate effect,temperature effect,dual-wavelength flash Raman(DF-Raman)method