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The role of botanical triterpenoids and steroids in bile acid metabolism,transport,and signaling:Pharmacological and toxicological implications

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3385-3415页

作者： Zichen Luo Wei Zhou Tong Xie weichen xu Chen Shi Zihan Xiao Yu Si Yan Ma Qingling Ren Liuqing Di Jinjun Shan Medical Metabolomics Center Institute of PediatricsJiangsu Key Laboratory of Children’s Health and Chinese MedicineNanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Natural Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China Jiangsu CM Clinical Medicine Innovation Center for Obstetrics Gynecologyand ReproductionAffiliated Hospital of Nanjing University of Chinese MedicineNanjing 210001China National Institute of Biological Sciences Beijing 102206China Jiangsu Engineering Research Center for Efficient Delivery System of TCM School of PharmacyNanjing University of Chinese MedicineNanjing 210023China

Bile acids(BAs)are synthesized by the host liver from cholesterol and are delivered to the intestine,where they undergo further metabolism by gut microbes and circulate between the liver and intestines through various *** serve to emulsify dietary lipids and act as signaling molecules,regulating the host’s metabolism and immune homeostasis through specific ***,disruptions in BA metabolism,transport,and signaling are closely associated with cholestasis,metabolic disorders,autoimmune diseases,and *** triterpenoids and steroids share structural similarities with BAs,and they have been found to modulate BA metabolism,transport,and signaling,potentially exerting pharmacological ortoxicological ***,we have updated the research progress on BA,with a particular emphasis on new-found microbial ***,the latest advancements in targeting BA metabolism and signaling for disease treatment are ***,the roles of botanical triterpenoids in BA metabolism,transport,and signaling are examined,analyzing their potential pharmacological,toxicological,or drug interaction effects through these ***,a research paradigm is proposed that utilizes the gut microbiota as a link to interpret the role of these important natural products in BA signaling.

关键词： Bile acid Triterpenoid Phytosterol Saponin Gut microbes Cholestasis Metabolic disorders Rheumatoid arthritis

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新建并行道路对高铁桥墩位移响应的可靠性研究

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中南大学学报（自然科学版） 2024年第1期55卷 162-171页

作者：唐冕徐伟宸宋旭明李思佳中南大学土木工程学院湖南长沙410075 湖南省交通规划勘察设计院有限公司湖南长沙410219

为了研究软土地区新建并行道路对既有高铁桥墩位移的时变影响,以沪宁杭高速铁路某工程为背景,构建三维有限元模型并进行桥墩位移的参数敏感性分析,利用时变响应面法得到桥墩位移与敏感系数较大的土体参数的相关关系,根据响应面函数进行... 详细信息

为了研究软土地区新建并行道路对既有高铁桥墩位移的时变影响,以沪宁杭高速铁路某工程为背景,构建三维有限元模型并进行桥墩位移的参数敏感性分析,利用时变响应面法得到桥墩位移与敏感系数较大的土体参数的相关关系,根据响应面函数进行桥墩位移的概率分布计算,并评估桥墩位移的可靠概率。研究结果表明:桥墩位移对土体泊松比、回弹曲线斜率、临界状态斜率的敏感性系数较大;高铁桥墩位移响应面函数预测值与有限元模型计算值的相对误差在5%以内,响应面函数预测结果可靠;随着土体固结时间延长,桥墩最大横向位移不断减小,稳定后大部分桥墩的横向位移保持在2 mm以内;通过时变响应面函数拟合有限元计算结果,可以提高计算效率,获得考虑软土固结效应时既有高铁桥墩位移的可靠概率,为类似桥墩位移的预测提供一种较实用的方法。

关键词：软土时变响应可靠度高铁桥梁

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基于GC-MS代谢组学的牛黄解毒片配伍减毒机制研究

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南京中医药大学学报 2024年第8期40卷 823-830页

作者：马袁静许伟辰单进军李永明吴骁南京中医药大学医学院江苏南京210023 南京中医药大学药学院江苏省方剂研究重点实验室/江苏省方剂高技术研究重点实验室/中药资源产业化与方剂创新药物国家地方联合工程研究中心/江苏省中药资源产业化过程协同创新中心江苏南京210023

目的采用气相色谱-质谱联用(GC-MS)的代谢组学技术探讨牛黄解毒片复方配伍的减毒作用及机制。方法将24只小鼠随机分为空白组、雄黄组(1.0 g·kg^(-1))和牛黄解毒片组(7.8 g·kg^(-1)),每组8只,连续口服给药14 d,采集各组小鼠的肝脏和肾... 详细信息

目的采用气相色谱-质谱联用(GC-MS)的代谢组学技术探讨牛黄解毒片复方配伍的减毒作用及机制。方法将24只小鼠随机分为空白组、雄黄组(1.0 g·kg^(-1))和牛黄解毒片组(7.8 g·kg^(-1)),每组8只,连续口服给药14 d,采集各组小鼠的肝脏和肾脏,观察病理形态学变化;测定肝脏中丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)和肾脏中肌酐(Cr)、尿酸(UA)的含量;GC-MS代谢组学分析肝脏和肾脏中内源性代谢物的差异。结果与雄黄组比较,牛黄解毒片组小鼠肝脏中ALT、AST和肾脏中Cr、UA含量发生显著变化(P<0.05),肝脏和肾脏病理损伤减轻;筛选出柠檬酸、抗坏血酸、天冬酰胺、左旋多巴、苯丙氨酸等17种与减毒相关的生物标志物,涉及谷氨酰胺和谷氨酸代谢、精氨酸的生物合成、色氨酸代谢、酪氨酸和色氨酸的生物合成、苯丙氨酸代谢等通路。结论牛黄解毒片复方配伍降低了雄黄的肝肾毒性,减毒作用可能与回调氨基酸代谢有关。

关键词：雄黄牛黄解毒片配伍减毒代谢组学气相色谱-质谱联用氨基酸代谢

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Scalable, fluorine free and hot water repelling superhydrophobic and superoleophobic coating based on functionalized Al_(2)O_(3) nanoparticles

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Journal of Materials Science & Technology 2021年第7期66卷 74-81页

作者： Binbin Zhang weichen xu Qingjun Zhu Baorong Hou CAS Key Laboratory of Marine Environmental Corrosion and Bio-fouling Institute of OceanologyChinese Academy of SciencesQingdao 266071China Open Studio for Marine Corrosion and Protection Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

Hot water droplet and oils induced air cushion failure, intensively used fluorine-containing chemicals,tedious preparation process, etc. are the main bottlenecks of the current artificially fabricated superhydrophobic materials, restricting their large-scale production and real-world applications. Herein, a facile,scalable, fluorine-free spray-coating strategy was employed to achieve superhydrophobic and superoleophobic polymerized organosilanes/Al2O3 nanoparticles(POS/Al_(2)O_(3) NPs) coatings. The POS/Al_(2)O_(3) NPs coating was achieved through hydrolytic condensation of tetraethyl orthoilicate(TEOS) and hexadecyltrimethoxysilane(HDTMS) in the presence of Al2O3 NPs. A variety of analytical techniques including scanning electron microscopy(SEM), X-ray photoelectron spectroscopy(XPS), energy dispersive X-ray photoelectron spectroscopy(EDS) were used to investigate the fabricated coatings. The POS/Al_(2)O_(3) NPs coating features high contact angle(>158°) and low sliding angle(<5°) for water, glycerol, and ethylene glycol droplets with different surface tensions, verifying both superhydrophobic and superoleophobic properties. Moreover, the coatings present extremely low surface adhesion force, excellent liquid-driven self-cleaning ability, and hot water repellency. The superamphiphobic POS/Al_(2)O_(3) NPs coating exhibits promising applications in various fields including self-cleaning, corrosion resistance, and preventing scald as this strategy is applicable on various substrates.

关键词： Al_(2)O_(3) Self-cleaning Surface coating Thermal stability Supehydrophobicity Wettability

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金属有机架构物Cu-BTC低温吸附储氢数值模拟研究

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热力发电 2024年第9期53卷 118-125页

作者：席肖桐田绅郭璐娜陈六彪许成杨徐伟宸孙志利天津市制冷技术重点实验室天津商业大学天津300134 中国科学院理化技术研究所低温科学与技术重点实验室北京100190 中国科学院大学北京100049

物理吸附储氢具有安全性能高、储氢密度大及充放氢速率快的优势,是一种极具应用潜力的储氢方式,其中金属有机架构物(MOFs)材料凭借其高度有序的孔隙结构和可调控特性已成为理想的吸氢材料。为探究吸附储氢过程热效应对储氢性能的影响,... 详细信息

物理吸附储氢具有安全性能高、储氢密度大及充放氢速率快的优势,是一种极具应用潜力的储氢方式,其中金属有机架构物(MOFs)材料凭借其高度有序的孔隙结构和可调控特性已成为理想的吸氢材料。为探究吸附储氢过程热效应对储氢性能的影响,首先建立了吸附储氢数值模型并进行验证,随后对比分析了Cu-BTC与活性炭AX-21的储氢特性,并探究不同温度下Cu-BTC的储氢能力。计算结果表明:相较于AX-21,采用Cu-BTC作为吸附剂材料,常温下储氢量提升了12.8%;将储氢温度降至77 K时,Cu-BTC储罐的最高压力降至0.97 MPa,储氢质量相较于常温300 K提升了174%。以上结论可为Cu-BTC材料储氢研究提供参考。

关键词：储氢吸附储氢金属有机架构物 Cu-BTC 低温吸附

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过敏性紫癜合并器官功能损害的研究现状

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安徽医药 2024年第5期28卷 1024-1028页

作者：徐玮琛张静黄蓉骆志成兰州大学第二医院皮肤科甘肃兰州730000

过敏性紫癜是临床中最常见的系统性血管炎类疾病,典型临床表现为双下肢的非血小板减少性紫癜,关节、胃肠道及肾损害。随着对此病不断地深入认识,累及其他少见器官的临床表现及诊断值得临床医师关注。该文就近年来国内外过敏性紫癜伴有... 详细信息

过敏性紫癜是临床中最常见的系统性血管炎类疾病,典型临床表现为双下肢的非血小板减少性紫癜,关节、胃肠道及肾损害。随着对此病不断地深入认识,累及其他少见器官的临床表现及诊断值得临床医师关注。该文就近年来国内外过敏性紫癜伴有各个系统损害的临床表现、诊断、危险因素和治疗做一简要综述。

关键词：紫癜,过敏性临床表现器官损害危险因素

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Corrosion behavior of Q235B carbon steel in simulated seawater pumped storage system under operational conditions

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Journal of Oceanology and Limnology 2020年第5期38卷 1537-1547页

作者： YANG Dan HUANG Yanliang LI Jianqiu GAO Yanming ZHAO Xia xu weichen CAS Key Laboratory of Marine Environmental Corrosion and Bio-fouling Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China CSG Power Generation Co. Ltd.Guangzhou 511400China Open Studio for Marine Corrosion and Protection Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237Chin a 5 Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

Seawater pumped storage systems have bright prospect for energy storage in the coming *** operational conditions of seawater pumped storage system are complex and harsh,where metal materials suff er from severe general and local *** corrosion behavior of Q235B carbon steel in simulated seawater pumped storage system under operational conditions was studied by potentiodynamic polarization,cyclic potentiodynamic polarization,and scanning electron microscope(SEM).The results confi rm that the working pressure aff ected the corrosion resistance of Q235B carbon steel during the whole immersion *** pressure promoted the electrochemical reaction of corrosion process and the corrosion rate increased with pressure at the initial immersion ***,the stable rust layer formed after longtime immersion at diff erent pressures increased the corrosion resistance of carbon steel,and decreased the corrosion degree of carbon ***,the working pressure aff ected the pitting corrosion behavior of Q235B carbon steel during the whole immersion *** pitting corrosion potential was more negative and the tendency of pitting corrosion was higher at 4 MPa during the whole immersion ***,pressure also accelerated the formation rate of protective rust layer on the steel surface.Q235B carbon steel has higher susceptibility to pitting corrosion at 4 MPa in the static seawater.

关键词： seawater pumped storage system seawater pipeline pressure corrosion resistance pitting corrosion

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Influence of Calcareous Deposit on Corrosion Behavior of Q235 Carbon Steel with Sulfate-Reducing Bacteria

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Journal of Ocean University of China 2017年第6期16卷 1213-1219页

作者： ZHANG Jie LI Xiaolong WANG Jiangwei xu weichen DUAN Jizhou CHEN Shougang HOU Baorong Key Laboratory of Marine Environmental Corrosion and Bio-fouling Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 P. R. China University of Chinese Academy of Sciences Beijing 10049 P. R. China Institute of Material Science and Engineering Ocean University of China Qingdao 266100 P. R. China

Cathodic protection is a very effective method to protect metals, which can form calcareous deposits on metal surface. Research on the interrelationship between fouling organism and calcareous deposits is very important but very limited, especially sulfate-reducing bacteria(SRB). SRB is a kind of very important fouling organism that causes microbial corrosion of metals. A study of the influence of calcareous deposit on corrosion behavior of Q235 carbon steel in SRB-containing culture medium was carried out using electrochemical impedance spectroscopy(EIS), scanning electron microscopy(SEM) and surface spectroscopy(EDS). The calcareous deposit was formed with good crystallinity and smooth surface under the gradient current density of -30 μA cm^(-2) in natural seawater for 72 h. Our results can help elucidate the formation of calcareous deposits and reveal the interrelationship between SRB and calcareous deposits under cathodic protection. The results indicate that the corrosion tendency of carbon steel was obviously affected by Sulfate-reducing Bacteria(SRB) metabolic activity and the calcareous deposit formed on the surface of carbon steel under cathodic protection was favourable to reduce the corrosion rate. Calcareous deposits can promote bacterial adhesion before biofilm formation. The results revealed the interaction between biofouling and calcareous deposits, and the anti-corrosion ability was enhanced by a kind of inorganic and organic composite membranes formed by biofilm and calcareous deposits.

关键词： microbiological corrosion sulfate-reducing bacteria calcareous deposit cathodic protection

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钢轨轨底上表面缝隙腐蚀研究现状

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高速铁路新材料 2024年第1期3卷 1-6页

作者：王泽先徐玮辰李国宝李灿明邓羽段继周侯保荣中国科学院海洋研究所中国科学院海洋环境腐蚀与生物污损重点实验室山东青岛266071 齐鲁工业大学(山东省科学院)材料科学与工程学部济南210353 山东钢铁集团日照有限公司山东日照276800

在潮湿的环境中,铁路系统中的轨底上表面和绝缘轨距块之间容易发生缝隙腐蚀,这种现象导致轨底逐渐变薄,造成严重的安全隐患。目前缝隙腐蚀研究主要涉及螺栓螺母、边缘板等异形结构,而对轨底上表面与绝缘轨距块之间的缝隙腐蚀的研究报道... 详细信息

在潮湿的环境中,铁路系统中的轨底上表面和绝缘轨距块之间容易发生缝隙腐蚀,这种现象导致轨底逐渐变薄,造成严重的安全隐患。目前缝隙腐蚀研究主要涉及螺栓螺母、边缘板等异形结构,而对轨底上表面与绝缘轨距块之间的缝隙腐蚀的研究报道较少。对轨底上表面的缝隙腐蚀现象进行深入分析,探讨了现阶段轨底上表面缝隙腐蚀的产生和机械辅助缝隙腐蚀机制、相关的检测技术和方法以及防护措施的研究现状。

关键词：钢轨轨底上表面缝隙腐蚀检测防护

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A New Edge Detection Method of Magnetic Flux Leakage Image Based on Wavelet Multi-Scale Registration and Modulus Maximum

A New Edge Detection Method of Magnetic Flux Leakage Image B...

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第30届中国控制与决策会议

作者： weichen xu Xi Liu Zhen Dai College of Information Science and Engineering Northeastern University

In this paper,a new edge detection method based on wavelet multi-scale registration and modulus maximum is proposed to better detect the edge of the defect magnetic flux ***,the axial image A and the radial image B are respectively carried out with binary wavelet transform in the selected *** modulus and phase angles of each image point（x,y） are then calculated and combined into a new magnitude to represent the correlation of the image points（x,y）.A new universal edge correlation criterion is defined as a measure of similarity in the registration ***,wavelet edge and modulus maximum methods are used to register and fuse edges of images to reconstruct *** experimental results show the effectiveness of the proposed method.

关键词： Wavelet Multi-Scale Registration Wavelet Multi-Scale Modulus Maximum Image Fusion Edge Detection

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