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Food Science and Human Wellness 2024年第5期13卷 2857-2865页

作者： Xiaomei Zhang Yaling Wang Junying Zhao weicang qiao Yanpin Liu Lijun Chen National Engineering Research Center of Dairy Health for Maternal and Child Beijing Sanyuan Foods Co.Ltd.Beijing 100163China Beijing Engineering Research Center of Dairy Beijing Technical Innovation Center of Human Milk ResearchBeijing Sanyuan Foods Co.Ltd.Beijing 100163China

Nutrients in human milk,including minerals,relate growth and development of breast-fed *** mother-infant dyads possess unique characteristics on early nutrition due to their featured long-lasting *** study longitudinally investigated the relationship between the mineral composition in human milk and the Z-scores of infants among Tibetan mother-infant dyads during their first 6 months postpartum through a prospective cohort *** results show that the minerals of Na,Mg,K,Ca,Cu,Zn,and Se were of higher levels in colostrum than other lactation *** minerals were below the recommended values for infants according to Chinese dietary ***,a large proportion of infant Z-scores were below-2 as lactation period *** statistical analysis revealed that classifications and correlations in varying degrees were observed between minerals in human milk and infant *** findings will be advantageous for research upon Chinese early nutrition and progress of tailor-made infant formula.

关键词： Tibetan mother-infant dyads Minerals Z-scores Classification and correlation Breastfeeding

Calcium-fortified fresh milk ameliorates postmenopausal osteoporosis via regulation of bone metabolism and gut microbiota in ovariectomized rats

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Food Science and Human Wellness 2024年第3期13卷 1258-1270页

作者： Qishan Wang Bin Liu Xianping Li Junying Zhao Zongshen Zhang weicang qiao Xinyue Wei Lijun Chen School of Bioengineering Dalian Polytechnic UniversityDalian 116034China National Engineering Research Center of Dairy Health for Maternal and Child Beijing Sanyuan Foods Co.Ltd.Beijing 100163China Beijing Engineering Research Center of Dairy Beijing Sanyuan Foods Co.Ltd.Beijing 100163China

The aging of the global population has made postmenopausal osteoporosis prevention essential;however,pharmacological treatments are ***,we evaluate the effect of calcium-fortified fresh milk(FM)in ameliorating postmenopausal osteoporosis in a rat model established using bilateral *** 3 months of FM(containing vitamin D,and casein phosphopeptides,1000 mg Ca/100 g)or control milk(110 mg Ca/100 g milk)supplementation,bone changes were assessed using dual-energy X-ray absorptiometry,microcomputed tomography,and bone biomechanical *** results revealed that FM can regulate bone metabolism and gut microbiota composition,which act on bone metabolism through pathways associated with steroid hormone biosynthesis,relaxin signaling,serotonergic synapse,and unsaturated fatty acid ***,FM administration significantly increased bone mineral content and density in the lumbar spine and femur,as well as femoral compressive strength,while improving femoral trabecular bone parameters and ***,we found that the effects may be due to increased levels of estrogen,bone formation marker osteocalcin,and procollagen typeⅠN-propeptide,and decreased expression of the bone resorption marker C-telopiptide and tartrate-resistant acid phosphatase ***,the findings suggest that FM is a potential alternative therapeutic option for ameliorating postmenopausal osteoporosis.

关键词： Dairy products Calcium Vitamin D Bone turnover markers Gut microbiota Postmenopausal osteoporosis

Potential of A Yogurt Enriched with Synbiotics for Influenza Prevention and Treatment

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Food Science and Human Wellness 2024年

作者： Liqiong Song Bin Liu Yuangming Huang Junying Zhao Xianping Li weicang qiao Siqin He Hanyu Ma Yanpin Liu Weicheng Nie Lijun Chen Zhihing Ren National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases， National Institute for Communicable Disease Control and Prevention， Chinese Center for Disease Control and Prevention National Engineering Research Center of Dairy Health for Maternal and Child， Beijing Sanyuan Foods Co.Ltd. Beijing Engineering Research Center of Dairy， Beijing Technical Innovation Center of Human Milk Research， Beijing Sanyuan Foods Co.Ltd. Institute of Basic Theory for Chinese Medicine， China Academy of Chinese Medical Sciences Beijing University of Chinese Medicine Third Affiliated Hospital

Probiotics show anti-influenza activity， offering a potential variant-resistant alternative for infection prevention and control. In this study， we evaluated whether a specially formulated yogurt enriched with synbiotics (named yogurt 1 in this study) with seven probiotics and six prebiotics， has anti-influenza effects and its underlying mechanisms using a mouse model challenged with influenza virus H1N1 PR8 strain. The mice were treated with phosphate-buffered saline (negative control)， yogurt matrix， yogurt 1， and oseltamivir (positive control)， respectively. yogurt 1 treatment improved the survival of infected mice (from 0% to 30%)， alleviated pathological injuries in the lungs and colon， and reduced the viral load of influenza virus on days 3 and 7 post-infection. yogurt 1 also downregulated some inflammation-related signaling pathways and reduced the levels of proinflammatory cytokines or chemokines in the lungs or serum， including interleukin (IL)-1β， IL-6， tumor necrosis factor-α (TNF-α) and keratinocyte chemoattractant (KC). The levels of short-chain fatty acids in the cecal content were increased， the diversity of the intestinal flora was partially restored， and influenza-specific IgG and interferon-secreting lymphocytes were enhanced following yogurt 1 administration. Thus， yogurt 1， as a commercial and easily accessible dairy product， demonstrated a notable anti-influenza effect in mice by inhibiting viral proliferation， suppressing excessive inflammatory responses， and promoting influenza virus-specific adaptive humoral and cellular immune responses， demonstrating its potential for influenza epidemic prevention and control.

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Effects of excessive body fat on colostrum lipid patterns: overweight/obese vs. normal weight mothers

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Food Science and Human Wellness 2024年第6期13卷 3708-3717页

作者： Qian Liu Yan Liu Di Yang Yanpin Liu Yan Liu weicang qiao Juncai Hou Yaling Wang Minghui Zhang Kai Yang Xiaofei Fan Ziqi Li Junying Zhao Lijun Chen Key Laboratory of Dairy Science Ministry of EducationFood Science CollegeNortheast Agricultural UniversityHarbin 150030China National Engineering Research Center of Dairy Health for Maternal and Child Beijing Sanyuan Foods Co.Ltd.Beijing 100163China Beijing Engineering Research Center of Dairy Beijing Technical Innovation Center of Human Milk ResearchBeijing Sanyuan Foods Co.Ltd.Beijing 100163China

Prenatal overweight/obesity(OW/OB)can alter colostrum lipid patterns,thereby affecting the lipid metabolism and even the cognitive and healthy development of ***,studies on changes in colostrum lipids in the context of OW/OB are limited,particularly for glycerides and polar ***,this study investigated the infl uence of maternal prenatal weight on colostrum in lipid subclasses and molecular *** concentration of triacylglycerols(TAGs)in the colostrum of the OW/OB group(35894.43 mg/L)was higher than that of the normal weight(NW)group(26639.20 mg/L),suggesting that colostrum from OW/OB mothers could provide more energy to their *** analysis of the fatty acid composition of TAGs revealed that elevated maternal body weight enhanced the concentration of TAGs containing saturated or n-6 fatty acids and shortened the carbon number of *** acid(DHA)/arachidonic acid(AA)/choline-containing lipids,such as DHA-containing TAGs,AA/DHA-containing phosphatidylethanolamine,and choline-containing phospholipids,were present in higher levels in the colostrum of OW/OB mothers than NW ***,the concentrations of palmitic acid-containing TAGs,linoleic acid-containing TAGs,dihomo-γ-linolenic acid-containing TAGs,and polar lipids and the ratio of TAGs containing n-6 fatty acid/n-3 fatty acid were signifi cantly higher in the colostrum of OW/OB mothers than in that of NW *** fatty acid composition and sphingoid bases of sphingolipids were also altered due to elevated body *** conclusion,OW/OB affects colostrum lipids with respect to composition,concentration,and *** the colostrum of healthy OW/OB mothers can provide suffi cient DHA/AA/choline-containing lipids to their infants,normalization of body weight and fat reserves should be considered as a strategy for highquality human milk lipids.

关键词： Overweight/obesity Colostrum Maternal diet Fat reserves Glycerides Phospholipids Sphingolipids

婴幼儿配方奶粉加工过程中美拉德反应指示物和过敏原的变化

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中国食品学报 2018年第8期18卷 178-184页

作者：刘斌姜铁民李菊芳乔为仓卜丹丹陈历俊北京三元食品股份有限公司国家母婴乳品健康工程技术中心北京100163

为探究婴幼儿配方奶粉生产加工过程中有害物质的变化情况,采用高效液相色谱-紫外检测器(HPLCUVD)和酶联免疫(ELISA)技术探究美拉德反应产物(5-羟甲基糠醛、糠氨酸)以及过敏原(α-乳白蛋白、β-乳球蛋白和β-酪蛋白)在一段和二段奶粉中... 详细信息

为探究婴幼儿配方奶粉生产加工过程中有害物质的变化情况,采用高效液相色谱-紫外检测器(HPLCUVD)和酶联免疫(ELISA)技术探究美拉德反应产物(5-羟甲基糠醛、糠氨酸)以及过敏原(α-乳白蛋白、β-乳球蛋白和β-酪蛋白)在一段和二段奶粉中的产生和变化机理。两种美拉德反应产物在奶粉中的含量范围分别为0.00~0.02 mg/g蛋白和0.00~0.075 mg/g,3种过敏原的含量范围分别为0.2~1.4 g/g,0.05~0.6 g/g和0.0~0.8 g/g。糠氨酸含量在浓缩阶段达到最高,然后迅速下降,5-羟甲基糠醛含量在流化床二次干燥阶段达到最高。一段奶粉的5-羟甲基糠醛和糠氨酸含量显著低于二段奶粉。过敏原在一段和二段奶粉中的变化并不完全一致,在前者中呈现前期高后期低的趋势,而在后者中浓缩阶段显著升高,随后迅速下降至较低水平。一段和二段奶粉的这些差异可能与营养成分的差异和喷雾干燥的温度有关。以上研究结果将对婴幼儿配方奶粉的加工工艺改善和优化,以及新产品的开发提供理论依据。

关键词：婴幼儿配方奶粉加工工艺美拉德反应过敏原

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饮食辅助治疗HIV患者的研究进展

中国食品学报 2024年第3期24卷 396-404页

作者：李曼赵军英刘彦品刘斌乔为仓陈历俊大连工业大学生物工程学院辽宁大连116000 北京三元食品股份有限公司国家母婴乳品健康工程技术研究中心、北京市乳品工程技术研究中心、母乳研究技术创新中心北京100163

人类免疫缺陷病毒(HIV)是造成人类免疫系统缺陷的一种病毒。HIV可异常激活免疫细胞,大量减少肠道的CD4+T淋巴细胞,导致对致病菌等的防御力减弱,使得肠道免疫功能紊乱,肠道菌群失衡,并引发其它系统异常。临床上采用抗逆转录病毒治疗(ART... 详细信息

人类免疫缺陷病毒(HIV)是造成人类免疫系统缺陷的一种病毒。HIV可异常激活免疫细胞,大量减少肠道的CD4+T淋巴细胞,导致对致病菌等的防御力减弱,使得肠道免疫功能紊乱,肠道菌群失衡,并引发其它系统异常。临床上采用抗逆转录病毒治疗(ART)的同时会伴有腹泻、恶心、过敏等不良反应。近年来有研究发现采用益生菌与ART治疗相结合的方法,可以调节肠道菌群,抑制细菌移位,降低HIV感染者的炎症系数。文章综述HIV引起肠道微生态变化后,通过补充多种益生菌辅助治疗HIV患者的功效及机制。已发表的文献研究表明:通过含益生菌的饮食辅助治疗HIV感染具有积极作用,是一种经济可行的辅助治疗方法。

关键词：抗逆转录病毒治疗肠道微生态功能食品复合益生菌发酵乳

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益生菌缓解高尿酸血症作用机制研究进展

食品科学 2023年第23期44卷 282-292页

作者：黄佳豪李先平赵军英乔为仓刘璐陈历俊吉林农业大学食品科学与工程学院吉林长春130118 北京三元食品股份有限公司国家母婴乳品健康工程技术研究中心北京100163 北京市乳品工程技术研究中心北京市母乳研究技术创新中心北京100163

高尿酸血症(hyperuricemia,HUA)是由于人体内尿酸(uric acid,UA)的生成过多或排泄过少引起的疾病,持续性的HUA会导致痛风。无症状的HUA与其他代谢性疾病存在密切关联,如慢性肾病、糖尿病、心血管疾病等。益生菌干预治疗改善HUA是一种潜... 详细信息

高尿酸血症(hyperuricemia,HUA)是由于人体内尿酸(uric acid,UA)的生成过多或排泄过少引起的疾病,持续性的HUA会导致痛风。无症状的HUA与其他代谢性疾病存在密切关联,如慢性肾病、糖尿病、心血管疾病等。益生菌干预治疗改善HUA是一种潜在的安全、经济、高效的治疗手段。本文主要阐述了益生菌降低UA水平的机制,包括抑制黄嘌呤氧化酶活性、吸收和降解肠道中嘌呤类物质、调节肠道菌群稳态、恢复肠道屏障。此外,益生菌通过促进尿酸盐排泄转运蛋白的表达和抑制尿酸盐重吸收蛋白的表达促进UA的排泄从而降低UA水平。益生菌在缓解HUA方面极具应用前景,本文对益生菌缓解HUA机制进行了探讨,期望能为后续研究提供理论基础。

关键词：高尿酸血症痛风益生菌机制研究进展

电感耦合等离子质谱法测定母乳中10种矿物元素

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食品科学 2021年第14期42卷 165-169页

作者：王亚玲赵军英乔为仓张明辉刘妍陈历俊北京三元食品股份有限公司国家母婴乳品健康工程技术研究中心北京市乳品工程技术研究中心母乳研究技术创新中心北京100163

建立电感耦合等离子体质谱(inductively coupled plasma-mass spectrometry,ICP-MS)的同时测定母乳中K、Ca、Na、Mg、P、Cu、Mn、Zn、Fe、Se共10种矿物元素的分析方法。以浓硝酸和双氧水为混合试剂,采用密闭高压消解技术对母乳样品消解... 详细信息

建立电感耦合等离子体质谱(inductively coupled plasma-mass spectrometry,ICP-MS)的同时测定母乳中K、Ca、Na、Mg、P、Cu、Mn、Zn、Fe、Se共10种矿物元素的分析方法。以浓硝酸和双氧水为混合试剂,采用密闭高压消解技术对母乳样品消解后,用ICP-MS检测,利用动态反应池技术有效地消除了分析过程中质谱的干扰,选取Rh作为内标元素校正基体效应和信号漂移。标准曲线用外标法定量,以相对标准偏差考察方法的重复性,以标准物质考察方法的准确性。实验测定的10种元素线性回归方程的相关系数均大于0.9990,回收率范围为80.00%~118.19%,对照分析的奶粉成分分析标准物质(GBW10017)和脱脂奶粉成分分析标准物质(GBW08509)的K、Ca、Na、Mg、P、Cu、Mn、Zn、Fe、Se测定值均在标示值范围内,相对标准偏差均小于10.0%。结果表明,实验方法具有较好的准确度和精密度,适用于测定批量母乳的矿物元素。

关键词：母乳矿物元素电感耦合等离子体质谱密闭高压消解

离子色谱-串联质谱检测牛奶和婴幼儿配方乳粉中的氯酸盐和高氯酸盐

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中国食品学报 2022年第9期22卷 239-247页

作者：张明辉贾舸乔为仓赵军英王亚玲陈历俊北京三元食品股份有限公司国家母婴乳品健康工程技术研究中心北京市乳品工程技术研究中心母婴研究技术创新中心北京100163

为建立高效阴离子交换色谱-串联质谱法检测牛乳和婴儿配方粉中高氯酸盐和氯酸盐的方法,通过优化沉淀蛋白试剂和婴儿配方粉的纯化条件,用乙腈沉淀蛋白,离子色谱前处理柱净化上清液,使用Dionex IonPac AS19高效阴离子色谱柱分离,以氢氧化... 详细信息

为建立高效阴离子交换色谱-串联质谱法检测牛乳和婴儿配方粉中高氯酸盐和氯酸盐的方法,通过优化沉淀蛋白试剂和婴儿配方粉的纯化条件,用乙腈沉淀蛋白,离子色谱前处理柱净化上清液,使用Dionex IonPac AS19高效阴离子色谱柱分离,以氢氧化钾淋洗液进行梯度洗脱,流速0.35 mL/min,进样体积50μL,柱温30℃,采用质谱检测器检测。结果表明:在该试验条件下,高氯酸盐和氯酸盐能够很好地分离,且在较宽的浓度范围与其对应的定量离子峰面积呈良好的线性关系(R2>0.999)。高氯酸盐和氯酸盐的检出限分别为7 ng/L和1.7 ng/L,定量限分别为20 ng/L和5 ng/L。牛乳和婴儿配方粉的加标回收率在88.95%~102.33%范围,RSD在1.86%~3.21%范围。该方法样品处理简单,具有较低的检出限与定量限,较好的稳定性,良好的重复性与回收率,能广泛用于牛奶及婴幼儿配方奶粉的检测。

关键词：离子色谱-串联质谱高氯酸盐氯酸盐婴幼儿配方奶粉

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牛乳β-乳球蛋白变异体检测方法研究进展

中国食品学报 2024年第3期24卷 446-457页

作者：王亚玲贾舸赵军英乔为仓张明辉陈历俊北京三元食品股份有限公司、国家母婴乳品健康工程技术研究中心、北京市乳品工程技术研究中心、母婴研究技术创新中心北京100163

β-乳球蛋白(β-LG)是牛乳中重要的天然活性营养物质,也是牛乳中主要的过敏原之一。β-乳球蛋白约为乳清蛋白总量的50%,是牛乳中主要的乳清蛋白,具有较强的热敏感性和致敏性,在优质乳品工业中起关键作用。其不仅作为牛奶热处理强度的评... 详细信息

β-乳球蛋白(β-LG)是牛乳中重要的天然活性营养物质,也是牛乳中主要的过敏原之一。β-乳球蛋白约为乳清蛋白总量的50%,是牛乳中主要的乳清蛋白,具有较强的热敏感性和致敏性,在优质乳品工业中起关键作用。其不仅作为牛奶热处理强度的评估指标,还作为食品中牛乳过敏原的标志蛋白,有效识别和检测牛乳β-乳球蛋白非常重要。已报道的牛乳β-乳球蛋白有13种变异体,其中A和B是牛乳β-LG的常见变异体,且含量最高。根据不同的检测原理,文章简述近年来牛乳β-乳球蛋白变异体的三大类检测方法,总结电泳法、色谱法和免疫法的原理、优缺点及部分应用实例,重点介绍液相色谱法和毛细管电泳法两种定量方法,并展望牛乳β-乳球蛋白未来的发展方向。

关键词： β-乳球蛋白变异体色谱法免疫法电泳法