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基于三级养护标准的沥青路面预养护方案多目标加权灰靶决策

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北京工业大学学报 2024年第5期50卷 591-599页

作者：李海莲司金忠贾卫东付琳李清华杨斯媛张茗兰州交通大学土木工程学院兰州730070 中铁十四局集团有限公司济南250101 中交一公局集团有限公司北京100024

针对沥青路面最佳预防性养护策略选择问题,结合关于沥青路面预防性养护指标及规范标准,建立了基于判断性指标、综合性指标和控制性指标的三级预防性养护判断标准。在此标准下,以多年度项目级养护规划为研究对象,结合GM(1,1)预测模型确... 详细信息

针对沥青路面最佳预防性养护策略选择问题,结合关于沥青路面预防性养护指标及规范标准,建立了基于判断性指标、综合性指标和控制性指标的三级预防性养护判断标准。在此标准下,以多年度项目级养护规划为研究对象,结合GM(1,1)预测模型确定预防性养护时段,并引入多目标智能加权灰靶决策模型对适用性预防性养护方案进行优化决策。在此过程中,确定了养护费用、耐久性等8个养护目标并利用博弈论组合赋权法确定权重,选取G30连霍高速甘肃省境内某路段进行决策分析。结果表明:该路段最早需要开展预防性养护的时间为第3年,在第6年底之后不宜再实施预防性养护,在该预防性养护时段内,方案4的综合效益值最大,其值为0.735 8,即应在第4年采取超薄层罩面预养护措施。该方法简单实用,可成为沥青路面预防性养护策略选择的一种新方法。

关键词：道路工程沥青路面预防性养护预防性养护标准多目标灰靶决策博弈论组合赋权

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气助式静电喷头感应电场及荷质比研究

农机化研究 2024年第10期46卷 192-196页

作者：汪明戴世群刘世超欧鸣雄贾卫东董祥陈宏江苏大学农业工程学院江苏镇江212013 中汽创智科技有限公司南京210000 中国农业机械化科学研究院北京100083

气助式静电喷雾技术在果园植保机械中被广泛应用,能够有效增加雾滴在叶片背面的沉积。为此,通过数值仿真计算了气助式静电喷头的电极环中心线上的电场分布,并根据电极环的轮廓参数设计正交试验研究了电极环外径、内径和厚度对电场强度... 详细信息

气助式静电喷雾技术在果园植保机械中被广泛应用,能够有效增加雾滴在叶片背面的沉积。为此,通过数值仿真计算了气助式静电喷头的电极环中心线上的电场分布,并根据电极环的轮廓参数设计正交试验研究了电极环外径、内径和厚度对电场强度影响的显著性;确定了最优工作参数为外径30mm、内径4mm和厚度1mm;根据最优工作参数研究了荷电电压对电场强度和荷质比的影响规律,当荷电电压为3kV时,荷质比达到3.41mC/kg。

关键词：静电喷雾电场强度荷质比数值仿真气助式

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Propagation Properties of Shock Waves in Polyurethane Foam based on Atomistic Simulations

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Defence Technology（防务技术） 2024年第1期31卷 117-129页

作者： Zhiqiang Hu jianli Shao Shiyu jia weidong Song Cheng Wang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

Porous materials are widely used in the field of protection because of their excellent energy absorption *** this work,a series of polyurethane microscopic models are established and the effect of porosity on the shock waves is studied with classical molecular dynamics ***,shock Hugoniot relations for different porosities are obtained,which compare well with the experimental *** pores collapse and form local stress wave,which results in the complex multi-wave structure of the shock *** microstructure analysis shows that the local stress increases and the local velocity decreases gradually during the process of pore collapse to complete ***,it leads to stress relaxation and velocity *** shock stress peaks can be fitted with two exponential functions,and the amplitude of attenuation coefficient decreases with the increase of ***,the pore collapse under shock or non-shock are discussed by the entropy increase rate of the *** energy is dissipated mainly through the multiple interactions of the waves under *** energy is dissipated mainly by the friction between atoms under non-shock.

关键词： Polyurethane foam Shock wave Attenuation Atomistic simulation

Progress in hepatectomy for hepatocellular carcinoma and peri-operation management

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Genes & Diseases 2020年第3期7卷 320-327页

作者： Hao Chen weidong jia Department of Hepatic Surgery The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHeFeiAnhui230001China Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery HeFeiAnhui230001China

The global incidence of liver cancer continues to *** cancer,especially hepatocellular carcinoma,has high recurrence and mortality ***,we review the past decade’s diagnostic,therapeutic,and management strategies for hepatocellular carcinoma,and summarize new patient management approaches,including enhanced recovery after surgery,targeted therapy,and *** compare traditional and innovative management methods,which comprise developments in precision medicine,and consider their *** innovation and technological advances enable surgeons to gain deeper understandings of the multidimensionality of hepatocellular carcinoma,thereby promoting the continuous development of precision therapy.

关键词： Enhanced recovery after surgery Hepatectomy Hepatocellular carcinoma Precision medicine Treatment

Assessing target optical camouflage effects using brain functional networks:A feasibility study

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Defence Technology（防务技术） 2024年第4期34卷 69-77页

作者： Zhou Yu Li Xue weidong Xu Jun Liu Qi jia jianghua Hu Jidong Wu National Key Laboratory of Lightning Protection and Electromagnetic Camouflage Army Engineering University Nanjing 210007JiangsuChina Unit 31608 of PLA Xiamen 361000FujianChina School of Biological Sciences&Medical Engineering Southeast UniversityNanjing 210096JiangsuChina

Brain functional networks model the brain's ability to exchange information across different regions,aiding in the understanding of the cognitive process of human visual attention during target searching,thereby contributing to the advancement of camouflage *** this study,images with various camouflage effects were presented to observers to generate electroencephalography(EEG)signals,which were then used to construct a brain functional *** topological parameters of the network were subsequently extracted and input into a machine learning model for *** results indicate that most of the classifiers achieved accuracy rates exceeding 70%.Specifically,the Logistic algorithm achieved an accuracy of 81.67%.Therefore,it is possible to predict target camouflage effectiveness with high accuracy without the need to calculate discovery *** proposed method fully considers the aspects of human visual and cognitive processes,overcomes the subjectivity of human interpretation,and achieves stable and reliable accuracy.

关键词： Camouflage effect evaluation Electroencephalography(EEG) Brain functional networks Machine learning

真实世界中经动脉化疗栓塞治疗肝细胞癌患者临床应用调研分析

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临床肿瘤学杂志 2024年第1期29卷 6-13页

作者：秦叔逵邱文生熊建萍古善智荚卫东王兴之朱宏青岛大学附属医院肿瘤科 266003 南昌大学第一附属医院肿瘤科 330006 湖南省肿瘤医院介入科 410031 中国科学技术大学附属第一医院普外科 230001 百时美施贵宝(中国)投资有限公司 200040 明智医疗科技(上海)有限公司 201103 中国药科大学附属南京天印山医院南京211112

目的肝细胞癌(HCC)是原发性肝癌最常见的病理学类型,约占90%。中国是全球肝癌发病率和病死亡人数最高的国家。与欧美国家相比,中国的HCC患者在病因、流行病学特征、临床表现与分期、治疗策略选择和预后等方面存在显著差异,即高度异质性... 详细信息

目的肝细胞癌(HCC)是原发性肝癌最常见的病理学类型,约占90%。中国是全球肝癌发病率和病死亡人数最高的国家。与欧美国家相比,中国的HCC患者在病因、流行病学特征、临床表现与分期、治疗策略选择和预后等方面存在显著差异,即高度异质性。在HCC的治疗中,经动脉化疗栓塞(TACE)作为一项重要的介入技术起着至关重要的作用。本研究对中国接受TACE治疗的HCC患者的临床病理特征、TACE治疗情况和临床结局等进行了系统调研和分析。方法以2012年至2019年中国原发性肝癌临床登记调查数据库中至少接受过1次TACE治疗的HCC患者为调研对象,对患者的临床病理特征、TACE治疗情况等进行描述分析,并且观察比较患者的治疗效果和生存期。结果本研究共纳入5342例至少接受过1次TACE治疗的HCC患者。中位年龄为56.9岁(范围:18.6~92.1岁),以男性为主(占84.0%);乙型肝炎病毒(HBV)感染占75.7%,丙型肝炎病毒(HCV)感染占3.2%;94.3%患者在治疗前ECOG评分为0~1分。在可进行临床分期的患者中,巴塞罗那临床肝癌(BCLC)分期中0~A期占31.9%,B~C期占65.0%,D期占3.1%;而在全部患者中,选择TACE治疗作为首次治疗的患者达到89.7%。中位随访10.7个月,全部患者1、3、5年生存率分别为60.2%、35.1%和25.6%。BCLC分期对接受TACE治疗患者的生存结局具有明显影响(P<0.05)。结论TACE治疗HCC时,可进一步考虑患者的临床病理特征和临床分期,以获得更好的治疗效果。

关键词：肝细胞癌经动脉化疗栓塞临床病理特征临床结局

Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer

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Protein & Cell 2022年第11期13卷 825-841页

作者： Junru Feng Hui Lu Wenhao Ma Wenjing Tian Zhuan Lu Hongying Yang Yongping Cai Pengfei Cai Yuchen Sun Zilong Zhou jiaqian Feng jiazhong Deng Ying Shu Kun Qu weidong jia Ping Gao Huafeng Zhang Anhui Key Laboratory of Hepatopancreatobiliary Surgery Department of General SurgeryAnhui Provincial HospitalThe First Affiliated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China Hefei National Laboratory for Physical Sciences at Microscale The Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China Shenzhen People’s Hospital Second Clinical Medical College of Jinan UniversityFirst Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518000China Department of Pathology School of MedicineAnhui Medical UniversityHefei 230032China School of Medicine and Institutes for Life Sciences South China University of TechnologyGuangzhou 510006China

Metformin is currently a strong candidate anti-tumor agent in multiple ***,its anti-tumor effectiveness varies among different cancers or sub-populations,potentially due to tumor *** thus remains unclear which hepatocellular carcinoma(HCC)patient subpopulation(s)can benefit from met-formin ***,through a genome-wide CRISPR-Cas9-based knockout screen,we find that DOCK1 levels determine the anti-tumor effects of met-formin and that DOCK1 is a synthetic lethal target of metformin in ***,metformin promotes DOCK1 phosphorylation,which activates RAC1 to facilitate cell survival,leading to metformin *** DOCK1-selective inhibitor,TBOPP,potentiates anti-tumor activity by metformin in vitro in liver cancer cell lines and patient-derived HCC organoids,and in vivo in xenografted liver cancer cells and immunocompetent mouse liver cancer ***,metformin improves overall survival of HCC patients with low DOCK1 levels but not among patients with high DOCK1 *** study shows that metformin effective-ness depends on DOCK1 levels and that combining metformin with DOCK1 inhibition may provide a promising personalized therapeutic strategy for met-formin-resistant HCC patients.

关键词： CRISPR screen DOCK1 hepatocellular carcinoma metformin small GTPase

Review of electrostatic system parameters,charged droplets characteristics and substrate impact behavior from pesticides spraying

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International Journal of Agricultural and Biological Engineering 2019年第2期12卷 1-9页

作者： Samuel Appah Pei Wang Mingxiong Ou Chen Gong weidong jia Key Laboratory of Modern Agricultural Equipment and Technology Ministry of EducationJiangsu UniversityZhenjiang 212013JiangsuChina Key Laboratory of Plant Protection Engineering Ministry of Agriculture and Rural AffairsJiangsu UniversityZhenjiang 212013JiangsuChina

Electrostatic spraying application is adopted in crop protection to prevent pest infestation,to improve product quality and to maximize *** involves a superposition of charges to pesticide spray droplets to attract substrate ions at obscured *** droplets wraparound effect reduces off-target deposition,enhances on-target spray and invariably improves spray *** spraying system works effectively at optimum parameters in combination with charging voltages,application pressures,spraying height regimes,flow rate,travel speed,electrode material,and nozzle *** combinations of the system parameter settings have been systematically used by researchers for the electrostatic application,but there are unknown specific optimum parameters combinations for pesticide *** droplets chargeability influences the effectiveness of electrostatic spraying system,the parameters that produce ideal charge to mass ratio determine the functionality of the spraying deposition,retention and surface *** article,therefore,analyses electrostatic system parameters that produce suitably charged droplets characteristics for effective impacting behavior of pesticides on *** applied voltages consequently maximizes charge-mass ratio to optimum and starts declining upon further increase in voltages beyond a critical *** review further proposes the selection of an optimum electrostatic parameters combination that yields optimum droplets chargeability in pesticide ***,it is necessary to investigate the charge property of substrates prior to pesticide application in order to superpose the right opposite charge on spray droplets at rupture time during electrostatic spraying system.

关键词： electrostatic spraying charged droplets substrates deposition wraparound charge-mass ratio

Assembling ionic liquid into porous molecular filler of mixed matrix membrane to trigger high gas permeability,selectivity,and stability for CO_(2)/CH_(4) separation

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Nano Research 2024年第5期17卷 4535-4543页

作者： Liting Yu Liqin Hao Yang Feng jia Pang Mengwei Guo Liangjun Li weidong Fan Lili Fan Rongming Wang Zixi Kang Daofeng Sun School of Materials Science and Engineering State Key Laboratory of Heavy Oil ProcessingChina University of Petroleum(East China)Qingdao 266580China College of Chemistry Nankai UniversityTianjin 300071China College of Chemistry and Chemical Engineering China University of Petroleum(East China)Qingdao 266580China College of New Energy China University of Petroleum(East China)Qingdao 266580China

As an emerging zero-dimensional nano crystalline porous material,porous organic cages(POCs)with soluble properties in organic solvents,are promising candidates as molecular fillers in mixed matrix membranes(MMMs).The pore structure of POCs should be adjusted to trigger efficient gas separation performance,and the interaction between filler and matrix should be *** this work,ionic liquid(IL)was introduced into the molecular fillers of CC3,to construct the IL@CC3/PIM-1 membrane to effectively separate CO_(2) from CH_(4).The advantages of doping IL include:(1)narrowing the cavity size of POCs from 4.4 to 3.9Åto enhance the diffusion selectivity,(2)strengthening the CO_(2) solubility to heighten the gas permeability,and(3)improving the compatibility between filler and matrix to upgrade membrane *** the optimization of the membrane composite,the IL@CC3/PIM-1-10%membrane possesses the CO_(2) permeability of 7868 Barrer and the CO_(2)/CH_(4) selectivity of 73.4,which compared to the CC3/PIM-1-10%membrane,improved by 15.9%and 106.2%,***,the membrane has maintained a stable separation performance at varied temperatures and pressures during the long-term *** proposed method offers an efficient way to improve the performance of POCs-based MMMs in gas separation.

关键词： porous organic cage mixed matrix membrane ionic liquid gas separation