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A Practical and Convenient Synthetic Process of 3-O-Decladinose-6-methyl 10,11-dehydrate-erythromycin-3-one-2'-acetate, an Important Intermediate of Ketolides Synthesis

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有机化学 2004年第Z1期24卷 366-页

作者： wei,xin YOU,Qi-dong Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009

　　3-O-Decladinose-6-methyl-10,11-dehydrate-erythromycin-3-one-2'-acetate (5) is an important intermediate for the synthesis of ketolides antibiotics.[1] In the improved synthetic method of compound 5, the more common reagent PCC[2]was used instead of the expensive reagent EDC and methanesulfonic anhydride.[3～4] In this way, compound 5 was obtained efficiently and economically in five steps from clathromycin 1 without being further purfied by column chromatography.……

关键词： column chromatography instead of method of

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日本能源设备管理的现状及发展趋势(英文)

华南理工大学学报（自然科学版） 2007年第B10期35卷 227-230页

作者：苏媛高伟俊韦新东北九州市立大学国际环境工学部

能源设备管理(FM)的理论起源于美国,随之在世界范围被普遍接受并发展,但最近才应用于亚洲.文中给出了FM系统的概念并对其作了概述,介绍了FM的内容、必要性和效果,并且以日本设备管理促进协会(JFMA)为例,分析了日本FM的应用现状和发展趋... 详细信息

能源设备管理(FM)的理论起源于美国,随之在世界范围被普遍接受并发展,但最近才应用于亚洲.文中给出了FM系统的概念并对其作了概述,介绍了FM的内容、必要性和效果,并且以日本设备管理促进协会(JFMA)为例,分析了日本FM的应用现状和发展趋势,并预测其将来可能的模式与发展状况.JFMA是日本一个为促进和实践设备管理机制、提高设备管理者技能而建立的组织,它针对各种有关设备管理的领域和该学科的远景研究等召开各种各样的讨论会.此研究对FM领域的远景研究将产生积极的影响.

关键词：设备管理现状效果发展趋势日本

A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li Yang wei Kang Zhou xin Huang xing Zhou Jie Xu Taoyi Kong Junwei Lucas Bao Xiaoli dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

北九州新热供给区域有效利用热电并给系统排热效果的评价(英文)

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华南理工大学学报（自然科学版） 2007年第B10期35卷 179-182页

作者：韦新东松本亨苏媛吉林建筑工程学院市政与环境工程学院吉林长春130021 北九州市立大学国际环境工学部

探讨了北九州市新规划热供给区域的热电并给系统导入效果.根据东京的能源消费功能单位,推测了北九州市的能源消费功能单位.利用不同建筑用途的建筑面积和能源消费功能单位,计算了北九州市新规划热供给区域的能源需要量.设定了单体空调... 详细信息

探讨了北九州市新规划热供给区域的热电并给系统导入效果.根据东京的能源消费功能单位,推测了北九州市的能源消费功能单位.利用不同建筑用途的建筑面积和能源消费功能单位,计算了北九州市新规划热供给区域的能源需要量.设定了单体空调系统、锅炉系统、电主热从及热主电从的热电并给系统等4种能源供给系统,并计算了各系统的能源消费量、二氧化碳排放量、初期投资、运行费用和单纯回收年数.计算结果表明,综合考虑能源消费量、二氧化碳排放量和运行费用,新规划热供给区域导入能源供给系统时,热电并给系统是最好的选择.

关键词：热电并给系统节能性环保性经济性分析综合评价

Deviation analysis of C2 translaminar screw placement assisted by a novel rapid prototyping drill template:a cadaveric study

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Deviation analysis of C2 translaminar screw placement assisted by a novel rapid prototyping drill template:a cadaveric study

2014年浙江省骨科学学术年会

作者： Yong Hu Zhen-shan Yuan Jian-bing Yuan wei-xin dong Cheng-tao Wang Department of Spinal Surgery Ningbo No.6 Hospital Institute of Biomedical Manufacturing and life Quality Engineering School of Mechanical and Power Energy EngineeringShanghai Jiaotong University

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基于网格的长三角PM_(2.5)分布影响因素及交互效应

2016年浙江省骨科学学术年会

Study *** developed a new technique for C2 translaminar screw insertion using a rapid prototyping drill ***.C2 translaminar screw(C2 TLS) can provide a rigid screw fixation combined with C1-C2 screwrod system or subaxial cervical fixation;however,their implementation is challenging due to the neurological *** this study,the authors explored and evaluated the use of patient-specific,rapid prototype drill templates for C2 TLS *** goal of the study was to validate the accuracy of a drill template in the placement of C2 TLS and analysis the deviation of screws *** of Background Data.C2 TLS fixation provides rigid fixation,and a high fusion *** insertion of screws,however,has a potential risk of neurological injury owing to the malposition of *** is necessary to determine a precise technique for screw *** CT scanning was performed in 32 cadaveric cervical *** computer software,the authors constructed drill templates with a predefined trajectory designed to match the posterior surface of C2 ***-two physical templates were created from the computer models using a rapid prototyping *** drill templates were used to guide pilot-hole drill,and postoperative CT was *** entry point and direction of the planned and inserted screws were measured after registering postoperative images to preoperative images,whose coordinate axis has been ***.64 C2 translaminar screws were smoothly accomplished with no broken bone *** is no statistically significant difference(p>0.05) in deviation of entry point and angle between the cylinder and *** the human factor in operation and the inherent factor of hardware and software are the main reasons of deviation of C2 TLS placement assisted by rapid prototyping drill *** of operation and design of individualized are the advantage of the drill template,which can greatly improv

关键词： rapid prototyping post-pre registration personalized drill template Computer-assisted C2 translaminar screws cervical spine

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环境科学 2021年第7期42卷 3107-3117页

作者：黄小刚赵景波辛未冬山西师范大学地理科学学院临汾041004 中国科学院地球环境研究所气溶胶化学与物理重点实验室西安710061 陕西师范大学地理科学与旅游学院西安710119

基于遥感反演数据,研究了2016年长三角地区PM_(2.5)浓度空间分布特征,从气象因素、地形、植被和大气污染物排放清单等方面选取评价因子,以0.25°×0.25°网格为评价单元,利用GAM模型研究了长三角PM_(2.5)空间分布的影响因素及交互效应.... 详细信息

基于遥感反演数据,研究了2016年长三角地区PM_(2.5)浓度空间分布特征,从气象因素、地形、植被和大气污染物排放清单等方面选取评价因子,以0.25°×0.25°网格为评价单元,利用GAM模型研究了长三角PM_(2.5)空间分布的影响因素及交互效应.结果表明:(1)长三角PM_(2.5)浓度总体呈北高南低、西高东低的分布态势,但以南北向差异为主.长三角南部PM_(2.5)浓度多低于35μg·m^(-3),PM_(2.5)超标零星出现在城镇周围,呈孤岛状分布.北部PM_(2.5)浓度多超过35μg·m^(-3),PM_(2.5)污染多呈连片状分布.(2)长三角PM_(2.5)浓度分布具有显著的正的空间自相关性,高高集聚区集中分布在长三角北部,低低集聚区集中分布在南部.(3)GAM模型分析表明,地形起伏度、气温和降水量对PM_(2.5)浓度主要呈负向影响;污染物排放量主要呈正向影响;风速<2.5 m·s^(-1)时影响不显著,风速≥2.5 m·s^(-1)后有显著的负向影响.地形起伏度、气温和降水量南高北低是造成长三角PM_(2.5)北高南低的重要原因,风速东高西低是造成长三角PM_(2.5)浓度东西向差异的原因之一.(4)除地形起伏度-PM_(2.5)排放量外,其余因素两两间的交互项均通过了显著性检验,对PM_(2.5)分布有显著的交互效应.

关键词：网格长三角 PM_(2.5) 空间分布影响因素交互效应

Transoral reduction and osteosynthesis C1 as a functionpreserving option in the treatment of unstable Jefferson fracture

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Single-cell omics: experimental workflow, data analyses and applications

2016年浙江省骨科学学术年会

作者： Yong Hu Rong-ming Xu Todd J.Albert wei-hu Ma Zhen-shan Yuan wei-xin dong MD Department of Spinal Surgery Ningbo No.6 Hospital Department of Orthopaedic Surgery Thomas Jefferson University & Rothman Institute

Purpose The aim of this study is to illustrate a new method and surgical technique in the treatment of Jefferson fractures which preserves the motion of the upper cervical *** and methods A retrospective review was performed of twelve patients with unstable Jefferson fractures treated with transoral osteosynthesis of CI between July 2008 and December 2011.A steel plate and C1 lateral mass screw fixation were placed to repair the unstable Jefferson *** study group included eight males and four females with the average age of 33 years(range,23-62 years).Results The patients were followed up for between 12 and 28 months after surgery(average 16 months).Range of motion of the cervical spine was approximately physiologic:average flexion 35°(range 28°-40°),average extension 42°(range 30°-48°).Lateral bending to the right and left averaged 30° and 28°,respectively(range,12°-36°,14°-32°,respectively).The average postoperative rotation of the atlantoaxial joint,evaluated by functional CT scan,was 60°(range 35°-72°).Total average lateral displacement of the lateral masses was 7.0 mm before surgery(range,5-12 mm) which improved to 3.5 mm after surgery(range 1-6.5 mm).The total average difference of the atlanto-dens interval in flexion-extension after surgery was 1.0 mm(range 1-3 mm).Conclusions Transoral osteosynthesis of the anterior ring using C1 lateral masses screws is a novel technique for treating unstable Jefferson fractures which allows maintenance of rotation at the C1-C2 joint and restoration of congruency of the atlanto-occipital and atlantoaxial joints.

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li dongqing Sun Shaliu Fu Lei Gu xin Shao Qinqin Wang xin dong Bin Duan Feiyang xing Jun Wu Minmin Xiao Fangqing Zhao Jing-dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening