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World Journal of Gastroenterology 2024年第39期30卷 4295-4304页

作者： Yi-Ru Zhao Xin-Jie Wang Meng-Jia Zhu Ang-Li Chen Dian Zhang Qin Du John J Kim wei-ling hu Department of Gastroenterology Sir Run Run Shaw HospitalMedical SchoolZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated HospitalMedical SchoolZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Keck School of Medicine University of Southern CaliforniaLos AngelesCA 90089-9021United States Institute of Gastroenterology Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina

BACKGROUND Helicobacter pylori(***)eradication rates have declined with the rise of antibiotic-resistant strains in recent *** highly effective with a low prevalence of resistance,standard dose tetracycline is associated with frequent adverse *** efficacy and safety of low-dose tetracycline as part of tetra-cycline and amoxicillin-containing bismuth quadruple therapy are not well *** To compare the efficacy and safety of low-dose compared to standard dose tetracycline with combined amoxicillin-containing bismuth quadruple therapy in patients with *** *** Consecutive patients with *** infection receiving tetracycline,amoxicillin,proton pump inhibitor,and bismuth for 14 days at Sir Run Run Shaw Hospital(1/2022-6/2023)were *** low-dose tetracycline group received tetracycline 500 mg twice daily(bid)while the standard dose group received 750 mg bid or 500 mg three times daily(tid).Primary endpoints were *** eradication rate and treatment-related adverse events.

关键词： Helicobacter pylori Tetracycline Amoxicillin Eradication Adverse events Bismuth quadruple therapy

Outcomes of furazolidone-and amoxicillin-based quadruple therapy for Helicobacter pylori infection and predictors of failed eradication

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World Journal of Gastroenterology 2018年第40期24卷 4596-4605页

作者： Ya-Wen Zhang wei-ling hu Yuan Cai Wen-Fang Zheng Qin Du John J Kim John Y Kao Ning Dai Jian-Min Si Department of Gastroenterology Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Institute of Gastroenterology Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of Gastroenterology The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Division of Gastroenterology Loma Linda UniversityLoma LindaCA 92354United States Division of Gastroenterology Department of Internal MedicineMichigan MedicineUniversity of MichiganAnn ArborMI 48109United States

AIM To evaluate the outcomes of furazolidone-and amoxicillin-based quadruple therapy for treatment of Helicobacter pylori(H. pylori) infection and identify predictors of failed *** Patients with H. pylori infection treated with furazolidone, amoxicillin, bismuth, and proton pump inhibitor therapy(January 2015 to December 2015) who received the ^(13)C-urea breath test > 4 wk after treatment were evaluated. Demographic and clinical data including prior H. pylori treatment attempts, medication adherence, alcohol and cigarette consumption during therapy, and treatment-related adverse events were recorded by reviewing medical records and telephone surveys. H. pylori eradication rates for overall and subgroups were evaluated. Multivariate analysis was performed to identify independent predictors of failed H. pylori *** Of the 992 patients treated and retested for H. pylori infection, the overall eradication rate was 94.5% [95% confidence interval(CI): 94.1%-95.9%]. H. pylori eradication rate of primary therapy was 95.0%(95%CI: 93.5%-96.5%), while that of rescue therapy was 91.3%(95%CI: 86.8%-95.8%). Among the 859 patients who completed the study protocol, 144(17%) reported treatment-related adverse events including 24(3%) leading to premature discontinuation. On multivariate analysis, poor medication adherence [adjusted odds ratio(AOR) = 6.7, 95%CI: 2.8-15.8], two or more previous H. pylori treatments(AOR = 7.4, 95%CI: 2.2-24.9), alcohol consumption during therapy(AOR = 4.4, 95%CI: 1.5-12.3), and possibly smoking during therapy(AOR = 1.9, 95%CI: 0.9-4.3) were associated with failed H. pylori eradication. CONCLUSION Furazolidone-and amoxicillin-based quadruple therapy for H. pylori infection in an area with a high prevalence of clarithromycin resistance demonstrated high eradication rates as primary and rescue therapies with a favorable safety profile. Patient education targeting abstinence from alcohol during therapy and strict medication a

关键词： Helicobacter pylori Furazolidone Quadruple regimen Side effects Eradication

Efficacy and safety of modified tetracycline dosing in a quadruple therapy for Helicobacter pylori:A retrospective single center study

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World Journal of Gastroenterology 2023年第22期29卷 3508-3518页

作者： Ying-Chao Sun Meng-Jia Zhu Xue-Qin Chen Lei Yue Yi-Ru Zhao Xin-Jie Wang John J Kim Qin Du wei-ling hu Department of Gastroenterology Sir Run Run Shaw HospitalMedical SchoolZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Division of Gastroenterology Loma Linda University HealthLoma LindaCA 92354United States Department of Gastroenterology Zhejiang University School of Medicine Second Affiliated HospitalHangzhou 310009Zhejiang ProvinceChina Institute of Gastroenterology Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina

BACKGROUND Although highly effective as a component of Helicobacter pylori(***)treatment regimen,tetracycline is associated with a high incidence of medicationrelated adverse *** dosing of tetracycline as part of quadruple therapy may improve safety while providing comparable eradication *** To evaluate the efficacy and safety of modified dosing of tetracycline in patients receiving tetracycline and furazolidone-containing quadruple therapy in patients with *** *** Consecutive patients(10/2020-12/2021)who received tetracycline and furazolidone quadruple therapy for *** infection at Sir Run Run Shaw Hospital were *** patients received tetracycline,furazolidone,proton pump inhibitor,and bismuth for 14 d as primary or rescue *** tetracycline dose group received tetracycline 500 mg twice daily while standard group received 750 mg twice daily or 500 mg three times *** Three hundred and ninety-four patients[mean age=46.3±13.9,male=137(34.8%),and 309(78.4%)primary therapy]completed tetracycline and furazolidone quadruple therapy for *** infection including those who received modified tetracycline dose in 157 and standard doses in 118(750 mg twice daily)and 119(500 mg three times daily).Eradication rates in the modified tetracycline dose group were 92.40%and in the standard groups,eradication rates were 93.20%for 750 mg twice daily group and 92.43%for 500 mg three times daily group,respectively,without statistical difference(P=0.959).The incidence of adverse events was lower in the modified tetracycline dose(15.3%vs 32.3%and 29.4%;P=0.002)compared to the standard dose *** In a real-world experience,modified tetracycline dosing as part of tetracycline and furazolidone quadruple therapy for 14 d demonstrated high efficacy,comparable to standard tetracycline dose regimens,with a favorable safety profile.

关键词： Helicobacter pylori Tetracycline Furazolidone Eradication Penicillin allergy Bismuth quadruple therapy

不同土壤环境下落叶松人工林昆虫群落结构及动态的差异

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林业科学 2017年第5期53卷 97-106页

作者：顾伟马玲孙虎王利东张子龙东北林业大学林学院哈尔滨150040 东北林业大学凉水自然保护区伊春153106

【目的】研究不同土壤条件下落叶松人工林昆虫群落结构及动态的差异,为森林经营管理、生物多样性保护提供理论基础和科学依据。【方法】以小兴安岭凉水自然保护区内封山育林状态下落叶松人工林为研究对象,根据地形土壤条件,选择埋藏潜... 详细信息

【目的】研究不同土壤条件下落叶松人工林昆虫群落结构及动态的差异,为森林经营管理、生物多样性保护提供理论基础和科学依据。【方法】以小兴安岭凉水自然保护区内封山育林状态下落叶松人工林为研究对象,根据地形土壤条件,选择埋藏潜育暗棕壤-落叶松人工林(A)、厚层埋藏暗棕壤-落叶松人工林(B)、暗棕壤性土-落叶松人工林(C)、典型暗棕壤-落叶松人工林(D)4种生境类型,分别设置3个20 m×20 m的样地,采用扫网法、巴氏罐诱法、震落法、高枝剪标准枝法对样地内昆虫群落进行系统的调查。【结果】共捕获昆虫样本5 204头,经鉴定分属10目77科250种,各生境均以双翅目和膜翅目为优势类群,但所占比例具有较大差异。各生境昆虫群落科级优势类群季节动态也表现出较大的差异。聚类分析表明4种生境昆虫群落归为2类,A、B生境归为一类,C、D生境归为一类。不同生境间昆虫群落物种多样性指数和均匀度指数大小均表现为C生境>A生境>B生境>D生境,丰富度指数大小表现为样地B生境>D生境>A生境>C生境,优势集中性指数大小表现为D生境>B生境>A生境>C生境。时间序列上,B生境和D生境昆虫群落物种多样性指数与均匀度指数及丰富度指数均呈显著的正相关,但前者相关系数均显著大于后者。各生境昆虫群落中不同营养类群物种数均表现为植食性类群>中性类群>捕食性类群>寄生性类群,但各生境中不同营养类群物种数所占比例具有明显差异。各生境昆虫群落相对稳定性为B生境>C生境>D生境>A生境。主分量分析表明对昆虫群落变化起着主导作用的因子在各生境中具有较大差异。【结论】不同土壤条件下落叶松人工林各昆虫群落结构动态具有较大差异,昆虫群落物种多样性指数与丰富度指数正相关系数越大,群落稳定性越强,同时中性昆虫对昆虫群落相对稳定性起到显著的调控作用。4种生境中厚层埋藏暗棕壤落叶松人工林综合环境条件最适宜昆虫群落发生发展。

关键词：昆虫群落稳定性分析主分量分析落叶松人工林凉水自然保护区

Electrochemical conversion of methane to bridge the gap in the artificial carbon cycle

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Journal of Energy Chemistry 2025年第1期100卷 286-308页

作者： Yuhao Peng Yuefeng Song Ihar Razanau Juanxiu Xiao wei Xiao Di hu Guoxiong Wang College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power Sources Wuhan University State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Dalian Institute of Chemical Physics Chinese Academy of Sciences Laboratory of Physical-Chemical Technologies SSPA Scientific and Practical Materials Research Centre of NAS of Belarus State Key Laboratory of Marine Resources Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University Department of Chemical and Environmental Engineering University of Nottingham Ningbo China

Methane, an abundant one-carbon（C1） resource, is extensively used in the industrial production of vital fuels and value-added chemicals. However, current industrial methane conversion technologies are energy-and carbon-intensive, mainly due to the high activation energy required to break the inert C–H bond, low selectivity, and problematic side reactions, including CO2emissions and coke deposition. Electrochemical conversion of methane（ECM） using intermittent renewable energy offers an attractive solution, due to its modular reactor design and operational flexibility across a broad spectrum of temperatures and pressures. This review emphasizes conversion pathways of methane in various reaction systems, highlighting the significance and advantages of ECM in facilitating a sustainable artificial carbon cycle. This work provides a comprehensive overview of conventional methane activation mechanisms and delineates the complete pathways of methane conversion in electrolysis contexts. Based on surface/interface chemistry, this work systematically analyzes proposed reaction pathways and corresponding strategies to enhance ECM efficiency towards various target products, including syngas, hydrocarbons, oxygenates, and advanced carbon materials. The discussion also encompasses opportunities and challenges for the ECM process, including insights into ECM pathways, rational electrocatalyst design, establishment of benchmarking protocols, electrolyte engineering, enhancement of CH4conversion rates, and minimization of CO2emission.

关键词： Methane Electrochemical conversion Reaction mechanism Catalyst design Electrode Electrocatalysis

Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

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Nano-Micro Letters 2025年第1期17卷 281-292页

作者： Xing Wang wei Pi Sheng hu Haifeng Bao Na Yao wei Luo State Key Laboratory of New Textile Materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

SensFL:Privacy-Preserving Vertical Federated Learning with Sensitive Regularization

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 385-404页

作者： Chongzhen Zhang Zhichen Liu Xiangrui Xu Fuqiang hu Jiao Dai Baigen Cai wei Wang School of Automation and Intelligence Beijing Jiaotong UniversityBeijing100044China Shuohuang Railway Development Co. Ltd.National Energy GroupCangzhou062350China Beijing Key Laboratory of Security and Privacy in Intelligent Transportation School of Computer Science and TechnologyBeijing Jiaotong UniversityBeijing100044China

In the realm of Intelligent Railway Transportation Systems,effective multi-party collaboration is crucial due to concerns over privacy and data *** Federated Learning(VFL)has emerged as a promising approach to facilitate such collaboration,allowing diverse entities to collectively enhance machine learning models without the need to share sensitive training ***,existing works have highlighted VFL’s susceptibility to privacy inference attacks,where an honest but curious server could potentially reconstruct a client’s raw data from embeddings uploaded by the *** vulnerability poses a significant threat to VFL-based intelligent railway transportation *** this paper,we introduce SensFL,a novel privacy-enhancing method to against privacy inference attacks in ***,SensFL integrates regularization of the sensitivity of embeddings to the original data into the model training process,effectively limiting the information contained in shared *** reducing the sensitivity of embeddings to the original data,SensFL can effectively resist reverse privacy attacks and prevent the reconstruction of the original data from the *** experiments were conducted on four distinct datasets and three different models to demonstrate the efficacy of *** results show that SensFL can effectively mitigate privacy inference attacks while maintaining the accuracy of the primary learning *** results underscore SensFL’s potential to advance privacy protection technologies within VFL-based intelligent railway systems,addressing critical security concerns in collaborative learning environments.

关键词： Vertical federated learning privacy defenses

基于多维液相色谱质谱组合分析的痢疾杆菌蛋白质基因组学

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中国人兽共患病学报 2016年第12期32卷 1064-1069页

作者：赵丽娜李巍伟贺宝玲胡芬王洋余源高爽华北理工大学生命科学学院唐山063000

目的应用多维液相色谱质谱组合体系为基础的蛋白质组学方法对福氏痢疾杆菌基因组注释进行完善。方法痢疾杆菌福氏2a型301株(Sf2a301)的全菌蛋白经胰酶消化,二维液相色谱分离后进行MALDI-TOF/TOF和ESI-MS/MS组合鉴定,质谱数据分别应用MAS... 详细信息

目的应用多维液相色谱质谱组合体系为基础的蛋白质组学方法对福氏痢疾杆菌基因组注释进行完善。方法痢疾杆菌福氏2a型301株(Sf2a301)的全菌蛋白经胰酶消化,二维液相色谱分离后进行MALDI-TOF/TOF和ESI-MS/MS组合鉴定,质谱数据分别应用MASCOT和SEQUEST软件检索基于Sf2a301全基因组构建的6个读码框数据库,完成对原基因组注释的验证和补充。结果研究表明多维液相色谱质谱组合体系能够增加鉴定蛋白的覆盖率,共鉴定Sf2a301的1231个蛋白编码基因产物,涵盖了COGs数据库22个功能分类组中的20个,包含306个功能未知的假定蛋白。发现了9个未注释的基因,得到RT-PCR和Northern blot的进一步验证。新基因大多数是重叠基因,包含3个嵌套基因。结论多维液相色谱质谱组合体系相对于单一的串联质谱技术能够更加有效验证、补充痢疾杆菌的基因组注释,更新后的基因组注释库为今后开展痢疾杆菌功能研究提供更多的靶点。

关键词：福氏痢疾杆菌基质辅助激光解吸电离电喷雾电离蛋白质基因组学基因组注释

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天然和饱水红砂岩三轴压缩蠕变变形试验研究

三峡大学学报（自然科学版） 2025年第1期47卷 9-15页

作者：刘桃根胡凯李玲王伟湖南工学院土木与建筑工程学院湖南衡阳421002 河海大学岩土工程科学研究所南京210098 江西职业技术大学建筑工程学院江西九江332007

蠕变特性和长期强度是红砂岩地区岩体工程安全评价的关键要素,饱水软化效应对红砂岩蠕变特性和长期强度具有重要影响.采用全自动岩石三轴压缩伺服流变仪,开展天然与饱水红砂岩的三轴压缩试验和三轴压缩蠕变试验.试验结果表明:峰值强度... 详细信息

蠕变特性和长期强度是红砂岩地区岩体工程安全评价的关键要素,饱水软化效应对红砂岩蠕变特性和长期强度具有重要影响.采用全自动岩石三轴压缩伺服流变仪,开展天然与饱水红砂岩的三轴压缩试验和三轴压缩蠕变试验.试验结果表明:峰值强度、弹性模量和蠕变破坏应力因饱水软化效应而降低,围压对其降幅有削弱作用,蠕变破坏应力与峰值强度的比值在0.75~0.98之间;饱水软化效应能增强蠕变瞬时变形,减弱蠕变变形及蠕变应变速率;环向应变比轴向应变更早进入稳态蠕变阶段和加速蠕变阶段;稳态蠕变速率与偏压的变化关系符合指数函数关系;长期强度因饱水软化作用而降低,却因围压增加而增大,长期强度与峰值强度的比值在0.62~0.92之间;裂纹损伤应力与长期强度相差较大,裂纹损伤应力视为长期强度有待进一步考究.

关键词：红砂岩蠕变特性长期强度饱水软化效应裂纹损伤应力

新冠疫情期间眼病患者线上问诊模式与影响因素分析

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国际眼科杂志 2020年第11期20卷 1996-2002页

作者：刘臻臻吴晓航陈睛晶晏丕松金玲胡伟玲张恩恩李伟林浩添中山大学中山眼科中心眼科学国家重点实验室广东省广州市510060

目的:新型冠状病毒疫情期间,中山大学中山眼科中心在严格防控疫情的前提下及时开展免费线上“专家问诊”服务,眼科医师在线答疑以满足眼病诊疗需求。本研究对疫情期间眼科患者线上问诊的需求与模式进行分析,为眼科互联网诊疗体系的优化... 详细信息

目的:新型冠状病毒疫情期间,中山大学中山眼科中心在严格防控疫情的前提下及时开展免费线上“专家问诊”服务,眼科医师在线答疑以满足眼病诊疗需求。本研究对疫情期间眼科患者线上问诊的需求与模式进行分析,为眼科互联网诊疗体系的优化提供依据。方法:前瞻性观察性研究。本研究分析了2020-02-01/03-15期间,使用中山眼科中心互联网医院“专家问诊”服务患者的基线特征。针对其中重复问诊的患者,随机抽取等量单次问诊患者作为对照,比较单次问诊与重复问诊患者的基线特征、就诊目的、疾病类型、眼病数量,并对患者问诊次数的影响因素进行分析。结果:研究期间“专家问诊”共线上服务患者9831人次,其中单次问诊3919人次,5912人次来源于1967人的重复问诊。随机抽取1967名单次问诊者与上述重复问诊者对比,单次问诊与重复问诊患者的年龄、性别分布无统计学差异(P=0.897,0.482)。两组就诊目的均以“旧病复诊”占比最高(59.7%,64.9%)。从构成比上看,与单次问诊患者相比,重复问诊患者中,就诊目的为新发不适者较少,旧病复诊与术后复查者较多,眼表、眼底、葡萄膜疾病患者较多,患有两种及以上眼病者占比较多。回归分析显示屈光患者倾向单次问诊,而旧病复诊、术后短期复诊患者,眼底、葡萄膜疾病患者倾向重复问诊。旧病复诊、术后随访较新发不适患者重复问诊的次数更多;晶状体与青光眼/疑似青光眼疾病重复问诊次数较少,眼表疾病重复问诊次数较多。结论:疫情期间眼科患者线上就诊主要目的为旧病复诊。疾病种类、就诊目的与眼病数量均影响患者是否重复问诊及问诊次数,应根据患者的就诊需求与模式调整眼科不同亚专科线上接诊医生的数量与排班。互联网医疗对新发不适患者的诊疗能力有待进一步提高。

关键词：新型冠状病毒引起的传染性疾病流行病互联网医疗