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Proteomic identification of tumor biomarkers associated with primary gallbladder cancer

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World Journal of Gastroenterology 2014年第18期20卷 5511-5518页

作者： Hai-Lin Huang Hou-Shan Yao Yi wang wei-jun wang Zhi-Qian Hu Kai-Zhou Jin Department of General Surgery Hospital of China Armed Police Forces Department of General Surgery Shanghai Chang Zheng HospitalSecond Military Medical University

AIM: To identify potential biomarkers of primary gallbladder cancer (PGC).

关键词： Primary gallbladder cancer Proteomic analysis Annexin A4 Dynein cytoplasmic 1 heavy chain 1 Heat shock protein 90-beta Biomarker

Review and prospects on the low-voltage Na_(2)Ti_(3)O_(7) anode materials for sodium-ion batteries

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Journal of Energy Chemistry 2024年第1期88卷 446-460,I0011页

作者： jun Dong Yalong Jiang Ruxing wang Qiulong wei Qinyou An Xiaoxing Zhang Hubei Key Laboratory for High-efficiency Utilization of Solar Energy and Operation Control of Energy Storage System Hubei University of TechnologyWuhan 430068HubeiChina State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200HubeiChina Xiamen Key Laboratory of High-Performance Metals and Materials College of MaterialsXiamen UniversityXiamen 361005FujianChina State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070HubeiChina

Due to its low cost and natural abundance of sodium,Na-ion batteries(NIBs)are promising candidates for large-scale energy storage *** development of ultralow voltage anode materials is of great significance in improving the energy density of ***-voltage anode materials,however,are severely lacking in *** all the reported insertion oxides anodes,the Na_(2)Ti_(3)O_(7) has the lowest operating voltage(an average potential of 0.3 V ***^(+)/Na)and is less likely to deposit sodium,which has excellent potential for achieving NIBs with high energy densities and high *** significant progress has been made,achieving Na_(2)Ti_(3)O_(7) electrodes with excellent performance remains a severe *** paper systematically summarizes and discusses the physicochemical properties and synthesis methods of Na_(2)Ti_(3)O_(7).Then,the sodium storage mechanisms,key issues and challenges,and the optimization strategies for the electrochemical performance of Na_(2)Ti_(3)O_(7) are classified and further ***,remaining challenges and future research directions on the Na_(2)Ti_(3)O_(7) anode are *** review offers insights into the design of high-energy and high-safety NIBs.

关键词： Sodium-ion batteries Low-voltage anode materials Na_(2)Ti_(3)O_(7) Electrochemical performances Electrochemical mechanism

Simple, Rapid and Sensitive Detection of Pseudomonas aeruginesa by Colorimetric Multiple Cross Displacement Amplification

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Current Medical Science 2020年第2期40卷 372-379页

作者： Dong-xun LI Gao-lin SHU wei-jun wang Yang WU Huan-cai NIU Changping District Center for Disease Control and Prevention Bejing 102206China

Pseudomonas aeruginosa(P:aeruginosa)is a major opportunistic pathogen in hospital-acquired ***,carly diagnosis is the best strategy for fighting against these *** this report,we incorporated multiple crOsS displacement amplification(MCDA)combined with the malachite green(MG)for rapid,sensitive,specific and visual detection of *** by targeting the oprl *** MCDA-MG assay was conducted at 67°C for only 40 min during the amplification stage,and then products were directly detected by using colorimetric indicators(MG),eliminating the use of an electrophoresis instrument or amplicon analysis *** entire process,including specimen processing(35 min),amplification(40 min)and detection(5 min),can be finished within 80 *** 30 *** strains tested negative,indicating the high specificity of the MCDA *** analytical sensitivity of the MCDA-MG assay was 100 fg of genomic templates per reaction in pure culture,which was in complete accordance with MCDA by gel clectrophoresis and real-time *** assay was also successfully applied to detecting *** in stool ***,the rapidity,simplicity,and nearly equipment free platform of the MCDA-MG technique make it possible for clinical diagnosis,and more.

关键词： Pseudomonas aeruginosa multiple cross displacement amplification malachite green multiple cross displacement amplification combined with the malachite green

Construct a 3D microsphere of HMX/B/Al/PTFE to obtain the high energy and combustion reactivity

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Defence Technology（防务技术） 2024年第2期32卷 45-54页

作者： Jian wang Jie Chen Yaofeng Mao Yongjun Deng wei Cao Fude Nie jun wang Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621999PR China Shock and Vibration of Engineering Materials and Structures Key Lab of Sichuan Province Mianyang 621010PR China

Metal(aluminum and boron)based energetic materials have been wildly applied in various fields including aerospace,explosives and micro-devices due to their high energy ***,the low combustion efficiency and reactivity of metal fuels,especially boron(B),severely limit their practical ***,multi-component 3D microspheres of HMX/B/Al/PTFE(HBA)have been designed and successfully prepared by emulsion and solvent evaporation method to achieve superior energy and combustion *** reactivity and energy output of HBA are systematically measured by ignitionburning test,constant-volume explosion vessel system and bomb *** to the increased interfacial contact and reaction area,HBA shows higher flame propagation rate,faster pressurization rate and larger combustion heat of 29.95 cm/s,1077 kPa/s,and 6164.43 J/g,which is 1.5 times,3.5 times,and 1.03 times of the physical mixed counterpart(HBA-P).Meanwhile,HBA also shows enhanced energy output and reactivity than 3D microspheres of HMX/B/PTFE(HB)resulting from the high reactivity of *** reaction mechanism of 3D microspheres is comprehensively investigated through combustion emission spectral and thermal analysis(TG-DSC-MS).The superior reactivity and energy of HBA originate from the surface etching of fluorine to the inert shell(Al_(2)O_(3) and B_(2)O_(3))and the initiation effect of Al to *** work offers a promising approach to design and prepare high-performance energetic materials for the practical applications.

关键词： HMX/B/Al/PTFE 3D microspheres Surface etching Reaction mechanism

Study of dynamic pressure roadway supporting scheme under condi- tion of thick composite roof

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Journal of Coal Science & Engineering(China) 2013年第2期19卷 119-125页

作者： wei-jun wang Li-Qiang LUO wei-Jian YU Hai WU Yan-Si QU Hunan Provincial Key Laboratory of Safe Mining Techniques of Coal Mines Hunan University of Science and TechnologyXiangtan 411201 China

This paper analyzed the strata behaviors of solid-coal roadway, gob-side entry driving and deformation law of surrounding rock in depth under high stress and thick composite roof based on the dynamic pressure roadway as engineering background in Fengcheng mining area, Jiangxi province. The results, both field measurement and numerical simulation show that gob-side entry driving results the deformation of coal roadway main wall, however, entity-coal roadway driving results deformation of main roof and floor. The maintenance state of gob-side entry driving is better than entity-coal roadway, this situation is relevant to thick composite roof layered and easy collapse characteristics. At the same time, this paper put fox＇ward and proved proper dynamic pressure roadway supporting scheme under the surrounding rock condition and stress environment.

关键词： thick composite roof dynamic pressurized roadway high stress surrounding rock control

Phase separation and transcriptional regulation in cancer development

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Journal of Biomedical Research 2024年第4期38卷 307-321页

作者： Yan Gu Ke wei jun wang Department of Thoracic Surgery Jiangsu Province Hospitalthe First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

Liquid-liquid phase separation,a novel biochemical phenomenon,has been increasingly studied for its medical *** underlies the formation of membrane-less organelles and is involved in many cellular and biological *** transcriptional regulation,dynamic condensates are formed through interactions between transcriptional elements,such as transcription factors,coactivators,and *** is a disease characterized by uncontrolled cell proliferation,but the precise mechanisms underlying tumorigenesis often remain to be *** evidence has linked abnormal transcriptional condensates to several diseases,especially cancer,implying that phase separation plays an important role in *** formed by phase separation may have an effect on gene transcription in *** the present review,we focus on the correlation between phase separation and transcriptional regulation,as well as how this phenomenon contributes to cancer development.

关键词： phase separation transcription regulation cancer super-enhancer condensates

The Consistency of LSE Estimators in Partial Linear Regression Models under Mixing Random Errors

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1244-1272页

作者： Yun Bao YAO Yu Tan LÜ Chao LU wei wang Xue jun wang School of Mathematical Sciences Anhui UniversityHefei 230601P.R.China School of Big Data and Artificial Intelligence Chizhou UniversityChizhou 247000P.R.China School of Big Data and Statistics Anhui UniversityHefei 230601P.R.China

In this paper,we consider the partial linear regression model y_(i)=x_(i)β^(*)+g(ti)+ε_(i),i=1,2,...,n,where(x_(i),ti)are known fixed design points,g(·)is an unknown function,andβ^(*)is an unknown parameter to be estimated,random errorsε_(i)are(α,β)-mix_(i)ng random *** p-th(p>1)mean consistency,strong consistency and complete consistency for least squares estimators ofβ^(*)and g(·)are investigated under some mild *** addition,a numerical simulation is carried out to study the finite sample performance of the theoretical ***,a real data analysis is provided to further verify the effect of the model.

关键词： (α,β)-mixing random variables partial linear regression model least squares estimator consistency

Arbitrarily rotating polarization direction and manipulating phases in linear and nonlinear ways using programmable metasurface

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Light(Science & Applications) 2024年第9期13卷 1789-1800页

作者： wei Liu Si Ran wang jun Yan Dai Lei Zhang Qiao Chen Qiang Cheng Tie jun Cui State Key Laboratory of Millimeter Waves Southeast UniversityNanjing 210096China Institute of Electromagnetic Space Southeast UniversityNanjing 210096China Frontiers Science Center for Mobile Information Communication and Security Southeast UniversityNanjing 210096China Electrical Engineering Department Chalmers University of TechnologyGothenburg 41258Sweden

Independent controls of various properties of electromagnetic(EM)waves are crucially required in a wide range of *** metasurface is a promising candidate to provide an advanced platform for manipulating EM ***,we propose an approach that can arbitrarily control the polarization direction and phases of reflected waves in linear and nonlinear ways using a stacked programmable ***,we extend the space-timecoding theory to incorporate the dimension of polarization,which provides an extra degree of freedom for manipulating EM *** proof-of-principle application examples,we consider polarization rotation,phase manipulation,and beam steering at linear and nonlinear *** validation,we design,fabricate,and measure a metasurface *** experimental results show good agreement with theoretical predictions and *** proposed approach has a wide range of applications in various areas,such as imaging,data storage,and wireless communication.

关键词： surface. nonlinear rotating

How interfacial electron-donating defects influence the structure and charge of gold nanoparticles on TiO_(2)support

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Nano Research 2024年第7期17卷 5965-5974页

作者： Guang-Jie Xia Yu Fu wei Cao jun Li Yang-Gang wang Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and TechnologyShenzhen 518055China School of Physical Sciences Great Bay UniversityDongguan 523000China Department of Chemistry Tsinghua UniversityBeijing 100084China

The reduction degree of TiO_(2)support is critical to the performances of metal *** many previous theoretical calculations,only the bridge oxygen vacancy(Ov)was considered as the electron-donating defect on reduced rutile TiO_(2)(r-TiO_(2−x))***,titanium adatoms(Tiad.),oxidized titanium islands(***),and acid hydroxyls(ObrH)also exist at the metal/support *** conducting density functional theory(DFT)calculations and ab initio molecular dynamics(AIMD)simulations,we compared r-TiO_(2−x)surfaces with Ov,Tiad.,***,and ObrH sites loaded with Au nanoparticles(NPs).The results showed the Au NPs were oxygen-phobic but titanium-philic,resulting in wetting of Ov and *** short contact with *** and *** Bader charges of Au NPs(QM)showed a good linear relationship with the ideal number of donating electrons(Ne)from the defective sites(QM=−KeNe+QM,S),demonstrating the intrinsic electron allocation at the *** Ov,Tiad.,and *** exhibited similar slopes(Ke),relatively steeper than that of *** means in the scope of Au NP charge state,the *** *** have a close electron-donating ability with Ov,but the ObrH donates relatively fewer *** linear relationship can be extended approximately to other *** higher the metal work function,the steeper the Ke for easier electron donation from defective *** stronger the metal oxygen affinity,the more positive the intercept(QM,S).That explains the easy generation of metallic or negative Pt and Au NPs on r-TiO_(2−x),but hard for Cu and Zn in *** provides theoretical guidance for regulating the charge of metal NPs over TiO_(2−x)supports.

关键词： metal-support interaction titanium oxide oxygen vacancy surface hydroxyl titanium adatom