Phase separation and transcriptional regulation in cancer development
作者机构：Department of Thoracic SurgeryJiangsu Province Hospitalthe First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China
出 版 物：《Journal of Biomedical Research》 (生物医学研究杂志（英文版）)
年 卷 期：2024年第38卷第4期
页 面：307-321页
核心收录：
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the Jiangsu Province Natural Science Foundation(Grant No.BK20201492) the Key Medical Research Project of Jiangsu Provincial Health Commission(Grant No.K2019002) the Clinical Capacity Improvement Project of Jiangsu Province People's Hospital(Grant No.JSPH-MA-2021-8)
主 题：phase separation transcription regulation cancer super-enhancer condensates
摘 要：Liquid-liquid phase separation,a novel biochemical phenomenon,has been increasingly studied for its medical *** underlies the formation of membrane-less organelles and is involved in many cellular and biological *** transcriptional regulation,dynamic condensates are formed through interactions between transcriptional elements,such as transcription factors,coactivators,and *** is a disease characterized by uncontrolled cell proliferation,but the precise mechanisms underlying tumorigenesis often remain to be *** evidence has linked abnormal transcriptional condensates to several diseases,especially cancer,implying that phase separation plays an important role in *** formed by phase separation may have an effect on gene transcription in *** the present review,we focus on the correlation between phase separation and transcriptional regulation,as well as how this phenomenon contributes to cancer development.
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