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Chinese Journal of Chemical Engineering 2021年第6期34卷 77-86页

作者： Zhibin Deng Xing Ge Wenting Zhang Shizhong Luo jun Shen Fangli Jing wei chu College of Civil Aviation Safety Engineering Civil Aviation Flight University of ChinaGuanghan 618307China Sinopec Petroleum Exploration and Production Research Institute Northwest Oilfield BranchUrumqi 830011China School of Chemical Engineering Sichuan UniversityChengdu 610065China

SBA-15 with varied pore size from 4 to 8 nm were synthesized by tuning the temperature of hydrothermal treatment,the supports were then used to load the active phase Cr Oxthrough a conventional impregnation *** resulting catalysts were characterized by small/wide angle XRD,N_(2) adsorption/desorption,FT-IR,TEM-EDX,XPS,TPR and CO_(2)-TPD to study the feature of structure,surface chemical state,redox and *** was found from these results that the metal species could be well dispersed on catalysts with larger pore ***^(6+)species could enter into the framework by substituting the Si atoms of SBA-15,and Cr^(3+)mainly exist on extra *** size had profound effects on reducibility,surface composition and ***^(6+)species were necessary to activate the C-H bonds of alkanes,while the basicity played an important role in activating C-O bonds of CO_(2).The best performances were achieved over the sample Cr supported on SBA-15 with a pore diameter of 7 nm in oxidative dehydrogenation of ethane in the presence of CO_(2).

关键词： Ethylene SBA-15 Pore size effect Cr catalysts Heterogeneous catalysis

Late Mesozoic extensional tectonics of the Liaodong Peninsula massif:Response of crust to continental lithosphere destruction of the North China Craton

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Science China Earth Sciences 2011年第6期54卷 843-857页

作者： LIN wei WANG QingChen WANG jun WANG Fei chu Yang CHEN Ke State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Graduate School of Chinese Academy of Sciences Beijing 100049 China

Unlike most Precambrian cratons that have thick sub-continental lithospheric roots,the Archean lithosphere beneath the North China Craton is thin (reduced from 200 km to about 80 km),and has been replaced by a geochemically juvenile lithospheric *** is a unique regional geological event,which has attracted worldwide *** the North China Block,Late Mesozoic extensional tectonics is evident by low-angle detachment faults,syntectonic plutons bounded by ductile faults,metamorphic core complexes (MCC) and widespread Jurassic to Cretaceous half-grabens filled by continental terrigenous deposits and volcanic *** a regional scale,these structures share the same NW-SE extensional direction,while maintaining their own individual *** other words,the MCC feature a top-to-the-NW sense of shear,and syntectonic plutons are typified by a top-to-the-SE shearing *** results indicate that the extensional structures were formed between 130-120 *** extensional events lead to magmatic rock emplacement,distributed at the footwall of the detachment *** different exhumation stages can be identified based on regional structural and magmatic interpretation:a Jurassic slow or negligible exhumation and a Cretaceous fast one assisted by normal *** two cooling stages correspond to distinct geodynamic processes that occurred during the Jurassic and *** tectonics appear to have been insignificant before the Early Cretaceous,and the process may be demonstrated by partial melting of the *** second stage,dominated by an extensional regime,developed after ca 120 Ma,and is tentatively correlated with crustal extension caused by lithospheric removal of the North China Craton.

关键词： Liaodong Peninsula massif geometry and kinematics Late Mesozoic extensional tectonics destruction of the North China Craton

Oxide Inclusions in Ferromanganese and Its Influence on the Quality of Clean Steels

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Journal of Iron and Steel Research International 2014年第S1期21卷 23-27页

作者： Pei-wei HAN Shao-jun chu Ping MEI Yi-fei LIN School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Jiangsu Jiangnan Ferroalloy Co. Ltd.

Low and medium carbon ferromanganese produced by oxygen decarburization process and electric silicothermic process was briefly introduced, and the quality of products by these two processes was analyzed. Results showed that the total oxygen content in medium carbon ferromanganese by electric silicothermic process in China, which ranged from 0.039% to 0.171%, was between those of the common and refined products by oxygen decarburization process outside of China. The increments of total oxygen content in liquid steel were estimated when ferromanganese was added for the purpose of Mn element adjustment at the end of smelting. Refined low and medium carbon ferromanganese, which had low total oxygen content, was recommended for composition adjustment of clean steels during final stage of a heat. It is possible that the inclusions in the ferromanganese alloy greatly influenced the quality of clean steel indirectly by affecting the amount, size and composition of inclusions in steel.

关键词： low carbon ferromanganese medium carbon ferromanganese oxide inclusions clean steels

A Survey on Mixed Spin P-Fields

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Chinese Annals of Mathematics,Series B 2017年第4期38卷 869-882页

作者： Huai-Liang CHANG jun LI wei-Ping LI Chiu-chu Melissa LIU Department of Mathematics Hong Kong University of Science and Technology Hong Kong China. Shanghai Center for Mathematical Sciences Fudan University Shanghai 200433 China Department of Mathematics Stanford University Stanford CA 94305-2125 USA. Department of Mathematics Columbia University New York NY 10027 USA.

The mixed spin P-fields （MSP for short） theory sets up a geometric platform to relate Gromov-Witten invariants of the quintic three-fold and Fan-Jarvis-Ruan-Witten invariants of the quintic polynomial in five variables. It starts with Wittens vision and the P-fields treatment of GW invariants and FJRW invaxiants. Then it briefly discusses the master space technique and its application to the set-up of the MSP moduli. Some key results in MSP theory are explained and some examples are provided.

关键词： Mixed Spin P-fields GW invariants FJRW invariants P-fields Cosection localization

Chimeric antigen receptor engineered innate immune cells in cancer immunotherapy

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Science China(Life Sciences) 2019年第5期62卷 633-639页

作者： chu Lin jun Zhang Department of Immunology School of Basic Medical Sciences NHC Key Laboratory of Medical Immunology (Peking University) Peking University Health Science Center

Introducing chimeric antigen receptor into immune cells against malignancies has contributed to a revolutionary innovation in cancer immunotherapy. As an important type of adaptive immune cells, T cells first caught researchers' attention and became great success in chimeric antigen receptor-based immunotherapy. However, engineered T cells seem to hit their bottleneck when resistance of cancerous cells, less encouraging responses in solid tumors and unwanted toxicities to the host remain to be ***, innate immune cells get to join the race. Representatives such as natural killer cells, natural killer T cells, γδT cells and macrophages also prove to be well redirected with chimeric antigen receptors. Compared to chimeric antigen receptor engineered T cells, these engineered innate immune cells may possess multiple targeting and killing mechanisms, have the potential to crack the barrier of solid tumors and have less side effects in the host. Besides, possible universal access to cell resources and improvements in expansion and transduction techniques make these cells promising candidates with huge potential in translational medicine. Therefore, innate immune cells claim a brand-new dimension and are likely to supplement T cells greatly in the field of chimeric antigen receptor-based immunotherapy.

关键词： chimeric antigen receptor cancer immunotherapy innate immune cell

Numerical Investigation of the Fluid Flow Characteristics in the Hub Plate Crown of a Centrifugal Pump

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Chinese Journal of Mechanical Engineering 2018年第4期31卷 182-191页

作者： wei Dong Wu-Li chu School of Power and Energy Northwestern Polytechnical University Collaborative Innovation Center of Advanced AeroEngine

Due to the lack of understanding in the flow mechanism of the hub plate crown, the current calculation of the disc friction loss and the axial thrust in the centrifugal pump often uses empirical formulas. Research on the flow characteristics of the hub plate crown is of practical significance. The shroud and hub cavities are respectively studied with regard to tangential and radial velocities at the four different angular positions(0°, 90°, 180°, and 270°) at the four different operational points(0.6 Qsp, 0.8 Qsp, 1.0 Qsp, and 1.2 Qsp). Results indicate that at the same operational point, the smaller the volute chamber sectional area is, the higher the tangential velocity of the fluid core zone of the shroud cavity is. Radial leakage flow from the volute to the seal ring at the same operational point appears in 0° and 90° direction;when the flow is large, the tangential and radial velocities of the shroud and hub cavities with the same radius tend to be equal with axial symmetry. The axial leakage flow through the balance holes significantly affects the radial distribution of both tangential and radial velocities of fluid flow in the hub cavity. The numerical calculation results of fluid leakage through the clearance of back sealing ring are in good agreement with the test results. Accordingly, the magnitude of leakage is closely related to the fluid pressure and velocity distribution in the hub plate crown of the centrifugal pump. The analysis of the flow characteristics in the hub plate crown of the centrifugal pump could reveal the cause of the disc friction loss from the mechanism, providing a significant guidance for improving the accuracy of calculation and balancing the axial thrust in the centrifugal pump.

关键词： Centrifugal pump Shroud cavity Hub cavity Leakage of clearance Numerical simulation

Synthesis, radiolabeling and biological evaluation of butene amine oxime containing nitrotriazole as a tumor hypoxia marker

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Nuclear Science and Techniques 2016年第2期27卷 35-43页

作者： Qiang Zhang Tai-wei chu Beijing National Laboratory for Molecular Sciences Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science College of Chemistry and Molecular Engineering Peking University

^(99m)Tc-BnAO, as a nonnitroaromatic hypoxia marker, is the subject of intensive research in recent years. In this study, a butene amine oxime–nitrotriazole(Bn AO–NT)was synthesized and radiolabeled with ^(99m)Tc in high *** uptakes of^(99m)Tc-Bn AO–NT and ^(99m)Tc-Bn AO were tested using murine sarcoma S180 and hepatoma H22 cell lines. The highest hypoxic cellular uptake of^(99m)TcBn AO–NT was 27.11 ± 0.73 and 14.85 ± 0.83 % for the S180 and H22 cell lines, respectively, whereas the normoxic cellular uptake of the complex was about 4–8 % for both cell lines. For^(99m)Tc-Bn AO, the highest hypoxic cellular uptake was 30.79 ± 0.44 and 9.66 ± 1.20 % for the S180 and H22 cell lines, respectively, while the normoxic cellular uptake was about 5 % for both cell lines. Both^(99m)Tc-Bn AO–NT and^(99m)Tc-Bn AO complexes showed hypoxic/normoxic differentials in the two cell lines, but the results were more significant for the S180 cell line. The in vitro results suggested that S180 may be better than H22 cell line in hypoxic biological evaluation of Bn AO complexes. The biodistribution study was tested using a S180 tumor model. The complex^(99m)Tc-Bn AO–NT showed a selective enrichment in tumor tissues: At 4 h, the tumor-to-muscle ratio was 3.79 ± 0.98 and the tumor-to-blood ratio was 2.31 ± *** with the results of ^(99m)Tc-Bn AO, the latter was at the same level. In vitro and in vivo studies demonstrated that ^(99m)Tc-Bn AO–NT could be a hypoxia-sensitive radiotracer for monitoring hypoxic regions in a sarcoma S180 tumor.

关键词：细胞缺氧肿瘤模型生物学评价标记合成胺肟丁烯 S180

Bear Bile Powder Inhibits Growth of Hepatocellular Carcinoma via Suppressing STAT3 Signaling Pathway in Mice

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Chinese Journal of Integrative Medicine 2020年第5期26卷 370-374页

作者： CHEN Hong-wei SHEN A-ling LIU Li-ya PENG jun chu Jian-feng Academy of Integrative Medicine Fujian University of Traditional Chinese MedicineFuzhou(350122)China Fujian Key Laboratory of Integrative Medicine on Geriatrics Fujian University of Traditional Chinese MedicineFuzhou(350122)China

Objective: To evaluate the inhibitory effect of bear bile powder(BBP) on hepatocellular carcinoma(HCC) growth in vivo and investigate the underlying mechanisms. Methods: A HCC xenograft mouse model was developed by producing with huh7 cells. After 5 days following xenograft implantation, ten HCC xenograft mice were given intra-gastric administration with 10 mg/(kg·d) dose of BBP or saline for 3 weeks. Tumor growth in HCC xenograft mice was evaluated by measuring the tumor weight and volume. Cell apoptosis, proliferation or tumor angiogenesis were examined via immunohistochemical(IHC) staining for transferase-mediated deoxyuridine triphosphate-biotin nick end labeling(TUNEL), proliferating cell nuclear antigen(PCNA) or cluster of differentiation 31(CD31), respectively. Phosphorylation of signal transducer and activator of transcription 3(STAT3) were determined by Western blot. The m RNA and protein expressions of Bcl-2, Bax, Cyclin D1 and Cyclin-dependent kinase 4(CDK4) in HCC tumor tissues were respectively determined by reverse transcription polymerase chain reaction(RT-PCR) and Western blot. The protein expression of vascular endothelial growth factor A(VEGF-A) in tumor tissues was examined by IHC staining. Results: BBP treatment led to a significant decrease on tumor volume and tumor weight in HCC mice(Pweight. In addition, BBP profoundly promoted cell apoptosis, inhibited cell proliferation and intratumoral microvessel density in HCC tumor tissues(P<0.05). Moreover, BBP treatment remarkably suppressed the STAT3 phosphorylation and modulated the expression of critical target genes including Bcl-2, Bax, Cyclin D1, CDK4 and VEGF-A in HCC mice. Conclusion: BBP exerts its anti-cancer activities via suppressing STAT3 signaling pathway and affecting multiple intracellular targets.

关键词： bear bile powder Chinese medicine hepatocellular carcinoma signal transducer and activator of transcription 3 pathway

Spatiotemporal variations and determinants of stream nitrogen and phosphorus concentrations from a watershed in the Three Gorges Reservoir Area,China

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International Soil and Water Conservation Research 2023年第3期11卷 507-517页

作者： jun Deng Yiwen Zhou Lin chu Yujie wei Zhaoxia Li Tianwei Wang Cuiting Dai College of Resources and Environment Huazhong Agricultural UniversityWuhan430070China

Socioeconomic development induced nonpoint source(NPS)pollution has aroused an increasing concern,however,most of the previous studies were concentrated on the impacts of environmental ***,total nitrogen(TN)and total phosphorus(TP)concentrations from 13 sampling sites were collected biweekly from January 2018 to October 2021,and 26 potential factors including environmental and socioeconomic were considered in the Wangjiaqiao watershed of the Three Gorges Reservoir Area,*** of these factors on TN and TP were evaluated by partial least squares regression(PLSR)*** showed that average TN and TP concentrations in wet seasons(TN,14.68 mg L^(-1):TP,0.113 mg L^(-1))were higher than that in dry seasons(TN,11.73 mg L^(-1);TP,0.087 mg L^(-1)).Additionally,the TN concentrations were greater in downstream than upstream,however,the highest TP concentrations were found in the middle of the *** optimal PLSR model explained 69.6%,73.1%and 66.1%of the variance in TN concentration,as well as 65.7%,79.5%and 67.4%of the variance in TP concentration during the annual,dry and wet seasons,***,TN was primarily influenced by topographic wetness index,planting structure,interspersion and juxtaposition index,orchard proportion,nitrogen fertilization,per capita income,and catchment area,whereas TP was mainly controlled by slope gradient,topographic wetness index,hypsometric integral,interspersion and juxtaposition index,and population ***,environmental factors had greater impacts on the TN and TP concentrations than socioeconomic *** farmers'awareness of the hazards of NPS pollution is beneficial to watershed NPS pollution control.

关键词： Total nitrogen Total phosphorus Environmental factors Socioeconomic factors Impact

Scutellaria barbata *** Inhibits Colorectal Cancer Growth via Suppression of Wnt/β-Catenin Signaling Pathway

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Chinese Journal of Integrative Medicine 2017年第11期23卷 858-863页

作者： wei Li-hui LIN Jiu-mao chu Jian-feng CHEN Hong-wei LI Qing-yu PENG jun Academy of Integrative Traditional Chinese Medicine.Medicine Fujian University of Fuzhou(350122)China Fujian Key Laboratory of Integrative Medicine on Geriatrics Fujian University of Traditional Chinese MedicineFuzhou(350122)China

Objective： To investigate the effect of the ethanol extract of Scutellaria barbata D. Don（EESB） on colorectal cancer（CRC） growth and Wnt/β-catenin signaling pathway in vivo and in vitro. Methods： In vivoexperiment, CRC xenograft mouse model was constructed with injection of HT-29 cells. Following xenograft implantation, twenty mice were randomly divided into EESB-treated group（n=10） and control group（n=10） by a random number table, and were given with intra-gastric administration of 2 g/kg EESB or saline, 5 days a week for 16 days, respectively. At the end of experiment, tumors were removed and weighed by electronic scales. The proliferation biomarker Ki-67 of tumor was evaluated by immunohistochemistry（IHC） assay. In vitro study, HT-29 cells were treated with 0, 0.5, 1.5, 2.5 mg/m L EESB for 24 h. At the end of the treatment, the viability and survival of HT-29 cells were determined by methylthiazolyldiphenyl-tetrazolium bromide（MTT） assay and colony formation assay, respectively. The m RNA expression of c-Myc, Survivin and adenomatous polyposis coli（APC） was examined by reverse transcription-polymerase chain reaction（RT-PCR） both in tumor tissues of CRC xenograft mice and HT-29 cells. Protein expression of c-Myc, Survivin, APC, and β-catenin as well as β-catenin phosphorylation level were evaluated by IHC assay or Western blotting. Results： EESB significantly reduced tumor weight in CRC xenografts mice, compared with the control group（P〈0.05）. IHC assay showed that EESB significantly inhibited protein expression of Ki-67 in tumor tissues（P〈0.05）. MTT assay showed that EESB significantly reduced HT-29 cell viability in a dose-dependent manner（P〈0.05）. Colony formation assay showed that EESB dose-dependently decreased the survival of HT-29 cells（P〈0.05）. In addition, RT-PCR assay showed that EESB decreased the m RNA expression of c-Myc and Survivin and increased APC expression, both in tumor tissues of CRC xenograft mice and HT-29 cells（P〈0.05）. IHC assay or Western

关键词： Scutellaria barbata D.Don colorectal cancer proliferation Wnt/β-catenin pathway