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Antiosteoporosis and bone protective effect of alpinumisoflavone in steroid-induced osteoporosis rats via alteration of apoptosis,inflammatory and RANK/RANKL/OPG signaling pathway

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Asian Pacific Journal of Tropical Biomedicine 2024年第10期14卷 436-447页

作者： Jie Lian Jun-Long Qu guo-wei zhao Xu-Biao Ji Department of Orthopaedics Luzhou Traditional Chinese Medicine HospitalLuzhouSichuan646000China Department of Orthopedic Rehabilitation Shengli Oilfield Central HospitalDongyingShandong257000China Department of Spinal Surgery Changzhou Wujin People's HospitalWujin Hospital Affiliated with Jiangsu UniversityChangzhouJiangsu213000China

Objective:To estimate the bone protective effect of alpinumisoflavone,a natural prenylated isoflavonoid,against glucocorticoid-induced osteoporosis in ***:Male Wistar rats received intramuscular administration of dexamethasone(4 mg/mL)at a dose level of 7 mg/kg for 5 weeks,and then alpinumisoflavone(5,10,and 15 mg/kg)and alendronate(2 mg/kg)from 2 *** body weight and organ weight(femoral,vagina,and uterus)were *** analysis,bone turnover markers,bone parameters,oxidative stress parameters,and inflammatory cytokines were *** expressions of related genes were also ***:Alpinumisoflavone remarkably boosted body weight and organ weight(ureters and vagina),improved microCT analysis parameters,and boosted levels of bone ***,alpinumisoflavone considerably(P<0.001)restored the level of bone turnover markers and oxidative stress parameters,remarkably suppressed the level of cytokines such as interleukin-1β,interleukin-6,tumor necrosis factor-α,and increased transforming growth factor-βand insulin-like growth *** also significantly restored the osteoprotegerin(OPG,RANKL,and OPG/RANKL ratio)levels and the mRNA expression of Caspase(3,6,7,9),BMPs,OPN,ALP,RUNX2,and ***:The current result suggests the bone protective effect of alpinumisoflavone against glucocorticoid-induced osteoporosis in rats.

关键词： Osteoporosis Alpinumisoflavone Bone parameters Inflammation Oxidative stress

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Enzymatic Synthesis of Agmatine by Immobilized Escherichia coli Cells with Arginine Decarboxylase Activity

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Chemical Research in Chinese Universities 2011年第6期27卷 992-995页

作者： ZHANG wei-guo zhao Gen-hai LIU Jun-zhong LIU Qian JIAO Qing-cai State Key Laboratory of Pharmaceutical Biotechnology School of Life Science Nanjing University Nanjing 210093 P. R. China

A new method for the enzymatic synthesis of agmatine by immobilized Escherichia coli cells with arginine decarboxylase（ADC） activity was established and a series of optimal reaction conditions was set down. The arginine decarboxylase showed the maximum activity when the pyridoxal phosphate（PLP） concentration was 50 mmol/L, pH=7 and 45 °C. The arginine decarboxylase exhibited the maximum production efficiency when the substrate concentration was 100 mmol/L and the reaction time was 15 h. It was also observed that the appropriate concentration of Mg2＋, especially at 0.5 mmol/L promoted the arginine decarboxylase activity; Mn2＋ had little effect on the arginine decarboxylase activity. The inhibition of Cu2＋ and Zn2＋ to the arginine decarboxylase activity was significant. The immobilized cells were continuously used 6 times and the average conversion rate during the six-time usage was 55.6%. The immobilized cells exhibited favourable operational stability. After optimization, the maximally cumulative amount of agmatine could be up to 20 g/L. In addition, this method can also catalyze D,L-arginine to agmatine, leaving the pure optically D-arginine simultaneously. The method has a very important guiding significance to the enzymatic preparation of agmatine.

关键词： Arginine decarboxylase Agmatine Enzymatic resolution Immobilized cell

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An improved deep dilated convolutional neural network for seismic facies interpretation

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Petroleum Science 2024年第3期21卷 1569-1583页

作者： Na-Xia Yang guo-Fa Li Ting-Hui Li Dong-Feng zhao wei-wei Gu State Key Laboratory of Petroleum Resources and Engineering CNPC Key Lab of Geophysical ExplorationChina University of Petroleum(Beijing)Beijing 102249China Dagang Branch Research InstituteBGPTianjin300280China

With the successful application and breakthrough of deep learning technology in image segmentation,there has been continuous development in the field of seismic facies interpretation using convolutional neural *** intelligent and automated methods significantly reduce manual labor,particularly in the laborious task of manually labeling seismic ***,the extensive demand for training data imposes limitations on their wider *** overcome this challenge,we adopt the UNet architecture as the foundational network structure for seismic facies classification,which has demonstrated effective segmentation results even with small-sample training ***,we integrate spatial pyramid pooling and dilated convolution modules into the network architecture to enhance the perception of spatial information across a broader *** seismic facies classification test on the public data from the F3 block verifies the superior performance of our proposed improved network structure in delineating seismic facies *** analysis against the traditional UNet model reveals that our method achieves more accurate predictive classification results,as evidenced by various evaluation metrics for image ***,the classification accuracy reaches an impressive 96%.Furthermore,the results of seismic facies classification in the seismic slice dimension provide further confirmation of the superior performance of our proposed method,which accurately defines the range of different seismic *** approach holds significant potential for analyzing geological patterns and extracting valuable depositional information.

关键词： Seismic facies interpretation Dilated convolution Spatial pyramid pooling Internal feature maps Compound loss function

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Coefficients of earth pressure at rest in thick and deep soils

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Mining Science and Technology 2009年第2期19卷 252-255页

作者： TIAN Qiu-hong XU Zhi-wei ZHOU guo-qing zhao Xiao-dong HU Kun State Key Laboratory for Geomechanics ＆ Deep Underground Engineering School of Architecture and Civil Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

The effect of test methods and stress paths on the experimental value of the coefficient of earth pressure at rest, K0, was investigated under high pressures. The results indicate that the rigid pressure chamber and flexible lateral confining pressure medium method gives a stress ratio at the initial stage that is not the real K0. Moreover, K0 increases during the loading process becoming greater at high pressures. In the unloading process, however, K0 increases only at the initial stage but decreases thereafter. In addition, the incremental magnitude definition, K0=dσ3/dσ1, gives higher values than the total magnitude definition, K0=σ3/σ1, under loading. This is also true during initial stages of unloading. The experiment results also indicate that earth pressure at rest in deep and thick soils can be estimated by a power function of axial and confining pressures. It is necessary to choose the appropriate Kn to avoid some accidents.

关键词： experimental research earth pressure at rest loading and unloading paths thick and deep soils

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New insights into the deposition of natural gas hydrate on pipeline surfaces:A molecular dynamics simulation study

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Petroleum Science 2024年第1期21卷 694-704页

作者： Jun Zhang Hai-Qiang Fu Mu-Zhi guo zhao Wang Li-Wen Li Qi Yin You-guo Yan wei wei wei-Feng Han Jie Zhong School of Materials Science and Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina Department of Alternative Energy PetroChina Research Institute of Petroleum Exploration&DevelopmentLangfang 065007HebeiChina

Natural gas hydrate(NGH)can cause pipeline blockages during the transportation of oil and gas under high pressures and low *** hydrate adhesion on pipelines is viewed as an efficient way to prevent NGH *** studies suggested the water film can greatly increase hydrate adhesion in gas-dominant ***,by performing the molecular dynamics simulations,we find in water-dominant system,the water film plays different roles in hydrate deposition on Fe and its corrosion ***,due to the strong affinity of water on Fe surface,the deposited hydrate cannot convert the adsorbed water into hydrate,thus,a water film *** water affinities decrease(Fe>Fe_(2)O_(3)>FeO>Fe_(3)O_(4)),adsorbed water would convert to amorphous hydrate on Fe_(2)O_(3)and form the ordered hydrate on FeO and Fe_(3)O_(4)after hydrate *** absorbed water film converts to amorphous or to hydrate,the adhesion strength of hydrate continuously increases(Fe

关键词： Deposition Natural gas hydrate Pipelines Water affinity Adhesion strength

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Low-Strain and High-Energy KVPO4F Cathode with Multifunctional Stabilizer for Advanced Potassium-Ion Batteries

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Energy & Environmental Materials 2024年第5期7卷 144-153页

作者： Yongli Heng Zhenyi Gu Jinzhi guo Haojie Liang Yan Liu wei guo Xinxin zhao Xiaotong Wang Xinglong Wu MOE Key Laboratory for UV Light-Emitting Materials and Technology Northeast Normal University Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province Gannan Normal University Department of Chemistry Northeast Normal University

KVPO4F with excellent structural stability and high operating voltage has been identified as a promising cathode for potassium-ion batteries （PIBs）,but limits in sluggish ion transport and severe volume change cause insufficient potassium storage ***,a high-energy and low-strain KVPO4F composite cathode assisted by multifunctional K2C4O4electrode stabilizer is exquisitely *** electrochemical investigations demonstrate that this composite cathode can deliver a remarkable energy density up to 530 Wh kg-1with 142.7 mAh g-1of reversible capacity at25 mA g-1,outstanding rate capability of 70.6 mAh g-1at 1000 mA g-1,and decent cycling ***,slight volume change （-5%） and increased interfacial stability with thin and even cathode-electrolyte interphase can be observed through in situ and ex situ characterizations,which are attributed to the synergistic effect from in situ potassium compensation and carbon deposition through self-sacrificing K2C4O4additive.

关键词： high energy density K2C4O4 KVPO4F composite cathode low strain potassium-ion batteries

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Effect of Y_(2)O_(3) on microstructure and properties of CoCrFeNiTiNb high entropy alloy coating on Ti-6Al-4V surface by laser cladding

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Journal of Rare Earths 2024年第3期42卷 586-599,I0006页

作者： Zhen Li wei zhao Kedong Yu Ning guo Guangchun Xiao Zhiming Wang Hui Zhang College of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan250353China Shandong Institute of Mechanical Design and Research Jinan250031China

The effects of Y_(2)O_(3) on the microstructure, microhardness, wear resistance, high-temperature oxidation resistance, hot corrosion resistance, and electrochemical corrosion behaviour of CoCrFeNiTiNb high entropy alloy coatings formed on Ti-6Al-4V alloy surfaces were studied. The results show that the addition of Y_(2)O_(3) changes the proportion of the phase but does not change its type. The average grain size is only 1/4.7 of that of the high entropy alloy(HEA) coating, and the fine-grained strengthening leads to increases in the microhardness and wear resistance of 21.8% and 26.9%, respectively. The addition of Y_(2)O_(3) enhances the denseness and bonding properties of the oxide and corrosion product layers, reducing the oxidation and hot corrosion rates by 60.3% and 40.3%, respectively. The addition of Y_(2)O_(3) doubles the corrosion resistance which is attributed to the refinement of the grains, the increased proportion of HCP and TiN, and the weakening of galvanic coupling corrosion.

关键词： Laser cladding High entropy alloy coatings Rare earths Wear properties High temperature properties Electrochemical corrosion

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Seismic safety assessment with non-Gaussian random processes for train-bridge coupled systems

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 241-260页

作者： zhao Han Gao Lei wei Biao Tan Jincheng guo Peidong Jiang Lizhong Xiang Ping Key Laboratory of Geomechanics and Embankment Engineering of Ministry of Education Hohai UniversityNanjing 210024China School of Civil Engineering Central South UniversityChangsha 410075China

Extensive high-speed railway(HSR)network resembled the intricate vascular system of the human body,crisscrossing *** events,known for their unpredictability,pose a significant threat to both trains and bridges,given the HSR’s extended operational ***,ensuring the running safety of train-bridge coupled(TBC)system,primarily composed of simply supported beam bridges,is *** methods like the Monte Carlo method fall short in analyzing this intricate system ***,efficient algorithm like the new point estimate method combined with moment expansion approximation(NPEM-MEA)is applied to study random responses of numerical simulation TBC *** of the NPEM-MEA’s feasibility is conducted using the Monte Carlo *** analysis confirms the accuracy and efficiency of the method,with a recommended truncation order of four to six for the ***,the influences of seismic magnitude and epicentral distance are discussed based on the random dynamic responses in the TBC *** methodology not only facilitates seismic safety assessments for TBC systems but also contributes to standard-setting for these systems under earthquake conditions.

关键词： train-bridge coupled(TBC)system random vibration new point estimate method(NPEM) seismic safety assessment moment expansion approximation(MEA) non-Gaussian distributions

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Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

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Food Science and Human Wellness 2024年第2期13卷 982-992页

作者： Guangsu Zhu Min guo Jianxin zhao Hao Zhang Gang Wang wei Chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China (Yangzhou)Institute of Food Biotechnology Jiangnan UniversityYangzhou 225004China National Engineering Center of Functional Food Jiangnan UniversityWuxi 214122China

The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease(AD),a neurodegenerative disease characterised by behavioural and cognitive ***,most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive ***,we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment(EE)*** this study,we found that compared with EE or *** treatment alone,*** intervention combined with EE amplified its neuroprotective effects on AD mice,as reflected by improved cognition,inhibited neuroinflammation and enhanced synaptic ***,using microbiome and metabolome profiling,we found that the combination of *** and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite ***,by integrating behavioural and neurological data with metabolomic profiles,we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain ***,combined *** intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut *** findings provide a promising multidomain intervention strategy,with a combination of dietary microbiome-based and lifestyle-targeted interventions,to promote brain function and delay the progression of AD.

关键词： Alzheimer’s disease Bifidobacterium breve Environmental enrichment Glutamine metabolism Microbiota-gut-brain axis

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Lysine-specific Demethylase 1 Represses THP-1 Monocyte-to-macrophage Differentiation

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Chinese Medical Sciences Journal 2013年第2期28卷 82-87页

作者： Rui-feng Yang guo-wei zhao Shu-ting Liang Hou-zao Chen De-pei Liu National Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences & Peking Union Medical College

Objective To investigate the role of lysine-specific demethylase 1 （LSD1） in the process of THP-1 monocyte-to-macrophage differentiation. Methods Quantitative reverse transcription-polymerase chain reaction （qRT-PCR） and Western blotting were performed to analyze the expression of LSD1 and interleukin-6 （IL-6） in THP-1 monocytes and THP-l-derived macrophages. Chromatin immunoprecipitation （ChiP） assay was applied to detect the occupancy of LSD1 and H3K4 methylation at IL-6 promoter during THP-1 monocyte-to-macrophage differentiation. IL-6 mRNA level and H3K4 methylation at IL-6 promoter were analyzed using qRT-PCR and ChiP assay in LSD 1 -knockdown THP- 1 cells treated with 12-O-tetradecanoylphorbol- 13-acetate （TPA） for 0 4, 8, 12, and 24 hours. Fluorescence activated flow cytometry was performed to reveal the percentage of macrophages differentiated from THP- 1 monocytes. Results The expression of LSD1 reduced during THP-1 monocyte-to-macrophage differentiation （P〈0.01）. LSD1 occupancy decreased and H3K4 methylation increased at IL-6 promoter during the differentiation. With knockdown of LSD1, H3K4 methylation at IL-6 promoter was found increased after TPA treatment at different times points （all P〈0.05, except 24 hours）. The percentage of macrophages increased significantly in theTHP-I cells with LSD1 knockdown （P〈0.05）. Conclusions LSD1 is repressed during the monocyte-to-macrophage differentiation of THP-1 cells. Suppression of LSD 1-mediated H3K4 demethylation may be required for THP-1 monocyte-to-macrophage differentiation.

关键词： lysine-specific demethylase 1 interleukin-6 H3K4 methylation monocyte-to-macrophage differentiation

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