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Surfing the nano-wave:Emerging trends in cancer diagnostics and therapy

Nano Research 2025年第1期18卷 520-544页

作者： Genping fu Yuting Weng Yunfan Li Carl Ho Yiyu fu Wenxuan Wang Songbin fu Wenjing Sun Jie lin Xiaoyu Fan Binbin Jia Mengdi Cai linlin Li Laboratory of Medical Genetics Harbin Medical UniversityHarbin 150081China Key Laboratory of Preservation of Human Genetics Resources and Disease Control in China(Harbin Medical University) Ministry of EducationHarbin 150081China Beijing Key Laboratory for Optical Materials and Photonic Devices Department of ChemistryCapital Normal UniversityBeijing 100048China College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China Washington University School of Medicine in St.Louis St.LouisMO 63110USA Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Aix-Marseille College Wuhan University of TechnologyWuhan 430070China

Facing the growing global challenge posed by cancer,the quest for more accurate and potent cancer diagnostic and therapeutic strategies continues to require a multidisciplinary integration *** review firstly summarizes various types of nanoparticles in cancer ***,it offers a comprehensive overview of signalenhancing techniques for visualizing in situ tumors,along with multimodal diagnostic methods for detecting *** for tumor therapy,cutting-edge drug delivery methods that can cross biological barriers and the pinpoint targeting of tumor lesions for precise medical intervention are *** the domain of therapeutic diagnostics,we elucidate the theoretical underpinnings and structural paradigms that underlie a spectrum of advanced diagnostic and therapeutic ***,we present a compendium of publications delineating the clinical applications of each nano-based theragnostic integration ***,this comprehensive review discusses the safety concerns pertaining to the clinical application of nanoparticles and proposes some strategic recommendations to enhance the precision and safety of theragnostic-guided,nanotechnology-based clinical practices.A deeper understanding of nanomaterials,together with intimate interdisciplinary collaborations,nano-wave will most probably guide human beings to win the battle against cancers.

关键词： nanoparticles drug delivery gastric cancer glioma glioblastoma

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XPZLIB:an HDF5-format multi-group cross-section library

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Nuclear Science and Techniques 2024年第11期35卷 46-60页

作者： Bin fu Le-Rui Zhang Ding She Chun-lin wei Alain Hébert Institute of Nuclear and New Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of the Ministry of EducationTsinghua UniversityBeijing 100084China National Key Laboratory of Nuclear Reactor Technology Nuclear Power Institute of ChinaChengdu 610041China Polytechnique Montreal MontrealCanada

A multi-group cross-section library is fundamental for deterministic lattice physics *** existing multi-group cross-section libraries are customized for particular computer codes,as well as for particular types of nuclear *** paper presents an HDF5-format multi-group cross-section library named *** was produced using a selfdeveloped XPZR module integrated into the NJOY2016 code,and an in-house PyNjoy2022 system was developed for *** contains detailed data content and well-organized data structures that are user-and *** typical XPZLIBs with different numbers of energy groups,nuclides,and depletion reaction types were released via the Tsinghua cloud ***,the applicability of the released XPZLIBs was investigated using HTGR and PWR lattice calculations,which can provide guidance for applying XPZLIB under different scenarios.

关键词： XPZLIB Multi-group library HDF5 format HTGR PWR

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Aerodynamic Optimization and Flow Mechanism for a Compressor Cascade at Low Reynolds Number

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Journal of Thermal Science 2025年第1期 92-109页

作者： LI lin ZHANG Jianshe CHEN Caiyan TAN wei ZHANG Yanfeng Key Laboratory of Light-Duty Gas-Turbine Institute of Engineering ThermophysicsChinese Academy of Sciences University of Chinese Academy of Sciences National Key Laboratory of Science and Technology on Advanced Light-duty Gas-turbine

Low-Reynolds-number effect is an important factor affecting the performance of compressors and other main components of high-altitude long-endurance unmanned aerial *** improve the flow condition and reduce flow loss under the condition of high altitude and low Reynolds number(Re),this paper proposes an optimization process based on a surrogate model,which combines the class-shape transformation method(CST),the Latin hypercube sampling(LHS) method,the light gradient-boosting machine algorithm(LightGBM),and a genetic algorithm(GA) to optimize a high-subsonic compressor *** surrogate model is verified to be accurate and can be used in the optimization *** accuracy of the GA is higher than the other algorithms under common test *** optimization results are verified by numerical simulation,and the flow differences before and after optimization are compared,especially the flow within the boundary *** changing the blade shape,the optimization process adjusts the loading distribution to delay the transition of the optimized blade on the suction surface,which changes the turbulent reattachment in the laminar separation bubble(LSB) into laminar ***,the mixing loss induced by the turbulent reattachment of the LSB and the wake loss of turbulent separation at the trailing edge are significantly reduced,and the performance of the compressor profile is finally *** addition,turbulent separation of the optimized profile is delayed reducing the range of the wake region on the suction *** this optimization process,the reduction of total pressure loss coefficient at Re of 2.5×10～5,3.5×10～5,and 4.5×10～5 are 16.32%,20.76%,and 22.16%,respectively.

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以创先争优活动为契机提高院前急救病人满意度

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医院管理论坛 2013年第6期30卷 18-20页

作者：付卫林张军根钱里娜张志伟汪丽红杭州市急救中心

在当前的医患关系下,病人的满意度是影响构建和谐医患关系的重要因素。在新医改的形势下,以创先争优活动为契机,本文结合工作实际,以科学实践的发展观角度分析目前影响院前急救病人满意度的问题,加强思想教育管理,提高医疗急救技能,结... 详细信息

在当前的医患关系下,病人的满意度是影响构建和谐医患关系的重要因素。在新医改的形势下,以创先争优活动为契机,本文结合工作实际,以科学实践的发展观角度分析目前影响院前急救病人满意度的问题,加强思想教育管理,提高医疗急救技能,结合现代化信息工具,建立健全监督机制,探索院前急救健康快速发展新思路。

关键词：院前急救病人满意度创先争优活动

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Heterologous biosynthesis of medicarpin using engineered Saccharomyces cerevisiae

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Synthetic and Systems Biotechnology 2023年第4期8卷 749-756页

作者： Chujie Lu Rui Du Hao fu Jizhao Zhang Ming Zhao Yongjun wei wei lin Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization NanjingChina School of Pharmacy Nanjing University of Chinese MedicineNanjingChina Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationSchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhouChina Department of Pathogen Biology School of Medicine&Holistic Integrative MedicineNanjing University of Chinese MedicineNanjingChina Xinjiang Institute of Traditional Chinese Medicine and Ethnic Medicine UrumqiChina

Medicarpin is an important bioactive compound with multiple medicinal activities,including anti-tumor,anti-osteoporosis,and anti-bacterial *** is associated with pterocarpans derived from medicinal plants,such as Sophora japonica,Glycyrrhiza uralensis Fisch.,and Glycyrrhiza glabra ***,these medicinal plants contain only low amounts of ***,the planting area for medicarpin-producing plants is limited;consequently,the current medicarpin supply cannot meet the high demands of medicinal *** this study,eight key genes involved in medicarpin biosynthesis were identified using comparative transcriptome and bioinformatic *** vitro and in vivo enzymatic reaction confirmed the catalytic functions of candidate enzymes responsible for the biosynthesis of medicarpin and medicarpin *** engineering of these genes in Saccharomyces cerevisiae achieved the heterologous biosynthesis of medicarpin using liquiritigenin as a substrate,with a final medicarpin yield of 0.82±0.18 mg/*** increasing the gene copy numbers of vestitone reductase(VR)and pterocarpan synthase(PTS),the final medicarpin yield was increased to 2.05±0.72 mg/*** study provides a solid foundation for the economic and sustainable production of medicarpin through a synthetic biology strategy.

关键词： Medicarpin Glycyrrhiza glabra L. Saccharomyces cerevisiae Medicarpin biosynthesis pathway Transcriptome sequencing Pterocarpan

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Exact Quantum Logic Gates with a Single Trapped Cold Ion

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Chinese Physics Letters 2001年第11期18卷 1533-1535页

作者： wei Lian-fu LIU Shi-Yong LEI Xiao-lin Department of Physics Shanghai Jiaotong UniversityShanghai 200030

We present an alternative scheme to exactly implement one-qubit and two-qubit quantum gates with a single trapped cold ion driven by a travelling laser field. The internal degree of freedom of the ion acts as the target qubit and the control qubit is encoded by two Fock states of the external vibration of the ion. The conditions to realize these operations, including the duration of each applied laser pulse and Lamb-Dicke parameter, are derived. In our scheme neither the auxiliary atomic level nor the Lamb-Dicke approximation is required. The multiquantum transition between the internal and external degrees of freedom of the ion is considered.

关键词： field Dicke quantum

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Internal Friction on the Bake-Hardening Behavior of 0.11C-1.67Mn-1.19Si TRIP Steel

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Journal of Materials Science & Technology 2009年第1期25卷 141-144页

作者： Renyu fu Yu Su Ping Ye Xicheng wei lin Li Jicheng Zhang School of Materials Science and Engineering Shanghai University Shanghai 200072 China Shanghai University of Engineering Science Shanghai 200336 China Automotive Engineering Academy of SAIC Motor Co. Ltd. Shanghai 201206 China Shanghai Baosteel Plates Co. Ltd. Shanghai 201900 China

The bake-hardening （BH） values and the ＂internal friction-temperature＂ spectrums were studied for the baked 0.11C-1.67Mn-1.19Si TRIP （transformation induced plasticity） specimens with 0%, 2% and 6% prestrain. Results show that the experimental TRIP steel deserves good bake-hardening ability and Cottrell atmosphere is the reason for its bake hardening characteristic. It is also concluded that both the number and the saturation degree of Cottrell atmosphere might affect the BH value of TRIP steel.

关键词： TRIP steel BH value Internal friction

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非专职化院外急救医生岗前培训实践与探索

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中国急救复苏与灾害医学杂志 2013年第3期8卷 240-242,246页

作者：付卫林张军根钱里娜鲁美丽浙江省杭州市急救中心医教培训科 310006

目的研究模拟现场急救的培训模式对非专职化院外急救医生的岗前培训是否实用、有效。方法选取101名2010年12月～2011年12月期间参加的非专职化院外急救医生岗前培训人员进行模拟现场急救的岗前培训，分析比较培训前、后考核成绩的差异... 详细信息

目的研究模拟现场急救的培训模式对非专职化院外急救医生的岗前培训是否实用、有效。方法选取101名2010年12月～2011年12月期间参加的非专职化院外急救医生岗前培训人员进行模拟现场急救的岗前培训，分析比较培训前、后考核成绩的差异。结果培训后的考核成绩显著高于培训前的考核成绩（均P〈0．01）。不同职称、不同年龄段的学员培训后的考核成绩均显著高于培训前的考核成绩（均P〈0．01）。结论模拟现场急救的培训模式对非专职化院外急救医生的岗前培训实用、有效。

关键词：模拟急救院外急救岗前培训非专职化

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Dynamic softening and microstructural evolution during hot deformation of Al-Cu-Mg-Zr alloys with different homogenization cooling rates

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Rare Metals 2021年第3期40卷 626-634页

作者： Guo-wei Bo Guan Wang fu-lin Jiang Can Liu Rong Chen Hui Zhang College of Materials Science and Engineering Hunan UniversityChangsha410082China School of Mechanical Engineering Ningxia UniversityYinchuan 750021China

An Al-Cu-Mg-Zr alloy,which obtained different homogenization cooling rates by changing the heattreated sample size,was compressed to various strains at the deformation temperature of 300℃ and strain rate of 0.01 s^(-1).The results showed that the homogenization cooling rate had strong effects on the hot deformation behavior of the *** flow stress and relative dynamic softening rate of the alloy were significantly higher under a high cooling rate(HCR) than those under a low cooling rate(LCR).furthermore,based on X-ray diffraction,scanning electron microscopy,transmission electron microscopy,and thermodynamic equilibrium phase calculation,the substructure evolution in the grain interior,morphology,and spatial distribution of the precipitates were studied to determine the differences in the flow softening *** main softening mechanism could be summarized as dynamic recovery and precipitation coarsening for the LCR alloy and dynamic precipitation for the HCR alloy.

关键词： Al-Cu-Mg-Zr alloy Homogenization Hot compression Flow softening Dynamic precipitation

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QCD at finite temperature and density within the fRG approach:an overview

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Communications in Theoretical Physics 2022年第9期74卷 299-355页

作者： wei-jie fu School of Physics Dalian University of TechnologyDalian116024China

In this paper,we present an overview on recent progress in studies of QCD at finite temperature and densities within the functional renormalization group(fRG)*** f RG is a nonperturbative continuum field approach,in which quantum,thermal and density fluctuations are integrated successively with the evolution of the renormalization group(RG)*** f RG results for the QCD phase structure and the location of the critical end point(CEP),the QCD equation of state(EoS),the magnetic EoS,baryon number fluctuations confronted with recent experimental measurements,various critical exponents,spectral functions in the critical region,the dynamical critical exponent,etc,are *** estimates of the location of the CEP from first-principle QCD calculations within f RG and Dyson-Schwinger equations,which pass through lattice benchmark tests at small baryon chemical potentials,converge in a rather small region at baryon chemical potentials of about 600 MeV.A region of inhomogeneous instability indicated by a negative wave function renormalization is found withμ_(B)■420 *** is found that the non-monotonic dependence of the kurtosis of the net-proton number distributions on the beam collision energy observed in experiments could arise from the increasingly sharp crossover in the regime of low collision energy.

关键词： QCD phase transition chiral phase transition QCD phase diagram functional renormalization group

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