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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第1期12卷 55-64页

作者： wei ZHANG Quan-wei wei Zheng-chao wang wei DING wei wang fang-xiong SHI Laboratory of Animal Reproduction College of Animal Science and Technology Nanjing Agricultural University Nanjing 210095 China

Objective: The present study is designed to investigate the cellular expressions and immunolocalizations of three different nitric oxide synthase (NOS) isoforms and the related nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway in the ovaries of neonatal and immature ***: The ovaries were obtained from ICR (Institute for Cancer Research) female Sprague-Dawley rats at postnatal days 1,5,7,10,and *** we carried out the histologic examination,immunohistochemistry,measurement of NOS activity,and modifications within the NO/cGMP ***: During postnatal days 1,5,7,10,and 19,all three isoforms of NOS were mainly localized to the oocytes and expressed as a gradual increase in granulosa cells and theca cells within the growing *** ovarian total NOS activities and NO levels were increased at postnatal days 7 and 10 compared with other ***: Our findings suggest that the locally produced NO and the NO/NOS signaling systems are involved in the follicular development to puberty.

关键词： Nitric oxide synthase Nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway Ovary Neonatal rats Prepuberty

CeO_2 as the Oxygen Carrier for Partial Oxidation of Methane to Synthesis Gas in Molten Salts: Thermodynamic Analysis and Experimental Investigation

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Journal of Natural Gas Chemistry 2007年第1期16卷 6-11页

作者： Yonggang wei Hua wang fang He Xianquan Ao Chiyuan Zhang Faculty of Materials and Metallurgy Engineering Kunming University of Science and Technology Kunming 650093 Yunnan China

A new technique -- the direct partial oxidation of methane to synthesis gas using lattice oxygen in molten salts medium has been introduced. Using CeO2 as the oxygen carrier, thermodynamic data were calculated in the reaction process, and the results indicated that direct partial oxidation of methane to synthesis gas using lattice oxygen of cerium oxide is feasible in theory. In a stainless steel reactor, the effects of temperature and varying amounts of γ-Al2O3 supported CeO2 on cn4 conversion, H2 and CO selectivity, were investigated, respectively. The results show that 10% CeO2/γ-Al2O3 has the maximal reaction activity at a temperature of 865 ℃ and above, the H2/CO ratio in the gas that has been produced reaches 2 and the CH4 conversion, H2 and CO selectivity reached the following percentages： i.e. 61%, 89%, and 91% at 870 ℃, respectively. In addition, increase of reaction temperature is favorable for the partial oxidation of methane.

关键词： partial oxidation methane cerium oxide synthesis gas molten salt

Selection and application of wavelet transform in high-frequency sequence stratigraphy analysis of coarse-grained sediment in rift basin

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Petroleum Science 2024年第5期21卷 3016-3028页

作者： Ling Li Zhi-Zhang wang Shun-De Yin wei-fang wang Zhi-Chao Yu Wen-Tian Fan Zhi-Heng Zhang National Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing) College of Geosciences China University of Petroleum(Beijing) Civil and Environmental Engineering Department University of Waterloo SINOPEC Petroleum Exploration and Production Research Institute

Wavelet transformation is a widely used method in high-frequency sequence stratigraphic ***, the application is problematic since different wavelets always return the same sequence analysis results. To address this issue, we applied five commonly used wavelets to theoretical sequence models to document some application criteria. Five gradual scale-change sequence models were simplified from the glutenite succession deposition by gravity flows to form the fining-upwards cycle sequences(FUCS) and coarsening-upwards cycle sequences(CUCS). After conducting theoretical sequence model tests, the optimal wavelet(sym4) was selected and successfully used with actual data to identify the sequence boundaries. We also proposed a new method to optimize the scale of continuous wavelet transformation(CWT) for sequence boundary determination. We found that the balloon-like marks in scalograms of db4, sym4, and coif4 wavelet determine, respectively, the fourth-order sequence boundary, the thick succession sequence boundaries in FUCS, and the thick succession sequence in FUCS and CUCS. Comparing the sequence identification results shows that the asymmetric wavelets had an advantage in high-frequency sequence boundary determination and sedimentary cycle discrimination through the amplitude trend of the coefficient, in which the sym4 wavelet is the most effective. In conclusion, the asymmetry of wavelets is the first selection principle, of which asymmetric wavelets are more sensitive to sediment deposition by flood flows. The match of the wavelet between the sequence is the second selection principle, in which the correlation of time-frequency impacts the accuracy of sequence surface localization. However, the waveform of the wavelet is a visual and abstract parameter for sequence boundary detection. The appropriate wavelet for lacustrine sequence analysis is the asymmetric wavelet with a weak number of side lobes. The depositional flows, depositional process,and autogeni

关键词： Wavelet analysis High-resolution sequence Sedimentary cyclicity Asymmetric wavelets

Zintl Phase BaAgSb: Low Thermal Conductivity and High Performance Thermoelectric Material in Ab Initio Calculation

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Chinese Physics Letters 2021年第4期38卷 87-90页

作者： Shao-Fei wang Zhi-Gang Zhang Bao-Tian wang Jun-Rong Zhang fang-wei wang Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523808China School of Nuclear Sciences and Technology University of Chinese Academy of SciencesBeijing 100049China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Songshan Lake Material Laboratory Dongguan 523808China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Thermoelectric materials are critical parts in thermal electric ***,Zintl phase BaAgSb in space group of P63/mmc is reported as a promising thermoelectric material in density function *** anisotropic lattice thermal conductivity and phonon transport properties are investigated in *** strong phonon-phonon scattering in BaAgSb exhibits ultra-low lattice thermal conductivity of 0.59 W·m^(-1)·K^(-1) along c-axis at 800 K,and high thermoelectric performance ZT=0.94 at 400 *** mix of covalent and ionic bond supports high carrier mobility and low thermal *** unusual features make BaAgSb a potential thermoelectric material.

关键词： conductivity. theory. Conductivity

Cloning and Characterization of Porcine TSARG7 Gene and Analysis of Its Tissue-Specific Expression

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Agricultural Sciences in China 2009年第11期8卷 1384-1391页

作者： LI Mei-li LI Gui-qiang fang wei wang wei SONG Xiao-guang LI Er-lin JIA Chao XU Yin-xue College of Animal Science and Technology Nanjing Agricultural University Nanjing 210095 P.R.China

TSARG7 is a novel member of the acyltransferase family since its sequence possesses the highly conserved phosphate acyltransferase （PlsC） domain existing in all acyltransferase-like proteins. The porcine TSARG7 had been identified by cloning in silico but had not been confirmed experimentally. The full-length mRNA of porcine TSARG7 gene was sequenced and two splice variants were discovered. The full-length cDNA of TSARG7 variant 1 was 2 513 bp and variant 2 was 2 634 bp. The putative porcine TSARG7 proteins, which were located in the cytoplasm, encoded 458 and 456 amino acids, respectively. Real-time PCR analysis showed that TSARG7 gene was expressed in various tissues, but at different levels. The expression levels of this gene were higher in the skeletal muscle, heart, and testis than that in other tissues, suggesting that the TSARG7 gene played a role in procine skeletal muscle, heart, and testis functions.

关键词： TSARG7 cDNA cloning pig bioinformatic analysis gene expression

Design and Synthesis of a Novel Peptidomimetic Inhibitor of Caspase-3

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Chemical Research in Chinese Universities 2006年第2期22卷 225-228页

作者： ZHANG Jin-liang LIU Lin-hua GUO Yang-hong YANG Jin-gang LI wei ZHONG Da-fang wang Ji-dong College of Life Science Jilin University Changchun 130021 P. R. China

Caspases, a family of cysteine proteases, comprise of highly homologous enzymes that play an important role in apoptotic cell death. Caspase-3 shows key functions in apoptosis, mediating apoptotic cascade from the intrinsic and extrinsic activation pathways. Therefore, caspase-3 is an attractive target for therapeutic intervention. For instance, inhibitors of caspase-3 have been described as promising cardioprotectants, neuroprotectants and antiarthritic agents. A novel peptidomimetic inhibitor of caspase-3, has been designed, which still has the properties of a reversible inhibitor, while the P1 site at the C-terminal remains, and only L-amino acid has been replaced by D-amino acid. Also presented here is the synthesis of the inhibitor and its inhibitory activity against caspase-3, which was tested by the fluorescent activity assay.

关键词： Caspase-3 Inhibitor Retro-inverso Peptidomimetie Synthesis

Semidefinite relaxation aided noncoherent detection in two-way relay transmission

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Frontiers of Information Technology & Electronic Engineering 2019年第9期20卷 1259-1265页

作者： Chan-fei wang Ji-ai HE wei-fang wang Ya-mei XU School of Computer and Communication Lanzhou University of TechnologyLanzhou 730050China

A high-performance noncoherent transmission scheme is proposed in the broadcasting phase of a twoway relay transmission(TWRT),where multiple-symbol differential detection(MSDD)is performed because of its excellent detection performance with no channel ***,the generalized likelihood ratio test aided MSDD(GLRT-MSDD)is developed for the ***,GLRT-MSDD is reformulated and a semidefinite relaxation aided MSDD(SDR-MSDD)is *** reformulation of GLRT-MSDD to SDR-MSDD is desirable owing to its reduced *** analysis and the simulations validate that the proposed SDR-MSDD provides the bit-error-rate performance close to that of GLRT-MSDD with reasonable complexity in TWRT.

关键词： Multiple-symbol differential detection Generalized likelihood ratio test Semidefinite relaxation Two-way relay transmission

Prospects of elafibranor in treating alcohol-associated liver diseases

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World Journal of Gastroenterology 2025年第2期31卷 132-137页

作者： wei-Tong Cui Hua-Ru Xue Dian-fang wei Xiao-Yu Feng Kai wang School of Basic Medicine Qilu Medical UniversityZibo 255300Shandong ProvinceChina School of Medical Imaging Qilu Medical UniversityZibo 255300Shandong ProvinceChina

Alcohol-related liver disease(ALD),which is induced by excessive alcohol con-sumption,is a leading cause of liver-related morbidity and *** pa-tients exhibit a spectrum of liver injuries,including hepatic steatosis,inflam-mation,and fibrosis,similar to symptoms of nonalcohol-associated liver diseases such as primary biliary cholangitis,metabolic dysfunction-associated steatotic liver disease,and nonalcoholic *** has been approved for the treatment of primary biliary cholangitis and has been shown to improve symptoms in both animal models and in vitro cell models of metabolic dysfunc-tion-associated steatotic liver disease and nonalcoholic ***,the efficacy of elafibranor in treating ALD remains *** this article,we comment on the recent publication by Koizumi et al that evaluated the effects of elafibranor on liver fibrosis and gut barrier function in an ALD mouse *** findings indicate the potential of elafibranor for ALD treatment,but further experimental investigations and clinical trials are warranted.

关键词： Elafibranor Alcohol-associated liver diseases Peroxisome proliferator-activated receptor Lipid Apoptosis Steatosis Inflammation Fibrosis

Molecular mechanism of Herba Eupatorii in treating COVID-19 based on network pharmacology and molecular docking

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Infectious Diseases Research 2022年第3期3卷 20-28页

作者： Xiao-Ying Zhao An-Lan Zhao Yu-Hui wang En-wei Yang Rui Gong fang-wei wang Tianjin University of Traditional Chinese Medicine Tianjin 301617China.

Objective:To explore the therapeutic target and molecular mechanism of Herba Eupatorii in the intervention of COVID-19(coronavirus disease 2019)by network ***:TCMSP(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform)and TCMIP V2.0(Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine)databases were used to search the active ingredients and corresponding drug targets of Herba *** targets of COVID-19 were searched in Genecards,pharmGKB,CTD,Drugbank and TTD *** the intersection targets were selected using VENNY 2.1 online platform,the PPI(protein-protein interaction)network was downloaded into STRING database,and the data were analyzed and sorted out using Cytoscape software to obtain the potential key targets for the treatment of COVID-19 by Herba *** the same time,using the data of active ingredients and intersection targets,a network of"TCM-active ingredients-key targets"was constructed in Cytoscape software to screen out chemical molecules with potential therapeutic ***(Gene Ontology)functional enrichment analysis and KEGG(Kyoto Encyclopedia of Genes)pathway enrichment analysis of key target proteins were performed by R *** Vina program was used for molecular docking of the top 5 active ingredients and key targets to calculate the minimum binding ***:There were 26 active ingredients,160 targets,and 1969 pathogenic genes of COVID-19,among which 59 genes were intersection targets of drugs and *** PPI network screening,the key target proteins were AKT1(RAC-alpha serine/threonine-protein kinase),JUN(transcription factor AP-1),TP53(cellular tumor antigen p53),ACTB(actin beta)and EGFR(epidermal growth factor receptor).Through the network of"TCM-Active Ingredients-Key Targets",Luteolin,Eupatolin,Stigmasterol,Eupatoriopicrin and Dammaradienyl acetate were identified as the active ingredients with potential therapeutic effec

关键词： Herba Eupatorii COVID-19 network pharmacology inflammatory response antiviral

Prognostic factors affecting the all-cause death and sudden cardiac death rates of post myocardial infarction patients with low left ventricular ejection fraction

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Chinese Medical Journal 2009年第7期122卷 802-806页

作者： DAI Shi-mo ZHANG Shu CHEN Ke-ping HUA wei wang fang-zheng CHEN Xin Center for Arrhythmia Diagnosis and Treatment Fu Wai Hospitaland Cardiovascular Institute Chinese Academy of MedicalSciences & Peking Union Medical College Beijing 100037 China

Background Post myocardial infarction （post-MI） patients with low left ventricular ejection fraction （LVEF） have been candidates for an implantable cardioverter-defibrillator （ICD） since the Multicenter Automatic Defibrillator Implantation Trail Ⅱ （MADIT Ⅱ）. However, due to the high costs of ICDs, widespread usage has not been accepted. Therefore, further risk stratification for post-MI patients with low LVEF may aid in the selection of patients that will benefit most from ICD treatment. Methods Four hundred and seventeen post-MI patients with low LVEF （≤35%） were enrolled in the study. All the patients received standard examination and proper treatment and were followed up to observe the all-cause death rate and sudden cardiac death （SCD） rate. Then COX proportional-hazards regression model was used to investigate the clinical factors which affect the all-cause death rate and SCD rate. Results Of 55 patients who died during （32±24） months of follow-up, 37 （67%） died suddenly. After adjusting for baseline clinical characteristics, multivariate COX proportional-hazards regression model identified the following variables associated with death from all causes： New York Heart Association （NYHA） heart failure class ≥Ⅲ （Hazard ratio： 2.361）, LVEF ≤20% （Hazard ratio： 2.514）, sustained ventricular tachycardia （Hazard ratio： 6.453）, and age 〉70 years （Hazard ratio： 3.116）. The presence of sustained ventricular tachycardia （Hazard ratio： 6.491） and age ≥70 years （Hazard ratio： 2.694） were specifically associated with SCD. Conclusions In the post-MI patients with low LVEF, factors as LVEF ≤20%, age ≥70 years, presence of ventricular tachycardia, and NYHA heart failure class ≥111 predict an adverse outcome. The presence of sustained ventricular tachycardia and age ≥70 years was associated with occurrence of SCD in these patients.

关键词： myocardial infarction death, sudden, cardiac heart failure