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从“脾虚毒损胃络”探讨CAG癌前病变的防治

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时珍国医国药 2018年第2期29卷 401-403页

作者：庞立伟刘冬梅曹志群胡冬青山东中医药大学2015级博士研究生山东济南250014 山东中医药大学附属医院山东济南250014

慢性萎缩性胃炎为胃癌癌前状态之一,伴有胃黏膜上皮不典型增生(异型增生)和(或)肠上皮化生的组织病理学改变时,视为胃癌前病变。胃癌前病变发展为胃癌需要经历较为漫长的过程,具有一定的可逆性,积极进行胃癌前病变的防治,逆转其癌变,阻... 详细信息

慢性萎缩性胃炎为胃癌癌前状态之一,伴有胃黏膜上皮不典型增生(异型增生)和(或)肠上皮化生的组织病理学改变时,视为胃癌前病变。胃癌前病变发展为胃癌需要经历较为漫长的过程,具有一定的可逆性,积极进行胃癌前病变的防治,逆转其癌变,阻断胃癌的发生具有重大意义。"脾虚毒损胃络"是CAG癌前病变的基本病机,将健脾通络解毒法用于慢性萎缩性胃炎癌前病变的防治,为临床CAG、PLGC的防治提供新思路,同时发挥中医"治未病-已病防变"的优势。

关键词：脾虚毒损胃络慢性萎缩性胃炎癌前病变健脾通络解毒

Recent progress in constructing fluorinated solid-electrolyte interphases for stable lithium metal anodes

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 270-291页

作者： Di Zhang Pengfei Lv wei Qin Xin He Yuanhua He Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of ChinaGuanghan 618307China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Lithium metal batteries(LMBs)are emerging as a promising energy storage solution owing to their high energy density and specific ***,the non-uniform plating of lithium and the potential rupture of the solid-electrolyte interphase(SEI)during extended cycling use may result in dendrite growth,which can penetrate the separator and pose significant short-circuit *** a stable SEI is essential for the long-term operation of the ***-rich SEI has garnered significant attention for its ability to effectively passivate electrodes,regulate lithium deposition,and inhibit electrolyte *** the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode *** paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal *** focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI *** instance,combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the *** metals with LiF significantly improves electrochemical performance at the SEI/anode interface,with a necessary focus on reducing electron tunneling ***,incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity,though maintaining structural stability over long cycles remains a critical area for future *** alloys combined with LiF increase surface energy and lithium affinity,challenges such as dendrite growth and volume expansion *** summary,this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

关键词： LiF lithium metal anodes solid-electrolyte interphase interface cycling stability

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting liu wei Huang Jiayi Wen Xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

应用激光扫描细胞仪分析GRP78在食管癌各级病变中的表达情况

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华中科技大学学报（医学版） 2009年第4期38卷 425-429页

作者：李伟董虹刘佳李双卢运萍马丁华中科技大学同济医学院附属同济医院妇科肿瘤实验室武汉430030

目的探索应用激光扫描细胞仪分析免疫组化结果的可行性、客观性及准确性,了解葡萄糖调节蛋白78(GRP78)蛋白在食管癌各级病变中的表达情况。方法应用激光扫描细胞仪对食管癌组织芯片中GRP78免疫组化结果进行分析,对激光扫描细胞仪分析结... 详细信息

目的探索应用激光扫描细胞仪分析免疫组化结果的可行性、客观性及准确性,了解葡萄糖调节蛋白78(GRP78)蛋白在食管癌各级病变中的表达情况。方法应用激光扫描细胞仪对食管癌组织芯片中GRP78免疫组化结果进行分析,对激光扫描细胞仪分析结果和传统光镜下评分结果的相关性进行分析。结果激光扫描细胞仪扫描整张组织芯片后获得选定组织区域的虚拟图及阳性像素点百分比;正常食管组织、中-重度异型增生、原位癌、食管鳞癌的GRP78阳性率分别为0%(0/8),90.4%(19/21)、83.3%(5/6)和47.4%(18/38)。GRP78在正常食管、中-重度异型增生加原位癌、食管鳞癌3组中表达的差异有显著性意义(P<0.01)。激光扫描细胞仪分析结果与传统光镜下评分结果具有高度相关性(P<0.01))。结论激光扫描细胞仪用于免疫组化结果的分析具有高通量、高度客观、准确的优点。GRP78在食管正常细胞向恶性细胞转化的过程中可能扮演了重要角色。

关键词：激光扫描细胞仪葡萄糖调节蛋白78 食管癌组织芯片

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关于增强体质的若干思考

体育学刊 2004年第1期11卷 84-86页

作者：姚卫宇刘东海陈永琛内蒙古民族大学体育学院内蒙古通辽028043

学校体育以增强体质为主 ,而“增强体质”这一概念具有模糊性和不确定性。从哲学、生物学角度 ,对学校体育的目标、目的进行了质与量的相关分析。

关键词：学校体育增强体质健康

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日间手术出院后并发症分析

中国现代医学杂志 2016年第17期26卷 90-93页

作者：林莉莫洋石峰华肖映平谭亮刘蔚东中南大学湘雅医院麻醉手术部湖南长沙410008 中南大学湘雅医院日间手术中心湖南长沙410008

目的探讨日间手术患者出院后并发症的发生与安全性。方法建立规范的日间手术随访档案，选取2015年1月一2015年12月中南大学湘雅医院日间手术中心出院患者，进行随访，获取并分析日间手术出院后主要并发症和异常反应。结果共实施日间手术... 详细信息

目的探讨日间手术患者出院后并发症的发生与安全性。方法建立规范的日间手术随访档案，选取2015年1月一2015年12月中南大学湘雅医院日间手术中心出院患者，进行随访，获取并分析日间手术出院后主要并发症和异常反应。结果共实施日间手术3380例（不含前列腺穿刺和胃肠镜下治疗等操作）。其中，男性1642例，女性1738例；年龄2～82岁，平均39．3岁；全身麻醉2153例（63．7％），局部麻醉1227例（36．3％）。随访发现并发症75例（2．2％），72h内急诊6例（0．2％），30d内再住院14例（0．4％），无非计划性再手术患者和死亡患者。出院后主要并发症为手术部位感染、剧烈疼痛、出血和恶心、呕吐，分别为10％（33／3380）、0．9％（30／3380）、0．4％（12／3380）和0．5％（11／2153）。结论日间手术患者出院后严重并发症发生少，建立规范的出院后随访和健康教育制度可以及早发现术后并发症并及时处理，日间手术是一种安全、可行的择期手术模式。

关键词：日间手术并发症随访术后恶心呕吐疼痛

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

Coupled bending-torsion vibration of a homogeneous beam with a single delamination subjected to axial loads and static end moments

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Acta Mechanica Sinica 2014年第4期30卷 607-614页

作者： Yang liu dong-wei Shu School of Mechanical and Aerospace Engineering Nanyang Technological University

Delaminations in structures may significantly reduce the stiffness and strength of the structures and may affect their vibration characteristics. As structural components, beams have been used for various purposes, in many of which beams are often subjected to axial loads and static end moments. In the present study, an analytical solution is developed to study the coupled bending-torsion vibration of a homogeneous beam with a single delamination subjected to axial loads and static end moments. Euler-Bernoulli beam theory and the ＂free mode＂ assumption in delamination vibration are adopted. This is the first study of the influences of static end moments upon the effects of delaminations on natural frequencies, critical buckling loads and critical moments for lateral instability. The results show that the effects of delamination on reducing natural frequencies, critical buckling load and critical moment for lateral instability are aggravated by the presence of static end moment. In turn, the effects of static end moments on vibration and instability characteristics are affected by the presence of delamination. The analytical results of this study can serve as a benchmark for finite element method and other numerical solutions.

关键词： Vibration · Delamination ·End moments · Nat-ural frequency · Critical moment for lateral instability

用反向遗传操作技术产生致弱的H5亚型重组流感病毒

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微生物学报 2005年第1期45卷 53-57页

作者：卢建红龙进学邵卫星韦栋平刘秀梵张艳梅扬州大学农业部畜禽传染病学重点开放实验室扬州225009

选择一株鹅源H5N1亚型禽流感病毒 (AIV) ,缺失其HA基因裂解序列的 4个碱性氨基酸、使HA裂解模式由高致病性的PQRERRRKKR↓GL突变为低致病性的PQRESR↓GL ,将修饰的HA基因克隆入转录表达载体pHW2 0 0 0、构建质粒pHW5 2 4_HA ,将该毒株... 详细信息

选择一株鹅源H5N1亚型禽流感病毒 (AIV) ,缺失其HA基因裂解序列的 4个碱性氨基酸、使HA裂解模式由高致病性的PQRERRRKKR↓GL突变为低致病性的PQRESR↓GL ,将修饰的HA基因克隆入转录表达载体pHW2 0 0 0、构建质粒pHW5 2 4_HA ,将该毒株和H9N2亚型毒株的NA全基因分别克隆入pHW2 0 0 0 ,构建质粒pHW5 0 6_NA和pHW2 0 6_NA。将pHW5 2 4_HA与pHW5 0 6_NA或pHW2 0 6_NA组合、均用A WSN 33(H1N1)提供 6个内部基因 ,两个组合的 8个质粒分别共转染COS_1细胞 ,产生了H5N1和H5N2两个亚型的基因重排病毒。通过在鸡胚中的连续传代和适应 ,2个重组病毒血凝价上升到 1∶2 9、表面基因稳定、对 6周龄SPF鸡不表现致病性 ,H5N2重组病毒对鸡胚的毒力低于H5N1病毒。

关键词：禽流感病毒 H5亚型反向遗传操作技术基因重排致弱