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Regulation of TMEM100 expression by epigenetic modification,effects on proliferation and invasion of esophageal squamous carcinoma

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World Journal of Clinical Oncology 2024年第4期15卷 554-565页

作者： Yue-Feng Xu Yan Dang wei-bo kong Han-Lin Wang Xiu Chen Long Yao Yuan Zhao Ren-Quan Zhang Department of Thoracic Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a prevalent malignancy with a high morbidity and mortality ***100 has been shown to be suppressor gene in a variety of tumors,but there are no reports on the role of TMEM100 in esophageal cancer(EC).AIM To investigate epigenetic regulation of TMEM100 expression in ESCC and the effect of TMEM100 on ESCC proliferation and *** Firstly,we found the expression of TMEM100 in EC through The Cancer Genome Atlas *** correlation between TMEM100 gene expression and the survival of patients with EC was further confirmed through Kaplan-Meier *** then added the demethylating agent 5-AZA to ESCC cell lines to explore the regulation of TMEM100 expression by epigenetic *** observe the effect of TMEM100 expression on tumor proliferation and invasion by overexpressing ***,we performed gene set enrichment analysis using the Kyoto Encyclopaedia of Genes and Genomes Orthology-Based Annotation System database to look for pathways that might be affected by TMEM100 and verified the effect of TMEM100 expression on the mitogen-activated protein kinases(MAPK)*** In the present study,by bioinformatic analysis we found that TMEM100 was lowly expressed in EC patients compared to normal ***-meier survival analysis showed that low expression of TMEM100 was associated with poor prognosis in patients with ***,we found that the demethylating agent 5-AZA resulted in increased expression of TMEM100 in ESCC cells[quantitative real-time PCR(qRT-PCR)and western blotting].Subsequently,we confirmed that overexpression of TMEM100 leads to its increased expression in ESCC cells(qRT-PCR and western blotting).Overexpression of TMEM100 also inhibited proliferation,invasion and migration of ESCC cells(cell counting kit-8 and clone formation assays).Next,by enrichment analysis,we found that the gene set was significantly enriched in the MAPK signaling *** involvement

关键词： Esophageal squamous cell carcinoma TMEM100 Invasion Mitogen-activated protein kinases pathway Epigenetic

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A facile synthesis of ω-aminoalkyl ammonium hydrogen phosphates

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Chinese Chemical Letters 2012年第8期23卷 923-926页

作者： wei bo kong Xiao Yong Zhou Yang Yang Xing Yi Xie Department of Polymeric Biomaterials and Artificial Organs College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

A series of og-aminoalkyl ammonium hydrogen phosphates were synthesized through a simple and efficient three-step method. The starting materials, co-aminoalkyl alcohols （AC-n, with carbon number n = 3, 4, 5, 6）, were amino-protected with 9- fluorenylmethyl chloroformate （Fmoc-C1）, followed by phosphorylation with POCI3 and deprotection in piperidine/DME The structures of each intermediate and final product were confirmed by 1H NMR, FTIR and mass spectrum. The yield of each step was about 77-92%, with a total yield higher than 56%. This new method was superior in low-cost raw materials, mild reaction temperatures （0-25 ℃） and easy purification methods.

关键词： Amino alcohol Phosphorus oxychloride Synthesis Aminoalkyl ammonium hydrogen phosphate

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Water dispersible hydroxyapatite nanoparticles functionalized by a family of aminoalkyl phosphates

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Chinese Chemical Letters 2015年第9期26卷 1121-1128页

作者： Yi-Rou Jiang Fu-Hua Sun Xiao-Yong Zhou wei-bo kong Xing-Yi Xie Department of Polymeric Biomaterials and Artificial Organs College of Polymer Science and EngineeringSichuan University

A series of aminoalkyi phosphates（AAP-n,with carbon number n ranging from 2 to 6） are used as surface modifiers to prepare hydroxyapatite *** resulting nanoparticles（Cn-HA） possess a coreshell structure where an ionized layer of calcium-（AAP-n） complex[^＋H3N-（CH2）n-OPO3Ca]encapsulates each hydroxyapatite ***-term colloidal stability is achieved due to the electrostatic repulsion among the suspending *** incorporation of AAP-n results in a preferential crystal growth along c-axis,showing an increasing aspect ratio of particles from C2-HA to *** cell culture using osteoblast-like MG63 cells shows no cytotoxicity associated with the as-prepared Cn-HA *** functional amino groups around the nanoparticles could be used to graft various organic chains to prepare homogeneous HA/polymer composites as bone grafting materials.

关键词： Hydroxyapatite Hydrocolloid Aminoalkyl phosphate Cytotoxicity

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Seasonal increase in nest defense,but not egg rejection,in a cuckoo host

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Avian Research 2024年第1期15卷 50-54页

作者： bo Zhou wei Liang Ministry of Education Key Laboratory for Ecology of Tropical Islands Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikou 571158China Institute of Biological Resources Jiangxi Academy of ScienceNanchang 330096China

The interactions between avian brood parasites and their hosts provide an informative and easy-to-handle system for studying *** brood parasitism reduces the reproductive success of hosts,and thus,hosts have evolved anti-parasitic strategies,such as rejecting parasitic eggs and adopting aggressive nest defense strategies,to avoid the cost brought on by brood *** test whether host anti-parasitic strategies are adjusted with the risk of being parasitized when the breeding seasons of brood parasites and hosts are not synchronous,we conducted a field experiment assessing nest defense and egg recognition behaviors of the Isabelline Shrike(Lanius isabellinus),a host of the Common Cuckoo(Cuculus canorus).In the local area,the host Isabelline Shrike begins to breed in April,whereas the summer migratory Common Cuckoo migrates to the local area in May and begins to lay parasitic *** showed that nest defense behaviors of the Isabelline Shrike increases significantly after cuckoo arrival,showing higher aggressiveness to cuckoo dummies,with no significant difference in attack rates among cuckoo,sparrowhawk and dove dummies,but their egg rejection did not change *** results imply that Isabelline Shrikes may adjust their nest defense behavior,but not egg rejection behavior,with seasonality.

关键词： Aggression Anti-parasite strategy Egg rejection Mismatch cuckoo parasitism Nest defense

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Almost Periodic Type Group Actions on Compact Quantum Metric Spaces

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Acta Mathematica Sinica,English Series 2024年第2期40卷 568-594页

作者： bo Tao LONG wei WU College of Mathematics MIIT Key Laboratory of Mathematical Modelling and High Performance Computing of Air VehiclesNanjing University of Aeronautics and AstronauticsNanjing 211106P.R.China School of Mathematical Sciences Shanghai Key Laboratory of Pure Mathematics and Mathematical PracticeEast China Normal UniversityShanghai 200241P.R.China

A compact quantum metric space is a complete order unit space A endowed with a Lipnorm *** give some characterizations of almost periodic type group actions on a compact quantum metric space(A,L)by means of several kinds of subsets of A,its induced equicontinuous actions on several important subsets of the dual Banach space A*,and the Lip-norm L with its induced metric space structures on the state space S(A)of A.

关键词： Lip-norm compact quantum metric space Lipschitz isomorphism almost periodicity Arzela-Ascoli theorem metric set

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Perenniality:From model plants to applications in agriculture

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Molecular Plant 2024年第1期17卷 141-157页

作者： bo Zhao Jia-wei Wang National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences(CEMPS)Institute of Plant Physiology and Ecology(SIPPE)Chinese Academy of Sciences(CAS)Shanghai 200032China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Plant Carbon Capture CASShanghai 200032China New Cornerstone Science Laboratory Shanghai 200032China

To compensate for their sessile nature,plants have evolved sophisticated mechanisms enabling them to adapt to ever-changing *** such prominent feature is the evolution of diverse life history strategies,particularly such that annuals reproduce once followed by seasonal death,while perennials live longer by cycling growth *** intrinsic phenology is primarily genetic and can be altered by environmental *** evolutionary transitions between annual and perennial life history strategies are common,perennials account for most species in nature because they survive well under year-round *** proportion,however,is reversed in ***,perennial crops promise to likewise protect and enhance the resilience of agricultural ecosystems in response to climate *** significant endeavors that have been made to generate perennial crops,progress is slow because of barriers in studying perennials,and many developed species await further *** findings in model species have illustrated that simply rewiring existing genetic networks can lead to lifestyle *** implies that engineering plant life history strategy can be achieved by manipulating only a few key *** this review,we summarize our current understanding of genetic basis of perenniality and discuss major questions and challenges that remain to be addressed.

关键词： perenniality developmental plasticity flowering time poplar Arabis alpina perennial crops life history strategy

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Numerical Investigations on the Resonance Errors of Multiscale Discontinuous Galerkin Methods for One-Dimensional Stationary Schrödinger Equation

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Communications on Applied Mathematics and Computation 2024年第1期6卷 311-324页

作者： bo Dong wei Wang Department of Mathematics University of Massachusetts DartmouthNorth DartmouthMA02747USA Department of Mathematics and Statistics Florida International UniversityMiamiFL33199USA

In this paper,numerical experiments are carried out to investigate the impact of penalty parameters in the numerical traces on the resonance errors of high-order multiscale discontinuous Galerkin(DG)methods(Dong et *** J Sci Comput 66:321–345,2016;Dong and Wang in J Comput Appl Math 380:1–11,2020)for a one-dimensional stationary Schrödinger *** work showed that penalty parameters were required to be positive in error analysis,but the methods with zero penalty parameters worked fine in numerical simulations on coarse *** this work,by performing extensive numerical experiments,we discover that zero penalty parameters lead to resonance errors in the multiscale DG methods,and taking positive penalty parameters can effectively reduce resonance errors and make the matrix in the global linear system have better condition numbers.

关键词： Discontinuous Galerkin(DG)method Multiscale method Resonance errors One-dimensional Schrödinger equation

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Novel Adaptive Memory Event-Triggered-Based Fuzzy Robust Control for Nonlinear Networked Systems via the Differential Evolution Algorithm

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1836-1848页

作者： wei Qian Yanmin Wu bo Shen School of Electrical Engineering and Automation Henan Polytechnic UniversityJiaozuo 454000China College of Information Science and Technology Donghua UniversityShanghai 201620China

This article mainly investigates the fuzzy optimization robust control issue for nonlinear networked systems characterized by the interval type-2(IT2)fuzzy technique under a differential evolution *** provide a more reasonable utilization of the constrained communication channel,a novel adaptive memory event-triggered(AMET)mechanism is developed,where two event-triggered thresholds can be dynamically adjusted in the light of the current system information and the transmitted historical *** conditions with less conservative design of the fuzzy imperfect premise matching(IPM)controller are presented by introducing the Wirtinger-based integral inequality,the information of membership functions(MFs)and slack ***,under the IPM policy,a new MFs intelligent optimization technique that takes advantage of the differential evolution algorithm is first provided for IT2 TakagiSugeno(T-S)fuzzy systems to update the fuzzy controller MFs in real-time and achieve a better system control ***,simulation results demonstrate that the proposed control scheme can obtain better system performance in the case of using fewer communication resources.

关键词： Adaptive memory event-triggered(AMET) differential evolution algorithm fuzzy optimization robust control interval type-2(IT2)fuzzy technique.

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Bed inventory balance and stability of dual circulating fluidized bed systems

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Particuology 2024年第1期84卷 98-106页

作者： Yangjun wei Leming Cheng David Pallares bo Leckner Institute for Thermal Power Engineering State Key Laboratory of Clean Energy UtilizationZhejiang UniversityHangzhou310027China Department of Space Earth and EnvironmentChalmers University of TechnologyS-41296GöteborgSweden

Experiments and modelling are conducted for general understanding on the imbalance phenomenon and for discussion on the strategies to improve the bed inventory balance and stability of a dual circulating fluidized bed(DCFB)*** experiments are carried out in a 15.5 m high pilot-scale DCFB cold test system.A fluid-dynamic DCFB model is developed based on a 1.5-dimensional semi-empirical model of an industrial CFB boiler,validated by experimental *** effects of control methods and operation conditions on the bed inventory balance and on the stability of the pilot-and large-scale DCFB systems are discussed.A"stable-unbalanced"state,where the system reaches a steady state,consisting of un-balanced bed inventories,is observed in both experiments and model *** maintain a balanced state and similar bed inventory in the DCFB systems with similar cross-sectional areas,it is recom-mended to keep similar total pressure drops or gas velocities in both reactors.

关键词： Bed inventory balance Stability Dual circulating fluidized bed(DCFB) Experiment Modelling

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Fixed-Time Antidisturbance Consensus Tracking for Nonlinear Multiagent Systems With Matching and Mismatching Disturbances

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1410-1423页

作者： Xiangmin Tan Chunyan Hu Guanzhen Cao Qinglai wei wei Li bo Han Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190 School of Aeronautics and Astronautics University of Chinese Academy of SciencesBeijing 100049China Institute of Automation Chinese Academy of SciencesBeijing 100190 School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China IEEE

In this paper,fixed-time consensus tracking for mul-tiagent systems(MASs)with dynamics in the form of strict feed-back affine nonlinearity is addressed.A fixed-time antidistur-bance consensus tracking protocol is proposed,which consists of a distributed fixed-time observer,a fixed-time disturbance observer,a nonsmooth antidisturbance backstepping controller,and the fixed-time stability analysis is conducted by using the Lyapunov theory *** paper includes three main ***,a distributed fixed-time observer is developed for each follower to obtain an estimate of the leader’s output by utilizing the topology of the communication ***,a fixed-time disturbance observer is given to estimate the lumped disturbances for feedforward ***,a nonsmooth antidisturbance backstepping tracking controller with feedforward compensation for lumped disturbances is *** order to mitigate the“explosion of complexity”in the tradi-tional backstepping approach,we have implemented a modified nonsmooth command filter to enhance the performance of the closed-loop *** simulation results show that the pro-posed method is effective.

关键词： Antidisturbance backstepping consensus tracking fixed-time stability multiagent system(MASs) strict feedback affine nonlinear systems.

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