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Albumin-to-alkaline phosphatase ratio: A novel prognostic index of overall survival in cholangiocarcinoma patients after surgery

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World Journal of Gastrointestinal Oncology 2019年第1期11卷 39-47页

作者： Jian-Ping Xiong Jun-yu Long wei-yu xu Jin Bian Han-Chun Huang Yi Bai Yi-Yao xu Hai-Tao Zhao Xin Lu Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College

AIM To clarify the prognostic significance of preoperative albumin-to-alkaline phosphatase ratio(AAPR) in cholangiocarcinoma(CCA) subjects receiving *** In this retrospective study, we included 303 CCA patients receiving surgery without preoperative therapy between 2002 and 2014. Clinicopathological characteristics(including AAPR) were analyzed to determine predictors of postoperative overall survival and recurrence-free survival(RFS). In addition,univariate and multivariate Cox proportional hazards models were conducted,followed by application of time-dependent receiver operating curves to identify the optimal *** Univariate and multivariate analyses revealed both decreased overall survival[hazard ratio(HR): 2.88, 95%CI: 1.19-5.78] and recurrence-free survival(HR: 2.31,95%CI: 1.40–3.29) in patients with AAPR < 0.41 compared to those with AAPR ≥0.41. The optimal cut-off of AAPR was 0.41. Of the 303 subjects, 253(83.5%) had an AAPR over 0.41. The overall 1-, 3- and 5-year survival rates were 70.2%, 38.0% and 16.5%, respectively in the low(< 0.41) AAPR group, which were significantly lower than those in the high(≥ 0.41) AAPR group(81.7%, 53.9%, and 33.4%,respectively)(P < 0.0001). Large tumor size, multiple tumors, and advanced clinical stage were also identified as significant predictors of poor *** Our outcomes showed that AAPR was a potential valuable prognostic indicator in CCA patients undergoing surgery, which should be further confirmed by prospective studies. Moreover, it is necessary to investigate the mechanisms concerning the correlation of low AAPR with poor post-operative survival in CCA patients.

关键词： Albumin-to-alkaline phosphatase ratio Cholangiocarcinoma Prognosis Surgery Survival

Multiple organ dysfunction and rhabdomyolysis associated with moonwort poisoning: Report of four cases

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World Journal of Clinical Cases 2020年第2期8卷 479-486页

作者： Fang Li An-Bao Chen Yong-Chun Duan Rui Liao yu-wei xu Li-Li Tao Department of Emergency Medicine The Second Affiliated Hospital of Kunming Medical University

BACKGROUND Moonwort is a widely used Chinese herbal medicine. It has various pharmacological effects, such as relieving cough and preventing asthma. To date,multiple organ dysfunction and rhabdomyolysis caused by moonwort poisoning have not been *** SUMMARY Here we report four cases of moonwort poisoning that presented with multiple organ dysfunction and rhabdomyolysis accompanied by vomiting, fatigue, and muscle aches. One patient was an adult male, two were adult females, and one was a boy, with an age range of 7–64 years. The adults were treated with hemoperfusion and symptomatic therapies, while the child was treated with plasma exchange and symptomatic therapies. All four patients *** Blood purification combined with symptomatic treatment may be an effective method for managing multiple organ dysfunction and rhabdomyolysis caused by acute moonwort poisoning.

关键词： Moonwort poisoning Multiple organ dysfunction Rhabdomyolysis Hemoperfusion Plasma exchange Case report

Self-assembly of Gold Nanoparticle Chains between Nanoelectrodes

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Chinese Chemical Letters 2006年第6期17卷 845-847页

作者： Ning GU Jian Hui LIAO Lan HUANG Zhi Rui GUO wei yu Li Na xu Jing WANG Key Laboratory of Molecular and Biomolecular Electronics Department of Biological Science and Medical Engineering Southeast University Nanjing 210096

A novel strategy has been developed for construction of nanoparticle chains between nanoelectrodes with bifunctional molecules by taking advantage of linear aggregation of colloidal particles in organis solvents. As confirmed by scanning electron microscopy （SEM）,an individual nanoparticle chain bridged the electrode pair. The present approach makes this technique to be cheap and may be applicable in microelectronic industry.

关键词： Self-assembly nanoparticle chain nanoelectrode.

Prognostic significance of combined preoperative fibrinogen and CA199 in gallbladder cancer patients

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World Journal of Gastroenterology 2018年第13期24卷 1451-1463页

作者： wei-yu xu Hao-Hai Zhang Xiao-Bo Yang Yi Bai Jian-Zhen Lin Jun-yu Long Jian-Ping Xiong Jun-wei Zhang Xin-Ting Sang Hai-Tao Zhao Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

AIM To investigate the prognostic value of the combination of preoperative plasma fibrinogen and CA199 in patients with gallbladder carcinoma(GBC).METHODS The clinicopathological data of 154 GBC patients were retrospectively reviewed after surgery. A receiver operating characteristic(ROC) curve was plotted to verify the optimum cut-off values for plasma fibrinogen and CA199. Univariate and multivariate survival analyses were performed to identify the factors associated with GBC prognosis. based on the HRs calculated via multivariate survival analyses, patients with elevated plasma fibrinogen and CA199 levels were allocated a score of 2.1; those with an elevated plasma fibrinogen level only were allocated a score of 1, those with an elevated CA199 level only were allocated a score of 1.1, and those with neither of these abnormalities were allocated a score of *** ROC curve analysis showed that the optimum cut-off values for preoperative plasma fibrinogen and CA199 were 3.47 g/L and 25.45 U/mL, respectively. Multivariate analysis indicated that elevated preoperative plasma fibrinogen and CA199 levels were significantly correlated with worse overall survival(OS)(HR = 1.711, 95%CI: 1.114-2.627, P = 0.014, and HR = 1.842, 95%CI: 1.111-3.056, P = 0.018). When we combined these two parameters, the area under the ROC curve increased from 0.735(for preoperative plasma fibrinogen only) and 0.729(for preoperative CA199 only) to 0.765. When this combined variable was added to the multivariate analysis, the combination of plasma fibrinogen and CA199(P < 0.001), resection margin(P < 0.001) and TNM stage(P = 0.010) were independent prognostic factors for *** The combination of plasma fibrinogen and CA199 may serve as a more efficient independent prognostic biomarker for postoperative GBC patients than either parameter alone.

关键词： Prognostic factor Plasma fibrinogen CA199 Survival Gallbladder cancer

The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats

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Biomedical and Environmental Sciences 2011年第5期24卷 550-559页

作者： YANG HaiBo xu ZhaoFa LIU wei DENG yu xu Bin Department of Environmental Health School of Public Health China Medical University Shenyang 110001 Liaoning China

Objective This study aims to investigate the protection of procyanidins and lycopene from the renal damage induced by mercuric *** Rats were treated with either procyanidins or lycopene 2h before HgCl 2 subcutaneously injection,once daily treatment for 2 successive *** In comparison with HgCl 2 group,markers of renal function such as blood urea nitrogen in serum and urinary protein were decreased to （18.45±11.63） mmol/L and （15.93±9.36） mmol/L,（4.54±0.78） g/（g Cr） and （4.40±1.12） g/（g Cr）.N‐acetyl‐beta‐D‐glucosaminidase,lactate dehydrogenase,alkaline phosphatase in urine were depressed to （125.49±11.68） U/（g Cr）,（103.73±21.79） U/（g Cr）,（101.99±12.28） U/（g Cr）,and （113.19±23.74） U/（g Cr）,（71.14±21.80） U/（g Cr）,（73.64±21.51） U/（g Cr） in procyanidins and lycopene *** of oxidative stress,for example,Glutathion was reduced to （45.58±9.89） μmol/（g pro） and （45.33±5.90） μmol/（g pro）,and antioxidant enzymes such as superoxide dismutase,glutathione‐peroxidase were enhanced to （43.07±10.97） U/（mg pro） and （39.94±6.04） U/（mg pro）,（83.85±18.48） U/（mg pro）,and （85.62±12.68） U/（mg pro）.Malondialdehyde was lowered to （0.95±0.12）（μmol/g pro） and （1.03±0.12） μmol/（g pro） in procyanidins and lycopene *** generation was decreased by 27.63% and 16.40% and apoptosis was also decreased in procyanidins and lycopene groups *** changes were much better as *** Procyanidins and Lycopene play some protective role against mercury kidney damage.

关键词： Mercuric chloride Procyanidins Lycopene Renal damage Protection

Threonine and tyrosine kinase may serve as a prognostic biomarker for gallbladder cancer

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World Journal of Gastroenterology 2017年第31期23卷 5787-5797页

作者： yuan Xie Jian-Zhen Lin An-Qiang Wang wei-yu xu Jun-yu Long yu-Feng Luo Jie Shi Zhi-Yong Liang Xin-Ting Sang Hai-Tao Zhao Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College

AIM To detect the expression of threonine and tyrosine kinase(TTK) in gallbladder cancer(GBC) specimens and analyze the associations between TTK expression and clinicopathological parameters and clinical *** A total of 68 patients with GBC who underwent surgical resection were enrolled in this study. The expression of TTK in GBC tissues was detected by immunohistochemistry. The assessment of TTKexpression was conducted using the H-scoring system. H-score was calculated by the multiplication of the overall staining intensity with the percentage of positive cells. The expression of TTK in the cytoplasm and nucleus was scored separately to achieve respective H-s c o r e v a l u e s. T h e c o r r e l a t i o n s b e t w e e n T T K expression and clinicopathological parameters and clinical prognosis were analyzed using Chi-square test, Kaplan-Meier method and Cox *** In both the nucleus and cytoplasm, the expression of TTK in tumor tissues was significantly lower than that in normal tissues(P < 0.001 and P = 0.026, respectively). Using the median H-score as the cutoff value, it was discovered that, GBC patients with higher levels of TTK expression in the nucleus, but not the cytoplasm, had favorable overall survival(P < 0.001), and it was still statistically meaningful in Cox regression analysis. Further investigation indicated that there were close negative correlations between TTK expression and tumor differentiation(P = 0.041), CA 19-9 levels(P = 0.016), T stage(P < 0.001), nodal involvement(P < 0.001), distant metastasis(P = 0.024) and TNM stage(P < 0.001). CONCLUSION The expression of TTK in GBC is lower than that in normal tissues. Higher levels of TTK expression in GBC are concomitant with longer overall survival. TTK is a favorable prognostic biomarker for patients with GBC.

关键词： Threonine and tyrosine kinase Biomarker Prognosis Gallbladder cancer

γ-glutamyl transferase-to-platelet ratio based nomogram predicting overall survival of gallbladder carcinoma

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World Journal of Gastrointestinal Oncology 2020年第9期12卷 1014-1030页

作者： Le-Jia Sun Ai Guan wei-yu xu Mei-Xi Liu Huan-Huan Yin Bao Jin Gang xu Fei-Hu Xie Hai-Feng xu Shun-Da Du Yi-Yao xu Hai-Tao Zhao Xin Lu Xin-Ting Sang Hua-yu Yang Yi-Lei Mao Department of Liver Surgery Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of Clinical Medicine Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of General Surgery Beijing Friendship HospitalCapital Medical UniversityBeijing 100730China

BACKGROUND Gallbladder carcinoma(GBC)carries a poor prognosis and requires a prediction ***-glutamyl transferase–to–platelet ratio(GPR)is a recently reported cancer prognostic *** the mechanism for the relationship between GPR and poor cancer prognosis remains unclear,studies have demonstrated the clinical effect of both gamma-glutamyl transferase and platelet count on GBC and related gallbladder *** To assess the prognostic value of GPR and to design a prognostic nomogram for *** The analysis involved 130 GBC patients who underwent surgery at Peking Union Medical College Hospital from December 2003 to April *** patients were stratified into a high-or low-GPR *** predictive ability of GPR was evaluated by Kaplan–Meier analysis and a Cox regression *** developed a nomogram based on GPR,which we verified using calibration *** nomogram and other prognosis prediction models were compared using timedependent receiver operating characteristic curves and the concordance *** Patients in the high-GPR group had a higher risk of jaundice,were older,and had higher carbohydrate antigen 19-9 levels and worse postoperative *** analysis revealed that GPR,age,body mass index,tumor–node–metastasis(TNM)stage,jaundice,cancer cell differentiation degree,and carcinoembryonic antigen and carbohydrate antigen 19-9 levels were related to overall survival(OS).Multivariate analysis confirmed that GPR,body mass index,age,and TNM stage were independent predictors of poor *** curves were highly consistent with actual *** of timedependent receiver operating characteristic curves and the concordance index showed advantages for the nomogram over TNM *** GPR is an independent predictor of GBC prognosis,and nomogram-integrated GPR is a promising predictive model for OS in GBC.

关键词： Gamma-glutamyl transferase-to-platelet ratio Gallbladder carcinoma Prognosis Nomogram Tumor-node-metastasis Patient management

Multidisciplinary management of hepatobiliary tumors in the era of precision medicine

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Hepatobiliary & Pancreatic Diseases International 2018年第5期17卷 381-382页

作者： Jian-Zhen Lin Yi Bai An-Qiang Wang Jun-yu Long wei-yu xu Ke Hu Lin Zhao Jie Pan Xin-Ting Sang Hai-Tao Zhao Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Gastrointestinal Surgery Peking University Cancer Hospital and InstituteBeijing 100142China Center of Radiotherapy Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Medical Oncology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Hepatobiliary tumor (HBT), one of the leading causes of cancer deaths globally, is more frequent in East Asia including China [1].HBTincludeslivercancer,cholangiocarcinomaandgallbladder *** ***isB-typevirus

关键词： Multidisciplinary management of hepatobiliary tumors in the era of precision medicine HBT

Nomogram to predict overall survival after gallbladder cancer resection in China

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World Journal of Gastroenterology 2018年第45期24卷 5167-5178页

作者： Yi Bai Zhi-Song Liu Jian-Ping Xiong wei-yu xu Jian-Zhen Lin Jun-yu Long Fei Miao Han-Chun Huang xue-Shuai Wan Hai-Tao Zhao Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Statistics Tianjin University of Finance and Economics Pearl River College

AIM To integrate clinically significant variables related to prognosis after curative resection for gallbladder carcinoma(GBC) into a predictive *** One hundred and forty-two GBC patients who underwent curative intent surgical resection at Peking Union Medical College Hospital(PUMCH) were included. This retrospective case study was conducted at PUMCH of the Chinese Academy of Medical Sciences and Peking Union Medical College(CAMS & PUMC) in China from January 1, 2003 to January 1, 2018. The continuous variable carbohydrate antigen 19-9(CA19-9) was converted into a categorical variable(cCA19-9) based on the normal reference range. Stages 0 to IIIA were merged into one category, while the remaining stages were grouped into another category. Pathological grade X(GX) was treated as a missing value. A multivariate Cox proportional hazards model was used to select variables to construct a nomogram. Discrimination and calibration of the nomogram were performed via the concordance index(C-index) and calibration plots. The performance of the nomogram was estimated using the calibration curve. Receiver operating characteristic(ROC) curve analysis and decision curve analysis(DCA) were performed to evaluate the predictive accuracy and net benefit of the nomogram, *** Of these 142 GBC patients, 55(38.7%) were male, and the median and mean age were 64 and 63.9 years, respectively. Forty-eight(33.8%) patients in this cohort were censored in the survival analysis. The median survival time was 20 months. A series of methods, including the likelihood ratio test and Akaike information criterion(AIC) as well as stepwise, forward, and backward analyses, were used to select the model, and all yielded identical results. Jaundice [hazard ratio(HR) = 2.9; 95% confidence interval(CI): 1.60-5.27], cCA19-9(HR = 3.2; 95%CI: 1.91-5.39), stage(HR = 1.89; 95%CI: 1.16-3.09), and resection(R)(HR = 2.82; 95%CI: 1.54-5.16) were selected as significant predictors and combi

关键词： Nomogram Survival Prognosis Gallbladder cancer Resection