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Science Bulletin 2024年第13期69卷 2059-2070页

作者： Chuanliang wei Zhengran Wang Peng Wang Xinlu Zhang Xuguang An Jinkui Feng Baojuan Xi Shenglin xiong School of Chemistry and Chemical Engineering School of Materials Science and EngineeringShandong UniversityJinan 250100China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

The practical application of lithium–sulfur(Li–S)batteries is inhibited by the shuttle effect of lithium polysulfides(LiPSs)and slow polysulfide redox kinetics on the S cathode as well as the uncontrollable growth of dendrites on the Li metal ***,both cathode and anode sides must be considered when modifying LiS ***,two-dimensional(2D)ultrathin CoSe_(2)nanobelts are in situ grown on 2D N-doped MXene nanosheets(CoSe_(2)@N-MXene)via one-step solvothermal process for the first *** to its unique 2D/2D structure,CoSe_(2)@N-MXene can be processed to crumpled nanosheets by freeze-drying and flexible and freestanding films by vacuum *** crumpled CoSe_(2)@NMXene nanosheets with abundant active sites and inner spaces can act as S hosts to accelerate polysulfide redox kinetics and suppress the shuttle effect of LiPSs owing to their strong adsorption ability and catalytic conversion effect with ***,the CoSe_(2)@N-MXene film(CoSe_(2)@NMF)can act as a current collector to promote uniform Li deposition because it contains lithiophilic CoSe_(2)and N *** the systematic effect of CoSe_(2)@N-MXene on S cathode and Li metal anode,the electrochemical and safety performance of Li–S batteries are ***_(2)@NMF also shows excellent storage performances in flexible energy storage devices.

关键词： Ultrathin CoSe_(2)nanobelts N-doped MXene nanosheets In situ growth Flexible MXene-based films Li-S batteries

Regulating CRISPR/Cas9 Using Streptavidin-Biotin Interactions

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Chinese Journal of Chemistry 2024年第12期42卷 1387-1393页

作者： wei Shen wei xiong Qianqian Qi xingyu Liu Zhongpao Xie Yuanyuan Zhang Jinxuan Hou Tian Tian Xiang Zhou College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei 430072China Department of Thyroid&Breast Surgery Zhongnan Hospitalof Wuhan University Wuhan Hubei43001Chin

Comprehensive Summary Currently,CRISPR/Cas9 technology has found widespread applications across various ***,the utility of CRISPR/Cas9 is encumbered by issues pertaining to its reliability and safety,primarily stemming from the uncontrolled activity of the ***,the design and development of CRISPR/Cas9 systems with controllable activity is of paramount ***,characterized by its small molecular weight,and streptavidin,distinguished by its substantial spatial steric hindrance,can be harnessed as an ideal OFF switch(termed a"bioactivity brake")due to their interaction *** this work,we present a strategy that employs the streptavidin-biotin interaction as a"brake system"for CRISPR/Cas9,effectively allowing for the shutdown of the enzymatic activity of CRISPR/Cas9.

关键词： Streptavidin-biotin CRISPR/Cas9 CRISPR-OFF Guide RNA 2'-OH acylation Gene technology DNA cleavage

Ferroptosis:a critical mechanism of N^(6)-methyladenosine modification involved in carcinogenesis and tumor progression

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Science China(Life Sciences) 2024年第6期67卷 1119-1132页

作者： Qingqing wei Changning Xue Mengna Li Jianxia wei Lemei Zheng Shipeng Chen Yumei Duan Hongyu Deng Faqing Tang wei xiong Ming Zhou NHC Key Laboratory of Carcinogenesis Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China Cancer Research Institute and School of Basic Medical Sciences Central South UniversityChangsha 410078China The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Central South UniversityChangsha 410078China Hunan Key Laboratory of Oncotarget Gene Hunan Key Laboratory of Cancer MetabolismHunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China

Ferroptosis is an iron-dependent regulatory cell necrosis induced by iron overload and lipid *** occurs when multiple redoxactive enzymes are ectopically expressed or show abnormal ***,the precise regulation of ferroptosis-related molecules is mediated across multiple levels,including transcriptional,posttranscriptional,translational,and epigenetic levels.N^(6)-methyladenosine(m^(6)A)is a highly evolutionarily conserved epigenetic modification in *** m^(6)A modification is commonly linked to tumor proliferation,progression,and therapy resistance because it is involved in RNA metabolic ***,accumulating evidence suggests that dysregulated ferroptosis caused by the m^(6)A modification drives tumor *** this review,we summarized the roles of m^(6)A regulators in ferroptosis-mediated malignant tumor progression and outlined the m^(6)A regulatory mechanism involved in ferroptosis *** also analyzed the potential value and application strategies of targeting m^(6)A/ferroptosis pathway in the clinical diagnosis and therapy of tumors.

关键词： ferroptosis m6A modification RNA methylation m^(6)A regulator tumor progression

Piezotronic neuromorphic devices:principle,manufacture,and applications

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International Journal of Extreme Manufacturing 2024年第3期6卷 363-385页

作者： Xiangde Lin Zhenyu Feng Yao xiong Wenwen Sun Wanchen Yao Yichen wei Zhong Lin Wang Qijun Sun Department of Research Shanghai University of Medicine and Health Sciences Affiliated Zhoupu HospitalShanghai 201318People’s Republic of China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400People’s Republic of China Center on Nanoenergy Research School of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004People’s Republic of China Shandong Zhongke Naneng Energy Technology Co. LtdDongying 257061People’s Republic of China Georgia Institute of Technology AtlantaGA 30332-0245United States of America

With the arrival of the era of artificial intelligence(AI)and big data,the explosive growth of data has raised higher demands on computer hardware and *** techniques inspired by biological nervous systems are expected to be one of the approaches to breaking the von Neumann *** neuromorphic devices modulate electrical transport characteristics by piezopotential and directly associate external mechanical motion with electrical output signals in an active manner,with the capability to sense/store/process information of external *** this review,we have presented the piezotronic neuromorphic devices(which are classified into strain-gated piezotronic transistors and piezoelectric nanogenerator-gated field effect transistors based on device structure)and discussed their operating mechanisms and related manufacture ***,we summarized the research progress of piezotronic neuromorphic devices in recent years and provided a detailed discussion on multifunctional applications,including bionic sensing,information storage,logic computing,and electrical/optical artificial ***,in the context of future development,challenges,and perspectives,we have discussed how to modulate novel neuromorphic devices with piezotronic effects more *** is believed that the piezotronic neuromorphic devices have great potential for the next generation of interactive sensation/memory/computation to facilitate the development of the Internet of Things,AI,biomedical engineering,etc.

关键词： piezotronics neuromorphic devices strain-gated transistors piezoelectric nanogenerators synaptic transistors

Joint UAV trajectory and communication design with heterogeneous multi-agent reinforcement learning

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Science China(Information Sciences) 2024年第3期67卷 225-245页

作者： Xuanhan ZHOU Jun xiong Haitao ZHAO Xiaoran LIU Baoquan REN Xiaochen ZHANG Jibo wei Hao YIN College of Electronic Science and Technology National University of Defense Technology Systems Engineering Institute Academy of Military Sciences PLA

Unmanned aerial vehicles(UAVs) are recognized as effective means for delivering emergency communication services when terrestrial infrastructures are unavailable. This paper investigates a multiUAV-assisted communication system, where we jointly optimize UAVs’ trajectories, user association, and ground users(GUs)’ transmit power to maximize a defined fairness-weighted throughput metric. Owing to the dynamic nature of UAVs, this problem has to be solved in real time. However, the problem’s non-convex and combinatorial attributes pose challenges for conventional optimization-based algorithms, particularly in scenarios without central controllers. To address this issue, we propose a multi-agent deep reinforcement learning(MADRL) approach to provide distributed and online solutions. In contrast to previous MADRLbased methods considering only UAV agents, we model UAVs and GUs as heterogeneous agents sharing a common objective. Specifically, UAVs are tasked with optimizing their trajectories, while GUs are responsible for selecting a UAV for association and determining a transmit power level. To learn policies for these heterogeneous agents, we design a heterogeneous coordinated QMIX(HC-QMIX) algorithm to train local Q-networks in a centralized manner. With these well-trained local Q-networks, UAVs and GUs can make individual decisions based on their local observations. Extensive simulation results demonstrate that the proposed algorithm outperforms state-of-the-art benchmarks in terms of total throughput and system fairness.

关键词： unmanned aerial vehicle (UAV) trajectory design resource allocation multi-agent deep reinforcement learning (MADRL) heterogeneous agents

Synthesis of poly(thiourethane-alt-thioester) by alternating ring-opening copolymerization of N-thiocarboxyanhydrides and episulfides

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Science China Chemistry 2024年第9期67卷 3091-3097页

作者： wei xiong Tianjun Yue Haiwang Lai Chunyan Lyu weimin Ren Hua Lu Beijing National Laboratory for Molecular Sciences Center for Soft Matter Science and Engineering Key Laboratory of Polymer Chemistry and Physics of Ministry of Education College of Chemistry and Molecular Engineering Peking University State Key Laboratory of Fine Chemicals Dalian University of Technology

Polythiourethanes(PTU) and polythioesters(PTE) derived from renewable sources are emerging sustainable polymers for their excellent degradability and recyclability. However, P(TU-alt-TE) copolymers have been rare and challenging to ***, we report the efficient synthesis of novel P(TU-alt-TE) copolymers via the alternating copolymerization of N-thiocarboxyanhydrides(NTA)/episufides(ES) and provide mechanistic insight into the alternating chain propagation process via density functional theory(DFT) calculation. The incorporation of ESs into traditional peptide backbone is capable of adjusting the glass transition temperature below thermal decomposition temperature, which confers better thermal processability by regulating the rigidity of the backbone and the hydrogen bond interaction among the polymer chains. Crosslinked PTUs with tailored properties are accessible by altering the feeding ratio of NTAs and(bifunctional) ESs. Moreover, the thiourethane in the backbone can endow interesting underwater adhesion properties to the materials. Considering the broad scope of NTA and ES monomers, this method is expected to provide a promising and general route to a wide range of P(TU-alt-TE) copolymers with diverse properties.

关键词： poly(thiourethane-alt-thioester) alternating ring-opening copolymerization N-thiocarboxyanhydrides episulfides

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Synthesis of Organic-Inorganic Hybrid Aluminum Hypophosphite Microspheres Flame Retardant and Its Flame Retardant Research on Thermoplastic Polyurethane

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Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 221-233页

作者：刘生鹏 XU Zhi ZHANG Xinyuan wei Huan xiong Yun DING Yigang HUANG Wenbo 许莉莉 Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Key Laboratory for Green Chemical Process of Ministry of EducationSchool of Chemical Engineering and PharmacyWuhan Institute of TechnologyWuhan 430205China Hubei Three Gorges Laboratory Yichang 443007China School of Technology Materials Science and Engineering Wuhan Institute of TechnologyWuhan 430205China

Aluminum hypophosphite microspheres(AHP) were synthesized by hydrothermal method using NaH2PO2·H2O and AlCl3·6H2O as raw materials, and then the AHP microspheres were polymerized by surface polymerization of micro-nanospheres with cyclic cross-linked poly(cyclotriphosphazene-co-4,4'-sulfonyldiphenol)(PZS). A new organic-inorganic poly(phosphonitrile)-modified aluminum hypophosphite microspheres(PZS-AHP) were synthesized by encapsulation and applied to flame retardant thermoplastic polyurethane(TPU). The microstructure and chemical composition of the PZS-AHP microsphere were characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy and X-ray spectroscopy. The thermal stability of PZS-AHP microsphere was explored with thermogravimetric analysis. Thermogravimetric data indicate that the PZS-AHP microspheres have excellent thermal stability. The thermal and flame-retarding properties of the TPU composites were evaluated by thermogravimetric(TG), limited oxygen index tests(LOI), and cone calorimeter test(CCT). The TPU composite achieved vertical burning(UL-94) V-0 grade and LOI value reached 29.2% when 10 wt% PZS-AHP was incorporated. Compared with those of pure TPU, the peak heat release rate(pHRR) and total heat release(THR) of TPU/10%PZS-AHP decreased by 82.2% and 42.5%, respectively. The results of CCT indicated that PZS-AHP microsphere could improve the flame retardancy of TPU composites.

关键词： polyphosphazene thermoplastic polyurethane flame retardancy aluminum hypophosphite surface polymerization

Clinical outcome and prognostic factors of T4N0M0 colon cancer after R0 resection:A retrospective study

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1869-1877页

作者： Bang Liu Zhao-xiong Zhang Xin-Yang Nie wei-Lin Sun Yong-Jia Yan wei-Hua Fu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China

BACKGROUND Paradoxically,patients with T4N0M0(stage II,no lymph node metastasis)colon cancer have a worse prognosis than those with T2N1-2M0(stage III).However,no previous report has addressed this *** To screen prognostic risk factors for T4N0M0 colon cancer and construct a prognostic nomogram model for these *** Two hundred patients with T4N0M0 colon cancer were treated at Tianjin Medical University General Hospital between January 2017 and December 2021,of which 112 patients were assigned to the training cohort,and the remaining 88 patients were assigned to the validation *** between the training and validation groups were *** training cohort was subjected to multi-variate analysis to select prognostic risk factors for T4N0M0 colon cancer,followed by the construction of a nomogram *** The 3-year overall survival(OS)rates were 86.2%and 74.4%for the training and validation cohorts,***(P=0.000),T stage(P=0.001),right hemicolon(P=0.025),irregular review(P=0.040),and carbohydrate antigen 199(CA199)(P=0.011)were independent risk factors of OS in patients with T4N0M0 colon cancer.A nomogram model with good concordance and accuracy was *** Enterostomy,T stage,right hemicolon,irregular review,and CA199 were independent risk factors for OS in patients with T4N0M0 colon *** nomogram model exhibited good agreement and accuracy.

关键词： T4N0M0 colon cancer Prognosis Multivariate analysis Nomogram Colon cancer

A Dual Yamabe Flow and Related Integral Flows

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Chinese Annals of Mathematics,Series B 2024年第3期45卷 319-348页

作者： Jingang xiong School of Mathematical Sciences Laboratory of Mathematics and Complex SystemsMinistry of EducationBeijing Normal UniversityBeijing 100875China

The author studies a family of nonlinear integral flows that involve Riesz potentials on Riemannian manifolds. In the Hardy-Littlewood-Sobolev (HLS for short)subcritical regime, he presents a precise blow-up profile exhibited by the flows. In the HLS critical regime, by introducing a dual Q curvature he demonstrates the concentrationcompactness phenomenon. If, in addition, the integral kernel matches with the Green’s function of a conformally invariant elliptic operator, this critical flow can be considered as a dual Yamabe flow. Convergence is then established on the unit spheres, which is also valid on certain locally conformally flat manifolds.

关键词： Hardy-Littlewood-Sobolev functional Dual Q curvature Integral flow

Consistency test of PMT SPE spectrum from dark-noise pulses and LED low-intensity light

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Radiation Detection Technology and Methods 2018年第1期2卷 76-79页

作者： Yu-ting wei Meng-yun Guan wei-xing xiong You-yu Gan Chang-gen Yang Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of ScienceBeijingChina School of Physics University of Chinese Academy of ScienceBeijingChina

Photomultiplier tube(PMT)has been an essential instrument for low background experiments,and the accuracy of single photoelectron(SPE)calibration will directly affect the energy reconstruction of the *** SPE spectrum can be acquired from the charge distribution of dark-noise pulses or the low-intensity light signal triggered by ***,there are arguments on whether the two methods are *** this paper,the Hamamatsu R5912-20mod PMT and the EMID642KNFL PMT have been tested adopting the two methods with signal waveform recording *** comparison,traditional charge-to-digital conversion system is also used to test SPE *** results show that they are consistent when the PMTs are working at typical recommended high voltage(HV).

关键词： PMT SPE Dark noise LED Waveform