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Glucose Metabolic and Gluconeogenic Pathways Disturbance in the Intrauterine Growth Restricted Adult Male Rats

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Chinese Medical Sciences Journal 2009年第4期24卷 208-212页

作者： Xiao-mei Liu Jing Kong wei-wei song Yan Lu Central Laboratory Department of Surgery Department of Gynaecology and Obstetrics Shengjing Hospital China Medical University Shenyang 110004 China

Objective To explore the molecular mechanism of type 2 diabetes in intrauterine growth restricted adult rats through determination of blood glucose and expression of gluconeogenic enzymes in *** Male intrauterine growth restriction(IUGR) offspring induced by maternal protein-malnutrition and normal controls were *** body weights of offspring rats were weighted from birth to 12 weeks of *** plasma glucose and insulin levels were determined by glucose oxidase method and enzyme-linked immunosorbent assay(ELISA) respectively at 1 week,8 weeks,and 12 *** proliferator-activated receptor-γ coactivator-1α(PGC-1α),phosphoenolpyruvate carboxykinase(PEPCK),and glucose-6-phosphatase(G6Pase) mRNA and protein levels in liver were measured by real time RT-PCR and Western blot in newborn rats(Week 1) and adult rats(Week 12).Results Birth weights of IUGR rats were significantly lower than those of controls until 4 weeks later,when IUGR rats caught up to *** 8 and 12 weeks,the growth of IUGR rats surpassed that of *** significant differences were observed in blood glucose and insulin levels at newborn rats between the two ***,by the end of 8 weeks IUGR rats developed hyperinsulinemia and high insulin resistance *** the age of 12 weeks,IUGR rats had mild fasting *** addition,hepatic PGC-1α mRNA and protein levels as well as hepatic mRNA levels of PEPCK and G6Pase at Week 1 and Week 12 in IUGR rats were all significantly higher than those of controls(P<0.05).Conclusions As a result of intrauterine malnutrition,the expression of gluconeogenic genes is exaggerated in *** change stays through adulthood and may contribute to the pathogenesis of type 2 diabetes.

关键词： intrauterine growth restriction insulin resistance gluconeogenesis

Effectiveness of a hydroxynaphthoquinone fraction from Arnebia euchroma in rats with experimental colitis

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World Journal of Gastroenterology 2013年第48期19卷 9318-9327页

作者： Hua-Ying Fan Zi-Liang Zhang Ke Liu Ming-Yan Yang wei-Hong Lv Xin Che Hui Xu wei-wei song School of Pharmacy Yantai University College of Life Science Jilin University Shandong Target Drug Research Co. Ltd.

AIM:To evaluate the potential effectiveness of hydroxynaphthoquinone mixture(HM)in rats with 2,4,6-trinitrobenzene sulfonic acid(TNBS)-induced ***:Colitis was induced by intracolonic administration of TNBS(80 mg/kg,dissolved in 50%ethanol).Rats were treated daily for 7 d with HM(2.5,5,10 mg/kg)and mesalazine 100 mg/kg 24 h after TNBS *** progression was monitored daily by observation of clinical signs and body weight *** the end of the experiment,macroscopic and histopathologic lesions of rats were scored,and myeloperoxidase(MPO)activity was *** also determined inflammatory cytokine tumor necrosis factor(TNF)-αlevel by ELISA,Western blotting and immunochemistry to explore the potential mechanisms of ***:After intracolonic instillation of TNBS,animals developed colitis associated with soft stool,diarrhea and marked colonic *** of HM significantly attenuated clinical and histopathologic severity of TNBS-induced colitis in a dose-dependent *** abrogated body weight loss,diarrhea and inflammation,decreased macroscopic damage score,and improved histological signs,with a significant reduction of inflammatory infiltration,ulcer size and the severity of goblet cell depletion(all P<0.05 vs TNBS alone group).HM could reduce MPO *** addition,it also decreased serum TNF-αlevel and down-regulated TNF-αexpression in colonic *** reduction was statistically significant when the dose of HM was 10 mg/kg(P<0.05 vs TNBS alone group),and the effect was comparable to that of mesalazine and showed no apparent adverse *** underlying mechanism may be associated with TNF-α***:These findings suggest that HM possesses favourable therapeutic action in TNBS-induced colitis,which provides direct pharmacological evidence for its clinical application.

关键词： Arnebia euchroma(Royle) Johnst Hydroxynaphthoquinones Inflammatory bowel disease 2,4,6-trinitrobenzene sulfonic acid-induced colitis Tumor necrosis factor

Design, Synthesis, Antifungal Activities and SARs of （R）-2-Aryl-4,5-dihydrothiazole-4-carboxylic Acid Derivatives

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Chinese Journal of Chemistry 2015年第11期33卷 1269-1275页

作者： Jingbo Liu Yuxin Li Youwei Chen Xuewen Hua Yingying Wan wei wei Haibin song Shujing Yu Xiao Zhang Zhengming Li State Key Laboratory of Elemento-Organic Chemistry Collaborative Innovation Center of Chemical Science DQG Engineering ( Tianjin) Nankai University Tianjin 300071 China

Based on the structure of natural product 2-aryl-4,5-dihydrothiazole-4-carboxylic acid, a series of novel （R）-2-aryl-4,5-dihydrothiazole-4-carboxylic acid derivatives were designed and synthesized. Their structures were characterized by ^1H NMR, ^13C NMR and HRMS. The single crystal structure of compound 9b was determined by X-ray diffraction analysis. The antifungal activities were evaluated for the first time. The bioassay results indicated that most compounds exhibited moderate to good antifungal activities. The antifungal activities of compound 13a （against Cercospora arachidicola Hori）, 13d （against Alternaria solani）, and 16e （against Cercospora arachidieola Hori） were 61.9%, 67.3% and 61.9%, respectively, which are higher than those of the commercial fungicides chlorothalonil and carbendazim. Moreover, compound 13d exhibited excellent antifungal activities against 7 kinds of the fungi tested （66.7%, 77.3%, 63.0%, 87.9%, 70.0%, 70.0% and 80.0% at 50 μg/mL）. Therefore, 13d can be used as a new lead structure for the development of antifungal agents.

关键词： (R)-2-aryl-4,5-dihydrothiazole-4-carboxylic acid synthesis antifungal activity structure-activity relationship

Cloning and Characterization of Porcine TSARG7 Gene and Analysis of Its Tissue-Specific Expression

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Agricultural Sciences in China 2009年第11期8卷 1384-1391页

作者： LI Mei-li LI Gui-qiang FANG wei WANG wei song Xiao-guang LI Er-lin JIA Chao XU Yin-xue College of Animal Science and Technology Nanjing Agricultural University Nanjing 210095 P.R.China

TSARG7 is a novel member of the acyltransferase family since its sequence possesses the highly conserved phosphate acyltransferase （PlsC） domain existing in all acyltransferase-like proteins. The porcine TSARG7 had been identified by cloning in silico but had not been confirmed experimentally. The full-length mRNA of porcine TSARG7 gene was sequenced and two splice variants were discovered. The full-length cDNA of TSARG7 variant 1 was 2 513 bp and variant 2 was 2 634 bp. The putative porcine TSARG7 proteins, which were located in the cytoplasm, encoded 458 and 456 amino acids, respectively. Real-time PCR analysis showed that TSARG7 gene was expressed in various tissues, but at different levels. The expression levels of this gene were higher in the skeletal muscle, heart, and testis than that in other tissues, suggesting that the TSARG7 gene played a role in procine skeletal muscle, heart, and testis functions.

关键词： TSARG7 cDNA cloning pig bioinformatic analysis gene expression

Deep venous thrombosis after gastrectomy for gastric carcinoma:A case report

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World Journal of Gastroenterology 2009年第7期15卷 885-887页

作者： Jia-Sen Gao Zhen-Jun Wang Guang-Hui wei wei-Liang song Bing-Qiang Yi Zhi-Gang Gao Bo Zhao Zuo Liu Ang Li Department of General Surgery Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China

The treatment of gastric carcinoma consists of neoadjuvant chemoradiation,partial gastrectomy,subtotal gastrectomy,total gastrectomy,extended resection,and postoperative ***,gastrectomy and extended lymphadenectomy is the optimal choice for late gastric *** complications are common after total gastrectomy including hemorrhage,anastomotic leakage,f istula,and ***,deep venous thrombosis(DVT) is an uncommon complication after gastrectomy for gastric *** describe a case of a 68-year-old female patient with DVT after gastrectomy for gastric *** patient was treated with anticoagulants and thrombolytics and subjected to necessary laboratory *** patient recovered well after treatment and was symptom-free during a 3-mo *** conclude that correct diagnosis and treatment of DVT are crucial.

关键词： Gastric carcinoma Gastrectomy, Deepvenous thrombosis Postoperative complication Anticoagulant Thrombolytic therapy Low molecularweight heparins Streptokinase Warfarin sodium

Redoing a bioprosthetic tricuspid valve replacement with pacemaker wire through the ruined bioprosthetic valve orifice

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Chinese Medical Journal 2011年第6期124卷 958-960页

作者： GUO Hong-wei PAN Shi-wei song Yun-hu HU Sheng-shou Department of Surgery Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical college Beijing 100037 China

Severe tricuspid regurgitation with permanent pacemaker wire passing through the orifice of bioprosthetic tricuspid valve is extremely rare. We present a case of such kind of patient and redid bioprosthetic tricuspid valve replacement. A hawk mouth forceps for bone surgery was used to cut off the mental ring of ruined bioprosthetic tricuspid valve and the ruined valve was removed. A new bioprosthetic tricuspid valve was implanted and the wire of permanent pacemaker was left outside the ring of bioprosthetic tricuspid valve. This method may be helpful for such kind of patient.

关键词： tricuspid valve replacement bioprosthetic valve complete atrioventricular block reoperation

Diagnosis and treatment of acute rejection in the first case of human living-related small bowel transplantation with a long-term survival in China

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World Journal of Gastroenterology 2005年第34期11卷 5332-5335页

作者： wei-Liang song wei-Zhong Wang Guo-Sheng Wu Meng-Bin Li Ji-Peng Li Gang Ji Guang-Long Don Hong-wei Zhang Department of Gastrointestinal Surgery Xijing HospitalFourth Military Medical University Xi'an 710032 Shaanxi Province China

AIM： To report the comprehensive diagnosis and treatment of acute rejection in the first case of living-related small bowel transplantation with a long-term survival in China. METHODS： A 18-year-old boy with short gut syndrome underwent living-related small bowel transplantation, with the graft taken from his father （44-year old）. A segment of 150-cm distal small bowel was resected from the donor. The ileo-colic artery and vein from the donor were anastomosed to the infrarenal aorta and vena cava of the recipient respectively. The intestinal continuity was restored with an end-to-end anastomosis between the recipient jejunum and donor ileum, and the distal end was fistulized. FK506, MMF and prednisone were initially used for post-transplant immunosuppression. Endoscopic observation and mucosal biopsies of the graft were carried out through the terminal ileum enterostomy; serum was collected to detect the levels of IL-2R, IL-4, IL-6 and IL-8. The change of the graft secretion and absorption was observed. RESULTS： Acute rejection was diagnosed promptly and cured. The patient was in good health, 5 years after living- related small bowel transplantation. CONCLUSION： The correct diagnosis and treatment of acute rejection are the key to the long-term survival after living-related small bowel transplantation.

关键词： Rejection Comprehensive diagnosis Small bowel transplantation

TRIPLET combined with microwave ablation:A novel treatment for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 10-12页

作者： Fei-Yu Zhao Guo-wei Si Nian-song Qian Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology Fourth Medical CentreGeneral Hospital of the People's Liberation ArmyBeijing 100142China Senior Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100091China

This editorial comments on a study by Zuo et *** focus is on the efficacy of he-patic arterial infusion chemotherapy combined with camrelizumab and apatinib(the TRIPLET regimen),alongside microwave ablation therapy,in treating advanced hepatocellular carcinoma(HCC).The potential application of this combination therapy for patients with advanced HCC is evaluated.

关键词： Microwave ablation Hepatic arterial infusion chemotherapy Apatinib Camrelizumab Hepatocellular carcinoma

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多通道相关分析用于宽频带地震仪自噪声检测

地球物理学报 2017年第9期60卷 3466-3474页

作者：许卫卫袁松湧艾印双徐天龙中国地震局地震观测与地球物理成像重点实验室(中国地震局地球物理研究所) 北京100081 中国科学院地质与地球物理研究所地球深部结构与过程研究室北京100029

将多通道相关分析方法用于宽频带地震仪的自噪声检测,测量分析了Reftek 130、130 B和130 S三种地震数据采集器的自噪声检测结果以及14套Reftek 130 S连接Guralp CMG-3T地震计的自噪声一致性检测结果,同时给出了地震计的三轴正交性估计.... 详细信息

将多通道相关分析方法用于宽频带地震仪的自噪声检测,测量分析了Reftek 130、130 B和130 S三种地震数据采集器的自噪声检测结果以及14套Reftek 130 S连接Guralp CMG-3T地震计的自噪声一致性检测结果,同时给出了地震计的三轴正交性估计.结果表明:Reftek数据采集器设置为普通增益时在0.3 Hz以上频段自噪声高于Guralp CMG-3T地震计自噪声,设置为32倍高增益时在测量频段远低于地震计自噪声;测量的多台Guralp CMG-3T地震计自噪声结果在不同频段一致性差异较大,垂直向分量0.3 Hz以下频段可作为一致性比对参考频段,采集配置选择普通增益时0.3~2 Hz频段可作为数据采集器一致性比对参考频段;Guralp CMG-3T地震计三轴正交性误差估计平均在0.5°以内.

关键词：宽频带地震仪自噪声多通道相关分析