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Neuroendocrine carcinoma of the common hepatic duct coexisting with distal cholangiocarcinoma:A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1449-1460页

作者： Fei Chen wei-wei li Juan-Fen Mo Min-Jie Chen Su-Hang Wang Shu-Ying Yang Zheng-wei Song Department of Hepatobiliary Surgery The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Graduate School Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina The Key Laboratory The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Pathology The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Intensive Medicine The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Neuroendocrine carcinoma(NEC)of the extrahepatic bile duct is very rare,and the treatment and prognosis are unclear.Herein,we report the case of a middleaged female with primary large cell NEC(LCNEC)of the common hepatic duct combined with distal cholangiocarcinoma(dCCA).Additionally,after a review of the relevant literature,we summarize and compare mixed neuroendocrine-nonneuroendocrine neoplasm(MiNEN)and pure NEC to provide a reference for selecting the appropriate treatment and predicting the prognosis of this rare disease.CASE SUMMARY A 62-year-old female presented to the hospital due to recurrent abdominal pain for 2 months.Physical examination showed mild tenderness in the upper abdomen and a positive Courvoisier sign.Blood tests showed elevated liver transaminase and carbohydrate antigen 199 levels.Imaging examination revealed node dissection was performed,and hepatic duct tumours were unexpectedly found during surgery.Pathology suggested poorly differentiated LCNEC(approximately 0.5 cm×0.5 cm×0.4 cm),Ki-67(50%),synaptophysin+,and chromogranin A+.dCCA pathology suggested moderately differentiated adenocarcinoma.The patient eventually developed lymph node metastasis in the liver,bone,peritoneum,and abdominal cavity and died 24 months after surgery.Gene sequencing methods were used to compare gene mutations in the two primary bile duct tumours.CONCLUSION The prognosis of MiNEN and pure NEC alone is different,and the selection of treatment options needs to be differentiated.

关键词： Neuroendocrine carcinoma Mixed neuroendocrine-non-neuroendocrine neoplasm Cholangiocarcinoma Extrahepatic bile duct Case report

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Comparative effectiveness of several adjuvant therapies after hepatectomy for hepatocellular carcinoma patients with microvascular invasion

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 554-570页

作者： Yin-Xuan Pei Chen-Guang Su Zheng liao wei-wei li Zi-Xiang Wang Jin-Long liu Department of Hepatobiliary Surgery The Affiliated Hospital of Chengde Medical UniversityChengde 067000Hebei ProvinceChina

BACKGROUND For resectable hepatocellular carcinoma(HCC),radical hepatectomy is commonly used as a curative treatment.However,postoperative recurrence significantly diminishes the overall survival(OS)of HCC patients,especially with microva-scular invasion(MVI)as an independent high-risk factor for recurrence.While some studies suggest that postoperative adjuvant therapy may decrease the risk of recurrence following liver resection in HCC patients,the specific role of adju-vant therapies in those with MVI remains unclear.AIM To conduct a network meta-analysis(NMA)to evaluate the efficacy of various adjuvant therapies and determine the optimal adjuvant regimen.METHODS A systematic literature search was conducted on PubMed,EMBASE,and Web of Science until April 6,2023.Studies comparing different adjuvant therapies or comparing adjuvant therapy with hepatectomy alone were included.Hazard ratios(HRs)with 95%confidence intervals were used to combine data on recurrence free survival and OS in both pairwise meta-analyses and NMA.RESULTS Fourteen eligible trials(2268 patients)reporting five different therapies were included.In terms of reducing the risk of recurrence,radiotherapy(RT)[HR=0.34(0.23,0.5);surface under the cumulative ranking curve(SUCRA)=97.7%]was found to be the most effective adjuvant therapy,followed by hepatic artery infusion chemotherapy[HR=0.52(0.35,0.76);SUCRA=65.1%].Regarding OS improvement,RT[HR:0.35(0.2,0.61);SUCRA=93.1%]demonstrated the highest effectiveness,followed by sorafenib[HR=0.48(0.32,0.69);SUCRA=70.9%].INTRODUCTION Hepatocellular carcinoma(HCC)is the sixth most common malignant tumor in the world and ranks third in terms of worldwide malignant tumor mortality rates in 2020[1].Curative treatments for HCC include ablation,radical hepatectomy,and liver transplantation.However,ablation is suitable only for early-stage HCC patients,who represent a small percentage of the overall HCC population.Although liver transplantation serves as the optimal treatment for HCC patients,the scarcity of donor or

关键词： Hepatocellular carcinoma Adjuvant therapy Network meta-analysis Transarterial chemoembolization Hepatic artery infusion chemotherapy Radiotherapy Sorafenib

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转录因子IRF3充分活化在调节先天抗病毒免疫反应中的作用机制解析

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中国兽医科学 2024年第2期54卷 282-282页

作者： wei-wei li Xu-Xu Fan Zi-Xiang Zhu Xue-Jing Cao Zhao-Yu Zhu Dan-Shi Pei Yi-Zhuo Wang Ji-Yan Zhang Yan-Yi Wang Hai-Xue Zheng State Key Laboratory for Animal Disease Control and Prevention College of Veterinary Medicine Lanzhou University Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Lanzhou China Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of Virology Center for Biosafety Mega-Science Chinese Academy of Sciences Wuhan China Gansu Province Research Center for Basic Disciplines of Pathogen Biology Lanzhou China

翻译后修饰在调节Ⅰ型干扰素分泌过程中发挥关键作用。转录因子IRF3作为关键接头分子,其活性受到多种翻译后修饰的严格调控,包括磷酸化、de SUMOylation、泛素化和乙酰化等。目前,关于TBK1介导的IRF3磷酸化如何驱动IRF3完全活化的文献... 详细信息

翻译后修饰在调节Ⅰ型干扰素分泌过程中发挥关键作用。转录因子IRF3作为关键接头分子,其活性受到多种翻译后修饰的严格调控,包括磷酸化、de SUMOylation、泛素化和乙酰化等。目前,关于TBK1介导的IRF3磷酸化如何驱动IRF3完全活化的文献报道非常有限。因此,了解IRF3磷酸化和活化状态之间的关联性具有重要的生理学意义。

关键词： Ⅰ型干扰素生理学意义翻译后修饰转录因子活化状态分泌过程文献报道泛素化

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Characteristics of air flow driven by the free surface of the open channel

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Journal of Hydrodynamics 2022年第1期34卷 69-75页

作者： Jing Gong Jun Deng Wang-ru wei wei-wei li State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu610065China

Spillway tunnels are a key structure in large-scale water conservancies. The high-head water inlet makes the water surface-velocity extremely high, and the air is driven by the free surface of the water to move downstream. This paper studies the air velocity distribution above the water surface through the model tests, under the assumption that the airflow is a turbulent boundary layer with a rough interface, and the influence of the water depth and the water velocity on the air velocity distribution is analyzed. It is shown that the air velocity is in an exponential distribution. As the measured position moves upward, the air velocity gradually decreases, and the gradient decreases. When the water depth increases, the air velocity increases but with the same distribution form. With the increase of the water surface-velocity, the air velocity at the same measuring point increases, the variation range near the water surface is large, the air boundary layer height increases slightly, and the index coefficient of the air velocity distribution function decreases. Through numerical fitting, the calculation formula of the air boundary layer thickness at different water surface velocities is obtained, along with the numerical value of the index coefficient.

关键词： Open channel air velocity distribution air boundary layer height index coefficient

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Synergistic Optimization of Toughness and EMI Shielding Properties in Rigid Polyurethane Composites by Designing Ring Structures on the Surface of Carbon Fibers

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Chinese Journal of Polymer Science 2023年第12期41卷 1958-1968,I0010页

作者： Yi-Long Zhou wei-wei li Hui-Xin liu Kai-Yuan Pei Shi-Ting li School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China

How to achieve both toughness and enhanced electromagnetic interference shielding effectiveness(EMI SE)of carbon fibers(CFs)reinforced rigid polyurethane(RPU)composites is a significative challenge at present.In this work,a ring-shaped zinc coating was deposited on the short CFs by electrodeposition technique.It is expected to improve the interfacial properties between the fibers and the resin matrix as well as enhance the EMI shielding properties of the composites by changing the surface morphology and roughness of the fibers.Results showed that the surface free energy of the ring-shaped zinc modified carbon fibers(RS-CFs)increased from 49.0 mJ/m^(2) to 53.2 mJ/m^(2),indicating that the surface roughness and wettability of the CFs were effectively improved.In comparison with the pristine short carbon fibers/rigid polyurethane(CFs/RPU)composites,tensile strength and tensile toughness of RS-CFs modified composites were increased by 27.1% and 121.4%,respectively.In addition,the bending and impact strengths of RS-CFs reinforced RPU composites were also improved.Notably,the electrical conductivity of RS-CFs/RPU composites reached 1.2×10^(-5) S/m,which was much higher than that of CFs/RPU composites at 1.4×10^(-10) S/m.Moreover,the EMI SE of the modified composites reached 22 dB,which was 152.9% higher than that of CFs/RPU composites.The enhanced electrical conductivity and EMI shielding properties of the composites could be attributed to the synergistic effect of the porous structure in the RPU matrix and the CFs modified by the metal coating.

关键词： Carbon fiber Surface decoration Rigid polyurethane Mechanical properties EMI shielding

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Quantitative evaluation of colorectal tumour vasculature using contrast-enhanced ultrasound:Correlation with angiogenesis and prognostic significance

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世界胃肠外科杂志:英文版(电子版) 2023年第9期15卷 2052-2062页

作者： Ming-Hui li wei-wei li ling He Jian-Fang li Sun-Yan Zhang Department of Ultrasound Tumor Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionsChina Department of Medical Imaging Baoding Maternal and Child Health HospitalBaoding 071023Hebei ProvinceChina Department of Ultrasonography Nantong Haimen District People’s HospitalNantong 226100Jiangsu ProvinceChina

BACKGROUND Ultrasound is a vital tool for the diagnosis and management of colorectal cancer(CRC).Contrast-enhanced ultrasound(CEUS)is a non-invasive,safe,and cost-effective method for evaluating tumour blood vessels,that play a crucial role in tumour growth and progression.AIM To explore CEUS’s role in the quantitative evaluation of CRC blood vessels and their correlation with angiogenesis markers and prognosis.METHODS This study prospectively enrolled 100 patients with CRC confirmed by histo-pathology.All patients received preoperative CEUS examinations.Quantitative parameters,such as peak intensity(PI),time to peak(TTP),and area under the curve(AUC),were derived from time-intensity curve(TIC)analysis.Tumour tissue samples were obtained during surgery and examined immunohistochem-ically to assess the expression of angiogenesis markers,including vascular endo-thelial growth factor(VEGF)and microvessel density(MVD).The correlation between CEUS parameters,angiogenesis markers,and clinicopathological features was evaluated using appropriate statistical tests.RESULTS Quantitative CEUS parameters(PI,TTP,and AUC)showed significant correlations with VEGF expression(Plink between tumour blood vessels and angiogenesis.Increased PI,reduced TTP,and expanded AUC values were significantly related to higher tumour stage(Plidate the clinical utility of CEUS in CRC management.

关键词： Contrast-enhanced ultrasound Colorectal cancer Tumour angiogenesis Prognosis Microvessel density Vascular endothelial growth factor Tumour

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Clinical study on tri-tongue acupuncture combined with lowfrequency electrical stimulation for treating post-stroke dysarthria

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World Journal of Clinical Cases 2022年第34期10卷 12587-12593页

作者： Bin Man wei-wei li Jun-Feng Xu Qian Wang Department of Acupuncture and Moxibustion The First Teaching Hospital of Tianjin University of Traditional Chinese MedicineNational Clinical Research Center for Chinese Medicine Acupuncture and MoxibustionTianjin 300381China

BACKGROUND Few studies have investigated low-frequency electrical stimulation combined with tri-tongue acupuncture for the treatment of post-stroke dysarthria.This randomized clinical study assessed the correlation between the clinical efficacy of low-frequency electrical stimulation combined with tri-tongue acupuncture in patients with post-stroke dysarthria.AIM To investigate the clinical effects of tri-tongue acupuncture combined with lowfrequency electrical stimulation for treating post-stroke dysarthria.METHODS Ninety patients with post-stroke dysarthria,who were admitted to our hospital from December 2019 to June 2021,were selected and equally divided into two groups(n=45/group)according to the random number table method.Tri-tongue acupuncture was administered in the control group.The treatment group received both tri-tongue acupuncture and low-frequency electrical stimulation.The clinical efficacy,Western Aphasia Battery(WAB)score,general quality of life inventory(GQOli-74)score,Frenchay Dysarthria Assessment score,and speech function grades were compared and analyzed between both groups.RESULTS The overall efficacy in the treatment group was better than that in the control group(Pli-74 scores(P>0.05)did not differ between the groups.After therapy,the WAB,Frenchay Dysarthria Assessment,and GQOli-74 scores in both groups increased significantly(P0.05),whereas significant improvements were observed in both groups after treatment(Plinical effect on post-stroke dysarthria.

关键词： Low-frequency pulse electrotherapy Tri-tongue acupuncture Dysarthria after stroke Clinical research

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Primary intra-abdominal paraganglioma:A case report

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World Journal of Clinical Cases 2023年第10期11卷 2276-2281页

作者： wei Guo wei-wei li Min-Jie Chen ling-Yu Hu Xiao-Guang Wang Graduate School Zhejiang Chinese Medicine UniversityHangzhou 310053Zhejiang ProvinceChina Department of General Surgery Jiaxing The Second HospitalJiaxing 314000Zhejiang ProvinceChina Department of Hepatobiliary Surgery Jiaxing The Second HospitalJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Paragangliomas are rare neuroendocrine tumors.We hereby report a case of a localized paraganglioma found in the abdominal cavity,and review the relevant literature to improve the understanding of this disease.CASE SUMMARY A 29-year-old Chinese female patient was referred to our hospital due to an abdominal mass found on physical examination.Imaging revealed a mass in the left upper abdomen,suggestive of either a benign stromal tumor or an ectopic accessory spleen.Laparoscopic radical resection was subsequently performed,and histopathological analysis confirmed the diagnosis of a paraganglioma.The patient was followed up 3 months post-operation,and reported good recovery with no metastasis.CONCLUSION Radical resection can effectively treat intra-abdominal paragangliomas,with few side effects and low recurrence risk.In addition,early and accurate diagnosis and timely intervention are essential for the prognosis of this disease.

关键词： Abdominal cavity Paraganglioma Surgical treatment Case report

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LncRNA cancer susceptibility 20 regulates the metastasis of human gastric cancer cells via the miR-143-5p/MEMO1 molecular axis

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World Journal of Gastroenterology 2022年第16期28卷 1656-1670页

作者： Ke-Shu Shan wei-wei li Wang Ren Shuai Kong li-Pan Peng Hong-Qing Zhuo Shu-Bo Tian Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong UniversityJinan 250021Shandong ProvinceChina Department of Critical Care Medicine The 960^(th)Hospital of the People's Liberation Army Joint Logistics Support ForceJinan 250031Shandong ProvinceChina Department of General Surgery People's Hospital of Sishui CountyJining 273200Shandong ProvinceChina

BACKGROUND Gastric cancer(GC)is considered as one of the most widespread malignancies.Emerging evidence has shown that lncRNAs can function as important oncogenes or tumor suppressors during GC progression.AIM To investigate the effect and mechanism of lncRNA cancer susceptibility 20(CASC20)in the proliferation and metastasis of GC cells.METHODS Data mining and clinical samples were used to evaluate the expression of CASC20 in GC and adjacent tissues.CASC20 was down-regulated in GC cells by shortinterfering RNA.Cell proliferation was evaluated by CCK-8 assay,and cell migration and invasion were detected by wound healing and Transwell assays.The expressions of proteins related to epithelial-mesenchymal transition were detected by western blot assay.RESULTS The expression of CASC20 was increased in GC tumor tissues and various GC cell lines.High CASC20 expression was correlated with a high risk of lymphatic metastasis and poor prognosis in GC patients.In vitro assays showed that silencing CASC20 reduced cell proliferation,migration,and invasion in GC cells.Mechanistic studies revealed that CASC20 exhibits oncogenic functions by regulating MEMO1 expression through competitive endogenous binding to miR-143-5p,leading to induction of epithelial-mesenchymal transition.CONCLUSION Our findings indicate that CASC20 serves as a tumor promoter by regulating metastasis in GC via the miR-143-5p/MEMO1 axis.CASC20 may be a potential therapeutic target for GC.

关键词： Gastric cancer LncRNA Cancer susceptibility 20 miR-143-5p MEMO1 Epithelialmesenchymal transition

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E3 ubiquitin ligase TRIM55 promotes metastasis of gastric cancer cells by mediating epithelial-mesenchymal transition

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2183-2194页

作者： wei-wei li Hao Yuan Shuai Kong Shu-Bo Tian Department of Pulmonary and Critical Care Medicine Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinan 250021Shandong ProvinceChina Department of Critical Care Medicine The 960th Hospital of the People's Liberation Army Joint Logistics Support ForceJinan 250031Shandong ProvinceChina Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Gastrointestinal Surgery Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinan 250021Shandong ProvinceChina

BACKGROUND Gastric cancer(GC)is considered a major global health problem.The role of TRIM55,a member of the three-domain protein family,in GC is unknown.AIM To determine the expression of TRIM55 in GC tissues and its relationship with clinicopathological characteristics,and to investigate the effects of TRIM55 on the malignant biological behavior of GC cells.METHODS Differential expression of TRIM55 in GC and para-cancer tissues was detected by immunohistochemistry,and the relationship between TRIM55 level and clinicopathological characteristics and prognosis was analyzed.Gain-of-function,lossof-function,cell counting kit-8 assay,colony formation,transwell assay,wound healing assay,and western blot analysis were used to assess the potential role of TRIM55 in the development of GC.RESULTS TRIM55 expression was significantly increased in GC tissues compared with adjacent normal tissues.High expression of TRIM55 was associated with advanced pathological stage and poor prognosis.Overexpression of TRIM55 promoted invasion and metastasis of GC cells in vitro by regulating epithelial-mesenchymal transition(EMT),whereas knockdown of TRIM55 had the opposite effect.Our data showed that TRIM55 is highly expressed in GC tissues,and is associated with poor prognosis.TRIM55 plays the role of an oncogene in GC,and it promotes metastasis of GC through the regulation of EMT.CONCLUSION TRIM55 may be a possible target for the diagnosis and prognosis of GC patients.

关键词： TRIM55 Gastric cancer Prognosis Epithelial-mesenchymal transition

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