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Connecting the P300 to the diagnosis and prognosis of unconscious patients

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Neural Regeneration Research 2015年第3期10卷 473-480页

作者： Ran Li wei-qun song Ju-bao Du Su Huo Gui-xiang Shan Department of Rehabilitation Medicine Xuanwu HospitalCapital Medical University

The residual consciousness of unconscious patients can be detected by studying the P300, a wave among event-related potentials. Previous studies have applied tones, the subject＇s name and other names as stimuli. However, the results were not satisfactory. In this study, we changed the constituent order of subjects＇ two-character names to create derived names. The subject＇s derived names, together with tones and their own names, were used as auditory stimuli in event-related potential experiments. Healthy controls and unconscious patients were included in this study and made to listen to these auditory stimuli. In the two paradigms, a sine tone followed by the subject＇s own name and the subject＇s derived name followed by the subject＇s own name were used as standard and deviant stimuli, respectively. The results showed that all healthy controls had the P300 using both paradigms, and that the P300 in the second paradigm had a longer latency and two peaks. All minimally conscious state patients had the P300 in the first paradigm and the majority of them had the P300 in the second paradigm. Most vegetative state patients had no P300. Patients who showed the P300 in the two paradigms had more residual consciousness, and patients with the two-peak P300 had a higher probability of awakening within a short time. Our experimental findings suggest that the P300 event-related potential could reflect the conscious state of unconscious patients.

关键词： nerve regeneration brain injury cognitive neuroscience event-related potential P300 electrophysiology nutritional state minimally conscious state consciousness disorders of consciousness unconsciousness evaluation prognosis NSFC grants neural regeneration

Visual-spatial neglect after right-hemisphere stroke:behavioral and electrophysiological evidence

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Chinese Medical Journal 2019年第9期132卷 1063-1070页

作者： Lin-Lin Ye Lei Cao Huan-Xin Xie Gui-Xiang Shan Yan-Ming Zhang wei-qun song Department of Rehabilitation Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Background:Visual-spatial neglect (VSN) is a neuropsychological syndrome,and right-hemisphere stroke is the most common cause.The pathogenetic mechanism of VSN remains unclear.This study aimed to investigate the behavioral and event-related potential (ERP) changes in patients with or without VSN after right-hemisphere stroke.Methods:Eleven patients with VSN with right-hemisphere stroke (VSN group) and 11 patients with non-VSN with righthemisphere stroke (non-VSN group) were recruited along with one control group of 11 age- and gender-matched healthy participants.The visual-spatial function was evaluated using behavioral tests,and ERP examinations were performed.Results:The response times in the VSN and non-VSN groups were both prolonged compared with those of normal controls (P 0.05).Conclusions:Visual-spatial attention function is impaired after right-hemisphere stroke,and clinicians should be aware of the subclinical VSN.Our findings provide neuroelectrophysiological evidence for the lateralization of VSN.

关键词： Visual-spatial neglect Right-hemisphere stroke Behavior Electrophysiology Event-related potentials Response time

Recovery from prolonged disorders of consciousness:A dual-center prospective cohort study in China

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World Journal of Clinical Cases 2020年第12期8卷 2520-2529页

作者： wei-Guan Chen Ran Li Ye Zhang Jian-Hui Hao Ju-Bao Du Ai-song Guo wei-qun song Department of Rehabilitation Medicine Xuan Wu HospitalCapital Medical UniversityBeijing 100053China Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

BACKGROUND Recent innovations in intensive care have improved the prognosis of patients with severe brain injuries and brought more patients with disorders of consciousness(DoC).Data are lacking regarding the long-term outcomes of those patients in China.It is necessary to study the long-term outcomes of patients with prolonged DoC in light of many factors likely to influence crucial decisions about their care and their life.AIM To present the preliminary results of a DoC cohort.METHODS This was a two-center prospective cohort study of inpatients with vegetative state(VS)/unresponsive wakefulness syndrome(UWS).The study outcomes were the recovery from VS/UWS to minimally conscious state(MCS)and the long-term status of patients with prolonged DoC considered in VS/UWS or MCS for up to 6 years.The patients were evaluated using the Glasgow coma scale,coma recovery scale-revised,and Glasgow outcome scale.The endpoint of follow-up was recovery of full consciousness or death.The changes in the primary clinical outcome improvement in clinical diagnosis were evaluated at 12 mo compared with baseline.RESULTS The study population included 93 patients(62 VS/UWS and 31 MCS).The postinjury interval range was 28-634 d.Median follow-up was 20 mo(interquartile range,12-37 mo).At the endpoint,33 transitioned to an emergence from MCS or full consciousness,eight had a locked-in syndrome,and there were 35 patients remaining in a VS/UWS and 11 in an MCS.Seven(including one locked-in syndrome)patients(7.5%)died within 12 mo of injury.Compared with the unresponsive group(n=52)at 12 mo,the responsive group(n=41)had a higher proportion of males(87.8%vs 63.5%,P=0.008),shorter time from injury(median,40.0 d vs 65.5 d,P=0.006),higher frequency of vascular etiology(68.3%vs 38.5%,P=0.007),higher Glasgow coma scale score at admission(median,9 vs 6,P<0.001),higher coma recovery scale-revised score at admission(median,9 vs 2.5,P<0.001),at 1 mo(median,14 vs 5,P<0.001),and at 3 mo(median,20 vs 6,P<0.001),lower frequency of VS/UWS(36.6%vs 90.0%,P<0.

关键词： Brain injury Disorders of consciousness Behavioral assessment Coma recovery scale-revised Prospective cohort study Neurorehabilitation

Immune cells in the B-cell lymphoma microenvironment: From basic research to clinical applications

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中华医学杂志(英文版) 2024年第7期137卷 776-790页

作者： Zhang Wenli Liu Mengmeng Li wei song Yongping Department of Hematology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450052 China Academy of Medical Sciences Zhengzhou University

B-cell lymphoma is a group of hematological malignancies characterized by variable genetic and biological features and clinical behaviors. The tumor microenvironment (TME) is a complex network in tumors, which consists of surrounding blood vessels, extracellular matrix, immune and non-immune cells, and signaling molecules. Increasing evidence has shown that the TME, especially immune cells within, is a double-edged sword, acting either as a tumor killer or as a promoter of tumor progression. These pro-tumor activities are driven by subpopulations of immune cells that express typical markers but have unique transcriptional characteristics, making tumor-associated immune cells good targets for human anti-cancer therapy by ablating immunosuppressive cells or enhancing immune-activated cells. Thus, exploring the role of immune cells in the TME provides distinct insights for immunotherapy in B-cell lymphoma. In this review, we elucidated the interaction between immune cells and tumor cells and their function in the initiation, progression, and prognosis of B-cell lymphoma, from preclinical experiments to clinical trials. Furthermore, we outlined potential therapeutic approaches and discussed the potential clinical value and future perspectives of targeting immune cells in patients with B-cell lymphoma.

关键词： Tumor microenvironment B-cell lymphoma Immune cells Immunotherapy Targeted therapy

Propagation form of internal cracks induced by continuous casting soft reduction and control strategy for internal quality

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Journal of Iron and Steel Research(International) 2024年第3期31卷 622-633页

作者： Pu Wang Liang Chen qun-wei Tang wei-tao Li Shao-xiang Li Jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China weifang Special Steel Group Co..Ltd. Weifang 262400ShandongChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

The propagation form of internal cracks induced by continuous casting soft reduction and the control strategy for enhancing the internal quality of 45 steel through industrial trials and a three-dimensional flow-heat transfer-solidification coupling model were investigated.The results showed that the internal cracks induced by soft reduction exhibited a characteristic of being"coarse in the middle and fine at both ends",and displayed an elliptical arc distribution on the loose side of the strand cross section.The cracks originated within the brittle temperature range and propagated inward to the liquid impenetrable temperature and outward to the zero ductility temperature or below.The control strategy for enhancing the internal quality of the 45 steel strand through soft reduction is to adjust the casting speed or the reduction zone appropriately,ensuring that the central solid fraction of the reduction zone falls within the range of 0.33-0.99.At this point,a reasonable reduction amount is allocated to eliminate the center shrinkage cavities and center segregation,even if it results in minor reduction-induced cracks.

关键词： Continuous casting Soft reduction Crack propagation Internal quality Control strategy

Torque Limit-based Inertial Control Method Based on Delayed Support for Primary Frequency Control of Wind Turbines

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 561-570页

作者： wei Gu Zaiyu Chen qun Li Minghui Yin Qiang Li Yun Zou School of Automation Nanjing University of Science and TechnologyNanjing 210094China State Grid Jiangsu Electric Power Co. Ltd.Research InstituteNanjing 211103China

To avoid the secondary frequency dip caused by the steep drop of the electrical power of wind turbines(WTs)at the end of frequency support stage,the torque limit-based iner-tial control(TLIC)method sets the power reference as a linear function of rotor speed,rather than the step form for the step-wise inertial control.However,the compensation effect on the frequency nadir(FN)caused by the load surge is weakened as the TLIC power is no longer in the step form.Specifically,the maximum point of the frequency response component(FRC)contributed by TLIC occurs earlier than the minimum point of FRC corresponding to the load surge,so that the FN cannot be adequately raised.Therefore,this paper first investigates the relation between the peak and nadir times of FRCs stimulated by the TLIC and load power.On this basis,with the compensation principle of matching the peak and nadir times of FRCs,the improved TLIC method based on delayed support is proposed.Finally,the effectiveness of the proposed method is validated via the experiments on the test bench of wind-integrated power system.

关键词： Wind turbine frequency response component torque limit inertial control delayed support

A self-organization formation configuration based assignment probability and collision detection

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Journal of Systems Engineering and Electronics 2024年第1期35卷 222-232页

作者： song wei WANG Tong YANG Guangxin ZHANG Peng School of Harbin Engineering University Harbin 150001China Chinese Aeronautical Establishment Beijing 100010China

The formation control of multiple unmanned aerial vehicles(multi-UAVs)has always been a research hotspot.Based on the straight line trajectory,a multi-UAVs target point assignment algorithm based on the assignment probability is proposed to achieve the shortest overall formation path of multi-UAVs with low complexity and reduce the energy consumption.In order to avoid the collision between UAVs in the formation process,the concept of safety ball is introduced,and the collision detection based on continuous motion of two time slots and the lane occupation detection after motion is proposed to avoid collision between UAVs.Based on the idea of game theory,a method of UAV motion form setting based on the maximization of interests is proposed,including the maximization of self-interest and the maximization of formation interest is proposed,so that multi-UAVs can complete the formation task quickly and reasonably with the linear trajectory assigned in advance.Finally,through simulation verification,the multi-UAVs target assignment algorithm based on the assignment probability proposed in this paper can effectively reduce the total path length,and the UAV motion selection method based on the maximization interests can effectively complete the task formation.

关键词： straight line trajectory assignment probability collision detection lane occupation detection maximization of interests

Mobile Crowdsourcing Task Allocation Based on Dynamic Self-Attention GANs

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Computers, Materials & Continua 2024年第4期79卷 607-622页

作者： Kai wei song Yu Qingxian Pan School of Computer and Control Engineering Yantai UniversityYantai264005China School of Computer and Information Science Southwest UniversityChongqing400715China

Crowdsourcing technology is widely recognized for its effectiveness in task scheduling and resource allocation.While traditional methods for task allocation can help reduce costs and improve efficiency,they may encounter challenges when dealing with abnormal data flow nodes,leading to decreased allocation accuracy and efficiency.To address these issues,this study proposes a novel two-part invalid detection task allocation framework.In the first step,an anomaly detection model is developed using a dynamic self-attentive GAN to identify anomalous data.Compared to the baseline method,the model achieves an approximately 4%increase in the F1 value on the public dataset.In the second step of the framework,task allocation modeling is performed using a twopart graph matching method.This phase introduces a P-queue KM algorithm that implements a more efficient optimization strategy.The allocation efficiency is improved by approximately 23.83%compared to the baseline method.Empirical results confirm the effectiveness of the proposed framework in detecting abnormal data nodes,enhancing allocation precision,and achieving efficient allocation.

关键词： Mobile crowdsourcing task allocation anomaly detection GAN attention mechanisms

A newly proposed heatstroke-induced coagulopathy score in patients with heat illness: A multicenter retrospective study in China

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Chinese Journal of Traumatology 2024年第2期27卷 83-90页

作者： Qing-wei Lin Lin-Cui Zhong Long-Ping He Qing-Bo Zeng wei Zhang Qing song Jing-Chun song Department of Critical Care Medicine The 908th Hospital of Chinese PLA Logistic Support ForcesNanchang360104Jiangsu ProvinceChina Department of Emergency Medicine The 900th Hospital of Chinese PLA Logistic Support ForcesFuzhou350000China Department of Critical Care Medicine Hainan Hospital of Chinese PLA General HospitalSanya572013Hainan ProvinceChina

Purpose:In patients with heatstroke, disseminated intravascular coagulation (DIC) is associated with greater risk of in-hospital mortality. However, time-consuming assays or a complex diagnostic system may delay immediate treatment. Therefore, the present study proposes a new heatstroke-induced coagulopathy (HIC) score in patients with heat illness as an early warning indicator for DIC.Methods:This retrospective study enrolled patients with heat illness in 24 Chinese hospitals from March 2021 to May 2022. Patients under 18 years old, with a congenital clotting disorder or liver disease, or using anticoagulants were excluded. Data were collected on demographic characteristics, routine blood tests, conventional coagulation assays and biochemical indexes. The risk factors related to coagulation function in heatstroke were identified by regression analysis, and used to construct a scoring system for HIC. The data of patients who met the diagnostic criteria for HIC and International Society on Thrombosis and Haemostasis defined-DIC were analyzed. All statistical analyses were performed using SPSS 26.0.Results:The final analysis included 302 patients with heat illness, of whom 131 (43.4%) suffered from heatstroke, including 7 death (5.3%). Core temperature (OR = 1.681, 95% CI 1.291 - 2.189, p < 0.001), prothrombin time (OR = 1.427, 95% CI 1.175 - 1.733, p < 0.001) and D-dimer (OR = 1.242, 95% CI 1.049 - 1.471, p = 0.012) were independent risk factors for heatstroke, and therefore used to construct an HIC scoring system because of their close relation with abnormal coagulation. A total score ≥ 3 indicated HIC, and HIC scores correlated with the score for International Society of Thrombosis and Hemostasis-DIC (r = 0.8848, p < 0.001). The incidence of HIC (27.5%) was higher than that of DIC (11.2%) in all of 131 heatstroke patients. Meanwhile, the mortality rate of HIC (19.4%) was lower than that of DIC (46.7%). When HIC developed into DIC, parameters of coagulation dysfunction changed significantly: platelet count decrea

关键词： Heat illness Heatstroke Coagulation disorders Diagnosis Disseminated intravascular coagulation