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Comparative proteomes change and possible role in different pathways of micro RNA-21a-5p in a mouse model of spinal cord injury

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Neural Regeneration Research 2020年第6期15卷 1102-1110页

作者： Almaghalsa-Ziad Mohammed Hong-Xia Du Hong-Liang Song wei-ming gong Bin Ning Tang-Hong Jia Department of Spinal Surgery Jinan Central Hospital Affiliated to Shandong University

Our previous study found that microRNA-21 a-5 p(miR-21 a-5 p)knockdown could improve the recovery of motor function after spinal cord injury in a mouse model,but the precise molecular mechanism remains poorly *** this study,a modified Allen's weight drop was used to establish a mouse model of spinal cord injury.A proteomics approach was used to understand the role of differential protein expression with miR-21 a-5 p knockdown,using a mouse model of spinal cord injury without gene knockout as a negative control *** found that after introducing miR-21 a-5 p knockdown,proteins that played an essential role in the regulation of inflammatory processes,cell protection against oxidative stress,cell redox homeostasis,and cell maintenance were upregulated compared with the negative control *** Encyclopedia of Genes and Genomes pathway enrichment analysis identified enriched pathways in both groups,such as the oxidative phosphorylation pathway,which is relevant to Parkinson's disease,Huntington's disease,Alzheimer's disease,and cardiac muscle *** also found that miR-21 a-5 p could be a potential biomarker for amyotrophic lateral sclerosis,as miR-21 a-5 p becomes deregulated in this *** results indicate successful detection of some important proteins that play potential roles in spinal cord *** the relationship between these proteins and the recovery of spinal cord injury will provide a reference for future research of spinal cord injury *** experimental procedures and protocols were approved by the Experimental Animal Ethics Committee of Shandong University of China on March 5,2014.

关键词： bioinformatics biomarker inflammation micro RNA mitochondria mouse pathway analysis proteomics spinal cord injury stathmin

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Neuroprotective mechanisms of rutin for spinal cord injury through anti-oxidation and anti-inflammation and inhibition of p38 mitogen activated protein kinase pathway

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Neural Regeneration Research 2018年第1期13卷 128-134页

作者： Hong-liang Song Xiang Zhang Wen-zhao Wang Rong-han Liu Kai Zhao ming-yuan Liu wei-ming gong Bin Ning Department of Spinal Surgery Jinan Central Hospital Affiliated to Shandong University Hospital Pharmacy Jinan Central Hospital Affiliated to Shandong University Department of Gynecology and Obstetrics Jinan Maternity and Child Care Hospital

Rutin has anti-inflammatory, antioxidant, anti-viral, anti-tumor and immune regulatory effects. However, the neuroprotective effects of rutin in spinal cord injury are unknown. The p38 mitogen activated protein kinase （p38 MAPK） pathway is the most important member of the MAPK family that controls inflammation. We assumed that the mechanism of rutin in the repair of spinal cord injury is associated with the inhibition of p38 MAPK pathway. Allen’s method was used to establish a rat model of spinal cord injury. The rat model was intraperitoneally injected with rutin （30 mg/kg） for 3 days. After treatment with rutin, Basso, Beattie and Bresnahan locomotor function scores increased. Water content, tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6 levels, p38 MAPK protein expression and caspase-3 and -9 activities in T8–9 spinal cord decreased. Oxidative stress related markers superoxide dismutase and glutathione peroxidase levels increased in peripheral blood. Rutin exerts neuroprotective effect through anti-oxidation, anti-inflammation, anti-apoptosis and inhibition of p38 MAPK pathway.

关键词： nerve regeneration spinal cord injury rutin oxidative stress antioxidant anti-inflammation p38 mitogen activated protein kinase pathway anti-apoptosis caspase-3 caspase-9 neural regeneration

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一类重调和方程边值问题解的奇点可去性

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上海理工大学学报 2013年第5期35卷 443-448页

作者：刘淼魏公明上海理工大学理学院上海200093

给出了一类重调和方程边值问题解的表示式,研究了其解的奇点可去性,利用判断反常积分收敛性的方法对解的表示式作了敛散性分析,给出了该类方程在限定条件下的具体表达式,研究了相应的解的积分表达式.将函数项幂次的取值范围在实数域上分... 详细信息

给出了一类重调和方程边值问题解的表示式,研究了其解的奇点可去性,利用判断反常积分收敛性的方法对解的表示式作了敛散性分析,给出了该类方程在限定条件下的具体表达式,研究了相应的解的积分表达式.将函数项幂次的取值范围在实数域上分为3段,分别讨论了每种情形下相应积分式的敛散性,得出了其在不同参数范围下解的奇点可去性.

关键词：重调和方程反常积分敛散性边值问题奇点可去性

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一类耦合的KdV型方程的周期解

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上海理工大学学报 2013年第6期35卷 516-522页

作者：丁丽娟魏公明上海理工大学理学院上海200093

讨论了一类耦合的KdV方程在一定条件下周期解的存在性.利用Sobolev不等式,给出了此方程解的估计以及它们的一二三阶导数的估计,然后根据Galerkin近似解及其先验估计,得到了耦合KdV方程弱解的局部存在性.

关键词： KdV方程周期解 Galerkin近似解先验估计

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一类拟线性椭圆方程组非平凡解的存在性

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上海理工大学学报 2010年第4期32卷 391-394,399页

作者：张兴丽魏公明上海理工大学理学院上海200093

研究了一类(p,q)-Laplace方程组非平凡解的存在性,利用Nehari流形的方法,证明了耦合项相互分离时,方程组至少存在一个非平凡解.

关键词： (p,q)-Laplace方程组极小能量解下半连续 Sobolev嵌入

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DFT Study of Alkali Metal Atom Adsorption on Defect-Free MgO（001）Surface

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Chinese Journal of Chemical Physics 2010年第5期23卷 538-542,621页

作者：徐闰贡伟明张旭王林军洪峰上海大学材料科学与工程学院上海200072 上海大学物理系上海200444

The adsorption of isolated alkali metal atoms （Li, Na, K, Rb, and Cs） on defect-free sur- face of MgO（001） has been systemically investigated with density functional theory using a pseudopotential plane-wave approach. The adsorption energy calculated is about -0.72 eV for the lithium on top of the surface O site and about one third of this value for the other alkali metals. The relatively strong interaction of Li with the surface O can be explained by a more covalent bonding involved, evidenced by results of both the projected density of states and the charge density difference. The bonding mechanism is discussed in detail for all alkali metals.

关键词： Alkali metal atom Adsorption Density functional theory

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带有导数项非线性Schrdinger方程行波解的存在性

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上海理工大学学报 2012年第6期34卷 593-597页

作者：杨林林孙宗玉魏公明上海理工大学理学院上海200093

研究了一类带有一阶导数摄动项的非线性Schrdinger方程行波解的性质,利用Lyapunov-Schmidt方法及压缩映射原理,证明了非线性Schrdinger方程行波解的存在性和集中性质,即相当于Planck常数的摄动参数趋于零时,证明了该非线性Schrdin... 详细信息

研究了一类带有一阶导数摄动项的非线性Schrdinger方程行波解的性质,利用Lyapunov-Schmidt方法及压缩映射原理,证明了非线性Schrdinger方程行波解的存在性和集中性质,即相当于Planck常数的摄动参数趋于零时,证明了该非线性Schrdinger方程的行波解的存在性,且这些解集中在其势函数的非退化临界点处.

关键词：非线性Schrdinger方程 Lyapunov-Schmidt方法压缩映射

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现代无人机测绘技术在金属矿山地质灾害中的地位与应用

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世界有色金属 2022年第21期 151-153页

作者：卫功明安徽省地质矿产勘查局311地质队安徽安庆246003

随着我国科学技术不断革新,给各个领域带来新契机,尤其是测绘领域。近些年,无人机测绘技术更是非常迅速地占领了测绘领域,该技术因为测绘效率高、干扰性小等特点深受行业的青睐,目前无人机拍摄技术迅速在各地区被广泛应用,并不断满足相... 详细信息

随着我国科学技术不断革新,给各个领域带来新契机,尤其是测绘领域。近些年,无人机测绘技术更是非常迅速地占领了测绘领域,该技术因为测绘效率高、干扰性小等特点深受行业的青睐,目前无人机拍摄技术迅速在各地区被广泛应用,并不断满足相关人员对多种数据要求。其中金属矿山由于地理环境复杂且地质灾害频发,如果只靠人力测量难免会给测量人员的人身安全造成伤害,因此相关部门开始将无人机测绘技术用于金属矿山的勘测中并取得了不错的成绩。今天本文从现代无人机测绘技术的相关概述出发,重点阐述了这项技术在金属矿山地质灾害中的地位和应用,希望能为行业发展尽绵薄之力。

关键词：无人机矿山测绘地质灾害应用

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Correlation analyse between thyroid hormone levels and severity of schizophrenia symptoms

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World Journal of Psychiatry 2025年第1期15卷 63-71页

作者： Qi-Hui Jiang wei-Dong gong Department of Endocrinology and Metabolism Hengyang Central HospitalHengyang 421000Hunan ProvinceChina Breast Tumor Surgical Outpatient Hengyang Central HospitalHengyang 421000Hunan ProvinceChina

BACKGROUND The imbalance of hormone levels in the body is closely related to the occurrence and progression of schizophrenia,especially thyroid *** To study the relationship between triiodothyronine(T3),thyroxine(T4),free T3(FT3),free T4(FT4),thyroid stimulating hormone(TSH)and *** In this study,100 schizophrenia patients were selected from our hospital between April 2022 and April *** clinical data were analyzed *** on the Positive and Negative Syndrome Scale(PANSS)score,patients were divided into mild(1-3 points,n=39),moderate(4 points,n=45),and severe groups(5-7 points,n=16).Additionally,55 healthy individuals served as a control *** blood samples were collected to measure T3,T4,FT3,FT4,TSH,and cortisol concentrations,analyzing their relationship with PANSS *** The serum levels of T3,FT3,FT4,TSH and cortisol in the schizophrenia group were lower than those in the control group(P<0.05).With the increase of the severity of the disease,the concentrations of T3 and T4 decreased,while the con-centrations of TSH and cortisol increased(P<0.05).The concentrations of TSH and cortisol were positively correlated with the PANSS score,while T3 and T4 were negatively correlated with the PANSS score(P<0.05).The receiver ope-rating characteristic curve results showed that T3,T4,TSH,and cortisol had good efficacy in the diagnosis of *** results showed that decreased T3 level,decreased T4 level,decreased TSH level and increased cortisol level may be independent risk factors for *** Thyroid hormone levels are associated with the severity of schizophrenia symptoms,which can provide new solutions for the diagnosis and treatment of schizophrenia.

关键词： Thyroid hormone Schizophrenia Symptom severity Positive and Negative Syndrome Scale score Cortisol

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Circulating MicroRNAs as Potential Biomarkers in the Diagnosis of Neurosyphilis: A Case Control Study

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International Journal of Dermatology and Venereology 2021年第1期4卷 16-25页

作者： Kai-Qi Wu Su-Fang Zhang Chao-Hui Bao Xin Zou Xin Gu Cui-Ni Wang wei-ming gong Mei Shi Yong-Liang Lou Jian Huang Ping-Yu Zhou Sexually Transmitted Disease Institute Shanghai Skin Disease HospitalShanghai 200050China Key Laboratory of Laboratory Medicine(Ministry of Education) School of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhouZhejiang 325035China Shanghai Skin Disease Hospital Clinical School of Anhui Medical UniversityShanghai 200050China Key Laboratory of Systems Biomedicine(Ministry of Education)and Collaborative Innovation Center of Systems Biomedicine Shanghai Center for Systems BiomedicineShanghai Jiao Tong UniversityShanghai 200240China

Objective:Laboratory diagnosis of neurosyphilis(NS)remains a great *** study was the aimed to identify miRNA candidates as biomarkers to distinguish between NS,non-neurosyphilis,and healthy controls(HCs).Methods:We analyzed miRNA expression profiles in peripheral blood mononuclear cells(PBMCs)from six patients with NS,eight patients with secondary syphilis(SS),and five HCs using microarray *** differentially expressed miRNAs were validated in 33 NS samples,31 SS samples,and 30 HC samples using TaqMan miRNA real-time qPCR(qRT-PCR).Results:Thirty-nine miRNAs were differentially expressed in SS and NS patients compared with *** miRNAs were randomly selected to validate their expression levels in the same samples used in microarray assay by *** miRNAs were upregulated in SS and NS samples compared with ***-PCR analysis of the expression of the 13 miRNAs in a second cohort(76 samples)showed that the average expression levels of nine miRNAs were higher in SS than in NS(SS:0.185,NS:0.136,P=3.8E-10),while the expressions of the other four miRNAs were lower in SS than in NS(SS:0.000757,NS:0.000873,P=0.022).ROC curve analysis of the 13 miRNAs showed the area under the curve value to be 1.00 for distinguishing SS patients from HCs,1.00 for distinguishing NS patients from HCs,1.00 for distinguishing SS and NS patients from HCs,and 0.968 for distinguishing NS from SS ***:The present study is the first one that identified differentially expressed miRNAs in PBMCs from patients with *** results suggest that the 13 candidate miRNAs in PBMCs may be novel noninvasive biomarkers for NS diagnosis.

关键词： diagnosis microRNAs neurosyphilis peripheral blood mononuclear cells syphilis

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