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Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben Chung-Lap Chan Grace Gar-Lee Yue LI Pei-ting Sharon Sze-Man Hon HUANG Dan-qi Miranda Sin-Man Tsang clara bik-san lau Ping-Chung Leung Chun-Kwok Wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(P<0.05),altered the hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(P<0.05).4HF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

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Inhibitory effect of different Dendrobium species on LPS-induced inflammation in macrophages via suppression of MAPK pathways

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Chinese Journal of Natural Medicines 2018年第7期16卷 481-489页

作者： ZENG Qiang Chun-Hay Ko Wing-Sum Siu LI Kai-Kai Chun-Wai Wong HAN xiao-Qiang YANG Liu clara bik-san lau HU Jiang-Miao Ping-Chung Leung Institute of Chinese Medicine The Chinese University of Hong Kong State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Shenzhen Research Institute The Chinese University of Hong Kong Kunming Institute of Botany Chinese Academy of Sciences

Dendrobii Caulis(DC), named ‘Shihu' in Chinese, is a precious herb in traditional Chinese medicine. It is widely used to nourish stomach, enhance body fluid production, tonify "Yin" and reduce heat. More than thirty Dendrobium species are used as folk medicine. Some compounds from DC exhibit inhibitory effects on macrophage inflammation. In the present study, we compared the anti-inflammatory effects among eight Dendrobium species. The results provided evidences to support Dendrobium as folk medicine, which exerted its medicinal function partially by its inhibitory effects on inflammation. To investigate the anti-inflammatory effect of Dendrobium species, mouse macrophage cell line RAW264.7 was activated by lipopolysaccharide. The nitric oxide(NO) level was measured using Griess reagent while the pro-inflammatory cytokines were tested by ELISA. The protein expressions of inducible NO synthase(iNOS), cyclooxygenase-2(COX-2) and mitogen-activated protein kinases(MAPKs) phosphorylation were evaluated by Western blotting analysis. Among the eight Dendrobium species, both water extracts of D. thyrsiflorum ***(DTW) and D. chrysotoxum Lindl(DCHW) showed most significant inhibitory effects on NO production in a concentration-dependent manner. DTW also significantly reduced TNF-α, MCP-1, and IL-6 production. Further investigations showed that DTW suppressed iNOS and COX-2 expression as well as ERK and JNK phosphorylation, suggesting that the inhibitory effects of DTW on LPS-induced macrophage inflammation was through the suppression of MAPK pathways. In conclusion, D. thyrsiflorum *** was demonstrated to have potential to be used as alternative or adjuvant therapy for inflammation.

关键词： Dendrobium species Anti-inflammation Macrophage MAPK pathways

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Seropharmacological Study on Osteogenic Effects of Post-Absorption Ingredients of An Osteoprotective Herbal Formula

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Chinese Journal of Integrative Medicine 2017年第1期23卷 25-32页

作者： SIU Wing-sum KO Chun-hay WONG Hing-lok GAO Si SHUM Wai-ting lau clara bik-san HUNG Lung-kim LEUNG Ping-chung Institute of Chinese Medicine Chinese University of Hong KongHong KongChina State Key Laboratory of Phytochemistry and Plant Resources in West China Chinese University of Hong KongHong KongChina Department of Orthopaedics and Traumatology Chinese University of Hong KonqHong KongChina

Objective： To further investigate the in vitro effects of an osteoprotective herbal formula ＂ELP＂（Herba Epimedii, Fructus Ligustri Lucidi and Fructus Psora/eae） using seropharmacological approach. Methods： Rats were fed with ELP or its individual component herbs for 2 days. The serum containing the post-absorbed ingredients of the herbal items were collected for cell culture using UMR106 cell, RAW264.7 cell and mesenchymal stem cell （MSC） isolated from the bone marrow of the rats. The effects of the herbal-containing serum on cell toxicity were detected by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay; bromodeoxyuridine assay was conducted to measure the cell proliferation of UMR106 cell and MSC; cell activity was measured using colorimetric method, and mRNA expression of runt-related transcription factor 2 （Runx2）, alkaline phosphatase （ALP） and osteopontin （OPN） of UMR106 and MSC as well as matrix metalloproteinase 9 （MMP-9）, tartrate-resistant acid phosphatase （TRAP） and cathepsin K of RAW264.7 were analyzed using real-time reverse-transcription polymerase chain reaction. Results： ELP and its component serum exhibited no cytotoxic effects on the cells. The ELP-containing serum increased the proliferation of UMR106 cell and MSC by 25.7% and 14.4%, respectively and the alkaline phosphatase activity of MSC was increased by 42.6%. On the contrary, it inhibited the RAW264.7 cell differentiation by 29.2%. ELP serum upregulated the Runx2 expression of UMR and MSC by 1.18 fold and 1.27 fold, respectively. It also upregulated ALP and OPN expression in MSC by 1.69- and 2.12-fold, respectively. On the other hand, ELP serum down-regulated MMP-9 and cathepsin K expression of RAW264.7 cell by 0.46- and 0.36-fold, respectively. Conclusions： The serum of the animals fed with ELP contains active ingredients which are effective in promoting osteogenesis and inhibiting osteoclastogenesis.

关键词： osteoporosis seropharmacology osteogenesis herbal formula

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A Commentary: Herbal Medicine Offers Great Potential in Support of Metronomic Cancer Therapy

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Journal of Cancer Therapy 2017年第2期8卷 86-95页

作者： clara bik-san lau Chun-Kwok Wong Ping-Chung Leung Partner State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Hong Kong Institute of Chinese Medicine The Chinese University of Hong Kong Hong Kong Department of Chemical Pathology The Chinese University of Hong Kong Hong Kong Metronomic Global Health Initiative Marseille France

Background: In spite of the advances in Cancer treatment, limitations exist. Refractory cases and late presentations are particularly worrying. The uncertainty of cure and the high costs have led to the popularly of complementary and alternative medicine in cancer treatment. Herbal medicine has particular attraction because it has been shown to be working on a multi-targets direction: promoting apoptosis of cancer cells, anti-angiogenesis and immunomodulating. Research on creating a simple herbal formula with multiple effects of cancer control has started and showed in laboratory platforms promising results. Metronomic Chemotherapy: Attention on the use of old oral cytotoxic drugs in small doses for refractory and late cancer cases has started more than a decade. Satisfactory and good results have been found to be related to anti-angiogenesis, immunomodulations and cancer cell apoptosis. These findings are comparable to the use of multiple targets herbal medicine. Conclusion: Assumption is made that metronomic chemotherapy, combined with herbal medicine could be achieving synergistic effects and would be affordable to all patients.

关键词： Cancer Metronomic Treatment Herbal Medicine

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Chinese topical herbal medicine gives additive effect on pharmaceutical agent on fracture healing

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Journal of Traditional Chinese Medicine 2019年第6期39卷 853-860页

作者： Siu Wing Sum Shiu Hoi Ting Shum Wai Ting Ko Chun Hay lau clara bik san Hung Leung Kim Leung Ping Chung Institute of Chinese Medicine The Chinese University of Hong KongShatinNew TerritoriesHong Kong China State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongShatinNew TerritoriesHong Kong China Department of Orthopaedics and Traumatology The Chinese University of Hong KongShatinNew TerritoriesHong Kong China

OBJECTIVE:To investigate the efficacy on the combination of oral strontium ranelate(Sr R)with a topical Chinese herbal paste on facilitation of fracture ***:An open fracture was created at the mid-shaft of the right tibia of rat.A herbal pastecalled CDR containing Honghua(Flos Carthami),Chuanxuduan(Radix Dipsaci Asperoidis)and Dahuang(Radix Et Rhizoma Rhei Palmati)was *** rats were treated with either CDR topically on the fracture site,or Sr R orally,or their *** turnover biochemical markers in serum were *** of the fracture was analyzed using micro-CT after 14 and 28 d,followed by histomorphometrical ***:Micro-computed tomography analysis revealed that the combined treatment of CDR with600 mg/g Sr R significantly increased the total callus density,mineralized callus volume fraction,mineralized callus mineral content and mineralized callus density of the callus after 28 d of *** result was consistent with the histomorphometrical analysis on the osteoid *** of biochemical markers showed that the combined treatments reduced the bone resorption that occurs temporarily after ***:This study demonstrated that the combined treatment of oral Sr R and topical CDR is effective to promote fracture healing by their additive effect on promoting bone formation and retarding bone resorption.

关键词： Fracture healing Osteogenesis Bone resorption Medicine,Chinese Traditional Integrative medicine Strontium ranelate

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乳腺癌干细胞近年的主要研究进展

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中国组织工程研究 2017年第21期21卷 3414-3419页

作者：罗智萍刘碧珊谭宁华中国药科大学中药学院江苏省南京市211198 香港中文大学中医中药研究所及植物化学与西部植物资源持续利用国家重点实验室伙伴实验室

背景:随着对乳腺癌发生、发展机制的不断深入研究,乳腺癌干细胞日益受到重视。目的:对乳腺癌干细胞的特征、调控乳腺癌干细胞的相关信号通路以及乳腺癌干细胞与上皮间质转化、乳腺癌转移、肿瘤微环境、治疗抵抗等方面的主要研究进展做... 详细信息

背景:随着对乳腺癌发生、发展机制的不断深入研究,乳腺癌干细胞日益受到重视。目的:对乳腺癌干细胞的特征、调控乳腺癌干细胞的相关信号通路以及乳腺癌干细胞与上皮间质转化、乳腺癌转移、肿瘤微环境、治疗抵抗等方面的主要研究进展做一综述。方法:由第一作者以"Breast cancer,Stem cells,Signaling pathway,Epithelial mesenchymal transition,Tumor microenvironment"为关键词,检索PubM ed等数据库从2001至2017年的相关文献,排除与文章研究目的无关及重复性的文章,纳入符合标准的60篇文献进行综述。结果与结论:肿瘤干细胞学说的提出解释了肿瘤转移和复发的根本原因,为肿瘤治疗提供一个新的研究思路,随着对乳腺癌干细胞的致病分子机制、特性和相关分子调控机制的深入研究,明确了乳腺癌干细胞在乳腺癌发生、发展中所扮演的角色,对靶向乳腺癌干细胞的肿瘤治疗方法的研究具有重要指导意义。

关键词：乳腺肿瘤肿瘤干细胞组织工程干细胞乳腺癌转移复发致瘤性分离鉴定信号通路上皮间质转化肿瘤微环境耐药性国家自然科学基金

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In vitro investigations on the effects of a natural cyclopeptide,RA-V on cell adhesion in human breast cancer cells

In vitro investigations on the effects of a natural cyclopep...

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第十四届全国中药和天然药物学术研讨会

作者： Hoi-Wing Leung Grace Gar-Lee Yue Kwok-Pui Fung Ping-Chung Leung Ning-Hua Tan clara bik-san lau Institute of Chinese Medicine State Key Laboratory of Phytochemistry and Plant Resources in West China(CUHK) School of Biomedical Sciences The Chinese University of Hong Kong State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences

＜正＞Cancer cell adhesion occurs in *** cells need to acquire adhesive ability to extracellular matrix（ECM）to provide a path for them to migrate to adjacent tissues and ultimately *** receptors（integrins）,vascular cell adhesion molecules（VCAMs）and intercellular adhesion molecules（ICAMs）,responsible for cell adhesion,are

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An Innovative Antiseptic, Antiperspirant and Deodourant Diaper for the Older and Frail Older People Suffering from Urinary Incontinence

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Advances in Aging Research 2017年第2期6卷 29-37页

作者： Elaine Wat Alex W. L. Lin Cyrus Mak Ivan Lam clara bik-san lau Frency Sau-Fun Ng Patrick Chi-Leung Hui Ping-Chung Leung Institute of Chinese Medicine The Chinese University of Hong Kong Hong Kong Partner State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Hong Kong Institute of Textiles and Clothing The Hong Kong Polytechnic University Hong Kong Neighbourhood Advice-Action Council Harmony Manor Hong Kong

Background: Urinary Incontinence is a common symptom among the older and frail older people. Apart from affecting the quality of life and skin complications, the demand on assistance could be too high for any sufferer. While conservative means of treatment do not work, special incontinence apparel could be a good compromise. Objective: To create an absorbent, antiseptic, antiperspirant and deodourant diaper for the older and dependent people suffering from urinary incontinence. Material and Methods: Antiperspirant and antiseptic medicinal materials have been reported in Traditional Chinese Medicine and two herbs were screened out to provide the required effects. A combination of Fraxini Cortex, Calamine and Zinc oxide made in powder forms was impregnated into a pocket of the diaper. Laboratory tests were performed to confirm the antiseptic, antiperspirant and deodourant effects of the materials. A self-control clinical trial on the diaper was organized in an elderly home. Results: Antibacterial effects against Staphylococcus, E. coli and Candida were proven. Antiperspirant effects were confirmed using acetylcholinesterase inhibitor testings. Volunteers using the Sudoscan machine further demonstrated the weak antiperspirant effects of the herbs. A pilot study on 31 dependent diaper users gave positive feedbacks of more comfort, less leakage, odour and better skin conditions. The overall satisfaction reached 79%. Conclusion: A special diaper with antiseptic, antiperspirant and deodourant effects could be created with inexpensive herbal powder impregnated and could be recommended to the older and frail older people with urinary incontinence.

关键词： Urinary Incontinence Older And Frail Older Toilet Assistance Rehabilitation Adult Diaper

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A Potential Anti-metastatic Chinese Herb Andrographis paniculata—Its In Vitro Activities in Esophageal Cancer Cells and Endothelial Cells

A Potential Anti-metastatic Chinese Herb Andrographis panicu...

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第十四届全国中药和天然药物学术研讨会

作者： Grace Gar-Lee Yue Julia Kin-Ming Lee Kar-Man Chan Kwok-Pui Fung Philip Wai-Yan Chiu clara bik-san lau The Chinese University of Hong Kong

＜正＞Esophageal cancer is associated with high postoperative recurrence and systemic *** adjuvant chemotherapy and concurrent radiation have shown favourable efficacies,searching for alternative treatments for metast...

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HYPOPIGMENTATION AND HEALTHY SKIN PROMOTING EFFECT OF A MODIFIED QI BAI san

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World Journal of Traditional Chinese Medicine 2016年第2期 81-82页

作者： Elaine Wat Yau Tsz Chan Tiffany Hoi Ka Tso Chun Fai Ng Ching Po lau Wing Sum Siu Chun Hay Ko Ka Keung lau Raymond Hu clara bik-san lau Ping Chung Leung Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong 5100 Cosmetic Company Ltd.

Introduction:Qi Bai san(QBS,七白散)is a traditional Chinese herbal formula used by ancient ladies for healthy skin and *** it is a popular product in the market,it contains animal drug and toxic herbs which

关键词： MSH HYPOPIGMENTATION AND HEALTHY SKIN PROMOTING EFFECT OF A MODIFIED QI BAI san

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