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Use of the Lecompte procedure for ventriculoarterial connection abnormalities in infants and children with congenital heart diseases

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Chinese Medical Journal 2008年第16期121卷 1554-1557页

作者： ZHENG Jing-hao LIU Jin-fen XU Zhi-wei SU zhao-kang DING Wen-xiang Department of Pediatric Thoracic & Cardiovascular Surgery Shanghai Children's Medical Center Medical College of Shanghai Jiaotong University Shanghai 200127 China

Background The Lecompte （REV） procedure is used to correct abnormal ventriculoarterial connections in patients with congenital heart diseases; it avoids the need for an extracardiac conduit for pulmonary outflow tract reconstruction. The present study aimed to investigate effectiveness and criteria of the REV procedure in children with abnormal ventriculoarterial connections. Methods Thirty-eight children （mean age, （2.2±1.7） years; mean weight, （11.5±3.8） kg） with abnormal ventriculoarterial connections who had an REV procedure in our hospital from January 1998 to May 2006 were studied. Only 10 patients had the usual anteropostedor relationship of the two great arteries. The infundibular septum between the two semilunar valves was aggressively resected to enlarge it and construct a straighter left ventricular outflow tract and a wide tunnel between the ventricular septal defect （VSD） and the aorta. Eighteen cases had the original REV procedure; 20 had a modified REV procedure. Results All patients are alive; none developed severe complications. The postoperative right ventricular （RV） to left ventricular （LV） pressure ratio was 0.20-0.45. Five patients had RV dysfunction; 2 patients had a pressure gradient in the RV ventricular outlet of 30.0-34.5 mmHg; 3 cases had a 37.5-47.3 mmHg pressure difference in the RPA. All patients had an RV pressure less than half the systemic pressure. These gradients＇ magnitudes in all patients were consistent with the post-operative RV to LV pressure ratio （P 〈0.05）. During the follow-up （mean, （4.2±0.6） years）, 2 patients had an RPA pressure gradient of 24.0-29.3 mmHg which abated to less than 10 mmHg after two years. Conclusions The REV procedure provides satisfactory short- to medium-term results. It may be superior tO the Rastelli procedure for treating ventriculoarterial connection abnormalities; it allows early, complete anatomic repair and reduces the need for late re-operation, since no extracardiac conduit is needed. Longer

关键词： heart defects, congenital pulmonary surgical procedures infant child

Effect of oxygen on regulation of properties of moderately boron-doped diamond films

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Chinese Physics B 2022年第12期31卷 591-597页

作者： Dong-Yang Liu Li-Cai Hao wei-kang zhao Zi-Ang Chen Kun Tang Shun-Ming Zhu Jian-Dong Ye Rong Zhang You-Dou Zheng Shu-Lin Gu School of Electronic Science and Engineering Nanjing UniversityNanjing 210093China The Shanghai Huahong Grace Semiconductor Manufacturing Corporation Shanghai 201203China Collaborative Innovation Center of Solid-State Lighting and Energy-Saving Electronics Nanjing UniversityNanjing 210093China

Regulation of oxygen on properties of moderately boron-doped diamond films is fully *** show that,with adding a small amount of oxygen(oxygen-to-carbon ratio<5.0%),the crystal quality of diamond is improved,and a suppression effect of residual nitrogen is *** increasing ratio of O/C from 2.5%to 20.0%,the hole concentration is firstly increased then *** change of hole concentration is also ***,the results of Hall effect measurement with temperatures from 300 K to 825 K show that,with adding a small amount of oxygen,boron and oxygen complex structures(especially B_(3)O and B_(4)O)are formed and exhibit as shallow donor in diamond,which results in increase of donor *** further increase of ratio of O/C,the inhibitory behaviors of oxygen on boron leads to decrease of acceptor concentration(the optical emission spectroscopy has shown that it is decreased with ratio of O/C more than 10.0%).This work demonstrates that oxygen-doping induced increasement of the crystalline and surface quality could be restored by the co-doping with *** technique could achieve boron-doped diamond films with both high quality and acceptable hole concentration,which is applicable to electronic level of usage.

关键词： moderately boron doped diamond crystal quality suppression effect boron and oxygen complex structures

Origin,characteristics,and suppression of residual nitrogen in MPCVD diamond growth reactor

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Chinese Physics B 2022年第12期31卷 606-611页

作者： Yan Teng Dong-Yang Liu Kun Tang wei-kang zhao Zi-Ang Chen Ying-Meng Huang Jing-Jing Duan Yue Bian Jian-Dong Ye Shun-Ming Zhu Rong Zhang You-Dou Zheng Shu-Lin Gu School of Electronic Science and Engineering Nanjing UniversityNanjing 210046China

Unintentional nitrogen incorporation has been observed in a set of microwave plasma chemical vapor deposition(MPCVD)-grown *** abnormality has been detected on the apparatus especially the base pressure and feeding gas *** a comprehensive investigation including the analysis of the plasma composition,we found that a minor leakage of the system could be significantly magnified by the thermal effect,resulting in a considerable residual nitrogen in the diamond ***,the doping mechanism of leaked air is different to pure nitrogen *** dosage of several ppm of pure nitrogen can lead to efficient nitrogen incorporation in diamond,while at least thousands ppm of leaked air is required for detecting obvious residual *** difference of the dosage has been ascribed to the suppression effect of oxygen that consumes *** the unintentional impurity is basically detrimental to the controllable fabrication of diamond for electronic application,we have provided an effective way to suppress the residual nitrogen in a slightly leaked system by modifying the susceptor *** study indicates that even if a normal base pressure can be reached,the nitrogen residing in the chamber can be“activated”by the thermal effect and thus be incorporated in diamond material grown by a MPCVD reactor.

关键词： microwave plasma chemical vapor deposition diamond residual nitrogen system leakage

Effect of Cardiopulmonary Bypass on Pulmonary Function in Infants

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上海交通大学学报（医学版） 2006年第8期26卷 925-925页

作者： ZHOU Yan-ping CAI Ji-ming SHI Zhen-ying CHEN Ling XU Zhi-wei SU zhao-kang Department of Pediatric Thoracic and Cardiovascular Surgery Shanghai Children＇s Medical Center School of Medicine Shanghai Jiaotong University Shanghai 200127 China

Objective To evaluate the effect of the cardiopulmonary bypass (CPB) on the pulmonary function in infants with or withoutpulmonary hypertension in congential ventricular septal defect (VSD). MethodsTwenty infants with VSD were enrolled in the study fromJan. to Dec.2004. They were divided into two groups: pulmonary hypertension group and non-pulmonary hypertension group, ten infantsrespectively. Pulmonary function parameters were measured before CPB and 3, 6, 9, 12, 15, 18, 21, 24h after CPB, the following datawere recorded: duration for mechanical ventilation (Tmv) and staying in the cardiac intensive care unit (Tcicu) after cardiac *** Before CPB, the pulmonary function parameters in non-pulmonary hypertension group were more superior than in pulmonary hy-pertension group (Pweight the neg-ative effects of CPB on pulmonary function. We should improve cardiac function to avoid the presence of the nadir trough in pulmonaryfunction. The infants with pulomonary hypertension also have ability to wean from mechanical ventilation as soon as possible, if the hemo-dynamics is stable, and without the responsive pulmonary hypertension or pulmonary hypertension crisis after surgical repair.

关键词： cardiopulmonary bypass pulmonary hypertension pulmonary function infant

Precise gradient separation of nanoparticles using reduced graphene oxide-polyoxomolybdate membranes

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Science China Chemistry 2025年第01期 209-216页

作者： Yixin Yang Wanlei zhao Ruoxuan Zheng Hongqiang Li wei Chen Yu-Fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Quzhou Institute for Innovation in Resource Chemical Engineering

The purification and size sieving of nanoparticles （NPs） represents a significant scientific ***,the r GO-polyoxometalates (POMs=PMo12,Mo132and Mo368) membranes were fabricated successfully via a simple and scalable POMsassisted in-situ photoreduction *** the mass ratio of r GO to PMo12was 1:30,the resultant r GO-PMo12membranes with highly ordered and uniform nanochannels of 1.0 nm can be obtained,which showed an accurate carbon quantum dots（CQDs） separation with a cut-off size approximately 1.0 *** increase of the size of the interlayered POMs from PMo12（1.0 nm）,{Mo132}（2.9 nm） to{Mo368}（3.8 nm）,the resultant r GO-PMo12,r GO-Mo132and r GO-Mo368exhibited precise gradient separation of CQDs and Au nanoparticles by size exclusion *** results pave a promising way to construct new twodimensional （2D） membranes for highly efficient size-selective separation.

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Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao wei Panpan zhao Yongchun Wang Mingxi Li Li Sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li wei Zhang Jian Wu Hui Hong wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao weijiang zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Suppression and compensation effect of oxygen on the behavior of heavily boron-doped diamond films

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Chinese Physics B 2023年第3期32卷 554-560页

作者：郝礼才陈子昂刘东阳赵伟康张鸣汤琨朱顺明叶建东张荣郑有炓顾书林 School of Integrated Circuits Anhui UniversityHefei 230039China School of Electronic Science and Engineering Nanjing UniversityNanjing 210093China Collaborative Innovation Center of Solid-State Lighting and Energy-Saving Electronics Nanjing UniversityNanjing 210093China

This work investigates the suppression and compensation effect of oxygen on the behaviors and characteristics of heavily boron-doped microwave plasma chemical vapor deposition(MPCVD)diamond *** suppression effect of oxygen on boron incorporation is observed by an improvement in crystal quality when oxygen is added during the diamond doping process.A relatively low hole concentration is expected and verified by Hall effect measurements due to the compensation effect of oxygen as a deep donor in diamond.A low acceptor concentration,high compensation donor concentration and relatively larger acceptor ionization energy are then induced by the incorporation of oxygen;however,a heavily boron-doped diamond film with high crystal quality can also be *** formation of an oxygen–boron complex structure instead of oxygen substitution,as indicated by the results of x-ray photoelectron spectroscopy,is suggested to be more responsible for the observed enhanced compensation effect due to its predicted low formation ***,density functional theory calculations show that the boron–oxygen complex structure is easily formed in diamond with a formation energy of-0.83 *** work provides a comprehensive understanding of oxygen compensation in heavily boron-doped diamond.

关键词： diamond boron–oxygen co-doping incorporation efficiency ionization energy compensation boron–oxygen complex

水迷宫重复测量数据的方差分析及其在SPSS中的实现

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中西医结合学报 2007年第1期5卷 101-105页

作者：邱宏金国琴金如锋赵伟康上海中医药大学基础医学院预防医学与卫生统计学教研室上海201203 上海中医药大学基础医学院生物化学教研室上海201203 上海中医药大学老年医学研究所上海201203

目的:介绍用SPSS11.0实现对水迷宫重复测量资料的方差分析,以期对采用重复测量设计方案的临床和基础科研工作者提供可借鉴的统计学分析方法。方法:应用SPSS11.0中一般线性模型(generallinearmodel,GLM)的repeatedmeasures和multivariat... 详细信息

目的:介绍用SPSS11.0实现对水迷宫重复测量资料的方差分析,以期对采用重复测量设计方案的临床和基础科研工作者提供可借鉴的统计学分析方法。方法:应用SPSS11.0中一般线性模型(generallinearmodel,GLM)的repeatedmeasures和multivariate过程对水迷宫重复测量数据进行重复测量方差分析和多元方差分析,并进行不同时间点和不同组间的两两比较。结果:首先通过球形检验(Mauchly’stestofsphericity)的结果判断重复测量数据之间是否存在相关性,如存在相关性(P≤0.05),宜进行多元方差分析,或采用Greenhouse-Geisser的校正结果;通过计算个体间(between-subject)变异,可分析处理因素有无效应;计算个体内(within-subject)变异,可分析时间因素有无效应,时间与处理因素之间有无交互效应;使用重复测量数据多重比较配对的t检验法(Bonferroni法),可进行每个分组每个时间点上作用的两两比较;使用多元方差分析的方法,可进行每个时间点上每个分组之间作用的两两比较。结论:对于重复测量数据的方差分析,宜采用一般线性模型的重复测量过程方法进行分析。SPSS统计软件易于实现重复测量数据的方差分析。

关键词：方差分析统计学 SPSS 线性模型