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Robust reliable control for a class of time-varying uncertain impulsive systems

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Journal of Central South University of Technology 2005年第z1期12卷 199-202页

作者： CHENG Xin-ming GUI wei-hua GAN Zheng-jia School of Information Science and Engineering Central South University Changsha 410083 China School of Information Science and Engineering Central South University Changsha 410083 China School of Computer and Communication Changsha University of Science and Technology Changsha 410076 China

The problem of robust and reliable control design for linear uncertain impulsive systems with both timevarying norm-bounded parameter uncertainty and actuator failures was studied. The actuators are classified into two groups. One set of actuators susceptible to failures is possible to fail, the other set of actuators robust to failures is assumed never to fail. The outputs of the actuator failures are regarded as zero. The purpose is to design the state feedback controller such that, for all admissible uncertainties as well as actuator failures occurring among a prespecified subset of actuators, the plant remains asymptotically stable. A modified algebraic Riccati equation approach was developed to solve the problem addressed and a robust reliable control law was obtained. An numerical example was also offered to prove the effectiveness of the proposed method.

关键词： reliable control uncertain impulsive systems state feedback stabilization

Potential factors associated with clinical stage of nasopharyngeal carcinoma at diagnosis: a case–control study

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Chinese Journal of Cancer 2017年第10期36卷 478-487页

作者： Jun-Ting Ren Meng-Yu Li Xiao-Wen Wang Wen-Qiong Xue Ze-Fang Ren wei-hua jia School of Public Health Sun Yat-sen University 74 Zhongshan 2nd RdGuangzhou 510080 Guangdong P. R. China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center 651 Dongfeng East Rd Guangzhou 510060 GuangdongP. R. China

Background: In China, most patients with nasopharyngeal carcinoma(NPC) are diagnosed at a late stage and con?sequently have a poor prognosis. This study aimed to investigate potential factors associated with the clinical stage of NPC at ***: Data were obtained from 118 patients with early?stage NPC and 274 with late?stage NPC who were treated at Sun Yat?sen University Cancer Center between August 2014 and July 2015. Patients were individually matched by age, sex, and residence, and a conditional logistic regression model was applied to assess the associa?tions of clinical stage at diagnosis with socioeconomic status indicators, knowledge of NPC, physical examinations, patient interval, and risk factors for ***: Although knowledge of early NPC symptoms, smoking cessation, and patient interval were important fac?tors, the number of cigarettes smoked per day, motorbike ownership, and physical examination exhibited the strong?est associations with the clinical stage of NPC at diagnosis. Compared with smoking fewer than ten cigarettes a day, smoking 10–30 cigarettes [odds ratio(OR) 4.03; 95% confidence interval(CI) 1.11–14.68] or more than 30 cigarettes(OR 11.46; 95% CI 1.26–103.91) was associated with an increased risk of late diagnosis. Compared with not owning a motorbike, owning a motorbike(OR 0.38; 95% CI 0.23–0.64) was associated with early diagnosis. Subjects who under?went physical examinations were less likely to receive a late diagnosis than those who did not undergo examinations(OR 0.50; 95% CI 0.28–0.89). However, indicators of wealth were not significant ***: Initiatives to improve NPC patient prognosis should aim to promote knowledge about early symptoms and detection, health awareness, and accessibility to health facilities among all patients, regardless of socioeconomic status.

关键词： Nasopharyngeal carcinoma Stage Socioeconomic status Cancer cognition China

A comprehensive genomic characterization of esophageal squamous cell carcinoma: from prognostic analysis to in vivo assay

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Chinese Journal of Cancer 2016年第9期35卷 435-437页

作者： Yuan-Bin Chen wei-hua jia Sun Yat?sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine

Background: Esophageal squamous cell carcinoma(ESCC) is a leading cause of cancer death worldwide and is char?acterized by numerous genetic mutations. TNM staging is not sufficient for predicting patient outcomes. Addition?ally, ESCC shows poor responsiveness to chemotherapy and radiation. Thus, there is an urgent need to find efficient therapy targets. Previous ESCC high?throughput genomic studies have lacked intensive survival analysis, particularly for copy number variation(CNV) and the genes *** body: In the study "Genomic Characterization of Esophageal Squamous Cell Carcinoma Reveals Critical Genes Underlying Tumorigenesis and Poor Prognosis" recently published in the American Journal of Human Genetics, we comprehensively analyzed the effects of CNVs, mutations, and relative gene expression on patient outcomes. To validate our findings for our 67 sequencing samples, we collected a 321?patient retrospective cohort with detailed 5?year follow?up information and carried out univariate and multivariate survival analyses. In addition, the biological functions of the survival predictors in ESCC were investigated both in vitro and in ***: We found the independent ESCC survival predictors and potential therapy targets. Nevertheless, the effects of numerous low?frequency mutations need to be explored using larger sample sequencing. Overall, con?structing multi?gene prognostic signatures will remain a great challenge in the future.

关键词：鳞状细胞癌基因组特征基因组学体内分析食管癌预后基因突变预测因子

Research development of Carpesii Fructus

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中国药理学与毒理学杂志 2018年第4期32卷 288-289页

作者： wei-hua jia Lin YIN Xi CHEN Nuo-qi WANG Xiu-ying YANG Guan-hua DU State Key Laboratory of Bioactive Substance and Function of Natural Medicines and Beijing Key Laboratory of Drug Target and Screening Research Institute of Materia Medica of Peking Union Medical College Beijing 100050 China

Carpesii Fructus is the fruit of Carpesium abrotanoides *** is recorded in the Chinese Pharmacopoeia(2015 Edition).Carpesium abrotanoides broadly distribute in ***,Carpesii Fructus was used as a parasiticide,especially for ascariasis,pinworms and tapeworm *** ancient times,the Carpesium plants were used as traditional Chinese,Korean and Japanese herbal medicines for the treatment of several *** Fructus was first recorded in the book "Newly Revised Canon of Materia Medica" in the Tang Dynasty of *** original plant is Compositae *** santonica(Seriphidium cinum) from middle east *** present,Carpesium abrotanoides issometimes confused with the Lappula family in species *** the Song Dynasty of China,"KaiYang Materia Medica" recorded that the best Carpesii Fructus was from *** main *** of Carpesii Fructusare terpenes,phenolic compounds,flavonoids and *** telekin,3-epi-isotelekin,11β-13-dihydro-1-epi-inuviscolide,carabrone,carabrol,terpene lactone,gerilin,carpesia,valeric acid,oleic acid,linolenic acid,thirty-one alkane,sterol,*** chemical components isolated from whole plants of carpesia are more than *** clinical practice,Carpesii Fructus is mainly used as antiparasitic drugs and usually combined with other drugs since the poor efficacy as single *** toxic reaction is closely related to the dose of the ***,asa main component of Carpesii Fructus,might lead to adverse reactions *** present,Major issuesof Carpesii Fructusare the lack of *** research,as well as lack of in-depth study on the material ***,further studies are needed on the drug development and clinical usuage.

关键词：荞麦中医治疗方法临床分析

Alcohol and tea consumption in relation to the risk ofnasopharyngeal carcinoma in Guangdong, China

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Frontiers of Medicine 2010年第4期4卷 448-456页

作者： Hong-Lian RUAN Feng-hua XU Wen-Sheng LIU Qi-Sheng FENG Li-Zhen CHEN Yi-Xin ZENG wei-hua jia State Key Laboratory of Oncology in Southern China Guangzhou 510060China School of Public Health Sun Yat-Sen UniversityGuangzhou 510080China Department of Experiment Research Sun Yat-sen UniversityCancer CenterGuangzhou 510060China

To investigate whether alcohol and tea con-sumption has an etiological association with nasophar-yngeal carcinoma(NPC)in a high-incident population,a large scale case-control study was *** study included 2846 individuals in Guangdong Province,China,with 1387 newly diagnosed cases of NPC and 1459 frequency-matched *** histories of alcohol and tea consumption were obtained via personal *** regarding socio-demographic charac-teristics(age,sex,education,dialect and household type),family history of NPC,Epstein-Barr virus(EBV)infection,dietary habits and other potential confounding factors was also *** analysis was performed using uncondi-tional logistic regression to calculate odds ratios(OR)and 95%conﬁdence intervals(CI).The risk of NPC was found to be associated with habitual alcohol consumption and tea *** consumption has been associated with a decreased occurrence of NPC(OR=0.62),while con-sumption of alcohol was associated with a complex ***ﬁcally,moderate consumption of alcohol was associated with decreased risk of NPC,while overuse,especially strong distillate spirits,appeared to be a risk factor.

关键词： nasopharyngeal carcinoma case-control study alcohol consumption tea consumption

Cumulative scores based on plasma D-dimer and serum albumin levels predict survival in esophageal squamous cell carcinoma patients treated with transthoracic esophagectomy

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Chinese Journal of Cancer 2016年第3期35卷 133-141页

作者： De-Qing Liu Fang-Fang Li wei-hua jia State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center Department of Radiation Oncology Chongqing Cancer Institute

Background:Recently,studies have shown that plasma D-dimer and serum albumin are prognostic markers for esophageal *** purpose of this study was to evaluate a novel prognostic scoring system—DA score(combination of preoperative plasma D-dimer and serum albumin levels)—and analyze the association between survival of patients with esophageal squamous cell carcinoma(ESCC) and their Glasgow prognostic ***:In this retrospective study,preoperative biochemical markers and clinicopathologic factors in 260 ESCC patients treated with transthoracic esophagectomy were *** to receiver operating characteristic analysis,the cutoff values of D-dimer and albumin were defined as 0.5 μg/mL and 43.8 g/L,*** with high D-dimer levels(>0.5 μg/mL) and low albumin levels(<43.8 g/L) were assigned a score of 2,those with only one of the two abnormalities were assigned a score of 1,and those with neither of the two abnormalities were assigned a score of ***:ESCC patients with a DA score of 0,l,and 2 numbered 55,116,and 89,*** analysis showed that patients with a DA score of 2 had lower overall survival(OS) rates than those with DA scores of 1 and 0(37.1%vs.52.6%and 76.4%,P < 0.001);similar findings were observed for disease-free survival(DFS) rates(32.6%vs.44.8%and67.3%,P < 0.001).In addition,the predictive value of the DA score was also significant in patients with stages l-IIA and stages IIB-IV *** Cox regression analyses indicated that hazard ratios(HRs) for predicting OS of patients with DA scores 1 and 2 were 2.25 {P — 0.010) and 3.14(P< 0.001),respectively,compared with those with a DA score of 0,and HRs for predicting DFS of patients with DA scores of 1 and 2 were 1.86(P = 0.023) and 2.68(P < 0.001),respectively,compared with those with a DA scores of ***:Our study suggests that preoperative DA scores are notably associated with postoperative survival of ESCC patients.

关键词： DA score, Esophageal squamous cell carcinoma, Survival, Prognostic factors, Transthoracicesophagectomy

Nasopharyngeal brushing: a convenient and feasible sampling method for nucleic acid-based nasopharyngeal carcinoma research

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Cancer Communications 2018年第1期38卷 95-104页

作者： Pei-Fen Zhang Xiao-Hui Zheng Xi-Zhao Li Tian Tian Shao-Dan Zhang Ye-Zhu Hu wei-hua jia Tumor Resource Bank State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center651 Dongfeng East RoadGuangzhou 510060Guang-dongP.R.China Affiliated Tumor Hospital of Xinjiang Medical University Ürümqi 830000XinjiangP.R.China

Background:Tissue specimens for nasopharyngeal carcinoma(NPC)research are scarce because of sampling *** studies have suggested non-invasive nasopharyngeal brushing as an effective sampling method for NPC *** present study aimed to evaluate the feasibility of nasopharyngeal brushing in the acquisition of NPC nucleic acids for ***:Nasopharyngeal brushing samples were acquired from 24 healthy individuals and 48 NPC *** from 48 NPC and 18 nasopharyngitis patients were collected by endoscopic *** expression levels of tumor suppressor genes(TSGs)and Epstein-Barr virus(EBV)-encoded microRNAs as well as EBV DNA copy number were measured by quantitative polymerase chain reaction in both types of ***:Among six TSGs examined,the expression levels of two genes were significantly decreased in nasopharyn-geal brushing and tissue samples from NPC patients as compared with those from healthy/nasopharyngitis *** EBV-encoded microRNAs,mir-bart1-5p,mir-bart5,mir-bart6-5p,and mir-bart17-5p,were significantly up-regulated in both NPC brushing and tissue samples compared with those from healthy/nasopharyngitis controls(P<0.001).EBV DNA was significantly increased in both nasopharyngeal brushing samples(P<0.001)and tissue sam-ples(P<0.001)from NPC patients in comparison with those from healthy ***:Nasopharyngeal brushing can obtain sufficient tumoral materials for the analysis of viral nucleic acid,including EBV-encoded microRNAs and EBV *** the detection of TSG expression,nasopharyngeal brushings was feasible but inferior to tissue *** study confirms nasopharyngeal brushing as an applicable sampling method that can aid in nucleic acid-based NPC research.

关键词： Nasopharyngeal brushing Tissue samples Nasopharyngeal carcinoma Nucleic acid Cancer research

Centrifugation: an important pre-analytic procedure that influences plasma microRNA quantification during blood processing

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Chinese Journal of Cancer 2013年第12期32卷 667-672页

作者： Xiao-Hui Zheng Cui Cui Xin-Xi Zhou Yi-Xin Zeng wei-hua jia State Key Laboratory of Oncology in South China Bank of Tumor Resource Sun Yat-sen University Cancer Center

Circulating microRNAs are robustly present in plasma or serum and have become a research focus as biomarkers for tumor diagnosis and *** is a necessary procedure for obtaining highquality blood ***,we investigated one-step and two-step centrifugations,two centrifugal methods routinely used in microRNA study,to explore their effects on plasma microRNA *** microRNAs obtained from one-step and two-step centrifugations were quantified by microarray and TaqMan-based real-time quantitative polymerase chain reaction(Q-PCR).Dynamic light scattering was performed to explore the difference underlying the two centrifugal *** results from the microarray containing 1,347 microRNAs showed that the signal detection rate was greatly decreased in the plasma sample prepared by two-step *** importantly,the microRNAs missing in this plasma sample could be recovered and detected in the precipitate generated from the second *** with the results from microarray,a marked decrease of three representative microRNAs in twostep centrifugal plasma was validated by *** to the size distribution of all nanoparticles in plasma,there were fewer nanoparticles with size>1,000 nm in two-step centrifugal *** experiments directly demonstrated that different centrifugation methods produced distinct quantities of plasma ***,exosomes or protein complexes containing microRNAs may be involved in large nanoparticle formation and may be precipitated after two-step *** results remind us that sample processing methods should be first considered in conducting research.

关键词： microRNA 离心分离血浆定量分析血液预分析小分子RNA 微小RNA

GWAS signals across the HLA regions:revealing a clue for common etiology underlying infectious tumors and other immunity diseases

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Chinese Journal of Cancer 2011年第4期30卷 226-230页

作者： Yin Yao Shugar Ying Wang wei-hua jia Yi-Xin Zeng Unit of Statistical Genomics Intramural Research Program National Institute of Mental Health National Institute of Health Bethesda Maryland 20892 USA Department of Psychiatry and Behavioral Sciences the Johns Hopkins University School of Medicine Baltimore Maryland 21287 USA State Key Laboratory ot Oncology in South China Guangzhou Guangdong 510060 P. R. China Department of Experimental Research Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China.

Increasing evidence suggests that multiple genes in the human leukocyte antigen(HLA) regions play an important role in development of cancers and immunity ***,the biological mechanisms of the HLA associations are not well *** recently conducted a survey of all genome-wide association studies(GWAS) with significant findings in the HLA regions and concluded that diseases such as cancer and immune disorders are more likely to be associated with genetic variants located in the HLA regions than other *** finding is suggestive for testing a hypothesis of a common etiology of infectious tumors and other immunity diseases.

关键词：免疫系统 HLA 传染性疾病病因肿瘤人类白细胞抗原信号