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Targeting stroma and tumor,silencing galectin 1 treats orthotopic mouse hepatocellular carcinoma

Acta Pharmaceutica Sinica B 2024年第1期14卷 292-303页

作者： Tahereh Setayesh Ying Hu Farzam Vaziri Xin Chen Jinping Lai Dongguang wei Yu-Jui Yvonne wan Department of Medical Pathology and Laboratory Medicine University of CaliforniaDavisSacramentoCA 95817USA Cancer Biology Program the University of Hawaii Cancer CenterHonoluluHI 96813USA Department of Pathology and Laboratory Medicine Kaiser Permanente Sacramento Medical CenterSacramentoCA 95825USA

This study examines inhibiting galectin 1(Gal1)as a treatment option for hepatocellular carcinoma(HCC).Gal1 has immunosuppressive and cancer-promoting roles.Our data showed that Gal1 was highly expressed in human and mouse HCC.The levels of Gal1 positively correlated with the stages of human HCC and negatively with survival.The roles of Gal1 in HCC were studied using overexpression(OE)or silencing using Igals1 siRNA delivered by AAV9.Prior to HCC initiation induced by RAS and AKT mutations,lgals1-OE and silencing had opposite impacts on tumor load.The treatment effect of lgals1 siRNAwas further demonstrated by intersecting HCC at different time points when the tumor load had already reached 9%or even 42%of the body weight.Comparing spatial transcriptomic profiles of Gal1 silenced and OE HCC,inhibiting matrix formation and recognition of foreign antigen in CD45t cell-enriched areas located at tumor-margin likely contributed to the anti-HCC effects of Gal1 silencing.Within the tumors,silencing Gal1 inhibited translational initiation,elongation,and termination.Furthermore,Gal1 silencing increased immune cells as well as expanded cytotoxic T cells within the tumor,and the anti-HCC effect of lgals1 siRNAwas CD8-dependent.Overall,Gal1 silencing has a promising potential for HCC treatment.

关键词： Liver Hepatocellular carcinoma Carbohydrate-binding lectin Galectin 1 Extracellular matrix Translation Spatial transcriptomics Tumor-margin

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Global Dynamics of a Kawasaki Disease Vascular Endothelial Cell Injury Model with Backward Bifurcation and Hopf Bifurcation

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Acta Mathematicae Applicatae Sinica 2024年

作者： Ke guo wan-biao MA School of Mathematics and Physics University of Science and Technology Beijing

Kawasaki disease（KD） is an acute, febrile, systemic vasculitis that mainly affects children under five years of age. In this paper, we propose and study a class of 5-dimensional ordinary differential equation model describing the vascular endothelial cell injury in the lesion area of KD. This model exhibits forward/backward bifurcation. It is shown that the vascular injury-free equilibrium is locally asymptotically stable if the basic reproduction number R0 1, and some explicit analytic expressions of ultimate lower bounds of the solutions of the model are given.Our results suggest that the control of vascular injury in the lesion area of KD is not only correlated with the basic reproduction number R0, but also with the growth rate of normal vascular endothelial cells promoted by the vascular endothelial growth factor.

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Polaron interfacial entropy as a route to high thermoelectric performance in DAE-doped PEDOT:PSS films

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National Science Review 2024年第3期11卷 259-270页

作者： Jiajia Zhang Caichao Ye Genwang wei Liang guo Yuhang Cai Zhi Li Xinzhi Wu Fangyi Sun Qikai Li Yupeng wang Huan Li Yuchen Li Shuaihua wang wei Xu Xuefeng guo Wenqing Zhang weishu Liu Department of Materials Science and Engineering Southern University of Science and Technology Academy for Advanced Interdisciplinary Studies and Guangdong Provincial Key Laboratory of Computational Science and Material Design Southern University of Science and Technology Department of Mechanical and Energy Engineering Southern University of Science and Technology Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences College of Chemistry and Molecular Engineering National Biomedical Imaging Centre Peking University Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and Technology

Enhancing the thermoelectric transport properties of conductive polymer materials has been a long-term challenge, in spite of the success seen with molecular doping strategies. However, the strong coupling between the thermopower and the electrical conductivity limits thermoelectric performance. Here, we use polaron interfacial occupied entropy engineering to break through this intercoupling for a PEDOT:PSS(poly（3,4-ethylenedioxythiophene）-poly（4-styrenesulfonate）) thin film by using photochromic diarylethene（DAE） dopants coupled with UV-light modulation. With a 10-fold enhancement of the thermopower from 13.5 μV K-1to 135.4 μV K-1and almost unchanged electrical conductivity, the DAE-doped PEDOT:PSS thin film achieved an extremely high power factor of 521.28 μW m-1K-2from an original value of 6.78 μW m-1K-2. The thermopower was positively correlated with the UV-light intensity but decreased with increasing temperature, indicating resonant coupling between the planar closed DAE molecule and PEDOT. Both the experiments and theoretical calculations consistently confirmed the formation of an interface state due to this resonant coupling. Interfacial entropy engineering of polarons could play a critical role in enhancing the thermoelectric performance of the organic film.

关键词： thermoelectric PEDOT: PSS interfacial occupied entropy resonant coupling UV-light modulation

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A highly sensitive fluorescent HClO probe for discrimination between cancerous and normal cells/tissues

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Chinese Chemical Letters 2024年第6期35卷 417-420页

作者： Linfang wang Jing Liu Minghao Ren wei guo Department of Chemistry Changzhi UniversityChangzhi 046011China School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan 030006China

Elevated level of hypochlorous acid(HClO)is closely associated with cancer development.Identifying HClO level in cancer cells would provide important evidence in either early-stage cancer diagnostics or monitoring of its treatment efficiency.In this work,a new pyronine-based fluorescent probe for rapid and sensitive detection of HClO was developed by condensing meso-formyl pyronine(PyCHO)with 2-hydrazinopyridine to form meso-pyridylhydrazone-functionalized pyronine PyHP,PyHP is nonfluorescent due to the excited-state C=N isomerization nonradiative decay,whereas the HClO-triggered formation of meso-triazolopyridyl pyronine PyTP abolishes the C=N isomerization and thus greatly enhances the fluorescence.With the probe,the cancer cells/tumor were distinguished with high-contrast from normal ones by laser confocal fluorescence imaging,and the tumor-to-normal(T/N)ratios obtained exceed the clinically acceptable threshold of 2.0.Moreover,its capability of in vivo imaging tumor was also demonstrated.These results indicate the potential of PyHP as an effective tool in the early clinical diagnosis of cancers.

关键词： Meso-pyridylhydrazone-functionalized pyronine Meso-substituents Tumor-to-normal(T/N)ratios Fluorescent probes Hypochlorous acid

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Integration of morphology and electronic structure modulation on cobalt phosphide nanosheets to boost photocatalytic hydrogen evolution from ammonia borane hydrolysis

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Green Energy & Environment 2024年第2期9卷 333-343页

作者： Chao wan Yu Liang Liu Zhou Jindou Huang Jiapei wang Fengqiu Chen Xiaoli Zhan Dang-guo Cheng School of Chemistry and Chemical Engineering Anhui Province Key Laboratory of Coal Clean Conversion and High Valued UtilizationAnhui University of TechnologyMa'anshan243002China College of Chemical and Biological Engineering Zhejiang UniversityZhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology38 Zheda RoadHangzhou310027China Key Laboratory of New Energy and Rare Earth Resource Utilization of State Ethnic Affairs Commission Key Laboratory of Photosensitive Materials&Devices of Liaoning ProvinceSchool of Physics and Materials EngineeringDalian Nationalities University 18 Liaohe West RoadDalian116600China Institute of Zhejiang University-Quzhou 78 Jiuhua Boulevard NorthQuzhou324000China Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology Changzhou University213164China

The controllable and safe hydrogen storage technologies are widely recognized as the main bottleneck for the accomplishment of sustainable hydrogen energy.Ammonia borane(AB)has regarded as a competitive candidate for chemical hydrogen storage.However,developing efficient yet high-performance catalysts towards hydrogen evolution from AB hydrolysis remains an enormous challenge.Herein,cobalt phosphide nanosheets are synthesized by a facile salt-assisted along with low-temperature phosphidation strategy for simultaneously modulating its morphology and electronic structure,and function as hydrogen evolution photocatalysts.Impressively,the Co_(2)P nanosheets display extraordinary performance with a record high turnover frequency of 44.9 min^(-1),outperforming most of the noble-metal-free catalysts reported to date.This remarkable performance is attributed to its desired nanosheets structure,featuring with high specific surface area,abundant exposed active sites,and short charge diffusion paths.Our findings provide a novel strategy for regulating metal phosphides with desired phase structure and morphology for energy-related applications and beyond.

关键词： Ammonia borane Hydrogen generation Hydrolysis Cobalt phosphide nanosheets Photocatalysis

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Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy

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Chinese Journal of Chemistry 2024年第10期42卷 1175-1189页

作者： guo-Feng Luo wei-Hai Chen Xian-Zheng Zhang state Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei KeyLaboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanHubei 430079China Key Laboratoryof Biomedical Polymers of Ministry of Education&Departmentof Chemistry Wuhan UniversityWuhanHubei 430072China

Tumor stroma composing diverse extracellular matrixes(ECM)and stromal cells shapes a condensed physical barrier,which severely hampers the efficient accessibility of nanomedicine to tumor cells,especially these deep-seated in the core of tumor.Such barrier significantly compromises the antitumor effects of drug-loaded nanomedicine,revealing the remarkable importance of disrupting stromal barrier for improved tumor therapy with deep penetration ability.To achieve this goal,various nanoparticle-based strategies have been developed,including direct depleting ECM components via delivering anti-fibrotic agents or targeting stromal cells to suppress ECM expression,dynamic regulation of nanoparticles’physicochemical properties(i.e.,size,surface charge,and morphology),mechanical force-driven deep penetration,natural/biomimetic self-driven nanomedicine,and transcytosis-inducing nanomedicine.All these nanostrategies were systemically summarized in this review,and the design principles for obtaining admirable nanomedicine were included.With the rapid development of nanotechnology,elaborate design of multifunctional nanomedicine provides new opportunities for overcoming the critical stromal barriers to maximize the therapeutic index of various therapies,such as chemotherapy,photodynamic therapy,and immunotherapy.

关键词： Nanomedicine Tumor stroma Deep penetration Enhanced drug perfusion Cancer therapy Drug carriers Biomaterials Nanotechnology

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Adverse effect of niobium and boron on hot deformation behavior of sulfur-containing steel

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Journal of Iron and Steel Research(International) 2024年第1期31卷 252-263页

作者： guo-ning He Shi-qi wan Bo Jiang Chao-lei Zhang Ya-zheng Liu Chun-jing Wu School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing100083China

The hot deformation behaviors of sulfur-containing gear steel 20MnCr5 containing three different contents of Nb and B(0,0.021%Nb,and 0.024%Nb-0.0022%B)were investigated.Hot compression and tenssion tests were carried out by Gleeble3800 at the austenite region from 850 to 1150℃and the adverse effects of Nb and B were analyzed by the fracture,microstructure and precipitate observations.Hot compression tests showed that the proportions of instable area in hot processing maps of 0.021%Nb and Nb-B steels were higher and the deformability of Nb free steel was better.The tensile deformation experiments showed that the reduction areas of Nb free,0.021%Nb and Nb-B steels were 92%-99%,84%-98%and 67%-97%,respectively.The addition of Nb or Nb and B inhibited the dynamic recrystallization during hot deformation,and consequently,more deformed grains were then formed in 0.021%Nb and Nb-B steels thus to obtain the microstructure with worse uniformity and then deteriorate the deformability.In addition,the interaction between inclusions and microalloyed elements was also significant.NbC particles of 0.021%Nb and Nb-B steels dynamically precipitated during deformation and precipitated together with MnS thus to worsen the deformability,resulting in the decrease of reduction area.

关键词： Hot deformation Gear steel Processing map Dynamic recrystallization Microalloying

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Hybrid vibration isolation optimization of a flexible manipulator based on neural network agent model

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Chinese Journal of Aeronautics 2024年第5期37卷 482-505页

作者： Yongxin ZHANG Liang LI Dingguo ZHANG wei-Hsin LIAO Xian guo School of Science Nanjing University of Science and TechnologyNanjing 210094China Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong KongChina

Segmented Active Constrained Layer Damping(SACLD)is an intelligent vibration-damping structure,which could be applied to the sectors of aviation,aerospace,and transportation engineering to reduce the vibration of flexible structures.Moreover,machine learning technology is widely used in the engineering field because of its efficient multi-objective optimization.The dynamic simulation of a rotational segmental flexible manipulator system is presented,in which enhanced active constrained layer damping is carried out,and the neural network model of Genetic Algorithm-Back Propagation(GA-BP)algorithm is investigated.Vibration suppression and structural optimization of the SACLD manipulator model are studied based on vibration mode and damping prediction.The modal responses of the SACLD manipulator model at rest and rotation are obtained.In addition,the four model indices are optimized using the GA-BP neural network:axial incision size,axial incision position,circumferential incision size,and circumferential incision position.Finally,the best model for vibration suppression is obtained.

关键词： Machine learning Vibration suppression Flexible manipulator Segmented active constrained layer damping Structural optimization

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Observer-based robust high-order fully actuated attitude autopilot design for spinning glide-guided projectiles

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Defence Technology（防务技术） 2024年第4期34卷 282-294页

作者： wei wang Yuchen wang Shiwei Chen Yongcang guo Zhongjiao Shi School of Aerospace Engineering Beijing Institute of TechnologyBeijing 10081China Northwest Industries Group CO. Ltd.Xi'an 710043China

This paper investigates the design of an attitude autopilot for a dual-channel controlled spinning glideguided projectile(SGGP),addressing model uncertainties and external disturbances.Based on fixed-time stable theory,a disturbance observer with integral sliding mode and adaptive techniques is proposed to mitigate total disturbance effects,irrespective of initial conditions.By introducing an error integral signal,the dynamics of the SGGP are transformed into two separate second-order fully actuated systems.Subsequently,employing the high-order fully actuated approach and a parametric approach,the nonlinear dynamics of the SGGP are recast into a constant linear closed-loop system,ensuring that the projectile's attitude asymptotically tracks the given goal with the desired eigenstructure.Under the proposed composite control framework,the ultimately uniformly bounded stability of the closed-loop system is rigorously demonstrated via the Lyapunov method.Validation of the effectiveness of the proposed attitude autopilot design is provided through extensive numerical simulations.

关键词： Spinning glide-guided projectile Attitude control Sliding mode disturbance observer Fixed-time stable theory High-order fully actuated approach

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A visual analysis approach for data imputation via multi-party tabular data correlation strategies

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Frontiers of Information Technology & Electronic Engineering 2024年第3期25卷 398-414页

作者： Haiyang ZHU Dongming HAN Jiacheng PAN Yating wei Yingchaojie FENG Luoxuan WENG Ketian MAO Yuankai XING Jianshu LV Qiucheng wan wei CHEN The State Key Lab of CAD&CG Zhejiang UniversityHangzhou 310058China Wuchan Zhongda Digital Technology Co. Ltd.Hangzhou 310020China Zhejiang Metals and Materials Co. Ltd.Hangzhou 310005China

Data imputation is an essential pre-processing task for data governance,aimed at filling in incomplete data.However,conventional data imputation methods can only partly alleviate data incompleteness using isolated tabular data,and they fail to achieve the best balance between accuracy and eficiency.In this paper,we present a novel visual analysis approach for data imputation.We develop a multi-party tabular data association strategy that uses intelligent algorithms to identify similar columns and establish column correlations across multiple tables.Then,we perform the initial imputation of incomplete data using correlated data entries from other tables.Additionally,we develop a visual analysis system to refine data imputation candidates.Our interactive system combines the multi-party data imputation approach with expert knowledge,allowing for a better understanding of the relational structure of the data.This significantly enhances the accuracy and eficiency of data imputation,thereby enhancing the quality of data governance and the intrinsic value of data assets.Experimental validation and user surveys demonstrate that this method supports users in verifying and judging the associated columns and similar rows using theirdomain knowledge.

关键词： Data governance Data incompleteness Data imputation Data visualization Interactive visual analysis

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