A highly sensitive fluorescent HClO probe for discrimination between cancerous and normal cells/tissues

作     者：Linfang Wang Jing Liu Minghao Ren Wei Guo Linfang Wang;Jing Liu;Minghao Ren;Wei Guo

作者机构：Department of ChemistryChangzhi UniversityChangzhi 046011China School of Chemistry and Chemical EngineeringShanxi UniversityTaiyuan 030006China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第6期

页      面：417-420页

核心收录：

学科分类：081704[工学-应用化学] 1002[医学-临床医学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Scientific and Technological Innovation Program of Colleges and Universities in Shanxi Province(Nos.2021L529,2021L530) the Fund for Shanxi“1331 Project” 

主　　题：Meso-pyridylhydrazone-functionalized pyronine Meso-substituents Tumor-to-normal(T/N)ratios Fluorescent probes Hypochlorous acid 

摘      要：Elevated level of hypochlorous acid(HClO)is closely associated with cancer *** HClO level in cancer cells would provide important evidence in either early-stage cancer diagnostics or monitoring of its treatment *** this work,a new pyronine-based fluorescent probe for rapid and sensitive detection of HClO was developed by condensing meso-formyl pyronine(PyCHO)with 2-hydrazinopyridine to form meso-pyridylhydrazone-functionalized pyronine PyHP,PyHP is nonfluorescent due to the excited-state C=N isomerization nonradiative decay,whereas the HClO-triggered formation of meso-triazolopyridyl pyronine PyTP abolishes the C=N isomerization and thus greatly enhances the *** the probe,the cancer cells/tumor were distinguished with high-contrast from normal ones by laser confocal fluorescence imaging,and the tumor-to-normal(T/N)ratios obtained exceed the clinically acceptable threshold of ***,its capability of in vivo imaging tumor was also *** results indicate the potential of PyHP as an effective tool in the early clinical diagnosis of cancers.