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Mineral metabolism disturbances are associated with the presence and severity of calcific aortic valve disease

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第5期16卷 362-369页

作者： Zhen-kun YANG Chen YING Hong-yan ZHAO Yue-hua FANG Ying CHEN wei-feng shen Department of Cardiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Department of Endocrinology and Metabolism Ruijin Hospital Shanghai Jiao Tong University School of Medicine

Objective：We investigated whether disturbance of calcium and phosphate metabolism is associated with the presence and severity of calcific aortic valve disease （CAVD） in patients with normal or mildly impaired renal function. Methods：We measured serum levels of calcium, phosphate, alkaline phosphatase （AKP）, intact parathyroid hormone （iPTH）, 25-hydroxyvitamin D （25-OHD）, and biomarkers of bone turnover in 260 consecutive patients with normal or mildly impaired renal function and aortic valve sclerosis （AVSc）（n=164） or stenosis （AVS）（n=96） and in 164 age- and gender-matched controls. Logistic regression models were used to determine the association of mineral metabolism parameters with the presence and severity of CAVD. Results：Stepwise increases were observed in serum levels of calcium, phosphate, AKP, and iPTH from the control group to patients with AVS, and with reverse changes for 25-OHD levels （al P〈0.001）. Similarly, osteocalcin, procol agen I N-terminal peptide, andβ-isomerized type I col agen C-telopeptide breakdown products were significantly increased stepwise from the control group to patients with AVS （al P〈0.001）. In patients with AVS, serum levels of iPTH were positively, in contrast 25-OHD levels were negatively, related to trans-aortic peak flow velocity and mean pressure gradient. After adjusting for relevant confounding varia-bles, increased serum levels of calcium, phosphate, AKP, and iPTH and reduced serum levels of 25-OHD were in-dependently associated with the presence and severity of CAVD. Conclusions： This study suggests an association between mineral metabolism disturbance and the presence and severity of CAVD in patients with normal or mildly impaired renal function. Abnormal bone turnover may be a potential mechanism.

关键词： Valve heart disease Aortic stenosis Mineral metabolism Calcium Phosphate

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Influence of perfusion by gaseous oxygen persufflation on rat donor liver

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Hepatobiliary & Pancreatic Diseases International 2006年第2期5卷 195-198页

作者： Hong-wei Sun, feng shen and Yan-Ming Zhou Division of Comprehensive Treatment, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200433, China Division of Comprehensive Treatment Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200433 China.

BACKGROUND: Hepatic ischemia-reperfusion injury is one of the major problems in liver transplantation. This study aimed to investigate the possible improvement of aerobic metabolism of ischemic donor livers through systemic persufflation with gaseous oxygen in rinse solution. METHODS: Thirty rats were randomly divided into 3 groups. In group A (control, n = 10), the livers were perfused with 4 ℃ lactic acid ringer's solution through the can-nulated portal vein for 25 minutes soon after warm ischemia for 30 minutes. In group B (n =10), the livers were treated the same way as in group A except for addition of gaseous oxygen in the rinse solution. In group C (n =10), the livers were treated similarly as in group B except for addition of superoxide dismutase (SOD) in the rinse solution. RESULTS: In group B, the malondialdehyde(MDA)levels in hepatic tissues after perfusion were significantly increased (P< 0. 01), whereas the SOD levels were markedly decreased (P <0.01). After combined use with antioxidant in group C, the levels of MDA and SOD in hepatic tissues after perfusion recovered significantly (P<0.01). CONCLUSION: Perfusion by gaseous oxygen persufQation in combination with antioxidative agents is promising for resuscitating the ischemically altered livers for successful transplantation.

关键词： liver transplantation gaseous oxygen persufilation ischemia reperfusion

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The effect of pinacidil on postshock activation and ventricular defibrillation threshold in canine hearts

The effect of pinacidil on postshock activation and ventricu...

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中华医学会第十五次全国心血管病学大会

作者： Qi Jin wei feng shen Li Qun Wu Department of Cardiology Rui Jin Hospital Shanghai Jiaotong University School of Medicine

Aim To determine the postshock activation patterns with both successful and failed shocks in a canine model of ventricular fibrillation, and whether piniacidil, an early after-depolarization (EAD) inhibitor, altered t...

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Serum Advanced Glycation End-Products and Receptors as Prognostic Biomarkers in Diabetics Undergoing Coronary Artery Stent Implantation

Serum Advanced Glycation End-Products and Receptors as Progn...

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中华医学会第十五次全国心血管病学大会

作者： Ying shen Lin Lu Qi Zhang Rui Yan Zhang wei feng shen Department of Cardiology Rui Jin Hospital Shanghai Jiaotong University School of Medicine

Background This study investigated the impact of elevated glycate albumin (GA) and reduced soluble receptor for advanced glycation endproducts sRAGE) and endogenous secretory receptor for advanced glycatio end-products (esRAGE) levels in serum on the severity of albuminuria, ccurrence of contrast-induced acute kidney injury (CI-AKI) an 1-year clinical outcome in type 2 diabetic patients

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Glycated Albumin Is Superior to Hemoglobin A 1c for Evaluating the Presence and Severity of Coronary Artery Disease in Type 2 Diabetic Patients

Glycated Albumin Is Superior to Hemoglobin A 1c for Evaluati...

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中华医学会第十五次全国心血管病学大会

作者： Ying shen Lin Lu Qi Zhang Rui Yan Zhang wei feng shen Department of Cardiology Rui Jin Hospital Shanghai Jiaotong University School of Medicine

Objective This study aimed to compare the value of serum glycated albumin (GA) level versus glycated hemoglobin A(1c) (HbA(1c)) for evaluating the presence and severity of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). Methods Serum GA and blood HbA(1c) levels were measured in 829 consecutive T2DM patients with or

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Valsartan Decreases Platelet Activity and Arterial Thrombotic Events in Elderly Patients with Hypertension

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Chinese Medical Journal 2015年第2期128卷 153-158页

作者： Fang Wu Hong-Yan Wang Fan Cai Ling-Jie Wang feng-Ru Zhang Xiao-Nan Chen Qian Yang Meng-Hui Jiang Xue-feng Wang wei-feng shen Department of Geriatrics Ruijin Hospital Jiao Tong University School of Medicine Shanghai 200025 China Department of Cardiology Ruijin Hospital Jiao Tong University School of Medicine Shanghai 200025 China Institute of Health Sciences Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200025 China Department of Laboratory Medicine Ruijin Hospital Jiao Tong University School of Medicine Shanghai 200025 China

Background：Angiotensin type 1 receptor （AT1R） antagonists are extensively used for blood pressure control in elderly patients with *** study aimed to investigate the inhibitory effects of AT1R antagonist valsartan on platelet aggregation and the occurrence of cardio-cerebral thrombotic events in elderly patients with ***：Two-hundred and ten patients with hypertension and aged 〉 60 years were randomized to valsartan （n =140） or amlodipine （n =70） on *** primary endpoint was platelet aggregation rate （PAR） induced by arachidonic acid at discharge,and the secondary endpoint was the rate of thrombotic events including brain infarction and myocardial infarction during *** aortic endothelial cells （HAECs） were stimulated by angiotensin Ⅱ （Ang Ⅱ,100 nmol/L） with or without pretreatment of valsartan （100 nmol/L）,and relative expression of cyclooxygenase-2 （COX-2） and thromboxane B2 （TXB2） and both p38 mitogen-activated protein kinase （p38MAPK） and nuclear factor-kB （NF-kB） activities were *** analyses were performed by GraphPad Prism 5.0 software （GraphPad Software,Inc.,California,USA）.Results：PAR was lower after treatment with valsartan （1 1.49 ± 0.69% vs.18.71 ± 2.47%,P 〈 0.001）,associated with more reduced plasmalevels of COX-2 （76.94 ± 7.07 U/L vs.116.4 ± 15.89 U/L,P 〈 0.001） and TXB2 （1667 ± 56.50 pg/ml vs.2207 ± 180.20 pg/ml）（all P 〈 0.001）.Plasma COX-2 and TXB2 levels correlated significantly with PAR in overall patients （r =0.109,P 〈 0.001）.During follow-up （median,18 months）,there was a significantly lower thrombotic event rate in patients treated with valsartan （14.3% vs.32.8%,P =0.002）.Relative expression of COX-2 and secretion of TXB2 with concordant phosphorylation ofp38MAPK and NF-kB were increased in HAECs when stimulated by Ang Ⅱ （100 nmol/L） but were significantly decreased by valsartan pretreatment （100 nmol/L）.Conclusions：AT1R antagonist valsartan decreases platelet activity by attenua

关键词： Angiotensin Type 1 Receptor Antagonist Elderly Hypertension Platelet Activity Thrombosis

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非正常晶状体眼行人工晶状体悬吊术的疗效观察

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国际眼科杂志 2012年第4期12卷 697-698页

作者：沈伟锋阜阳泽明眼科医院中国安徽省阜阳市236000

目的:观察由各种原因导致的非正常晶状体眼因无足够后囊膜支撑而施行人工晶状体悬吊术的疗效。方法:使用美国ALCON公司CZ70BD悬吊式人工晶状体对8例9眼非正常晶状体白内障患者(过熟期白内障3眼,外伤性白内障伴晶状体半脱位4眼,马凡氏综... 详细信息

目的:观察由各种原因导致的非正常晶状体眼因无足够后囊膜支撑而施行人工晶状体悬吊术的疗效。方法:使用美国ALCON公司CZ70BD悬吊式人工晶状体对8例9眼非正常晶状体白内障患者(过熟期白内障3眼,外伤性白内障伴晶状体半脱位4眼,马凡氏综合征2眼)因术中无后囊膜支撑施行人工晶状体悬吊术;对8例8眼Ⅰ期白内障术后非正常晶状体眼患者(伴有瞳孔异常的无晶状体眼7眼,人工晶状体严重偏位1眼)施行Ⅱ期人工晶状体悬吊术,观察其术中、术后并发症及术后视力情况。随访1～6mo。结果:术中或术后5眼(29%)出现前房或玻璃体少量出血,10d左右基本吸收;术后1眼(6%)发生脉络膜脱离,1mo恢复;切口微漏致低眼压2眼(12%),加压包扎5d恢复。术后1d,裸眼视力>0.1者13眼(76%);术后10d,裸眼视力>0.1者17眼(100%),术后10,30d,裸眼视力>0.3者分别为11眼(65%)和12眼(71%)。结论:人工晶状体悬吊术是治疗易发生无后囊膜支撑的非正常晶状体眼的一种较好的选择。

关键词：非正常晶状体眼人工晶状体悬吊术

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Cloning and Alternative Splicing Analysis of Bombyx mori Transformer-2 Gene using Silkworm EST Database

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Acta Biochimica et Biophysica Sinica 2005年第11期37卷 728-736页

作者： Bao-Long NIU Zhi-Qi MENG Yue-Zhi TAO Shun-Lin LU Hong-Biao WENG Li-Hua HE wei-feng shen Sericultural Research Institute,Zhejiang Academy of Agricultural Sciences,Hangzhou 310021,China Department of Sericulture and Apiculture,College of Animal Sciences,Zhejiang University,Hangzhou 310029,China Sericultural Research Institute Zhejiang Academy of Agricultural SciencesHangzhou 310021 China Department of Sericulture and Apiculture College of Animal Sciences Zhejiang UniversityHangzhou 310029 China

We have identified Bombyx mori transformer-2 gene(Bmtra-2)cDNA by blasting the ESTdatabase of *** was expressed in the whole life of the male and female silkworm and was observed asa band of 1.3 kb by Northern blot *** comparing corresponding ESTs to the Bmtra-2 DNA sequence,it was revealed that there were eight exons and seven introns,and all splice sites of exons/introns conformedto the GT/AG ***-2 pre-mRNA can produce multiple mRNAs encoding six distinct isoforms ofBmTRA-2 protein using an alternative splicing pathway during *** types of Bmtra-2 cDNAclones were identified by reverse transcription-polymerase chain *** isoforms of BmTRA-2 proteincontain two arginine/serine-rich domains and one RNA recognition motif,showing striking organizationalsimilarity to Drosophila TRA-2 proteins.

关键词： EST database transformer-2 gene Bmtra-2 alternative splicing gene clone Bombyxmori

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角膜清创联合结膜瓣遮盖术治疗真菌性角膜溃疡

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国际眼科杂志 2012年第5期12卷 839-840页

作者：沈伟锋阜阳泽明眼科医院中国安徽省阜阳市236000

目的:观察角膜清创联合结膜瓣遮盖术治疗真菌性角膜溃疡的临床疗效。方法:对2011-01/11收治的30例30眼真菌性角膜溃疡患者行患眼角膜清创联合结膜瓣遮盖术治疗,术后继续药物治疗。结果:17例17眼1次手术,结膜瓣遮盖良好,角膜溃疡治愈;7例... 详细信息

目的:观察角膜清创联合结膜瓣遮盖术治疗真菌性角膜溃疡的临床疗效。方法:对2011-01/11收治的30例30眼真菌性角膜溃疡患者行患眼角膜清创联合结膜瓣遮盖术治疗,术后继续药物治疗。结果:17例17眼1次手术,结膜瓣遮盖良好,角膜溃疡治愈;7例7眼1次手术,1wk内结膜瓣脱落或溶解,继续用药10d～2mo角膜溃疡治愈;2例2眼1次手术,1wk内结膜瓣脱落或溶解,经2次手术,结膜瓣遮盖良好,角膜溃疡治愈;4例4眼1次手术,1wk内结膜瓣脱落或溶解,治疗过程中角膜溃疡穿孔,而行角膜移植术。30例30眼通过结膜瓣遮盖总治愈26例26眼,治愈率87%。结论:角膜清创联合结膜瓣遮盖术是一种治疗真菌性角膜溃疡的有效方法,适合基层医院,可以尽可能挽救眼球,保留残存视力,为进一步行角膜移植术提供条件。

关键词：真菌角膜溃疡结膜瓣遮盖

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Increased serum high-mobility group box-1 and cleaved receptor for advanced glycation endproducts levels and decreased endogenous secretory receptor for advanced glycation endproducts levels in diabetic and non-diabetic patients with heart failure

Increased serum high-mobility group box-1 and cleaved recept...

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中华医学会第十五次全国心血管病学大会

作者： Ling Jie Wang Lin Lu Qiu Jing Chen wei feng shen Department of Cardiology Rui Jin Hospital Shanghai Jiaotong University School of Medicine

Aims High-mobility group box-1 (HMGB1) is a ligand for the receptor for advanced glycation endproducts (RAGE). An HMGB1-RAGE interaction has been implicated in cardiac dysfunction. We assessed the association of HMGB1...

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