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SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors

Signal Transduction and Targeted Therapy 2024年第5期9卷 2285-2297页

作者： Hui Qian Chen-Hong Ding Fang Liu Shi-Jie Chen Chen-Kai Huang Meng-Chao Xiao Xia-Lu Hong Ming-Chen Wang Fang-Zhi Yan Kai Ding Ya-Lu Cui Bai-Nan Zheng Jin Ding Cheng Luo Xin Zhang wei-fen xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Gastroenterology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Drug Discovery and Design Center CAS Key Laboratory of Receptor ResearchState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina Department of Gastroenterology First Affiliated Hospital of Nanchang UniversityNanchangChina Clinical Cancer Institute Center for Translational MedicineNaval Medical UniversityShanghaiChina

The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor ***,the precise molecular mechanisms governing the nuclear import of YAP are not fully *** this study,we have uncovered a crucial role of SOX9 in the activation of ***9 promotes the nuclear translocation of YAP by direct ***,we have identified that the binding between Asp-125 of SOX9 and Arg-124 of YAP is essential for SOX9-YAP interaction and subsequent nuclear entry of ***,we have discovered a novel asymmetrical dimethylation of YAP at Arg-124(YAP-R124me2a)catalyzed by ***-R124me2a enhances the interaction between YAP and SOX9 and is associated with poor prognosis in multiple ***,we disrupted the interaction between SOX9 and YAP using a competitive peptide,S-A1,which mimics anα-helix of SOX9 containing Asp-125.S-A1 significantly inhibits YAP nuclear translocation and effectively suppresses tumor *** study provides the first evidence of SOX9 as a pivotal regulator driving YAP nuclear translocation and presents a potential therapeutic strategy for YAP-driven human cancers by targeting SOX9-YAP interaction.

关键词： interaction interaction precise

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Effects of Low-dose and High-dose Rifaximin in the Treatment of Covert Hepatic Encephalopathy

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1099-1106页

作者： wei Tan Jian Wang Pei-Mei Shi Ling-Mei feng Jian Shi Bei-Fang Ning Zong-Li Yuan Xin Zeng wei-fen xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Gastro-enterology Shanghai East HospitalTongji University School of MedicineShanghaiChina

Background and Aims:Rifaximin is effective in prevent-ing and treating hepatic encephalopathy(HE).This study aimed to investigate the efficacy and safety of different dosages of rifaximin in the treatment of cirrhotic patients with covert HE(CHE).Methods:In this single-center,ran-domized,controlled,open-label study,CHE was diagnosed using a combination of the psychometric HE score and the EncephalApp Stroop *** patients with CHE were recruited and randomly assigned to low-dose rifaximin 800 mg/day,high-dose rifaximin(1,200 mg/day),and control groups,and were treated for 8 *** sickness impact profile(SIP)scale was used to evaluate the health-relat-ed quality of life(HRQOL)of *** patients were included in the study,12 were assigned to the low-dose group,14 to the high-dose group,and 14 patients to the control ***:The percentage of patients with CHE reversal was significantly higher in both the low-dose(41.67%,5/12)and high-dose(57.14%,8/14)groups than in the control group(7.14%,1/14)at 8 weeks(p=0.037 and p=0.005,respectively).In addition,both doses of ri-faximin resulted in significant improvement of the total SIP score compared with the control *** were no sig-nificant differences in the CHE reversal rate,total SIP score improvement,and incidence of adverse event between the low-dose and high-dose groups(p>0.05).Conclusions:Low-dose rifaximin reverses CHE and improves HRQOL in cirrhotic patients with comparable effects and safety to high-dose rifaximin.

关键词： Single-center open-label study Randomized prospective study Liver cirrhosis Covert hepatic encephalopathy Rifaximin

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The prevalence and associated factors of simple hepatic cysts in Shanghai:a population-based cross-sectional study

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Chinese Medical Journal 2021年第10期134卷 1248-1250页

作者： Wen-Ping Xu Xiao-Hang Wang Shao-Ping Wu Pei-Mei Shi Zong-Li Yuan Yi-Bin Guo Xin Zeng wei-fen xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghai 200003China Endoscopy Center Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of Health Statistics Naval Medical UniversityShanghai 200433China Department of Gastroenterology Shanghai East HospitalTongji University School of MedicineShanghai 200120China

To the Editor:Simple hepatic cyst is a common reason for consultation with gastroenterologists and *** most patients have a benign course,some suffer from serious complications,such as intracystic infection,hemorrhage,and even rupture,or symptoms caused by severe oppression of the surrounding tissues and *** the prevalence of,and characteristics of,and factors associated with simple hepatic cysts is helpful for better treatment of symptomatic *** reported prevalence of the disease varies widely,ranging from 2.5%to 18.0%,and most of them were based on hospital surveys.[1,2,3,4]As an asymptomatic disease in most cases,simple hepatic cysts are usually discovered incidentally on abdominal ***,surveys based on hospital populations cannot represent true ***,due to the absence of healthy controls,surveys with hospital populations have been unable to identify associated factors for simple hepatic cysts.[1,2,3,4].

关键词： prevalence hepatic organs

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Sophocarpine attenuates liver fibrosis by inhibiting the TLR4 signaling pathway in rats

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World Journal of Gastroenterology 2014年第7期20卷 1822-1832页

作者： Hui Qian Jian Shi Ting-Ting Fan Jiao Lv Si-Wen Chen Chun-Yan Song Zhi-Wu Zheng wei-fen xie Yue-Xiang Chen Department of Gastroenterology Shanghai Changzheng HospitalSecond Military Medical University Department of Gastroenterology the 411~(th) Hospital of PLA

AIM: To explore the effect of sophocarpine on experimental liver fibrosis and the potential mechanism involved.

关键词： Liver fibrosis Sophocarpine Toll-like receptor 4 Hepatic stellate cells Cytokines

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The presence of NAFLD in nonobese subjects increased the risk of metabolic abnormalities than obese subjects without NAFLD:a population-based cross-sectional study

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Hepatobiliary Surgery and Nutrition 2021年第6期10卷 811-824,I0008-I0010页

作者： Ping-Fang Hu Xin Zeng Zi-Yuan Zou wei Tang Yi-Bin Guo Zong-Li Yuan Pei-Mei Shi Yu Tan Yan Song Yong-Quan Shi wei-fen xie Department of Gastroenterology Changzheng HospitalSecond Military Medical UniversityShanghaiChina Department of Gastroenterology East HospitalTongji University School of MedicineShanghaiChina The First Clinical School Nanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Endocrinology Changzheng HospitalSecond Military Medical UniversityShanghaiChina Department of Health Statistics Second Military Medical UniversityShanghaiChina

Background:With lifestyle modification and over-nutrition,the prevalence of nonalcoholic fatty liver disease(NAFLD)has been increasing *** we aimed to assess the updated prevalence of NAFLD,and to evaluate the association of NAFLD with metabolic abnormalities according to gender,body mass index and ***:A population-based cross-sectional study was conducted in Shanghai from December 2016 to July *** a three-stage stratified sampling strategy,3,717 eligible participants were enrolled for the ***:In total,1,217 subjects(32.7%)had *** them,400(16.3%)of the nonobese and 817(65.0%)of the obese subjects had *** prevalence of NAFLD was increased according to the quartiles of age and waist circumference(WC)in the nonobese *** with nonobese NAFLD had 1.6-,2.6-,2.0-,2.3-and 3.3-fold higher risks for metabolic syndrome,diabetes mellitus,hyperglycemia,hypertriglycerdemia(high TG)and low high-density lipoprotein cholesterol than obese subjects without NAFLD,*** had comparable metabolic profiles in both groups,except for a 2.0-fold higher risk of high TG in nonobese NAFLD subjects compared with obese subjects without *** impressively,the homeostasis metabolic assessment insulin resistance index was comparable between the two ***:The increase of age and WC had significant impact on the risk of NAFLD in nonobese *** presence of NAFLD in nonobese subjects increased the risk of metabolic diseases than obese subjects without NAFLD,especially in female.

关键词： Non-alcoholic fatty liver disease(NAFLD) obesity metabolic syndrome(MetS) insulin resistance

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New formula for predicting standard liver volume in Chinese adults

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World Journal of Gastroenterology 2017年第27期23卷 4968-4977页

作者： Ling-Mei feng Pei-Qin Wang Hong Yu Ru-Tan Chen Jian Wang Xia Sheng Zong-Li Yuan Pei-Mei Shi wei-fen xie Xin Zeng Department of Gastroenterology Shanghai Changzheng HospitalSecond Military Medical University Department of Radiology Shanghai Changzheng HospitalSecond Military Medical University

AIM To obtain a reference range of morphological indices and establish a formula to accurately predict standard liver volume(SLV) in Chinese *** Computed tomography(CT)-estimated total liver volume(CTLV) was determined in 369 Chinese adults. Age,sex,body weight,body height,body mass index,and body surface area(BSA) were recorded using CT. Total splenic volume,portal venous diameter(PVD),splenic venous diameter(SVD),and portal venous cross-sectional area(PVCSA) were also measured by CT. Stepwise multiple linear regression analysis was performed to evaluate the impact of each parameter on CTLV and to develop a new SLV formula. The accuracy of the new formula was compared with the existing formulas in a validation *** The average CTLV was 1205.41 ± 257.53 cm3(range,593.80-2250.10 cm3). The average of PVD,SVD and PVCSA was 9.34 ± 1.51 mm,7.40 ± 1.31 mm and 173.22 ± 48.11 mm2,respectively. The CT-estimated splenic volume of healthy adults varied markedly(range,46.60-2892.30 cm3). Sex,age,body height,body weight,body mass index,and BSA were significantly correlated with CTLV. BSA showed the strongest correlation(r = 0.546,P 70 years of age,and underestimated liver volume when CTLV was > 1800 *** Our new BSA-based formula is more accurate than other formulas in estimating SLV in Chinese adults.

关键词： Standard liver volume Reference range Morphological indices Chinese adults

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NONMONOTONE LOCAL MINIMAX METHODS FOR FINDING MULTIPLE SADDLE POINTS

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Journal of Computational Mathematics 2024年第3期42卷 851-884页

作者： wei Liu Ziqing xie Wenfan Yi South China Research Center for Applied Mathematics and Interdisciplinary Studies South China Normal UniversityGuangzhou 510631China Key Laboratory of Computing and Stochastic Mathematics(Ministry of Education) Hunan Normal UniversityChangshaHunan 410081China Hunan Provincial Key Laboratory of Intelligent Information Processing and Applied Mathematics School of MathematicsHunan UniversityChangshaHunan 410082China

In this paper,by designing a normalized nonmonotone search strategy with the BarzilaiBorwein-type step-size,a novel local minimax method(LMM),which is a globally convergent iterative method,is proposed and analyzed to find multiple(unstable)saddle points of nonconvex functionals in Hilbert *** to traditional LMMs with monotone search strategies,this approach,which does not require strict decrease of the objective functional value at each iterative step,is observed to converge faster with less ***,based on a normalized iterative scheme coupled with a local peak selection that pulls the iterative point back onto the solution submanifold,by generalizing the Zhang-Hager(ZH)search strategy in the optimization theory to the LMM framework,a kind of normalized ZH-type nonmonotone step-size search strategy is introduced,and then a novel nonmonotone LMM is *** feasibility and global convergence results are rigorously carried out under the relaxation of the monotonicity for the functional at the iterative ***,in order to speed up the convergence of the nonmonotone LMM,a globally convergent Barzilai-Borwein-type LMM(GBBLMM)is presented by explicitly constructing the Barzilai-Borwein-type step-size as a trial step-size of the normalized ZH-type nonmonotone step-size search strategy in each ***,the GBBLMM algorithm is implemented to find multiple unstable solutions of two classes of semilinear elliptic boundary value problems with variational structures:one is the semilinear elliptic equations with the homogeneous Dirichlet boundary condition and another is the linear elliptic equations with semilinear Neumann boundary *** numerical results indicate that our approach is very effective and speeds up the LMMs significantly.

关键词： Multiple saddle points Local minimax method Barzilai-Borwein gradient method Normalized nonmonotone search strategy Global convergence

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Reinfection and Risk Factors of SARS-CoV-2 during an Omicron Wave 2022 in Shanghai

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Biomedical and Environmental Sciences 2024年第2期37卷 204-209页

作者： WANG Pei Qin WANG Xiao Hang WANG Jian SHI Zhi Wen CHU Dong Mei WANG Zhi Fei ZHANG Mu Bai LIU wei ZHOU Zi Jie xie wei fen Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghai 200003China Health examination center Changzheng HospitalNaval Medical UniversityShanghai 200003China

Multiple waves of coronavirus disease 2019(COVID-19) outbreaks have affected numerous countries worldwide. The first case of SARS-CoV-2 reinfection was reported in Hong Kong in August 2020^([1]), leading to increased interest in the effectiveness of natural immunity acquired from primary infection. While data reports vary across countries, all findings indicate that prior SARS-CoV-2 infection provides substantial protection against reinfection^([2]). However, natural immunity from infection with previous non-Omicron or early Omicron sub-lineages offers lower levels of protection against Omicron reinfection, with rates below 60%^([3]) and approximately 75%[4], respectively.

关键词： immunity infection Omi

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Conductive and stable polyphenylene/CNT composite membrane for electrically enhanced membrane fouling mitigation

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 35-47页

作者： Huijuan xie Haiguang Zhang Xu Wang Gaoliang wei Shuo Chen xie Quan Key Laboratory of Industrial Ecology and Environmental Engineering(Ministry of Education) School of Environmental Science and TechnologyDalian University of TechnologyDalian 116024China

Nanocarbon-based conductive membranes, especially carbon nanotube (CNT)-based membranes, have tremendous potential for wastewater treatment and water purification because of their excellent water permeability and selectivity, as well as their electrochemically enhanced performance (e.g., improved antifouling ability). However, it remains challenging to prepare CNT membranes with high structural stability and high electrical conductivity. In this study, a highly electroconductive and structurally stable polyphenylene/CNT (PP/CNT) composite membrane was prepared by electropolymerizing biphenyl on a CNT hollow fiber membrane. The PP/CNT membrane showed 3.4 and 5.0 times higher electrical conductivity than pure CNT and poly(vinyl alcohol)/CNT (PVA/CNT) membranes, respectively. The structural stability of the membrane was superior to that of the pure CNT membrane and comparable to that of the PVA/CNT membrane. The membrane fouling was significantly alleviated under an electrical assistance of −2.0 V, with a flux loss of only 11.7% after 5 h filtration of humic acid, which is significantly lower than those of PP/CNT membranes without electro-assistance (56.8%) and commercial polyvinylidene fluoride (PVDF) membranes (64.1%). Additionally, the rejection of negatively charged pollutants (humic acid and sodium alginate) was improved by the enhanced electrostatic repulsion. After four consecutive filtration-cleaning cycle tests, the flux recovery rate after backwashing reached 97.2%, which was much higher than those of electricity-free PP/CNT membranes (67.0%) and commercial PVDF membranes (61.1%). This study offers insights into the preparation of stable conductive membranes for membrane fouling control in potential water treatment applications.

关键词： Polyphenylene CNTs Membrane Electro-assistance Membrane fouling mitigation

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The dawn−dusk asymmetry in mesosphere and lower thermosphere temperature disturbances during geomagnetic storms at high latitude

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Earth and Planetary Physics 2024年第2期8卷 356-367页

作者： GuanChun wei JianYong Lu fen Tang JingYuan Li Meng Sun Institute of Space Weather School of Atmospheric PhysicsNanjing University of Information Science&TechnologyNanjing 210044China College of Information and Communication National University of Defense TechnologyWuhan 430019China

Utilizing observations by the Sounding of the Atmosphere using Broadband Emission Radiometry(SABER)instrument,we quantitatively assessed the dawn-dusk asymmetry in temperature disturbances within the high-latitude mesosphere and lower thermosphere(MLT)during the main phase of geomagnetic storms in this *** analysis of five geomagnetic superstorm events indicated that during the main phase,negative temperature disturbances were more prevalent on the dawn side than on the dusk side in the high-latitude MLT *** of a statistical analysis of 54 geomagnetic storm events also revealed a notable disparity in temperature disturbances between the dawn and dusk *** high latitudes,38.2%of the observational points on the dawn side exhibited negative temperature disturbances(less than−5 K),whereas on the dusk side,this percentage was only 29.5%.In contrast,at mid-latitudes,these proportions were 34.1%and 36.5%,respectively,showing no significant *** also conducted a statistical analysis of temperature disturbances at different altitudes,which revealed an increase in the proportion of warming disturbances with ***,the proportion of cooling disturbances initially rose with altitude,reaching a peak around 105 km,and subsequently *** temperature disturbance differences could be explained by the day-night asymmetry in vertical wind disturbances during storm conditions.

关键词： dawn dusk asymmetry SABER(Sounding of the Atmosphere using Broadband Emission Radiometry) geomagnetic storms mesosphere and lower thermosphere

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