The presence of NAFLD in nonobese subjects increased the risk of metabolic abnormalities than obese subjects without NAFLD:a population-based cross-sectional study

作     者：Ping-Fang Hu Xin Zeng Zi-Yuan Zou Wei Tang Yi-Bin Guo Zong-Li Yuan Pei-Mei Shi Yu Tan Yan Song Yong-Quan Shi Wei-Fen Xie 

作者机构：Department of GastroenterologyChangzheng HospitalSecond Military Medical UniversityShanghaiChina Department of GastroenterologyEast HospitalTongji University School of MedicineShanghaiChina The First Clinical SchoolNanfang HospitalSouthern Medical UniversityGuangzhouChina Department of EndocrinologyChangzheng HospitalSecond Military Medical UniversityShanghaiChina Department of Health StatisticsSecond Military Medical UniversityShanghaiChina 

出 版 物：《Hepatobiliary Surgery and Nutrition》 (肝胆外科与营养（英文）)

年 卷 期：2021年第10卷第6期

页      面：811-824,I0008-I0010页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work was supported by grants from the Three-year Action Program of Shanghai Municipality for Strengthening the Construction of the Public Health System(2015-2017)(No.GWIV-27.7) 

主　　题：Non-alcoholic fatty liver disease(NAFLD) obesity metabolic syndrome(MetS) insulin resistance 

摘      要：Background:With lifestyle modification and over-nutrition,the prevalence of nonalcoholic fatty liver disease(NAFLD)has been increasing *** we aimed to assess the updated prevalence of NAFLD,and to evaluate the association of NAFLD with metabolic abnormalities according to gender,body mass index and ***:A population-based cross-sectional study was conducted in Shanghai from December 2016 to July *** a three-stage stratified sampling strategy,3,717 eligible participants were enrolled for the ***:In total,1,217 subjects(32.7%)had *** them,400(16.3%)of the nonobese and 817(65.0%)of the obese subjects had *** prevalence of NAFLD was increased according to the quartiles of age and waist circumference(WC)in the nonobese *** with nonobese NAFLD had 1.6-,2.6-,2.0-,2.3-and 3.3-fold higher risks for metabolic syndrome,diabetes mellitus,hyperglycemia,hypertriglycerdemia(high TG)and low high-density lipoprotein cholesterol than obese subjects without NAFLD,*** had comparable metabolic profiles in both groups,except for a 2.0-fold higher risk of high TG in nonobese NAFLD subjects compared with obese subjects without *** impressively,the homeostasis metabolic assessment insulin resistance index was comparable between the two ***:The increase of age and WC had significant impact on the risk of NAFLD in nonobese *** presence of NAFLD in nonobese subjects increased the risk of metabolic diseases than obese subjects without NAFLD,especially in female.