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Impact of intracellular innate immune receptors on immunometabolism

Cellular & Molecular Immunology 2022年第3期19卷 337-351页

作者： wei-chun chou Elena Rampanelli Xin Li Jenny P-Y.Ting Lineberger Comprehensive Cancer Center University of North Carolina at Chapel HillChapel HillNC27599USA Department of Genetics University of North Carolina at Chapel HillChapel HillNC27599USA Amsterdam UMC(University Medical Center location AMC)Department of Experimental Vascular MedicineAGEM(Amsterdam Gastroenterology Endocrinology Metabolism)InstituteMeibergdreef 91105 AZAmsterdamThe Netherlands Comparative Immunology Research Center College of Veterinary MedicineChina Agricultural UniversityBeijing100193China

Immunometabolism,which is the metabolic reprogramming of anaerobic glycolysis,oxidative phosphorylation,and metabolite synthesis upon immune cell activation,has gained importance as a regulator of the homeostasis,activation,proliferation,and differentiation of innate and adaptive immune cell subsets that function as key factors in *** changes in epithelial and other stromal cells in response to different stimulatory signals are also crucial in infection,inflammation,cancer,autoimmune diseases,and metabolic *** crosstalk between the PI3K-AKT-mTOR and LKB1-AMPK signaling pathways is critical for modulating both immune and nonimmune cell *** bidirectional interaction between immune cells and metabolism is a topic of intense ***-like receptors(TLRs),cytokine receptors,and T and B cell receptors have been shown to activate multiple downstream metabolic ***,how intracellular innate immune sensors/receptors intersect with metabolic pathways is less well *** goal of this review is to examine the link between immunometabolism and the functions of several intracellular innate immune sensors or receptors,such as nucleotide-binding and leucine-rich repeat-containing receptors(NLRs,or NOD-like receptors),absent in melanoma 2(AIM2)-like receptors(ALRs),and the cyclic dinucleotide receptor stimulator of interferon genes(STING).We will focus on recent advances and describe the impact of these intracellular innate immune receptors on multiple metabolic *** appropriate,this review will provide a brief contextual connection to pathogenic infections,autoimmune diseases,cancers,metabolic disorders,and/or inflammatory bowel diseases.

关键词： Immunometabolism NLRs NLRP3/AIM2 inflammasomes innate sensors/receptors STING AKT-mTOR

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Eco-Environmental Impact Assessment of Pre-Leisure Beach Nourishment on the Benthic Invertebrate Community at Anping Coast

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China Ocean Engineering 2011年第2期25卷 215-236页

作者： chun-Han SHIH Yi-Yu KUO Ta-Jen CHU Wen-Chieh chou wei-Tse CHANG Ying-chou LEE Institute of Fisheries Science National Taiwan University Taipei 10617 China Department of Civil Engineering National Chiao Tung University Hsinchu 30010 China Department of Leisure and Recreation Management Chung Hua University Hsinchu 30012 China Department of Civil Engineering Chung Hua University Hsinchu 30012 China

In recent years, owing to global warming and the rising sea levels, beach nourishment and groin building have been increasingly employed to protect coastal land from shoreline erosion. These actions may degrade beach habitats and reduce biomass and invertebrate density at sites where they were employed. We conducted an eco-environmental evaluation at the Anping artificial beach-nourishment project area. At this site, sand piles within a semi-enclosed spur groin have been enforced by use of eco-engineering concepts since 2003. Four sampling sites were monitored during the study period from July 2002 to September 2008. The environmental impact assessment and biological investigations that we conducted are presented here. The results from this study indicate that both biotic （number of species, number of individual organisms, and Shannon-Wiener diversity） and abiotic parameters （suspended solids, biological oxygen demand, chemical oxygen demand, dissolved inorganic nitrogen, dissolved inorganic phosphorus, total phosphorus, total organic carbon, median diameter, and water content） showed significant differences before and after beach engineering construction. Biological conditions became worse in the beginning stages of the engineering but improved after the restoration work completion. This study reveals that the composition of benthic invertebrates changed over the study period, and two groups of organisms, Bivalvia and Gastropoda, seemed to be particularly suitable to this habitat after the semi-enclosed artificial structures completion.

关键词： beach nourishment benthic invertebrate eco-engineering ecological restoration spur groin

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The status evaluation of the permafrost environment along the Chaida'er-Muli Railway in southern Qilian Mountains in northern Qinghai Province,China

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Journal of Mountain Science 2016年第12期13卷 2124-2134页

作者： CAO wei SHENG Yu chou Ya-ling WU Ji-chun LI Jing WANG Sheng-ting State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences Key Laboratory of Disaster Prevention and Mitigation in Civil Engineering of Gansu Province Lanzhou University of Technology

Engineering construction has major influence on the permafrost *** paper analyzes the interaction between engineering construction and permafrost environment along the Chaidaer-Muli Railway(simply,CMR) based on the press-state-response(PSR) *** permafrost environmental system is divided into three subsystems,consisting of permafrost thermal stability,proneness to the freeze-thawing erosion and permafrost ecological *** subsystem considers its most important influencing *** Progression Method(CPM) is applied to calculate the current environment condition along the *** result indicates that:(1) as far as the thermal stability is concerned,most sections along the CMR are mainly concentrated in rank Ⅲ(fair situation),and a few in Ⅱ(good situation) and Ⅳ(bad situation),respectively;(2) for the proneness tothe freeze-thawing erosion,the entire railway route falls largely in rank Ⅱ(good situation);(3) along the CMR,the ecological fragility of the permafrost environment is in rank Ⅱ(good situation),or slightly fragile;(4) overall,the permafrost environments along the CMR are in rank Ⅲ(fair situation) or Ⅱcondition(good situation).In general,the permafrost environment along the CMR is *** is mainly because a series of active measures of protecting permafrost were taken for stabilizing the CMR foundation *** the one hand,we should try our best to minimize the influences that engineering activities have exerted on ecology and environment,on the other hand,the positive measures have made improvements to prevent the permafrost environment from deterioration.

关键词： Permafrost environment Press-stateresponse framework Catastrophe theory Chaida'erMu Railway Environmental impact

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Modeling of turbulent,isothermal and cryogenic cavitation under attached conditions

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Acta Mechanica Sinica 2010年第3期26卷 325-353页

作者： Chien-chou Tseng Yingjie wei GuoyuWang wei Shyy Department of Mechanical Engineering University of Michigan2350 Hayward Ann Arbor MI 48109 USA School of Astronautics Harbin Institute of Technology 92 West Da-Zhi Street Harbin 150001 China School of Vehicle and Transportation Engineering Beijing Institute of Technology 5 South Zhongguancun Street Beijing 100081 China Department of Aerospace Engineering University of Michigan 1320 Beal Ann Arbor MI 48109 USA

Cavitation is often triggered when the fluid pres- sure is lower than the vapor pressure at a local thermo- dynamic state. The present article reviews recent progress made toward developing modeling and computational strat- egies for cavitation predictions under both isothermal and cryogenic conditions, with an emphasis on the attached cav- ity. The review considers alternative cavitation models along Reynolds-averaged Navier-Stokes and very lager eddy simu- lation turbulence approaches to ensure that the computational tools can handle flows of engineering interests. Observing the substantial uncertainties associated with both modeling and experimental information, surrogate modeling strategies are reviewed to assess the implications and relative impor- tance of the various modeling and materials parameters. The exchange between static and dynamic pressures under the influence of the viscous effects can have a noticeable impact on the effective shape of a solid object, which can impact the cavitation structure. The thermal effect with respect to evaporation and condensation dynamics is examined to shed light on the fluid physics associated with cryogenic cav- itation. The surrogate modeling techniques are highlighted in the context of modeling sensitivity assessment. Keywords

关键词： Cavitation Cryogenic liquidThermal effects Turbulence model - Surrogate model

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Identifying Indicator Species in Habitats Created by Coastal Structures

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China Ocean Engineering 2010年第1期24卷 117-134页

作者： Yi-Yu KUO chun-Han SHIH Ying-chou LEE wei-Tse CHANG Ta-Jen CHU Department of Civil Engineering National Chiao Tung University Hsinchu 30010 China Institute of Fisheries Science National Taiwan University Taipei 10617 China Department of Leisure and Recreation Management Chung Hua Univershy Hsinchu 30012 China

In this paper, three approachs were developed to find indicator species from the habitat created by coastal structures. These approachs consist of a model of species co-occurrence probability, a model of k-environmental factor probability and a composite model. Simultaneously, a case study was conducted in Hsinchu Fishing Port of north-western Taiwan. Based on the aforementioned models, three primary producer species, Ahnfeltiopsis flabelliformis, Chondrus ocellatus and Sarcodia montagneana, were chosen as the indicator species which had the highest co-occurrence probabilities and showed greater tolerance to more critical environment. It is imperative to understand how the three species under particular co-occurring conditions and environmental factors influence the composition of sessile assemblages in coastal water. The results indicate that for the purpose of increasing biodiversity, these models are feasible to find indicator species of artificial structures, and to help make it possible to design coastal structures based on biological considerations. This study provides an innovative approach for further advanced application in the artificial habitat of coast management.

关键词： coastal structures indicator species sessile organisms ecological restoration

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Role of peripheral eosinophilia in acute exacerbation of chronic obstructive pulmonary disease

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World Journal of Clinical Cases 2020年第13期8卷 2727-2737页

作者： Chih-wei Wu chou-Chin Lan Po-chun Hsieh I-Shiang Tzeng Yao-Kuang Wu Division of Pulmonary Medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City 23142Taiwan Department of Chinese Medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City 23142Taiwan Department of Research Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City 23142Taiwan

BACKGROUND Eosinophil counts are a promising guide to systemic steroid administration for chronic obstructive pulmonary disease(COPD).AIM To study the role of peripheral eosinophilia in hospitalized patients with acute exacerbation of COPD(AECOPD).METHODS From January 2014 to May 2017,patients with AECOPD hospitalized in Taipei Tzu Chi Hospital were retrospectively stratified into two groups according to their peripheral eosinophil count:The EOS group(eosinophil count≥2%)and the non-EOS group(eosinophil count<2%).Demographics,comorbidities,laboratory data,steroid use,length of hospital stay,and COPD-related readmissions were compared between the *** A total of 625 patients were recruited,with 176 patients(28.2%)in the EOS *** EOS group showed a lower prevalence of infection,lower cumulative doses of prednisolone equivalents,shorter length of hospital stay,and higher number of COPD-related readmissions than the non-EOS *** were significantly linear correlations between eosinophil percentage and number of readmissions and between eosinophil percentage and length of hospital stay P<0.001,and a lower percent-predicted value of forced expiratory volume in one second(FEV1)were associated with shorter time to first COPD-related readmission[adjusted hazard ratio(***)=1.488,P<0.001;***=0.985,P<0.001,respectively].CONCLUSION The study findings suggest that the EOS group had the features of a shorter length of hospital stay,and lower doses of systemic steroids,but more frequent *** EOS group and lower percent-predicted FEV1 values were risk factors for shorter time to first COPD-related readmission.

关键词： Chronic obstructive pulmonary disease Exacerbation Eosinophil Readmission Systemic steroid Length of hospital stay Forced expiratory volume in one second

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Review of epidermal growth factor receptor-tyrosine kinase inhibitors administration to non-small-cell lung cancer patients undergoing hemodialysis

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World Journal of Clinical Cases 2022年第19期10卷 6360-6369页

作者： chou-Chin Lan Po-chun Hsieh chun-Yao Huang Mei-Chen Yang Wen-Lin Su Chih-wei Wu Yao-Kuang Wu Division of Pulmonary Medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City 23142Taiwan Department of Chinese Medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City 23142Taiwan

Non-small-cell lung cancer(NSCLC)causes significant mortality *** with chronic renal failure have an increased risk of developing *** Patients with chronic renal failure undergoing hemodialysis(HD)often exhibit poor performance,and chemotherapy is generally *** epidermal growth factor receptor(EGFR)-tyrosine kinase inhibitors(TKIs)are effective treatment agents for NSCLC ***,the benefits andadverse effects of EGFR-TKIs in NSCLC undergoing HD are *** are noclinical studies on the effects of EGFR-TKIs on NSCLC patients undergoing *** reviewed all previous case reports about EGFR-TKIs in NSCLC patientsundergoing *** is difficult to design studies about the effects of EGFR-TKIs inpatients undergoing HD,and this review is quite ***-TKIs are welltolerated in patients undergoing *** main routes of elimination of EGFRTKIsare metabolism via the liver,and renal elimination is *** doses and pharmacokinetics of these EGFR-TKIs for patientsundergoing HD are similar to those for patients with normal renal *** protein binding of EGFR-TKIs is very high,and it is not necessary toadjust the dose after *** conclusion,EGFR-TKIs are effective and welltolerated in patients undergoing HD.

关键词： Hemodialysis Non-small-cell lung cancer Epidermal growth factor receptor Tyrosine-kinase inhibitors

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Cholecystoenteric fistula in a patient with advanced gallbladder cancer: A case report and review of literature

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World Journal of Clinical Cases 2023年第36期11卷 8519-8526页

作者： chun-Yu Wang Sung-Hua Chiu wei-chou Chang Meng-Hsing Ho Ping-Ying Chang Department of General Medicine Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Radiology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of General Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Hematology/Oncology Department of Internal MedicineTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND Cholecystoenteric fistula(CEF)involves the formation of a spontaneous ano-malous tract between the gallbladder and the adjacent gastrointestinal *** gallbladder inflammation can lead to tissue necrosis,perforation,and *** most prevalent cause of CEF is chronic cholelithiasis,which rarely results from *** the symptoms and laboratory findings associated with CEF are nonspecific,the condition is often misdiagnosed,pre-senting a challenge to the surgeon when detected ***,a preoperative diagnosis of CEF is *** present the case of a 57-year-old male with advanced gallbladder cancer(GBC)who arrived at the emergency room with persistent vomiting,abdominal pain,and *** abdominopelvic computed tomography scan revealed a contracted gallbladder with bubbles in the fundus connected to the second por-tion of the duodenum and transverse *** suspected that GBC had invaded the adjacent gastrointestinal tract through a cholecystoduodenal fistula(CDF)or a cholecystocolonic fistula(CCF).He underwent multiple examinations,including esophagogastroduodenoscopy,an upper gastrointestinal series,colo-noscopy,and magnetic resonance cholangiopancreatography;the results of these tests con-firmed a diagnosis of synchronous CDF and *** patient underwent a Roux-en-Y gastrojejunostomy and loop ileostomy to address the severe adhesions that were previously observed to cover the second portion of the duodenum and hepatic flexure of the *** symptoms improved with supportive treatment while *** initiated oral targeted therapy with lenvatinib for further anticancer *** The combination of imaging and surgery can enhance preoperative diagnosis and alleviate symptoms in patients with GBC complicated by CEF.

关键词： Cholecystoenteric fistula Biliary enteric fistula Cholecystoduodenal fistula Cholecystocolonic fistula Gallbladder neoplasms Case report

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Risk factors predict microscopic extranodal tumor deposits in advanced stage Ⅲ colon cancer patients

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World Journal of Gastroenterology 2023年第11期29卷 1735-1744页

作者： Yi-Han Jhuang Yu-Ching chou Yu-chun Lin Je-Ming Hu Ta-wei Pu Chao-Yang Chen Division of Cardiovascular Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina School of Public Health National Defense Medical CenterTaipei 114TaiwanChina Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Division of Colorectal Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Division of Colorectal Surgery Tri-Service General Hospital Song-shan BranchNational Defense Medical CenterTaipei 114TaiwanChina

BACKGROUND Colorectal cancer is a frequent cause of cancer-related mortality in patients with lymph node or distant *** tumor deposits(TDs)are considered prognostically distinct from lymph node *** To investigate risk factors for extranodal TDs in stage III colon *** This was a retrospective cohort *** selected 155 individuals diagnosed with stage III colon cancer from the database of the Cancer Registry of the Tri-Service General *** patients were allocated into the groups with/without *** Cox regression analysis and Kaplan-Meier method were *** primary outcomes investigate the association between the covariates and extranodal TDs,and prognostic significance of the covariates regarding the *** There were 136 individuals in the non-N1c group and 19 individuals in the N1c *** with lymphovascular invasion(LVI)had a higher risk of *** survival rates of patients with and without LVI were 6.64 years and 8.61 years,respectively(P=0.027).The N1c patients without LVI had higher overall survival than those who with LVI(7.73 years vs 4.42 years,P=0.010).CONCLUSION Patients having stage III colon cancer with LVI have a higher probability of having TDs than those with stage III colon cancer without *** III colon cancer patients with TDs and LVI could have poor prognosis and outcome.

关键词： Colon cancer Tumor deposits Lymphovascular invasion Risk factor

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Comprehensive analysis and mitigation strategies for safety issues of sodium-ion batteries

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Rare Metals 2024年第4期43卷 1343-1349页

作者： Tao wei Xiao-Ling Xian Shi-Xue Dou wei Chen Shu-Lei chou Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou325035China Wenzhou Key Laboratory of Sodium-Ion Batteries Wenzhou University Technology Innovation Institute for Carbon NeutralizationWenzhou325035China Zhejiang Key Laboratory of Carbon Materials College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou325035China Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongInnovation CampusWollongongNSW2522Australia

Sodium-ion batteries show great potential as an alternative energy storage system,but safety concerns remain a major hurdle to their mass *** paper analyzes the key factors and mechanisms leading to safety issues,including thermal runaway,sodium dendrite,internal short circuits,and gas *** promising solutions are proposed,such as high-safety electrode materials in the cathode and anode,high-safety electrolytes,and external battery management *** in also we emphasize the importance of selecting appropriate analysis methods and developing reliable failure models while suggesting advanced machine learning tools for *** a comprehensive approach,this study offers valuable recommendations to optimize materials and solutions for improving the safety of sodium-ion batteries.

关键词： Sodium-ion batteries Safety issues Thermal runaway Sodium dendrites

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