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Age exerts a continuous effect in the outcomes of Asian breast cancer patients treated with breast-conserving therapy

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Cancer Communications 2018年第1期38卷 410-420页

作者： Fuh Yong Wong wei ying tham Wen Long Nei Cindy Lim Hui Miao Division of Radiation Oncology National Cancer Centre Singapore11 Hospital DriveSingapore 169610Singapore Saw Swee Hock School of Public Health National University of SingaporeSingaporeSingapore

Background:Asians are diagnosed with breast cancer at a younger age than Caucasians *** studied the effect of age on locoregional recurrence and the survival of Asian breast cancer patients treated with breast-conserving ***:Medical records of 2492 patients treated with breast-conserving therapy between 1989 and 2012 were *** Kaplan-Meier method was used to estimate locoregional recurrence,breast cancer-free survival,and breast cancer-specific survival *** rates were then compared using log-rank *** and age were modeled by Cox proportional *** polynomials were then used to test for non-linear relationships between age and ***:Patients≤40 years old were more likely to have locoregional recurrence than were older patients(Hazard ratio[HR]=2.32,P<0.001).Locoregional recurrence rates decreased year-on-year by 4%for patients with luminal-type breast cancers,compared with 8%for those with triple-negative ***,breast cancer-free survival rates increased year-on-year by 4%versus 8%for luminal-type and triple-negative cancers,*** cancer-spe-cific survival rates increased with age by 5%*** breast cancer-free survival and breast cancer-specific survival rates in patients with luminal cancers exhibited a non-linear(“L-shaped”)relationship-where decreasing age at presentation was associated with escalating risks of relapse and *** influence of age on overall survival was confounded by competing non-cancer deaths in older women,resulting in a“U-shaped”***:Young Asian breast cancer patients have a continuous year-on-year increase in rates of disease relapse and cancer deaths compared with older patients with no apparent threshold.

关键词： Breast cancer Breast-conserving therapy Locoregional recurrence Breast cancer-specific survival Breast cancer-free survival Younger age

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年龄对接受保乳治疗的亚洲乳腺癌患者结局的影响呈现连续性

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癌症 2018年第6期37卷 229-239页

作者： Fuh Yong Wong wei ying tham Wen Long Nei Cindy Lim Hui Miao Division of Radiation Oncology National Cancer Centre Singapore Saw Swee Hock School of Public Health National University of Singapore

背景与目的亚洲人被诊断为乳腺癌的年龄比高加索人年轻。我们研究了年龄对接受保乳治疗的亚洲乳腺癌患者的局部区域复发及生存期的影响。方法分析了1989年至2012年接受保乳治疗的2492例乳腺癌患者的病历。采用Kaplan-Meier法分析了局部... 详细信息

背景与目的亚洲人被诊断为乳腺癌的年龄比高加索人年轻。我们研究了年龄对接受保乳治疗的亚洲乳腺癌患者的局部区域复发及生存期的影响。方法分析了1989年至2012年接受保乳治疗的2492例乳腺癌患者的病历。采用Kaplan-Meier法分析了局部区域复发率、无乳腺癌生存期和乳腺癌特异生存期,log-rank检验进行差异比较。采用Cox比例风险回归模型分析了结局与年龄的关系。分段多项式函数法用于评估年龄与结局之间的非线性关系。结果年龄≤40岁的患者出现局部区域复发的可能性更大(风险比[hazard ratio,HR]=2.32,P<0.001)。管腔型乳腺癌局部区域复发率降低4%,同比三阴性乳腺癌降低8%。与之相似,管腔型和三阴性乳腺癌患者的无乳腺癌生存率分别增加4%和8%。乳腺癌特异生存率随年龄同比增加5%。管腔型乳腺癌患者的无乳腺癌生存率和乳腺癌特异生存率都呈非线性("L型")关系:递减的发病年龄与逐步增加的复发和死亡风险相关。在年老女性中年龄对总生存的影响受到非癌症死亡的混杂,导致"U-型"关系。结论与年老患者相比,年轻亚洲乳腺癌患者的疾病复发率和癌症死亡率呈持续逐年递增趋势,但无明显年龄阈值。

关键词：乳腺癌保乳治疗局部区域复发乳腺癌特异生存期无乳腺癌生存期较年轻

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu wei Wan Xiuqin Rao Yue Lin Gen wei Jun ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu wei Wu ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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谱系1和8重组猪繁殖与呼吸综合征病毒的分离鉴定与遗传进化分析

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动物医学进展 2025年第1期46卷 29-37页

作者：邹舟黎颖韦莹莹刘惠僮韦祖樟广西大学动物科学技术学院动物传染病与分子免疫学实验室广西南宁530005 广西壮族自治区兽用生物制品工程研究中心广西南宁530005 广西畜禽繁育与疾病防控重点实验室广西南宁530004

2023年从广西疑似发生猪繁殖与呼吸综合征病毒(PRRSV)感染猪场的病猪肺脏组织中分离到1株PRRSV,将其命名为GXWZ20230831。采用RT-PCR扩增其全基因组序列并测序,分析遗传进化特点。结果显示,GXWZ20230831能够在Marc-145细胞上增殖,且产... 详细信息

2023年从广西疑似发生猪繁殖与呼吸综合征病毒(PRRSV)感染猪场的病猪肺脏组织中分离到1株PRRSV,将其命名为GXWZ20230831。采用RT-PCR扩增其全基因组序列并测序,分析遗传进化特点。结果显示,GXWZ20230831能够在Marc-145细胞上增殖,且产生明显的细胞病变;该毒株全基因组长度为15019个核苷酸(nt),与基因2型PRRSV谱系1 NADC30-like毒株的同源性最高,为94.0%,与基因1型PRRSV代表毒株Lelystad virus同源性最低,仅为60.0%;通过Nsp2氨基酸序列比对,结果发现GXWZ20230831存在NADC30-like典型的131(111+1+19)个氨基酸的不连续缺失模式;与美洲型代表株VR2332相比,GXWZ20230831的GP5蛋白在非中和抗原表位发生了V27A、V185A以及R191K 3处突变,同时在GP5蛋白中存在4个潜在的N-糖基化位点;构建的全基因组序列、nsp2基因、ORF5基因遗传进化树均显示该毒株处于谱系1的分支;重组分析表明,GXWZ20230831是1株以谱系1经典毒株NADC30为骨架,谱系8毒株提供重组片段的重组毒株,重组断点位于基因组的nsp1(458-1821 nt)和Nsp4(5405-8179 nt)中。研究结果可为掌握广西地区的PRRSV遗传变异规律提供参考,为制定防控措施提供科学依据。

关键词：猪繁殖与呼吸综合征病毒分离鉴定重组遗传进化分析

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Electrochemical mechanism of high Na-content P2-type layered oxides for sodium-ion batteries

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Rare Metals 2020年第4期39卷 332-334页

作者： ying Yang wei-Feng wei State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

The development on capacity and structure issues of P2-type cathode has so far focused on ion-doping/substitution *** a recent report published in Journal of the American Chemical Society,Hu and colleagues demonstrate... 详细信息

关键词： Na-content P2-type sodium-ion batteries structure

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Peptide hydrogelation triggered by enzymatic induced pH switch

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Science China(Physics,Mechanics & Astronomy) 2016年第7期59卷 76-81页

作者： wei Cheng ying Li Nanjing Stomatological Hospital Medical School of Nanjing University Jiangsu Engineering Technology Research Centre of Environmental Cleaning Materials Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution ControlJiangsu Joint Laboratory of Atmospheric Pollution ControlCollaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science &Technology National Laboratory of Solid State Microstructures Nanjing University

It remains challenging to develop methods that can precisely control the self-assembling kinetics and thermodynamics of peptide hydrogelators to achieve hydrogels with optimal *** we report the hydrogelation of peptide hydrogelators by an enzymatically induced pH switch,which involves the combination of glucose oxidase and catalase with D-glucose as the substrate,in which both the gelation kinetics and thermodynamics can be controlled by the concentrations of *** novel hydrogelation method could result in hydrogels with higher mechanical stability and lower hydrogelation *** further illustrate the application of this hydrogelation method to differentiate different D-glucose levels.

关键词： glucose oxidase and catalase peptide hydrogel pH switch mechanical properties

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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan ying Liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

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Composite Quantile Estimation for Kink Model with Longitudinal Data

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Acta Mathematica Sinica,English Series 2023年第3期39卷 412-438页

作者： Chuang WAN wei ZHONG ying FANG School of Statistics and Data Science Nankai UniversityTianjin 300071P.R.China MOE Key Lab of Econometrics WISEDepartment of Statistics and Data ScienceSchool of EconomicsXiamen UniversityXiamen 361000P.R.China

Kink model is developed to analyze the data where the regression function is two-stage piecewise linear with respect to the threshold covariate but continuous at an unknown kink *** quantile regression for longitudinal data,kink point where the kink effect happens is often assumed to be heterogeneous across different ***,the kink point tends to be the same across different quantiles,especially in a region of neighboring quantile *** such homogeneity information could increase the estimation efficiency of the common kink *** this paper,we propose a composite quantile estimation approach for the common kink point by combining information from multiple neighboring *** normality of the proposed estimator is *** addition,we also develop a sup-likelihood-ratio test to check the existence of the kink effect at a given quantile level.A test-inversion confidence interval for the common kink point is also developed based on the quantile rank score *** simulation studies show that the proposed composite kink estimator is more efficient than the single quantile regression *** also illustrate the proposed method via an application to a longitudinal data set on blood pressure and body mass index.

关键词： Asymptotical normality composite quantile estimation estimation efficiency kink design model longitudinal data

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Hierarchical Cluster Coordination Control Strategy for Large-scale Wind Power Based on Model Predictive Control and Improved Multi-time-scale Active Power Dispatching

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Journal of Modern Power Systems and Clean Energy 2023年第3期11卷 827-839页

作者： ying Zhu Yanan Zhang Zhinong wei College of Energy and Electrical Engineering Hohai UniversityNanjing 210098China

The grid-connection of large-scale and high-penetration wind power poses challenges to the friendly dispatching control of the power *** coordinate the complicated optimal dispatching and rapid real-time control,this paper proposes a hierarchical cluster coordination control(HCCC)strategy based on model predictive control(MPC)*** the time-varying characteristics of wind power generation,the proposed HCCC strategy constructs an improved multitime-scale active power dispatching model,which consists of five parts:formulation of cluster dispatching plan,rolling modification of intra-cluster plan,optimization allocation of wind farm(WF),grouping coordinated control of wind turbine group(WTG),and real-time adjustment of single-machine *** time resolutions are sequentially given as 1 hour,30 min,15 min,5 min,and 1 *** addition,a combined predictive model based on complete ensemble empirical mode decomposition with adaptive noise(CEEMDAN),wavelet thresholding(WT),and least squares support vector machine(LSSVM)is *** fast predictive feature of this model cooperates with the HCCC strategy that effectively improves the predictive control *** results show that the proposed HCCC strategy enables rapid response to active power control(APC),and significantly improves dispatching control accuracy and wind power accommodation capabilities.

关键词： Wind power active power dispatching model predictive control(MPC) hierarchical control wind power prediction

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