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The Mechanism of Celastrol in the Treatment of Metastatic Lung Adenocarcinoma Revealed by Network Pharmacology and Molecular Docking

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Journal of Biosciences and Medicines 2024年第6期12卷 275-285页

作者： Caihua Zhang wei Du The First Affiliated Hospital of Yangtze University Jingzhou China Peoples Hospital Affiliated to Chongqing Three Gorges Medical College Chongqing China

Background: Celastrol is an active ingredient extracted from Traditional Chinese Medicine (TCM), which can restrain the progression of lung cancer, whereas its underlying mechanism is unclear. In our study, the underlying mechanism of celastrol in the treatment of lung adenocarcinoma (LUAD) with metastasis was investigated by network pharmacology and molecular docking. Method: Potential targets of celastrol were collected from TCMSP, Batman-TCM and GeneCard database, and its potential targets were predicted using the STP platform and the TargetNet server. Metastasis marker genes (MGs) were obtained from the HCMDB. The genes correlated with LUAD were gathered from the GeneCard and OMIM database. And the common targets among celastrol potential targets, MGs and LUAD were analyzed. The protein-protein interaction (PPI) networks were obtained from the STRING database. SangerBox and the Xiantao bioinformatics tool were applied to visualize GO and KEGG analysis. Molecular docking tested the binding affinity between celastrol and core genes. Result: A total of 107 targets of celastrol against metastasis LUAD were obtained. The core targets were obtained from the PPI network, namely AKT1, JUN, MYC, STAT3, IL6, TNF, NFKB1, BCL2, IL1B, and HIF1A. GO and KEGG enrichment analysis indicated celastrol for the treatment of metastasis LUAD most refers to cellular response to chemical stress, DNA-binding transcription factor binding, transcription regulator complex and pathways in cancer. And some of these targets are associated with differential expressions and survival rates in LUAD. Moreover, Molecular docking shows celastrol can bind with BCL2 well by hydrogen bond and hydrophobic interaction. Conclusion: This finding roundly expounded the core genes and potential mechanisms of celastrol for the treatment of metastasis LUAD, offering the theoretical basis and antitumor mechanism of TCM in the treatment of lung cancer.

关键词： Celastrol Lung Adenocarcinoma Metastasis Network Pharmacology Molecular Docking

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基于改进同态滤波的遥感图像去云算法

无线电工程 2015年第3期45卷 14-18页

作者：周小军郭佳周承仙谭薇甘肃工业职业技术学院甘肃天水741025 西安应用光学研究所陕西西安710065 厦门理工学院福建厦门361024

去云处理是遥感图像处理以及大气纠正的重要步骤。在研究传统同态滤波算法的基础上,通过构建一个适当的带阻滤波函数,提出一种新方法来滤除图像中的云雾。在Matlab软件大量实验的基础上,分别对高斯高通滤波、巴特沃斯高通滤波和提出的... 详细信息

去云处理是遥感图像处理以及大气纠正的重要步骤。在研究传统同态滤波算法的基础上,通过构建一个适当的带阻滤波函数,提出一种新方法来滤除图像中的云雾。在Matlab软件大量实验的基础上,分别对高斯高通滤波、巴特沃斯高通滤波和提出的新算法进行了比较,并结合主观和客观的评价方法对去云效果做出评价。结果表明,新算法优于传统滤波方法,且对于薄云图像效果更佳。

关键词：遥感图像同态滤波去云处理

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中国扁蜂亚科二新种(膜翅目:扁蜂科)

Entomotaxonomia 2024年第2期46卷 160-166页

作者：左传莘夏固成谭贝贝魏美才井冈山国家级自然保护区管理局江西井冈山343600 宁夏固原市六盘山林业局宁夏泾源756401 江西师范大学生命科学学院江西南昌330022

本文记述中国扁蜂亚科2新种:对斑齿扁蜂Onycholyda xiansui wei&Zuo ***.和初尘扁蜂Pamphilius chuchen wei&Xia ***.,前者发现于江西井冈山和湖南齐云山,后者发现于宁夏六盘山、陕西秦岭和湖北神农架。简要讨论了2个新种与近缘种类的... 详细信息

本文记述中国扁蜂亚科2新种:对斑齿扁蜂Onycholyda xiansui wei&Zuo ***.和初尘扁蜂Pamphilius chuchen wei&Xia ***.,前者发现于江西井冈山和湖南齐云山,后者发现于宁夏六盘山、陕西秦岭和湖北神农架。简要讨论了2个新种与近缘种类的形态差异。

关键词：扁蜂总科叶蜂齿扁蜂属扁蜂属分类

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地下矿无人驾驶铲运机系统设计与应用

金属矿山 2024年第7期 181-188页

作者：崔冰赵辉军魏威姜海博谭丽龙刘永春北方矿业有限责任公司北京100053 长沙迪迈科技股份有限公司湖南长沙410205 长沙施玛特迈科技有限公司湖南长沙410012 智能软硬件(嵌入式)长沙市新一代人工智能开放创新平台湖南长沙410012

随着我国矿产资源开发工作向深部发展,复杂的应力条件和恶劣的开采环境严重威胁到井下人员的安全,开采装备无人化是解决井下安全和效率问题的有效手段。结合自动驾驶和远程遥控技术,设计并应用了地下铲运机无人驾驶系统,在千米深井中实... 详细信息

随着我国矿产资源开发工作向深部发展,复杂的应力条件和恶劣的开采环境严重威胁到井下人员的安全,开采装备无人化是解决井下安全和效率问题的有效手段。结合自动驾驶和远程遥控技术,设计并应用了地下铲运机无人驾驶系统,在千米深井中实现了铲运机出矿作业的全流程无人化。在应用试验中,自动驾驶直线行驶的最大速度达10 km/h以上,转弯最大速度为3 km/h,远程遥控的延迟在10 ms以下。该系统可有效提高矿山生产效益、降低安全事故风险,并有助于推动我国矿山智能化转型升级。

关键词：自动驾驶远程遥控铲运机无人采矿智能化

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电力系统在线主动解列控制算法

广东电力 2011年第12期24卷 9-13,108页

作者：谭伟杨银国倪敬敏广东电网电力调度控制中心广东广州510600 清华大学电机系北京100084

对在线主动解列策略的判定及控制框架进行简要介绍,提出电力系统在线主动解列算法:借助机组分群情况确定各个孤岛的主要电源,按照发电机和负荷的功率分配关系,研究负荷分群算法和设计解列断面搜索算法,实现负荷分群;考虑孤岛中功率调节... 详细信息

对在线主动解列策略的判定及控制框架进行简要介绍,提出电力系统在线主动解列算法:借助机组分群情况确定各个孤岛的主要电源,按照发电机和负荷的功率分配关系,研究负荷分群算法和设计解列断面搜索算法,实现负荷分群;考虑孤岛中功率调节特性,计算各个孤岛的不平衡功率情况,确定进一步切机、切负荷控制措施;在IEEE标准系统及实际电力系统上对在线主动解列控制算法进行验证,分析其可行性和有效性。

关键词：主动解列解列断面潮流跟踪孤岛控制

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洋甘菊与其误用品黄花补血草的鉴别

西北药学杂志 2012年第2期27卷 104-106页

作者：徐芳谭为陈燕何江赵军新疆维吾尔自治区药物研究所乌鲁木齐830004

目的建立维吾尔药洋甘菊与其误用品黄花补血草的鉴别方法。方法采用性状、显微与理化鉴别的方法。结果洋甘菊与黄花补血草的性状鉴别特征为:洋甘菊花为头状花序,茎表面草绿色;黄花补血草花呈漏斗状或倒圆锥状,茎中空,表面浅褐色。显微... 详细信息

目的建立维吾尔药洋甘菊与其误用品黄花补血草的鉴别方法。方法采用性状、显微与理化鉴别的方法。结果洋甘菊与黄花补血草的性状鉴别特征为:洋甘菊花为头状花序,茎表面草绿色;黄花补血草花呈漏斗状或倒圆锥状,茎中空,表面浅褐色。显微特征区别:洋甘菊茎横切面可见厚角组织、中柱鞘维管束,黄花补血草茎横切面无厚角组织、中柱鞘维管束;粉末鉴别中洋甘菊的花粉粒外具钝刺状突起,黄花补血草花粉粒有的外壁有1列排列整齐的小型细胞。结论该研究结果可以作为两者的鉴别依据。

关键词：洋甘菊黄花补血草鉴别

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复方白毛藤提取液防治稻瘟病初报

中国农学通报 2007年第3期23卷 373-375页

作者：罗诗龙易国辉谭巍易图永湖南省新田县农业局新田425700 湖南农业大学生物安全科技学院长沙410128

通过室内毒力测定和温室盆栽试验探讨复方白毛藤提取液在植物病害防治上的作用。室内毒力测定发现,稀释500倍的复方白毛藤提取液对水稻纹枯病菌、油菜菌核病菌、小麦赤霉病菌、烟草炭疽病菌、水稻恶苗病菌、稻瘟病菌的菌丝生长抑制率分... 详细信息

通过室内毒力测定和温室盆栽试验探讨复方白毛藤提取液在植物病害防治上的作用。室内毒力测定发现,稀释500倍的复方白毛藤提取液对水稻纹枯病菌、油菜菌核病菌、小麦赤霉病菌、烟草炭疽病菌、水稻恶苗病菌、稻瘟病菌的菌丝生长抑制率分别是:26.2%、17.1%、43.2%、10.2%、33.2%、46.3%。盆栽试验发现稀释800倍的复方白毛藤提取液对稻瘟病具有一定的防治作用,防治效果为67.4%。研究表明复方白毛藤提取液是一种潜在的防治稻瘟病的植物性农药。

关键词：复方白毛藤提取液植物病原菌稻瘟病

Association between physical activity and risk of gastroesophageal reflux disease:A systematic review and meta-analysis

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Journal of Sport and Health Science 2024年第5期13卷 687-698页

作者： Chuting Yu Tinglu Wang Ye Gao Yunfei Jiao Huishan Jiang Yan Bian wei Wang Han Lin Lei Xin Luowei Wang Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 200433China National Clinical Research Center for Digestive Diseases(Shanghai) Shanghai 200433China

Background:Lifestyle plays an important role in preventing and managing gastroesophageal reflux disease(GERD).In response to the conflicting results in previous studies,we performed a systematic review and meta-analysis to investigate this ***:Relevant studies published until January 2023 were retrieved from 6 databases,and the prevalence of symptomatic gastroesophageal reflux(GER)or GERD was determined from the original studies.A random effects model was employed to meta-analyze the association by computing the pooled relative risk(RR)with 95%confidence intervals(95%CIs).Furthermore,subgroup and dose-response analyses were performed to explore subgroup differences and the association between cumulative physical activity(PA)time and ***:This meta-analysis included 33 studies comprising 242,850 participants.A significant negative association was observed between PA and the prevalence of symptomatic GER(RR=0.74,95%CI:0.66-0.83;p<0.01)or GERD(RR=0.80,95%CI:0.76-0.84;p<0.01),suggesting that engaging in PA might confer a protective benefit against *** analyses consistently indicated the presence of this association across nearly all subgroups,particularly among the older individuals(RR_(<40 years):RR_(≥40 years)=0.85:0.69,p<0.01)and smokers(RR_(smoker):RR_(non-smoker)=0.67:0.82,p=0.03).Furthermore,a dose-response analysis revealed that individuals who engaged in 150 min of PA per week had a 72.09%lower risk of developing ***:Maintaining high levels of PA decreased the risk of GERD,particularly among older adults and *** the recommended PA level of 150 min per week may significantly decrease the prevalence of GERD.

关键词： Physical activity Gastroesophageal reflux disease Prevalence Systematic review

Phase Ib study of anti-EGFR antibody(SCT200)in combination with anti-PD-1 antibody(SCT-I10A)for patients with RAS/BRAF wild-type metastatic colorectal cancer

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Cancer Biology & Medicine 2024年第7期21卷 636-650页

作者： Ming Bai Yao Lu Chunmei Shi Jianwei Yang wei Li Xianli Yin Chenghui Huang Lin Shen Liangzhi Xie Yi Ba Department of GI Medical Oncology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin Key Laboratory of Digestive CancerTianjin 300060China Fujian Medical University Union Hospital Fuzhou 350001China Fujian Provincial Cancer Hospital Fuzhou 350014China Cancer Center The First Hospital of Jilin UniversityChangchun 130021China Department of Medical Oncology Gastroenterology and Urology Hunan Cancer HospitalAffiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China Department of Oncology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Bejing)Peking University Cancer Hospital and InstituteBeijing 100142China Beijing Engineering Research Center of Protein and Antibody Sinocelltech Ltd.Bejing 100176China Department of Cancer Center Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100010China

Objective:This study evaluated the safety and efficacy of an anti-epidermal growth factor receptor(EGFR)antibody(SCT200)and an anti-programmed cell death 1(PD-1)antibody(SCT-I10A)as third-line or subsequent therapies in patients with rat sarcoma viral oncogene(RAS)/v-raf murine sarcoma viral oncogene homolog B(BRAF)wild-type(wt)metastatic colorectal cancer(mCRC).Methods:We conducted a multicenter,open-label,phase Ib clinical *** with histologically confirmed RAS/BRAF wt m CRC with more than two lines of treatment were enrolled and treated with SCT-I10A and *** primary endpoints were the objective response rate(ORR)and *** secondary endpoints included disease control rate(DCR),progression-free survival(PFS),and overall survival(OS).Results:Twenty-one patients were enrolled in the study through January 28,*** ORR was 28.57%and the DCR was 85.71%(18/21).The median PFS and OS were 4.14 and 12.84 months,*** treatment-related adverse events(TRAEs)were ***,compared with the monotherapy cohort from our previous phase I study evaluating SCT200 for RAS/BRAF wt m CRC in a third-line setting,no significant improvements in PFS and OS were observed in the combination ***:SCT200 combined with SCT-I10A demonstrated promising efficacy in previously treated RAS/BRAF wt m CRC patients with an acceptable safety *** head-to-head studies with larger sample sizes are needed to validate whether the efficacy and safety of combined anti-EGFR and anti-PD-1 therapy are superior to anti-EGFR monotherapy in the third-line setting.(Registration ***04229537).

关键词： Colorectal cancer SCT-I10A SCT200 epidermal growth factor receptor programmed cell death 1