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Maternal weight and its association with risk of overweight in offspring:a trajectory analysis from a birth cohort in China

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World Journal of Pediatrics 2024年第5期20卷 496-505页

作者： Rui Deng wei-Qin Li Xing-Xiu Li Liu-mei wei Jie Hu Jun-Hong Leng Bin Dong Institute of Child and Adolescent Health School of Public HealthPeking University Health Science CenterNo.38 Xueyuan RdHaidian DistrictBeijing100191China Tianjin Women and Children’s Health Center No.96 Guizhou RdHeping DistrictTianjin300070China Menzies Health Institute Queensland Griffith UniversityNathanQLD4111Australia

Background Most studies on the association of maternal pregnancy weight with offspring weight trajectory have a short follow-up *** study aimed to explore the associations of maternal prepregnancy body mass index(BMI)and gestational weight gain(GWG)with childhood weight trajectories in a 7-year birth *** A total of 946 mother–child pairs(467 boys and 479 girls)from a longitudinal birth cohort in Tianjin City,China,were included in this study,ranging from pregnancy to offspring at 7 *** outcome variable was defined as overweight or not overweight in offspring at the last round.A group-based trajectory model was applied to identify childhood BMI trajectory *** Five discrete BMI trajectory groups were identified and characterized as constant underweight(25.2%),constant normal weight(42.8%),and high or increasing trajectory[at risk of overweight(16.9%),progressive overweight(11.0%)and progressive obesity(4.1%)].Maternal prepregnancy overweight was associated with 1.72(95%CI 1.14–2.60,P=0.01)to 4.02(95%CI 1.94–8.36,Pweight[relative risk ratio(RRR)2.09,95%CI 1.27–3.46,P=0.004]and progressive obesity(RRR 3.33,95%CI 1.13–9.79,P=0.029).Children in all high or increasing trajectory groups were associated with greater overweight risk at the last round[risk ratios(RRs)ranged from 3.54(95%CI 2.53–4.95,Pweight and excessive gestational weight gain were associated with increasing or high-level childhood body mass index trajectories as well as a greater risk of overweight at 7 years.

关键词： Body-weight trajectory Child Gestational weight gain Overweight Pregnancy

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Activation of G-protein-coupled receptor 39 reduces neuropathic pain in a rat model

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Neural Regeneration Research 2024年第3期19卷 687-696页

作者： Longqing Zhang Xi Tan Fanhe Song Danyang Li Jiayi Wu Shaojie Gao Jia Sun Daiqiang Liu Yaqun Zhou wei mei Department of Anesthesiology Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Healthand Wuhan Clinical Research Center for Geriatric AnesthesiaTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Activated G-protein-coupled receptor 39(GPR39)has been shown to attenuate inflammation by interacting with sirtuin 1(SIRT1)and peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α).However,whether GPR39 attenuates neuropathic pain remains *** this study,we established a Sprague-Dawley rat model of spared nerve injury-induced neuropathic pain and found that GPR39 expression was significantly decreased in neurons and microglia in the spinal dorsal horn compared with sham-operated *** injection of TC-G 1008,a specific agonist of GPR39,significantly alleviated mechanical allodynia in the rats with spared nerve injury,improved spinal cord mitochondrial biogenesis,and alleviated *** changes were abolished by GPR39 small interfering RNA(siRNA),Ex-527(SIRT1 inhibitor),and PGC-1α*** together,these findings show that GPR39 activation ameliorates mechanical allodynia by activating the SIRT1/PGC-1αpathway in rats with spared nerve injury.

关键词： G-protein-coupled receptor 39(GPR39) neuroinflammation neuropathic pain nuclear respiratory factor 1(NRF1) peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α) sirtuin 1(SIRT1) spinal cord mitochondrial transcription factor A(TFAM)

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Radiofrequency ablation combined with transcatheter arterial chemoembolization for recurrent liver cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1756-1764页

作者： Jin-You Guo Li-Li Zhao Hui-Jun Cai Hui Zeng wei-Dong mei Department of Oncology The Second People's Hospital of Zhejiang Province Taizhou Yuhuan CityTaizhou 317605Zhejiang ProvinceChina Department of Interventional China's Zhejiang Province Tumor HospitalHangzhou 310000Zhejiang ProvinceChina

BACKGROUND The recurrence rate of liver cancer after surgery is *** ablation(RFA)combined with transcatheter arterial chemoembolization(TACE)is an effective treatment for liver cancer;however,its efficacy in recurrent liver cancer remains *** To investigate the clinical effect of TACE combined with RFA in the treatment of recurrent liver *** Ninety patients with recurrent liver cancer were divided into 2 groups according to treatment plan:Control(RFA alone);and experimental[TACE combined with RFA(TACE+RFA)].The incidence of increased alanine aminotransferase levels,complications,and other indices were compared between the two groups before and after the *** One month after the procedures,the short-term efficacy rate and Karnofsky Performance Status scores of the experimental group were significantly higher than those of the control group(P0.05).CONCLUSION TACE+RFA was effective for the treatment of recurrent liver cancer and significantly reduced AFP levels and improved various indices of liver function.

关键词： Transcatheter arterial chemoembolization Radiofrequency ablation Recurrent liver cancer Clinical efficacy Overall response rate Disease control rate

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先秦儒家、纵横家的道术异同及其历史评价

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济宁学院学报 2024年第1期45卷 56-62页

作者：梅伟武汉大学文学院湖北武汉430027

先秦儒家与纵横家在诸子争鸣的时代彼此诘难,又互相吸收。看似水火不容的两派,实则有着精神层面的共同点:不惧苦难并坚守志向、皆有辩才且不畏王权。但其行为方式又存在巨大分野:纵横家着眼于大争之世,运用纵横捭阖的实践哲学,彰显进取... 详细信息

先秦儒家与纵横家在诸子争鸣的时代彼此诘难,又互相吸收。看似水火不容的两派,实则有着精神层面的共同点:不惧苦难并坚守志向、皆有辩才且不畏王权。但其行为方式又存在巨大分野:纵横家着眼于大争之世,运用纵横捭阖的实践哲学,彰显进取精神;儒家则高扬先王之道,运用仁义礼仪的理论武器,显得迂阔而酸腐。在诸子博弈过程中,纵横家胜出并开启属于时代的义利之辩。因此,通过对二者道术异同的梳理与历史评价,从而更好地挖掘先秦纵横家的思想价值与进步意义。

关键词：儒家先王之道纵横家进取之道历史评价

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Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study

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Neural Regeneration Research 2024年第5期19卷 1126-1132页

作者： Hengxing Zhou Yongfu Lou Lingxiao Chen Yi Kang Lu Liu Zhiwei Cai David BAnderson wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang wei mei Yueming Song Yue Zhou Maosheng Xia Huan Wang Jie Zhao Guoyong Yin Tao Zhang Feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng Department of Orthopedics The Second HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Shandong University Center for OrthopedicsQilu HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Tianjin Medical University General HospitalInternational Science and Technology Cooperation Base of Spinal Cord InjuryTianjin Key Laboratory of Spine and Spinal CordTianjinChina Faculty of Medicine and Health The Back Pain Research TeamSydney Musculoskeletal HealthThe Kolling InstituteUniversity of SydneySydneyNSWAustralia Department of Spine Surgery Honghui HospitalXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General HospitalBeijingChina Faculty of Medicine and Health School of Health SciencesUniversity of SydneyNSWAustralia Sydney Spine Institute BurwoodSydneyNSWAustralia Laboratory of Epidemiology Tianjin Neurological InstituteDepartment of NeurologyTianjin Medical University General Hospital&Tianjin Neurological InstituteKey Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina Department of Orthopedics Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Department of Spinal Surgery The Third Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Spine Surgery Zhengzhou Orthopedics HospitalZhengzhouHenan ProvinceChina Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqingChina Department of Orthopedics The First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Spinal Surgery Shengj

Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even *** has the largest population of patients with traumatic spinal cord *** studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been *** the best of our knowledge,no national-level study of treatment status and economic burden has been *** retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national *** included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of *** epidemiological and clinical features,treatment status,and total and daily costs were *** in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression *** percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent *** 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 *** total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 ho

关键词： China clinical features costs epidemiology methylprednisolone sodium succinate methylprednisolone retrospective study traumatic spinal cord injury treatment

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大学生“双创”教育课程建设与实践育人融合研究——以省级创新创业示范校为例

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创新创业理论研究与实践 2024年第4期7卷 62-65页

作者：魏梅南京工程学院江苏南京211167

随着社会对“双创”型人才的需求日益迫切,高校作为人才培养的基地,应积极开展大学生“双创”教育和实践训练。课程是高校实施“双创”教育的关键载体,必须与时俱进。加强“双创”教育课程建设,优化和更新教学内容,改革教学方式方法及... 详细信息

随着社会对“双创”型人才的需求日益迫切,高校作为人才培养的基地,应积极开展大学生“双创”教育和实践训练。课程是高校实施“双创”教育的关键载体,必须与时俱进。加强“双创”教育课程建设,优化和更新教学内容,改革教学方式方法及搭建实践育人载体,以彰显课程的教育指导性作用,是至关重要的。当前,“双创”教育课程应顺应时代发展,改变传统教学模式,使用现代信息技术,整合优质网络资源,打造高质量网络“金课”,同时,融入实践训练,提升大学生的“双创”意识、素质和能力,促进大学生从想创业到敢创业。

关键词： “双创”教育网络课程实践育人融合建设方案人才培养

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新课标背景下英语课内外阅读教学的探索

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成才之路 2024年第21期 97-100页

作者：魏梅贵州省黔西市学生资助服务中心贵州毕节551500

新课标背景下,英语课内外阅读教学不再仅仅局限于知识传授,还要注重跨文化意识、批判性思维和创造性思维培养。教育体系的落差、教师角色的转变以及如何平衡课内外阅读资源等,都是英语阅读教学实施过程中需面对的挑战。为解决这些问题,... 详细信息

新课标背景下,英语课内外阅读教学不再仅仅局限于知识传授,还要注重跨文化意识、批判性思维和创造性思维培养。教育体系的落差、教师角色的转变以及如何平衡课内外阅读资源等,都是英语阅读教学实施过程中需面对的挑战。为解决这些问题,文章提出一系列教学探索方案,包括个性化教学、技术赋能、社群互动和跨学科联动,旨在为初中英语课内外阅读教学提供可行路径和策略。

关键词：新课标初中英语课内外阅读教学策略批判性创造性

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本科院校电子商务课程教学效果评价指标体系的构建

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黑龙江科学 2024年第1期15卷 72-74页

作者：魏梅西安思源学院西安710038

为构建本科院校电子商务课程教学效果评价指标体系,采用质性分析与量性分析相结合的研究方法进行调研,以数据结果为支撑开展研究。结果显示,教学效果评价指标的信效度水平较高,可以借助教学方法、教学能力、教学管理、教学质量等四个评... 详细信息

为构建本科院校电子商务课程教学效果评价指标体系,采用质性分析与量性分析相结合的研究方法进行调研,以数据结果为支撑开展研究。结果显示,教学效果评价指标的信效度水平较高,可以借助教学方法、教学能力、教学管理、教学质量等四个评价指标考察和评价电子商务课程的教学效果。为此,高校应重视社会需求的变化,通过问卷调查等方式收集教师和学生对电子商务课程教学效果评价指标的需求,利用权重计算其对评价指标的重要程度,实时调整教学效果评价指标。

关键词：教学能力教学管理教学质量

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电商环境下塑料物流包装选材策略分析

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塑料助剂 2024年第2期 54-57页

作者：魏梅西安思源学院商学院陕西西安710038

电商行业的快速发展给物流包装材料带来了新的挑战和机遇,探讨电商环境下塑料物流包装的选材,对电商产业发展具有重要意义。通过收集、整理和分析相关资料,了解电商环境下物流包装的作用及其面临的挑战,分析塑料物流包装在电商领域的应... 详细信息

电商行业的快速发展给物流包装材料带来了新的挑战和机遇,探讨电商环境下塑料物流包装的选材,对电商产业发展具有重要意义。通过收集、整理和分析相关资料,了解电商环境下物流包装的作用及其面临的挑战,分析塑料物流包装在电商领域的应用优势与可行性。同时,根据电商产业物流需求,从合规性、环保性、成本效益几个方面,分析了塑料物流包装的选材策略。因此,电商产业选择塑料物流包装时,应优先选择可降解和可循环利用的材料,以减少对环境的影响,综合考虑包装材料的价格、运输成本和包装效率等经济因素,根据商品的特性和运输环境的需求,选择合适的包装材料,以确保商品在物流过程中的安全和完好,提升用户体验。

关键词：电子商务物流包装塑料包装

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贵州省水田土壤-水稻Hg含量特征与安全种植区划

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环境科学 2024年第5期45卷 3005-3015页

作者：韦美溜周浪黄燕玲庞瑞王佛鹏宋波桂林理工大学环境科学与工程学院桂林541004 桂林理工大学岩溶地区水污染控制与用水安全保障协同创新中心桂林541004

贵州省Hg储量和产量均居全国第一,水稻是其第一大粮食作物.为研究贵州省级尺度上土壤-水稻Hg含量特征与污染成因,并进行安全种植区划,采集土壤-水稻成对样品1564组,自然土样470个,水田土样203个,测试其Hg含量和土壤基本理化性质.结果表... 详细信息

贵州省Hg储量和产量均居全国第一,水稻是其第一大粮食作物.为研究贵州省级尺度上土壤-水稻Hg含量特征与污染成因,并进行安全种植区划,采集土壤-水稻成对样品1564组,自然土样470个,水田土样203个,测试其Hg含量和土壤基本理化性质.结果表明:①水田土壤pH呈中性偏酸为主,水田土壤ω(Hg)范围为0.005~93.06 mg·kg^(−1),几何平均值为0.864 mg·kg^(−1),显著高于自然土壤(0.16mg·kg^(−1),P<0.05);与筛选值和管制值比较,土壤样品超标率分别为63.25%和14.71%;就区域性而言,黔东南州的丹寨县、遵义市的务川县、黔西南州的贞丰县和铜仁市的万山区土壤Hg污染较为突出;②水稻ω(Hg)范围为0.0005~0.52 mg·kg^(−1),几何均值为0.010 mg·kg^(−1),水稻Hg含量超标率为25.87%,超标点位主要分布于遵义市的绥阳县、黔西南州的贞丰县、安顺市的西秀区和铜仁市的碧江区等工矿业活动密集区;③研究区绝大部分为优先保护类(占比为74.75%),安全利用类(占比为24.62%),严格管控类(占比为0.93%)零星分布在黔南州和黔东南州交界的丹寨县,黔西南州的贞丰县和铜仁市的万山地区,不建议种植水稻,稻米可作为饲料再生产.

关键词：贵州省汞(Hg) 水田土壤水稻安全种植区划

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