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CA IX-targeted Ag_(2)S quantum dots bioprobe for NIR-II imaging-guided hypoxia tumor chemo-photothermal therapy

Journal of Pharmaceutical Analysis 2024年第6期14卷 878-888页

作者： Xinyue Cui Zhuang Hu Ruihan Li Peng Jiang yongchang wei Zilin Chen Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan University and School of Pharmaceutical SciencesWuhan UniversityWuhan430071China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of EducationHubei Province Engineering and Technology Research Center for Fluorinated PharmaceuticalsWuhan430071China

Hypoxia is the common characteristic of almost all solid tumors,which prevents therapeutic drugs from reaching the ***,the development of new targeted agents for the accurate diagnosis of hypoxia tumors is widely *** carbonic anhydrase IX(CA IX)is abundantly distributed on the hypoxia tumor cells,it is considered as a potential tumor biomarker.4-(2-Aminoethyl)benzenesulfonamide(ABS)as a CA IX inhibitor has inherent inhibitory activity and good targeting *** this study,Ag_(2)S quantum dots(QDs)were used as the carrier to prepare a novel diagnostic and therapeutic bioprobe(Ag_(2)S@polyethylene glycol(PEG)-ABS)through ligand exchange and amide condensation ***_(2)S@PEG-ABS can selectively target tumors by surface-modified ABS and achieve accurate tumor imaging by the near infrared-II(NIR-II)fluorescence characteristics of Ag_(2)S *** modification of Ag_(2)S QDs greatly improves its water solubility and stability,and therefore achieves high photothermal stability and high photothermal conversion efficiency(PCE)of 45.17%.Under laser irradiation,Ag_(2)S@PEG-ABS has powerful photothermal and inherent antitumor combinations on colon cancer cells(CT-26)in *** also has been proved that Ag_(2)S@PEG-ABS can realize the effective treatment of hypoxia tumors in vivo and show good ***,it is a new efficient integrated platform for the diagnosis and treatment of hypoxia tumors.

关键词： CA IX-targeted Hypoxia tumor combination therapy NIR-II imaging Photothermal effect

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Prioritization of risk genes in colorectal cancer by integrative analysis of multi-omics data and gene networks

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Science China(Life Sciences) 2024年第1期67卷 132-148页

作者： Ming Zhang Xiaoyang Wang Nan Yang Xu Zhu Zequn Lu Yimin Cai Bin Li Ying Zhu Xiangpan Li yongchang wei Shaokai Zhang Jianbo Tian Xiaoping Miao Department of Epidemiology and Biostatistics School of Public HealthDepartment of Gastrointestinal OncologyZhongnan Hospital of Wuhan UniversityDepartment of Radiation OncologyRenmin Hospital of Wuhan UniversityTaiKang Center for Life and Medical SciencesWuhan UniversityWuhan 430071China Research Center of Public Health Renmin hospital of Wuhan UniversityWuhan UniversityWuhan 430060China Department of Cancer Epidemiology The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalHenan Engineering Research Center of Cancer Prevention and ControlHenan International Joint Laboratory of Cancer PreventionZhengzhou 450008China Department of Gastrointestinal Surgery Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Radiation Oncology Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Gastrointestinal Oncology Hubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhan 430062China Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430073China Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing 211166China

Genome-wide association studies(GWASs)have identified over 140 colorectal cancer(CRC)-associated loci;however,target genes at the majority of loci and underlying molecular mechanisms are poorly ***,we utilized a Bayesian approach,integrative risk gene selector(iRIGS),to prioritize risk genes at CRC GWAS loci by integrating multi-omics *** a result,a total of 105 high-confidence risk genes(HRGs)were identified,which exhibited strong gene dependencies for CRC and enrichment in the biological processes implicated in *** the 105 HRGs,CEBPB,located at the 20q13.13 locus,acted as a transcription factor playing critical roles in *** subsequent assays indicated the tumor promoter function of CEBPB that facilitated CRC cell proliferation by regulating multiple oncogenic pathways such as MAPK,PI3K-Akt,and Ras ***,by integrating a fine-mapping analysis and three independent case-control studies in Chinese populations consisting of 8,039 cases and 12,775 controls,we elucidated that rs1810503,a putative functional variant regulating CEBPB,was associated with CRC risk(OR=0.90,95%CI=0.86–0.93,P=1.07×10^(−7)).The association between rs1810503 and CRC risk was further validated in three additional multi-ancestry populations consisting of 24,254 cases and 58,741 ***,the rs1810503 A to T allele change weakened the enhancer activity in an allele-specific manner to decrease CEBPB expression via longrange promoter-enhancer interactions,mediated by the transcription factor,REST,and thus decreased CRC *** summary,our study provides a genetic resource and a generalizable strategy for CRC etiology investigation,and highlights the biological implications of CEBPB in CRC tumorigenesis,shedding new light on the etiology of CRC.

关键词： susceptibility genes gene screening models multi-omics GWAS CEBPB long-range promoter-enhancer interactions

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A genetic variant in the immune-related gene ERAP1 affects colorectal cancer prognosis

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Chinese Medical Journal 2024年第4期137卷 431-440页

作者： Danyi Zou Yimin Cai Meng Jin Ming Zhang Yizhuo Liu Shuoni Chen Shuhui Yang Heng Zhang Xu Zhu Chaoqun Huang Ying Zhu Xiaoping Miao yongchang wei Xiaojun Yang Jianbo Tian Department of Clinical Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Epidemiology and Biostatistics School of Public HealthTaiKang Center for Life and Medical SciencesWuhan UniversityWuhanHubei 430071China Department of Gastrointestinal Oncology Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Gastrointestinal Surgery Renmin Hospital of Wuhan UniversityWuhanHubei 430071China Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhanHubei 430071China Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Sciences and TechnologyWuhanHubei 430030China Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjingJiangsu 211166China

Background:Findings on the association of genetic factors and colorectal cancer(CRC)survival are limited and inconsistent,and revealing the mechanism underlying their prognostic roles is of great *** study aimed to explore the relationship between functional genetic variations and the prognosis of CRC and further reveal the possible ***:We first systematically performed expression quantitative trait locus(eQTL)analysis using The Cancer Genome Atlas(TCGA)***,the Kaplan-Meier analysis was used to filter out the survival-related eQTL target genes of CRC patients in two public datasets(TCGA and GSE39582 dataset from the Gene Expression Omnibus database).The seven most potentially functional eQTL single nucleotide polymorphisms(SNPs)associated with six survival-related eQTL target genes were genotyped in 907 Chinese CRC patients with clinical prognosis *** regulatory mechanism of the survival-related SNP was further confirmed by functional ***:The rs71630754 regulating the expression of endoplasmic reticulum aminopeptidase 1(ERAP1)was significantly associated with the prognosis of CRC(additive model,hazard ratio[HR]:1.43,95%confidence interval[CI]:1.08-1.88,P=0.012).The results of dual-luciferase reporter assay and electrophoretic mobility shift assay showed that the A allele of the rs71630754 could increase the binding of transcription factor 3(TCF3)and subsequently reduce the expression of *** results of bioinformatic analysis showed that lower expression of ERAP1 could affect the tumor immune microenvironment and was significantly associated with severe survival ***:The rs71630754 could influence the prognosis of CRC patients by regulating the expression of the immune-related gene *** Registration:***00454519(https://***/)

关键词： Colorectal cancer Prognosis Genetic variation Quantitative trait loci TCF3 rs71630754 Single nucleotide polymorphisms

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ADAM12、MUC3A和MUC17在胃癌中的表达及生存预后分析

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数理医药学杂志 2024年第8期37卷 600-609页

作者：李雨欣郭唐曦魏永长武汉大学中南医院胃肠肿瘤放化疗科武汉430071

目的探讨去整合素金属蛋白酶12(a disintergin and metalloprotease 12,ADAM12)、黏蛋白3A(mucin 3A,MUC3A)和黏蛋白17(mucin 17,MUC17)基因在胃癌中的表达及生存预后关系。方法收集癌症基因组图谱(The Cancer Genome Atlas,TCGA)、基因表达谱交互分析2(Gene Expression Profiling Interactive Analysis 2,GEPIA2)数据库信息,采用R 4.2.2和SPSS软件分析ADAM12、MUC3A和MUC17基因在胃癌中的差异性表达、生存预后关系、泛癌表达,以及不同临床病理特征与基因表达量之间的相关性。通过人类蛋白质图谱(Human Protein Atlas,HPA)数据库分析三种基因在正常组织中的表达水平。利用基因本体论(Gene Ontology,GO)和京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)功能富集分析评估三种基因在胃癌中的潜在功能。采用实时荧光定量聚合酶链反应(quantitative real-time polymerase chain reaction,q-PCR)进一步验证肿瘤组织与癌旁组织中ADAM12、MUC3A和MUC17的表达情况。结果生物信息学及q-PCR结果显示,ADAM12、MUC3A和MUC17在正常组织中表达量较低,在胃癌组织中表达量均被上调(P<0.05),且ADAM12在胃癌中伴随着不良预后(P<0.05)。三种基因在肿瘤相关通路富集,与胃癌的发生发展有关。结论ADAM12、MUC3A和MUC17在胃癌中高表达,其中ADAM12是胃癌预后的影响因素。三种基因参与肿瘤的进展,均有可能成为胃癌潜在的治疗靶点。

关键词：去整合素金属蛋白酶12 黏蛋白3A 黏蛋白17 胃癌生存预后靶向治疗

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淋巴瘤患者不同抑郁临床亚型与部分血液学指标的相关性分析

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武汉大学学报（医学版） 2024年第8期45卷 953-957页

作者：王新宇刘亚琼方倩玲刘攀魏永长李丹武汉大学中南医院肿瘤放化疗科湖北武汉430071

目的:分析淋巴瘤患者不同抑郁临床亚型抑郁程度与血液学指标的相关性。方法:对2022年1—8月在武汉大学中南医院住院治疗的74例淋巴瘤患者采用抑郁自评量表(SDS)自编问卷进行问卷调查,并收集调查当天患者的血液学指标。使用Pearson相关... 详细信息

目的:分析淋巴瘤患者不同抑郁临床亚型抑郁程度与血液学指标的相关性。方法:对2022年1—8月在武汉大学中南医院住院治疗的74例淋巴瘤患者采用抑郁自评量表(SDS)自编问卷进行问卷调查,并收集调查当天患者的血液学指标。使用Pearson相关分析患者的抑郁评分与血液学指标的相关性。结果:55.4%的淋巴瘤患者出现了抑郁表征。淋巴瘤患者的抑郁情绪评分与血清乳酸脱氢酶之间呈显著正相关(r=0.338,P=0.008),快感缺失与血清超氧化物歧化酶之间呈显著负相关(r=-0.239,P=0.040),认知抑郁与血清钙呈显著负相关(r=-0.211,P=0.036),躯体症状和红细胞之间呈显著负相关(r=-0.322,P=0.005)。结论:血清乳酸脱氢酶、超氧化物歧化酶、钙和红细胞计数4项指标可能分别是评估抑郁情绪、快感缺失、认知抑郁和躯体症状这4种亚型抑郁程度的潜在标志物。

关键词：淋巴瘤 SDS抑郁自评量表抑郁亚型血液学指标

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Nanofluidic memristor based on the elastic deformation of nanopores with nanoparticle adsorption

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National Science Review 2024年第04期11卷 46-54页

作者： Xi Zhou Yuanyuan Zong yongchang Wang Miao Sun Deli Shi wei Wang Guanghua Du Yanbo Xie Department of Chemistry and Chemical Engineering Northwestern Polytechnical University School of Physical Science and Technology Northwestern Polytechnical University School of Aeronautics and Institute of Extreme Mechanics Northwestern Polytechnical University Institute of Modern Physics Chinese Academy of Sciences

The memristor is the building block of neuromorphic computing. We report a new type of nanofluidic memristor based on the principle of elastic strain on polymer nanopores. With nanoparticles absorbed at the wall of a single conical polymer nanopore, we find a pinched hysteresis of the current within a scanning frequency range of 0.01–0.1 Hz, switching to a diode below 0.01 Hz and a resistor above 0.1 Hz. We attribute the current hysteresis to the elastic strain at the tip side of the nanopore, caused by electrical force on the particles adsorbed at the inner wall surface. Our simulation and analytical equations match well with experimental results, with a phase diagram for predicting the system transitions. We demonstrate the plasticity of our nanofluidic memristor to be similar to a biological synapse. Our findings pave a new way for ionic neuromorphic computing using nanofluidic memristors.

关键词： nanofluidics memristor neurocomputing elastic deformation

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Design Strategies for Aqueous Zinc Metal Batteries with High Zinc Utilization: From Metal Anodes to Anode-Free Structures

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Nano-Micro Letters 2024年第4期16卷 305-349页

作者： Xianfu Zhang Long Zhang Xinyuan Jia Wen Song yongchang Liu School of Materials Science and Engineering University of Science and Technology Beijing30 College RoadBeijing 100083People’s Republic of China Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyState Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China

Aqueous zinc metal batteries(AZMBs)are promising candidates for next-generation energy storage due to the excellent safety, environmental friendliness, natural abundance, high theoretical specific capacity, and low redox potential of zinc(Zn) metal. However,several issues such as dendrite formation, hydrogen evolution, corrosion, and passivation of Zn metal anodes cause irreversible loss of the active materials. To solve these issues, researchers often use large amounts of excess Zn to ensure a continuous supply of active materials for Zn anodes. This leads to the ultralow utilization of Zn anodes and squanders the high energy density of AZMBs. Herein, the design strategies for AZMBs with high Zn utilization are discussed in depth, from utilizing thinner Zn foils to constructing anode-free structures with theoretical Zn utilization of 100%, which provides comprehensive guidelines for further research. Representative methods for calculating the depth of discharge of Zn anodes with different structures are first summarized. The reasonable modification strategies of Zn foil anodes, current collectors with pre-deposited Zn, and anode-free aqueous Zn metal batteries(AF-AZMBs) to improve Zn utilization are then detailed. In particular, the working mechanism of AF-AZMBs is systematically introduced. Finally, the challenges and perspectives for constructing high-utilization Zn anodes are presented.

关键词： Aqueous zinc metal batteries Zinc anodes High zinc utilization Depth of discharge Anode-free structures

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安格斯牛和渤海黑牛杂交后代与渤海黑牛生产性能、肉质品质的比较研究

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中国畜禽种业 2024年第6期20卷 38-43页

作者：岳庆磊魏永昌李超任思凯张裕体李明贵袁方章峰陈托陈维滨山东省枣庄市台儿庄区畜牧水产服务中心山东枣庄277400 山东省枣庄市牧天牛养殖开发有限公司山东枣庄277400 山东省枣庄市台儿庄区农业农村事业发展中心山东枣庄277400

该试验旨在提高渤海黑牛的生产性能,利用引进的国际优秀肉牛品种黑色安格斯牛的冷冻精液与渤海黑牛人工授精杂交,试验对安格斯牛×渤海黑牛(安×渤) F1代牛和渤海黑牛的屠宰性能及肉质品质进行观测,并比较分析。结果表明:6月龄、 18月龄... 详细信息

该试验旨在提高渤海黑牛的生产性能,利用引进的国际优秀肉牛品种黑色安格斯牛的冷冻精液与渤海黑牛人工授精杂交,试验对安格斯牛×渤海黑牛(安×渤) F1代牛和渤海黑牛的屠宰性能及肉质品质进行观测,并比较分析。结果表明:6月龄、 18月龄、 24月龄时安×渤F1代牛的体重显著高于渤海黑牛(P0.05)。可见,利用安格斯牛与渤海黑牛杂交改良效果显著,可以提高后代胴体重、屠宰率,同时也可以提高牛肉的产量。

关键词：安格斯牛渤海黑牛安×渤F1代杂交效果屠宰性能肉质品质

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Multi-scale detector optimized for small target

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Optoelectronics Letters 2024年第4期20卷 243-248页

作者： ZHU yongchang YANG Sen TONG Jigang WANG Zenghui School of Electrical Engineering and Automation Tianjin University of TechnologyTianjin 300384China Center of Artificial Intelligence and Data Science University of South AfricaFlorida 1709South Africa Department of Electrical Engineering University of South AfricaFlorida 1709South Africa

The effectiveness of deep learning networks in detecting small objects is limited,thereby posing challenges in addressing practical object detection *** this research,we propose a small object detection model that operates at multiple *** model incorporates a multi-level bidirectional pyramid structure,which integrates deep and shallow networks to simultaneously preserve intricate local details and augment global ***,a dedicated multi-scale detection head is integrated into the model,specifically designed to capture crucial information pertaining to small *** comprehensive experimentation,we have achieved promising results,wherein our proposed model exhibits a mean average precision(mAP)that surpasses that of the well-established you only look once version 7(YOLOv7)model by 1.1%.These findings validate the improved performance of our model in both conventional and small object detection scenarios.

关键词： networks details thereby

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Recent advances and perspectives in MXene-based cathodes for aqueous zinc-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1752-1765页

作者： Aiduo Wu Tianhao Wang Long Zhang Chen Chen Qiaomin Li Xuanhui Qu yongchang Liu Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyState Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China School of Economics and Management University of Science and Technology BeijingBeijing 100083China

Aqueous zinc-ion batteries(AZIBs)show great potential for applications in grid-scale energy storage,given their intrinsic safety,cost effectiveness,environmental friendliness,and impressive electrochemical ***,strong electrostatic interactions exist between zinc ions and host materials,and they hinder the development of advanced cathode materials for efficient,rapid,and stable Zn-ion *** and their derivatives possess a large interlayer spacing,excellent hydrophilicity,outstanding electronic conductivity,and high redox *** materials are considered“rising star”cathode candidates for *** comprehensive review discusses recent advances in MXenes as AZIB cathodes from the perspectives of crystal structure,Zn-storage mechanism,surface modification,interlayer engineering,and conductive network design to elucidate the correlations among their composition,structure,and electrochemical *** work also outlines the remaining challenges faced by MXenes for aqueous Zn-ion storage,such as the urgent need for improved toxic preparation methods,exploration of potential novel MXene cathodes,and suppression of layered MXene restacking upon cycling,and introduces the prospects of MXene-based cathode materials for high-performance AZIBs.

关键词： aqueous zinc-ion batteries MXenes terminal groups interlayer engineering conductive network design

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