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Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu Hai-Feng zhou wei Yang Di Zhu Bi-Fei Wu Hai-Bin Shi Sheng Liu wei-Zhong zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis

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Masquelet technique using an allogeneic cortical bone graft for a large bone defect:A case report

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World Journal of Clinical Cases 2025年第5期13卷 36-43页

作者： Hai-Yang Zong Yu Liu Xing Yin wei zhou Nan Li Department of Orthopedics The People’s Liberation Army Joint Logistic Support Force 920th HospitalKunming 650032Yunnan ProvinceChina Department of Orthopedics 96603 Military Hospital of PLAHuaihua 418000Hunan ProvinceChina

BACKGROUND The induced-membrane technique was initially described by Masquelet as an effective treatment for large bone defects,especially those caused by ***,we report a case of chronic osteomyelitis of the radius associated with a 9 cm bone defect,which was filled with a large allogeneic cortical bone graft from a bone *** bony union was achieved after 14 months of *** studies have used autogenous bone as the primary bone source for the Masquelet technique;in our case,the exclusive use of allografts is as successful as the use of autologous bone *** the advent of bone banks,it is possible to obtain an unlimited amount of allograft,and the Masquelet technique may be further improved based on this new way of bone *** SUMMARY In this study,we reported a case of repair of a long bone defect in a 40-year-old male patient,which was characterized by the utilization of allograft cortical bone combined with the Masquelet technique for the treatment of the patient's long bone defect in the *** patient's results of functional recovery of the forearm were surprising,which further deepens the scope of application of Masquelet technique and helps to strengthen the efficacy of Masquelet technique in the treatment of long bones *** Allograft cortical bone combined with the Masquelet technique provides a new method of treatment to large bone defect.

关键词： Osteomyelitis Bone defect Allogeneic cortical bone Masquelet technique Membrane induction technique Case report

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Complex Dynamical Behaviors in a Dual Channel Supply Chain Model with Retailer's Service Input

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Journal of Systems Science & Complexity 2023年第3期36卷 1144-1168页

作者： ZHANG Yapeng zhou wei School of Mathematics and Physics Lanzhou Jiaotong UniversityLanzhou 730070China School of Traffic and Transportation Lanzhou Jiaotong UniversityLanzhou 730070China Key Laboratory of Railway Industry of Plateau Railway Transportation Intelligent Management and Control Lanzhou 730070China

Based on bounded rationality,this paper established a price game model of dual channel supply chain composed of manufacturers and *** to the eigenvalue of Jacobi matrix and Jury criterion,the stability of the equilibrium point is analyzed,and then the dynamic evolution process under the parameters of price adjustment speed and retailer's service input is studied through stability region,bifurcation diagram,maximum Lyapunov exponent diagram and attraction *** results show that the system enters chaos through flip and Neimark-Sacker bifurcation,and increase of price adjustment speed and service input value will make the system produce more dynamic *** addition,it can be found that the impact of service input value on itself is much greater than that on ***,when adjustment speed is selected as bifurcation parameter,the change curve of sales price is inconsistent,in which the change of retailers mainly remains in periodic state,while manufacturers will gradually enter ***,studies the evolution of attraction basin in which three kinds of attractors *** particular,coexistence of boundary attractors and internal attractors increases the complexity of ***,enterprises need to carefully adjust parameters of the game model to control the stability of system and maintain the long-term stability of market competition.

关键词： Bifurcation analysis boundary equilibrium coexistence of attractors flip bifurcation global bifurcation

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三七土壤参数测定及挖掘铲优化研究

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农机化研究 2025年第1期47卷 165-172页

作者：刘梦飞周伟李西兴湖北工业大学机械工程学院武汉430068

针对三七挖掘过程中挖掘铲所受阻力过大的问题,对传统的平面三七挖掘铲进行了优化。首先,对三七土壤参数进行了试验测定,并通过离散元仿真得到了土壤的堆积角,经试验验证所选土壤参数的准确性;其次,采用离散元软件EDEM建立了挖掘铲的仿... 详细信息

针对三七挖掘过程中挖掘铲所受阻力过大的问题,对传统的平面三七挖掘铲进行了优化。首先,对三七土壤参数进行了试验测定,并通过离散元仿真得到了土壤的堆积角,经试验验证所选土壤参数的准确性;其次,采用离散元软件EDEM建立了挖掘铲的仿真模型,计算了其在挖掘过程中所受到的阻力,通过与平面铲对比验证了该结构可以降低挖掘铲在行驶过程中所受到的阻力;再次,以行进过程中所受阻力为指标对挖掘铲进行优化,分析挖掘铲的铲面弧度、铲尖角度、铲的间距和入土角度等参数对挖掘阻力的影响,结果表明:铲面弧度为116°、铲尖角度为120°、铲的间距为86 mm、入土角度为12°时,挖掘阻力最小,相较于传统挖掘铲阻力降低了23.6%;最后,对优化后的挖掘铲进行了试验验证,结果表明:平均误差为2.78%,在5%以内,满足设计需求。研究结果可为块茎类农作物挖掘铲的设计提供参考。

关键词：挖掘铲三七阻力离散元

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Auto-normalization algorithm for robotic precision drilling system in aircraft component assembly

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Chinese Journal of Aeronautics 2013年第2期26卷 495-500页

作者： Tian wei zhou weixue zhou wei Liao Wenhe Zeng Yuanfan College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics

A novel approach is proposed to detect the normal vector to product surface in real time for the robotic precision drilling system in aircraft component assembly, and the auto-normalization algorithm is presented based on the detection system. Firstly, the deviation between the normal vector and the spindle axis is measured by the four laser displacement sensors installed at the head of the multi-function end effector. Then, the robot target attitude is inversely solved according to the auto-normalization algorithm. Finally, adjust the robot to the target attitude via pitch and yaw rotations about the tool center point and the spindle axis is corrected in line with the normal vector simultaneously. To test and verify the auto-normalization algorithm, an experimental platform is established in which the laser tracker is introduced for accurate measurement. The results show that the deviations between the corrected spindle axis and the normal vector are all reduced to less than 0.5°, with the mean value 0.32°. It is demonstrated the detection method and the autonormalization algorithm are feasible and reliable.

关键词： Aircraft assembly Auto-normalization Industrial robots Normal vector detection Robotic precision drilling

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Modeling and applying credible interval intuitionistic fuzzy reciprocal preference relations in group decision making

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Journal of Systems Engineering and Electronics 2017年第2期28卷 301-314页

作者： wei zhou Zeshui Xu Business School Sichuan University International Business School Yunnan University of Finance and Economics

Intuitionistic fuzzy preference relations are powerful techniques used to express uncertain preference information. However, simultaneously providing the exact priority and non-priority intensities could be difficult in real applications. A credible interval intuitionistic fuzzy number (CIIFN) is introduced and a credible interval intuitionistic fuzzy reciprocal preference relation (CIIFRPR) is developed to solve this issue. Unlike intuitionistic fuzzy preference relations, the new preference relations use the CIIFNs to express the preference information such that the decision makers simply provide the priority intensity with interval-valued numbers and calculate the non-preference intensity with the transformed method, which avoids a complex evaluation of non-priority information. Furthermore, some basic operations and comparison laws are investigated, based on which three credible interval intuitionistic fuzzy aggregation operators are proposed. Two models are presented to manage the group decision-making. Finally, a practical case is used to demonstrate the feasibility and reasonability of the proposed preference relations and aggregation operators. © 2017 Beijing Institute of Aerospace Information.

关键词： Fuzzy rules Fuzzy sets Mathematical operators

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Least-Squares Seismic Inversion with Stochastic Conjugate Gradient Method

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Journal of Earth Science 2015年第4期26卷 463-470页

作者： wei Huang Hua-wei zhou Department of Earth & Atmospheric Sciences University of Houston College of Marine Geosciences Ocean University of China

With the development of computational power, there has been an increased focus on data-fitting related seismic inversion techniques for high fidelity seismic velocity model and image, such as full-waveform inversion and least squares migration. However, though more advanced than conventional methods, these data fitting methods can be very expensive in terms of computational cost. Recently, various techniques to optimize these data-fitting seismic inversion problems have been implemented to cater for the industrial need for much improved efficiency. In this study, we propose a general stochastic conjugate gradient method for these data-fitting related inverse problems. We first prescribe the basic theory of our method and then give synthetic examples. Our numerical experiments illustrate the potential of this method for large-size seismic inversion application.

关键词： least-squares seismic inversion stochastic conjugate gradient method data fitting,Kirchhoff migration.

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Abelian Subgroup Separability of Certain Generalized Free Products of Groups

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Algebra Colloquium 2020年第4期27卷 651-660页

作者： wei zhou Goansu Kim School of Mathematics and Statistics Southwest University Chongqing 400715China Yeungnam University Kyongsan712-749Korea

We prove that generalized free products of certain abelian subgroup separable groups are abelian subgroup *** this,we show that tree products of polycyclic-by-finite groups,amalgamating central subgroups or retracts a... 详细信息

关键词： subgroup separable residually finite generalized free products tree products retracts

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Ullmann-Ma Reaction:Development,Scope and Applications in Organic Synthesis

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Chinese Journal of Chemistry 2020年第8期38卷 879-893页

作者： Qian Cai wei zhou College of Pharmacy Jinan UniversityNo.601 Huangpu Avenue WestGuangzhouGuangdong 510632China

Copper-catalyzed cross-couplings of aryl halides and nucleophiles,traditionally called Ullmann-type coupling reactions,were initially reported by Ullmann et *** 1901-1929.A seminal report in 1998 by Ma et *** Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences revealed an accelerating effect caused by amino acids,which brought Ullmann-type coupling reactions into a ligand-accelerating *** 1999 to the first 10 years of 2000s,the first-generation ligands were developed by many researchers and promoted Ullmann-type coupling reactions of aryl iodides and bromides under relatively mild *** acid ligands,developed by Ma and coworkers,are one class of the most important first-generation *** the second 10 years of 2000s,Ma et *** the discovery of second-generation ligands for copper-catalyzed cross-coupling *** great breakthroughs have been realized by using second-generation oxalic diamide and related amide ligands,with aryl chlorides as general coupling partner and with low catalyst *** copper-catalyzed cross coupling reactions of aryl halides and nucleophiles with amino acids or oxalic diamides and related amides as ligands are recognized as Ullmann-Ma reactions and have found extensive applications in organic synthesis.

关键词： synthesis coupling Ullmann

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2D all-organic perovskites refine flexible electronics

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Science China Materials 2024年第7期67卷 2365-2366页

作者： wei zhou Bing Chen College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China

Recent years have witnessed a paradigm shift with the advent of perovskites,a class of materials with a distinct CaTiO_(3)-type crystalline structure that show remarkable promise across a wide array of applications,including photovoltaics,photodetectors,lighting,lasers,and so *** them,the development of two-dimensional(2D)perovskites has garnered significant attention due to their tunable structures(mainly Dion-Jacobson and Ruddlesden-Popper structures)and enhanced stability in comparison with their 3D counterparts[1].Amidst the burgeoning research on perovskites,on the other side,all-organic perovskites stand out as a particularly intriguing subset[2].Unlike traditional perovskites that typically comprise all-inorganic(e.g.,CsPbBr_(3))or organic-inorganic hybrid components(e.g.,(PEA)_(2)PbI_(4)),all-organic perovskites are composed entirely of carbon-or nitrogen-based molecules.

关键词： perovskite inorganic entirely

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